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30 results on '"Previato, Jose Osvaldo"'

1. A novel protocol for the synthesis of 1,2,4-oxadiazoles active against trypanosomatids and drug-resistant leukemia cell lines

Author

Pitasse-Santos, Paulo, Salustiano, Eduardo, Pena, Raynna Bittencourt, Chaves, Otavio Augusto, Fonseca, Leonardo Marques da, da Costa, Kelli Monteiro, Nascimento Santos, Carlos Antonio do, Reis, Jhenifer Santos Dos, Santos, Marcos Andre Rodrigues da Costa, Previato, Jose Osvaldo, Previato, Lucia Mendonca, Freire-de-Lima, Leonardo, Romeiro, Nelilma Correia, Pinto-da-Silva, Lucia Helena, Freire-de-Lima, Celio G, Decote-Ricardo, Debora, and Freire-de-Lima, Marco Edilson

Published
2022

2. Effect of liming in plinthic and petroplinthic soils for soybean cultivation in the brazilian savanna

Author

da Costa Leite, Olavo, Silva da Luz, Joao Henrique, Lima, Saulo de Oliveira, da Silva, Rubens Ribeiro, Fidelis, Rodrigo Ribeiro, Manhaes, Carmen Maria Coimbra, Peluzio, Joenes Mucci, Previato, Jose Osvaldo, dos Santos, Mauro Gomes, de Oliveira Pinto, Ismael, de Araujo Filho, Renisson Neponuceno, da Silva, Allan Deyvid Pereira, Cachoeira, Jader Nunes, and Scheidt, Gessiel Newton

Published
2024

4. Expression of O-glycosylated oncofetal fibronectin in alternatively activated human macrophages

Author

da Costa Santos, Marcos Andre Rodrigues, dos Reis, Jhenifer Santos, do Nascimento Santos, Carlos Antonio, da Costa, Kelli Monteiro, Barcelos, Pedro Marçal, de Oliveira Francisco, Karen Queiroz, Barbosa, Pedro Antônio Guimarães Notaroberto, da Silva, Emanuelle Damasceno Souza, Freire-de-Lima, Celio Geraldo, Morrot, Alexandre, Decote-Ricardo, Debora, Diniz-Lima, Israel, Previato, Jose Osvaldo, Mendonca-Previato, Lucia, da Fonseca, Leonardo Marques, and Freire-de-Lima, Leonardo

Published
2023
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5. Correction to: Expression of O-glycosylated oncofetal fibronectin in alternatively activated human macrophages

Author

da Costa Santos, Marcos Andre Rodrigues, dos Reis, Jhenifer Santos, do Nascimento Santos, Carlos Antonio, da Costa, Kelli Monteiro, Barcelos, Pedro Marçal, de Oliveira Francisco, Karen Queiroz, Barbosa, Pedro Antônio Guimarães Notaroberto, da Silva, Emanuelle Damasceno Souza, Freire-de-Lima, Celio Geraldo, Morrot, Alexandre, Decote-Ricardo, Debora, Diniz-Lima, Israel, Previato, Jose Osvaldo, Mendonca-Previato, Lucia, da Fonseca, Leonardo Marques, and Freire-de-Lima, Leonardo

Published
2023
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6. The role of Toll-like receptor 9 in a murine model of Cryptococcus gattii infection

Author

da Silva-Junior, Elias Barbosa, Firmino-Cruz, Luan, Guimarães-de-Oliveira, Joyce Cristina, De-Medeiros, Juliana Valente Rodrigues, de Oliveira Nascimento, Danielle, Freire-de-Lima, Matheus, de Brito-Gitirana, Lycia, Morrot, Alexandre, Previato, Jose Osvaldo, Mendonça-Previato, Lucia, Decote-Ricardo, Debora, de Matos Guedes, Herbert Leonel, and Freire-de-Lima, Celio Geraldo

Published
2021
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7. X-linked immunodeficient (XID) mice exhibit high susceptibility to Cryptococcus gattii infection

Author

Diniz-Lima, Israel, da Rosa, Pablo Rodrigo, da Silva-Junior, Elias Barbosa, Guimarães-de-Oliveira, Joyce Cristina, de Freitas, Elisangela Oliveira, de Oliveira Nascimento, Danielle, Morrot, Alexandre, Nimrichter, Leonardo, Previato, Jose Osvaldo, Mendonça-Previato, Lucia, Freire-de-Lima, Leonardo, Decote-Ricardo, Debora, and Freire-de-Lima, Celio Geraldo

