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4. High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster

Author

Jasra, Sakshi, Giricz, Orsi, Zeig-Owens, Rachel, Pradhan, Kith, Goldfarb, David G., Barreto-Galvez, Angelica, Silver, Alexander J., Chen, Jiahao, Sahu, Srabani, Gordon-Mitchell, Shanisha, Choudhary, Gaurav S., Aluri, Srinivas, Bhagat, Tushar D., Shastri, Aditi, Bejan, Cosmin A., Stockton, Shannon S., Spaulding, Travis P., Thiruthuvanathan, Victor, Goto, Hiroki, Gerhardt, Jeannine, Haider, Syed Hissam, Veerappan, Arul, Bartenstein, Matthias, Nwankwo, George, Landgren, Ola, Weiden, Michael D., Lekostaj, Jacqueline, Bender, Ryan, Fletcher, Frederick, Greenberger, Lee, Ebert, Benjamin L., Steidl, Ulrich, Will, Britta, Nolan, Anna, Madireddy, Advaitha, Savona, Michael R., Prezant, David J., and Verma, Amit

Published
2022
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8. Normal Lung Function and Mortality in World Trade Center Responders and National Health and Nutrition Examination Survey III Participants.

Author

Cannon, Madeline F., Goldfarb, David G., Zeig-Owens, Rachel A., Hall, Charles B., Choi, Jaeun, Cohen, Hillel W., Prezant, David J., and Weiden, Michael D.

Subjects
HEALTH & Nutrition Examination Survey, PROPORTIONAL hazards models
Abstract

Rationale: Low FEV1 is a biomarker of increased mortality. The association of normal lung function and mortality is not well described. Objectives: To evaluate the FEV1–mortality association among participants with normal lung function. Methods: A total of 10,999 Fire Department of the City of New York (FDNY) responders and 10,901 Third National Health and Nutrition Examination Survey (NHANES III) participants, aged 18–65 years with FEV1 ⩾80% predicted, were analyzed, with FEV1 percent predicted calculated using Global Lung Function Initiative Global race-neutral reference equations. Mortality data were obtained from linkages to the National Death Index. Cox proportional hazards models estimated the association between FEV1 and all-cause mortality, controlling for age, sex, race/ethnicity, smoking history, and, for FDNY, work assignment. Cohorts were followed for a maximum of 20.3 years. Measurements and Main Results: We observed 504 deaths (4.6%) of 10,999 for FDNY and 1,237 deaths (9.4% [weighted]) of 10,901 for NHANES III. Relative to FEV1 ⩾120% predicted, mortality was significantly higher for FEV1 100–109%, 90–99%, and 80–89% predicted in the FDNY cohort. In the NHANES III cohort, mortality was significantly higher for FEV1 90–99% and 80–89% predicted. Each 10% higher predicted FEV1 was associated with 15% (hazard ratio, 0.85; 95% confidence interval, 0.80–0.91) and 23% (hazard ratio, 0.77; 95% confidence interval, 0.71–0.84) lower mortality for FDNY and NHANES III, respectively. Conclusions: In both cohorts, higher FEV1 is associated with lower mortality, suggesting higher FEV1 is a biomarker of better health. These findings demonstrate that a single cross-sectional measurement of FEV1 is predictive of mortality over two decades, even when FEV1 is in the normal range. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Cancer incidence in World Trade Center rescue and recovery workers by race and ethnicity.

Author

Khalifeh, Malak, Goldfarb, David G., Zeig‐Owens, Rachel, Todd, Andrew C., Shapiro, Moshe Z., Carwile, Madeline, Dasaro, Christopher R., Li, Jiehui, Yung, Janette, Farfel, Mark R., Brackbill, Robert M., Cone, James E., Qiao, Baozhen, Schymura, Maria J., Prezant, David J., Hall, Charles, and Boffetta, Paolo

Subjects
RACE, ETHNICITY, WORKING class white people, THYROID cancer, BLACK people, POISSON regression
Abstract

Introduction: It is unclear whether differences in health outcomes by racial and ethnic groups among World Trade Center (WTC) rescue and recovery workers reflect those of the population of New York State (NYS) or show distinct patterns. We assessed cancer incidence in WTC workers by self‐reported race and ethnicity, and compared it to population figures for NYS. Methods: A total of 61,031 WTC workers enrolled between September 11, 2001 and January 10, 2012 were followed to December 31, 2015. To evaluate the association between race/ethnicity and cancer risk, Poisson regression analysis was used to estimate hazard ratios (HR) adjusted for WTC exposure, age, calendar year, sex and, for lung cancer, cigarette smoking. Results: In comparison to Whites, Black workers had a higher incidence of prostate cancer (HR = 1.99, 95% CI = 1.69−2.34) and multiple myeloma (HR = 3.57, 95% CI = 1.97−6.45), and a lower incidence of thyroid (HR = 0.41, 95% CI = 0.22−0.78) and colorectal cancer (HR = 0.57; 95% CI = 0.33−0.98). Hispanic workers had a higher incidence of liver cancer (HR = 4.03, 95% CI = 2.23−7.28). Compared with NYS population, White workers had significantly higher incidence of prostate cancer (HR = 1.26, 95% CI = 1.18−1.35) and thyroid cancer (HR = 1.80, 95% CI = 1.55−2.08), while Black workers had significantly higher incidence of prostate cancer (HR = 1.22, 95% CI = 1.05−1.40). Conclusion: Cancer incidence in WTC workers generally reflects data from the NYS population, but some differences were identified that merit further investigation. [ABSTRACT FROM AUTHOR]