Published
2021
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8. Increased expression of the pathological O-glycosylated form of oncofetal fibronectin in the multidrug resistance phenotype of cancer cells

Author

Reis, Jhenifer Santos dos, primary, Santos, Marcos André Rodrigues da Costa, additional, da Costa, Kelli Monteiro, additional, Freire-de-Lima, Celio Geraldo, additional, Morrot, Alexandre, additional, Previato, Jose Osvaldo, additional, Previato, Lucia Mendonça, additional, da Fonseca, Leonardo Marques, additional, and Freire-de-Lima, Leonardo, additional

Published
2023
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9. The Blessed Union of Glycobiology and Immunology: A Marriage That Worked

Author

dos Reis, Jhenifer Santos, primary, Diniz-Lima, Israel, additional, Santos, Marcos André Rodrigues da Costa, additional, Barcelos, Pedro Marçal, additional, da Costa, Kelli Monteiro, additional, Valente, Raphael do Carmo, additional, Chaves, Lorrane de Souza, additional, de Campos, Luma Petel, additional, dos Santos, Ariely Costa, additional, Correia de Lima, Rafaela Gomes, additional, Decote-Ricardo, Debora, additional, Morrot, Alexandre, additional, Previato, Jose Osvaldo, additional, Mendonça-Previato, Lucia, additional, Freire-de-Lima, Celio Geraldo, additional, Fonseca, Leonardo Marques da, additional, and Freire-de-Lima, Leonardo, additional

Published
2023
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10. Involvement of the capsular GalXM-induced IL-17 cytokine in the control of Cryptococcus neoformans infection

Author

LaRocque-de-Freitas, Isabel Ferreira, Rocha, Juliana Dutra B., Nunes, Marise Pinheiro, Oliveira, Priscila Angelica V., Nascimento, Danielle de Oliveira, Freire-de-Lima, Leonardo, Takiya, Christina Maeda, Morrot, Alexandre, Decote-Ricardo, Debora, Previato, Jose Osvaldo, DosReis, George A., Mendonça-Previato, Lucia, and Freire-de-Lima, Celio Geraldo

Published
2018
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11. Correction to: Expression of O-glycosylated oncofetal fibronectin in alternatively activated human macrophages

Author

da Costa Santos, Marcos Andre Rodrigues, primary, dos Reis, Jhenifer Santos, additional, do Nascimento Santos, Carlos Antonio, additional, da Costa, Kelli Monteiro, additional, Barcelos, Pedro Marçal, additional, de Oliveira Francisco, Karen Queiroz, additional, Barbosa, Pedro Antônio Guimarães Notaroberto, additional, da Silva, Emanuelle Damasceno Souza, additional, Freire-de-Lima, Celio Geraldo, additional, Morrot, Alexandre, additional, Decote-Ricardo, Debora, additional, Diniz-Lima, Israel, additional, Previato, Jose Osvaldo, additional, Mendonca-Previato, Lucia, additional, da Fonseca, Leonardo Marques, additional, and Freire-de-Lima, Leonardo, additional

Published
2022
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12. Expression of O-glycosylated oncofetal fibronectin in alternatively activated human macrophages

Author

da Costa Santos, Marcos Andre Rodrigues, primary, dos Reis, Jhenifer Santos, additional, do Nascimento Santos, Carlos Antonio, additional, da Costa, Kelli Monteiro, additional, Barcelos, Pedro Marçal, additional, de Oliveira Francisco, Karen Queiroz, additional, Barbosa, Pedro Antônio Guimarães Notaroberto, additional, da Silva, Emanuelle Damasceno Souza, additional, Freire-de-Lima, Celio Geraldo, additional, Morrot, Alexandre, additional, Decote-Ricardo, Debora, additional, Diniz-Lima, Israel, additional, Previato, Jose Osvaldo, additional, Mendonca-Previato, Lucia, additional, da Fonseca, Leonardo Marques, additional, and Freire-de-Lima, Leonardo, additional

Published
2022
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14. Cryptococcus: History, Epidemiology and Immune Evasion