Published
2023
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23. 282 Food Intake REstriction for Health OUtcome Support and Education (FIREHOUSE): a Proof of Concept Randomized Clinical Trial

Author

Kwon, Sophia, primary, Lam, Rachel, additional, Crowley, George, additional, Zeig-Owens, Rachel, additional, Schwartz, Theresa, additional, Colbeth, Hilary, additional, Lou Pompeii, Mary, additional, St-Jules, David E., additional, Prezant, David J., additional, Sevick, Mary Ann, additional, Liu, Mengling, additional, and Nolan, Anna, additional

Published
2023
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24. Supplementary Table 1 from Initial Whole-Genome Sequencing of Plasma Cell Neoplasms in First Responders and Recovery Workers Exposed to the World Trade Center Attack of September 11, 2001

Author

Maura, Francesco, primary, Diamond, Benjamin, primary, Maclachlan, Kylee H., primary, Derkach, Andriy, primary, Yellapantula, Venkata D., primary, Rustad, Even H., primary, Hultcrantz, Malin, primary, Shah, Urvi A., primary, Hong, Jessica, primary, Landau, Heather J., primary, Iacobuzio-Donahue, Christine A., primary, Papaemmanuil, Elli, primary, Irby, Shani, primary, Crowley, Laura, primary, Crane, Michael, primary, Webber, Mayris P., primary, Goldfarb, David G., primary, Zeig-Owens, Rachel, primary, Giricz, Orsi, primary, Verma, Amit, primary, Prezant, David J., primary, Dogan, Ahmet, primary, Shah, Sohrab P., primary, Zhang, Yanming, primary, and Landgren, Ola, primary

Published
2023
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25. Supplementary Table 2 from Initial Whole-Genome Sequencing of Plasma Cell Neoplasms in First Responders and Recovery Workers Exposed to the World Trade Center Attack of September 11, 2001

Author

Maura, Francesco, primary, Diamond, Benjamin, primary, Maclachlan, Kylee H., primary, Derkach, Andriy, primary, Yellapantula, Venkata D., primary, Rustad, Even H., primary, Hultcrantz, Malin, primary, Shah, Urvi A., primary, Hong, Jessica, primary, Landau, Heather J., primary, Iacobuzio-Donahue, Christine A., primary, Papaemmanuil, Elli, primary, Irby, Shani, primary, Crowley, Laura, primary, Crane, Michael, primary, Webber, Mayris P., primary, Goldfarb, David G., primary, Zeig-Owens, Rachel, primary, Giricz, Orsi, primary, Verma, Amit, primary, Prezant, David J., primary, Dogan, Ahmet, primary, Shah, Sohrab P., primary, Zhang, Yanming, primary, and Landgren, Ola, primary

Published
2023
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26. A 15-year follow-up study of mortality in a pooled cohort of World Trade Center rescue and recovery workers

Author

Li, Jiehui, primary, Hall, Charles B., additional, Yung, Janette, additional, Kehm, Rebecca D., additional, Zeig-Owens, Rachel, additional, Singh, Ankura, additional, Cone, James E., additional, Brackbill, Robert M., additional, Farfel, Mark R., additional, Qiao, Baozhen, additional, Schymura, Maria J., additional, Shapiro, Moshe Z., additional, Dasaro, Christopher R., additional, Todd, Andrew C., additional, Prezant, David J., additional, and Boffetta, Paolo, additional

Published
2023
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29. Bronchial Reactivity and Lung Function After World Trade Center Exposure

Author

Aldrich, Thomas K., Weakley, Jessica, Dhar, Sean, Hall, Charles B., Crosse, Tesha, Banauch, Gisela I., Weiden, Michael D., Izbicki, Gabriel, Cohen, Hillel W., Gupta, Aanchal, King, Camille, Christodoulou, Vasilios, Webber, Mayris P., Zeig-Owens, Rachel, Moir, William, Nolan, Anna, Kelly, Kerry J., and Prezant, David J.

Published
2016
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32. 2009 – WORLD TRADE CENTER 9/11 DISASTER EXPOSURE IS ASSOCIATED WITH CLONAL HEMATOPOIESIS IN FIRST RESPONDERS AND IS CHARACTERIZED BY INNATE IMMUNE INFLAMMATION.

Author

Verma, Divij, primary, Giricz, Orsi, additional, Zeig-Owens, Rachel, additional, Pradhan, Kith, additional, Zou, yiyu, additional, Goldfarb, David D, additional, Sahu, Srabani, additional, Jasra, Sakshi, additional, kelly, Susheian, additional, Aluri, Srinivas, additional, Gordon-Mitchell, Shanisha, additional, Nolan, Anna, additional, Weiden, Michael, additional, Hall, Charles, additional, Shastri, Aditi, additional, Madireddy, Advaitha, additional, Savona, Michael, additional, Steidl, Ulrich G, additional, Prezant, David J, additional, and Verma, Amit, additional

Published
2023
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39. Temporal association of prostate cancer incidence with World Trade Center rescue/recovery work

Author

Goldfarb, David G, Zeig-Owens, Rachel, Kristjansson, Dana, Li, Jiehui, Brackbill, Robert M, Farfel, Mark R, Cone, James E, Yung, Janette, Kahn, Amy R, Qiao, Baozhen, Schymura, Maria J, Webber, Mayris P, Dasaro, Christopher R, Shapiro, Moshe, Todd, Andrew C, Prezant, David J, Boffetta, Paolo, Hall, Charles B, Goldfarb D.G., Zeig-Owens R., Kristjansson D., Li J., Brackbill R.M., Farfel M.R., Cone J.E., Yung J., Kahn A.R., Qiao B., Schymura M.J., Webber M.P., Dasaro C.R., Shapiro M., Todd A.C., Prezant D.J., Boffetta P., and Hall C.B.

Subjects
Adult, Male, Time Factors, Time Factor, Emergency Responder, Urology, Population, environmental exposure, Medical Oncology, Article, materials, Young Adult, symbols.namesake, Prostate cancer, exposures or occupational group, Risk Factors, Occupational Exposure, longitudinal studies, Humans, Medicine, Poisson regression, Workplace, education, education.field_of_study, Models, Statistical, business.industry, Incidence, Risk Factor, longitudinal studie, Hazard ratio, Emergency Responders, Public Health, Environmental and Occupational Health, risk assessment, Prostatic Neoplasms, Environmental exposure, medicine.disease, Prostate-specific antigen, material, Prostatic Neoplasm, exposures or occupational groups, Cohort, symbols, New York City, September 11 Terrorist Attacks, Risk assessment, business, Human, Demography
Abstract

BackgroundThe World Trade Center (WTC) attacks on 11 September 2001 created a hazardous environment with known and suspected carcinogens. Previous studies have identified an increased risk of prostate cancer in responder cohorts compared with the general male population.ObjectivesTo estimate the length of time to prostate cancer among WTC rescue/recovery workers by determining specific time periods during which the risk was significantly elevated.MethodsPerson-time accruals began 6 months after enrolment into a WTC cohort and ended at death or 12/31/2015. Cancer data were obtained through linkages with 13 state cancer registries. New York State was the comparison population. We used Poisson regression to estimate hazard ratios and 95% CIs; change points in rate ratios were estimated using profile likelihood.ResultsThe analytic cohort included 54 394 male rescue/recovery workers. We observed 1120 incident prostate cancer cases. During 2002–2006, no association with WTC exposure was detected. Beginning in 2007, a 24% increased risk (HR: 1.24, 95% CI 1.16 to 1.32) was observed among WTC rescue/recovery workers when compared with New York State. Comparing those who arrived earliest at the disaster site on the morning of 11 September 2001 or any time on 12 September 2001 to those who first arrived later, we observed a positive, monotonic, dose-response association in the early (2002–2006) and late (2007–2015) periods.ConclusionsRisk of prostate cancer was significantly elevated beginning in 2007 in the WTC combined rescue/recovery cohort. While unique exposures at the disaster site might have contributed to the observed effect, screening practices including routine prostate specific antigen screening cannot be discounted.

Published
2021

40. Inhalation Injury

Author

Prezant, David J., Smith, Dorsett D., Mohr, Lawrence C., Jr., Huang, Yuh-Chin T., editor, Ghio, Andrew J., editor, and Maier, Lisa A., editor

Published
2012
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44. Clinical Course of Sarcoidosis in World Trade Center-Exposed Firefighters

Author

Hena, Kerry M., Yip, Jennifer, Jaber, Nadia, Goldfarb, David, Fullam, Kelly, Cleven, Krystal, Moir, William, Zeig-Owens, Rachel, Webber, Mayris P., Spevack, Daniel M., Judson, Marc A., Maier, Lisa, Krumerman, Andrew, Aizer, Anthony, Spivack, Simon D., Berman, Jessica, Aldrich, Thomas K., Prezant, David J., Christodoulou, Vasilios, Hena, Zachary, Plotycia, Steven M., Soghier, Israa, Gritz, David, Acuna, Dianne S., Weiden, Michael D., Nolan, Anna, Diaz, Keith, Ortiz, Viola, and Kelly, Kerry

Published
2018
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