Author

Diniz-Lima, Israel, primary, Fonseca, Leonardo Marques da, additional, Silva-Junior, Elias Barbosa da, additional, Guimarães-de-Oliveira, Joyce Cristina, additional, Freire-de-Lima, Leonardo, additional, Nascimento, Danielle Oliveira, additional, Morrot, Alexandre, additional, Previato, Jose Osvaldo, additional, Mendonça-Previato, Lucia, additional, Decote-Ricardo, Debora, additional, and Freire-de-Lima, Celio Geraldo, additional

Published
2022
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15. Glycobiology of Cancer: Sugar Drives the Show

Author

dos Reis, Jhenifer Santos, primary, Rodrigues da Costa Santos, Marcos André, additional, Mendonça, Daniella Pereira, additional, Martins do Nascimento, Stefani Ingrid, additional, Barcelos, Pedro Marçal, additional, Correia de Lima, Rafaela Gomes, additional, da Costa, Kelli Monteiro, additional, Freire-de-Lima, Celio Geraldo, additional, Morrot, Alexandre, additional, Previato, Jose Osvaldo, additional, Mendonça Previato, Lucia, additional, da Fonseca, Leonardo Marques, additional, and Freire-de-Lima, Leonardo, additional

Published
2022
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17. Non-self glycan structures as possible modulators of cancer progression: would polysaccharides from Cryptococcusspp. impact this phenomenon?

Author

Diniz-Lima, Israel, da Fonseca, Leonardo Marques, Dos Reis, Jhenifer Santos, Decote-Ricardo, Debora, Morrot, Alexandre, Previato, Jose Osvaldo, Previato, Lucia Mendonça, Freire-de-Lima, Celio Geraldo, and Freire-de-Lima, Leonardo

Abstract

Invasive fungal infections (IFI) are responsible for a large number of annual deaths. Most cases are closely related to patients in a state of immunosuppression, as is the case of patients undergoing chemotherapy. Cancer patients are severely affected by the worrisome proportions that an IFI can take during cancer progression, especially in an already immunologically and metabolically impaired patient. There is scarce knowledge about strategies to mitigate cancer progression in these cases, beyond conventional treatment with antifungal drugs with a narrow therapeutic range. However, in recent years, ample evidence has surfaced describing the possible interferences that IFI may have both on the progression of pre-existing cancers and in the induction of newly transformed cells. The leading gambit for modulation of tumor progression comes from the ability of fungal virulence factors to modulate the host’s immune system, since they are found in considerable concentrations in the tumor microenvironment during infection. In this context, cryptococcosis is of particular concern, since the main virulence factor of the pathogenic yeast is its polysaccharide capsule, which carries constituents with high immunomodulatory properties and cytotoxic potential. Therefore, we open a discussion on what has already been described regarding the progression of cryptococcosis in the context of cancer progression, and the possible implications that fungal glycan structures may take in both cancer development and progression.

Published
2023
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18. Supplementary_material – Supplemental material for Resistance to paclitaxel induces glycophenotype changes and mesenchymal-to-epithelial transition activation in the human prostate cancer cell line PC-3

Author

Fonseca, Leonardo Marques Da, Calvalhan, Danilo Macedo, Previato, Jose Osvaldo, Previato, Lucia Mendonça, and Freire-De-Lima, Leonardo

Subjects
FOS: Clinical medicine, Cell Biology, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplementary_material for Resistance to paclitaxel induces glycophenotype changes and mesenchymal-to-epithelial transition activation in the human prostate cancer cell line PC-3 by Leonardo Marques da Fonseca, Danilo Macedo Calvalhan, Jose Osvaldo Previato, Lucia Mendonça Previato and Leonardo Freire-de-Lima in Tumor Biology

Published
2020
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20. Piperine Inhibits TGF-β Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells

Author

Marques da Fonseca, Leonardo, primary, Jacques da Silva, Lucas Rodrigues, additional, Santos dos Reis, Jhenifer, additional, Rodrigues da Costa Santos, Marcos André, additional, de Sousa Chaves, Victoria, additional, Monteiro da Costa, Kelli, additional, Sa-Diniz, Julliana de Nazareth, additional, Freire de Lima, Celio Geraldo, additional, Morrot, Alexandre, additional, Nunes Franklim, Tatiany, additional, de Alcântara-Pinto, Douglas Chaves, additional, Freire de Lima, Marco Edilson, additional, Previato, Jose Osvaldo, additional, Mendonça-Previato, Lucia, additional, and Freire-de-Lima, Leonardo, additional

Published
2020
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21. Immunomodulatory Role of Capsular Polysaccharides Constituents of Cryptococcus neoformans

Author

Decote-Ricardo, Debora, primary, LaRocque-de-Freitas, Isabel Ferreira, additional, Rocha, Juliana Dutra B., additional, Nascimento, Danielle O., additional, Nunes, Marise P., additional, Morrot, Alexandre, additional, Freire-de-Lima, Leonardo, additional, Previato, Jose Osvaldo, additional, Mendonça-Previato, Lucia, additional, and Freire-de-Lima, Celio Geraldo, additional

Published
2019
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22. Theft and Reception of Host Cell's Sialic Acid: Dynamics of Trypanosoma Cruzi Trans-sialidases and Mucin-Like Molecules on Chagas' Disease Immunomodulation

Author

Fonseca, Leonardo Marques da, primary, da Costa, Kelli Monteiro, additional, Chaves, Victoria de Sousa, additional, Freire-de-Lima, Célio Geraldo, additional, Morrot, Alexandre, additional, Mendonça-Previato, Lucia, additional, Previato, Jose Osvaldo, additional, and Freire-de-Lima, Leonardo, additional

Published
2019
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26. Modulation of Sodium Pumps by Steroidal Saponins

Author

de Souza, Aloa Machado, primary, Silva Lara, Lucienne da, additional, Previato, Jose Osvaldo, additional, Lopes, Aníbal Gil, additional, Caruso-Neves, Celso, additional, da Silva, Bernadete Pereira, additional, and Paz Parente, José, additional

Published
2004
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30. Theft and Reception of Host Cell's Sialic Acid: Dynamics of Trypanosoma Cruzi Trans -sialidases and Mucin-Like Molecules on Chagas' Disease Immunomodulation.

Author

da Fonseca LM, da Costa KM, Chaves VS, Freire-de-Lima CG, Morrot A, Mendonça-Previato L, Previato JO, and Freire-de-Lima L

Subjects
Animals, Chagas Disease drug therapy, Chagas Disease parasitology, Glycoproteins metabolism, Humans, Immune Evasion, Immunomodulation, Molecular Targeted Therapy, Mucins metabolism, Neuraminidase metabolism, Polysaccharides metabolism, T-Lymphocytes immunology, T-Lymphocytes metabolism, Trypanosoma cruzi drug effects, Chagas Disease immunology, Chagas Disease metabolism, Host-Parasite Interactions immunology, N-Acetylneuraminic Acid metabolism, Trypanosoma cruzi physiology
Abstract

The last decades have produced a plethora of evidence on the role of glycans, from cell adhesion to signaling pathways. Much of that information pertains to their role on the immune system and their importance on the surface of many human pathogens. A clear example of this is the flagellated protozoan Trypanosoma cruzi , which displays on its surface a great variety of glycoconjugates, including O -glycosylated mucin-like glycoproteins, as well as multiple glycan-binding proteins belonging to the trans -sialidase (TS) family. Among the latter, different and concurrently expressed molecules may present or not TS activity, and are accordingly known as active (aTS) and inactive (iTS) members. Over the last thirty years, it has been well described that T. cruzi is unable to synthesize sialic acid (SIA) on its own, making use of aTS to steal the host's SIA. Although iTS did not show enzymatic activity, it retains a substrate specificity similar to aTS (α-2,3 SIA-containing glycotopes), displaying lectinic properties. It is accepted that aTS members act as virulence factors in mammals coursing the acute phase of the T. cruzi infection. However, recent findings have demonstrated that iTS may also play a pathogenic role during T. cruzi infection, since it modulates events related to adhesion and invasion of the parasite into the host cells. Since both aTS and iTS proteins share structural substrate specificity, it might be plausible to speculate that iTS proteins are able to assuage and/or attenuate biological phenomena depending on the catalytic activity displayed by aTS members. Since SIA-containing glycotopes modulate the host immune system, it should not come as any surprise that changes in the sialylation of parasite's mucin-like molecules, as well as host cell glycoconjugates might disrupt critical physiological events, such as the building of effective immune responses. This review aims to discuss the importance of mucin-like glycoproteins and both aTS and iTS for T. cruzi biology, as well as to present a snapshot of how disturbances in both parasite and host cell sialoglycophenotypes may facilitate the persistence of T. cruzi in the infected mammalian host.

Published
2019
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