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630 results on '"Pribitkin, Edmund"'

3. Design and Implementation of an Opioid Scorecard for Hospital System-Wide Peer Comparison of Opioid Prescribing Habits: Observational Study

Author

Slovis, Benjamin, Huang, Soonyip, McArthur, Melanie, Martino, Cara, Beers, Tasia, Labella, Meghan, Riggio, Jeffrey, Pribitkin, Edmund, Slovis, Benjamin, Huang, Soonyip, McArthur, Melanie, Martino, Cara, Beers, Tasia, Labella, Meghan, Riggio, Jeffrey, and Pribitkin, Edmund

Abstract

BACKGROUND: Reductions in opioid prescribing by health care providers can lead to a decreased risk of opioid dependence in patients. Peer comparison has been demonstrated to impact providers' prescribing habits, though its effect on opioid prescribing has predominantly been studied in the emergency department setting. OBJECTIVE: The purpose of this study is to describe the development of an enterprise-wide opioid scorecard, the architecture of its implementation, and plans for future research on its effects. METHODS: Using data generated by the author's enterprise vendor-based electronic health record, the enterprise analytics software, and expertise from a dedicated group of informaticists, physicians, and analysts, the authors developed an opioid scorecard that was released on a quarterly basis via email to all opioid prescribers at our institution. These scorecards compare providers' opioid prescribing habits on the basis of established metrics to those of their peers within their specialty throughout the enterprise. RESULTS: At the time of this study's completion, 2034 providers have received at least 1 scorecard over a 5-quarter period ending in September 2021. Poisson regression demonstrated a 1.6% quarterly reduction in opioid prescribing, and chi-square analysis demonstrated pre-post reductions in the proportion of prescriptions longer than 5 days' duration and a morphine equivalent daily dose of >50. CONCLUSIONS: To our knowledge, this is the first peer comparison effort with high-quality evidence-based metrics of this scale published in the literature. By sharing this process for designing the metrics and the process of distribution, the authors hope to influence other health systems to attempt to curb the opioid pandemic through peer comparison. Future research examining the effects of this intervention could demonstrate significant reductions in opioid prescribing, thus potentially reducing the progression of individual patients to opioid use disorder an

Published
2024

4. Mcl-1 Mediates Intrinsic Resistance to RAF Inhibitors in Mutant BRAF Papillary Thyroid Carcinoma

Author

Cavallo, Maria, Yo, Jacob, Gallant, Kayla, Cunanan, Camille, Amirfallah, Amirali, Daniali, Marzieh, Sanders, Alyssa, Aplin, Andrew, Pribitkin, Edmund, Hartsough, Edward, Cavallo, Maria, Yo, Jacob, Gallant, Kayla, Cunanan, Camille, Amirfallah, Amirali, Daniali, Marzieh, Sanders, Alyssa, Aplin, Andrew, Pribitkin, Edmund, and Hartsough, Edward

Abstract

Papillary thyroid carcinoma (PTC) is the most frequent form of thyroid cancer. PTC commonly presents with mutations of the serine/threonine kinase BRAF (BRAFV600E), which drive ERK1/2 pathway activation to support growth and suppress apoptosis. PTC patients often undergo surgical resection; however, since the average age of PTC patients is under 50, adverse effects associated with prolonged maintenance therapy following total thyroidectomy are a concern. The development of mutant-selective BRAF inhibitors (BRAFi), like vemurafenib, has been efficacious in patients with metastatic melanoma, but the response rate is low for mutant BRAF PTC patients. Here, we assay the therapeutic response of BRAFi in a panel of human PTC cell lines and freshly biopsied patient samples. We observed heterogeneous responses to BRAFi, and multi-omic comparisons between susceptible and resistant mutant BRAF PTC revealed overrepresented stress response pathways and the absence of compensatory RTK activation – features that may underpin innate resistance. Importantly, resistant cell lines and patient samples had increased hallmarks of failed apoptosis; a cellular state defined by sublethal caspase activation and DNA damage. Further analysis suggests that the failed apoptotic phenotypes may have features of “minority mitochondrial outer membrane permeabilization (MOMP)” – a stress-related response characterized by fragmented and porous mitochondria known to contribute to cancer aggressiveness. We found that cells presenting with minority MOMP-like phenotypes are dependent on the apoptotic regulator, Mcl-1, as treatment with the Mcl-1 inhibitor, AZD5991, potently induced cell death in resistant cells. Furthermore, PI3K/AKT inhibitors sensitized resistant cells to BRAFi; an effect that was at least in part associated with reduced Mcl-1 levels. Together, these data implicate minority MOMP as a mechanism associated with intrinsic drug resistance and underscore the benefits of targeting Mcl-1 in m

Published
2024

5. Design and Implementation of an Opioid Scorecard for Hospital System–Wide Peer Comparison of Opioid Prescribing Habits: Observational Study.

Author

Slovis, Benjamin Heritier, Huang, Soonyip, McArthur, Melanie, Martino, Cara, Beers, Tasia, Labella, Meghan, Riggio, Jeffrey M, and Pribitkin, Edmund deAzevedo

Subjects
OPIOIDS, MEDICAL care, DEATH rate, SCOREBOARDS, CELL phones
Abstract

Background: Reductions in opioid prescribing by health care providers can lead to a decreased risk of opioid dependence in patients. Peer comparison has been demonstrated to impact providers' prescribing habits, though its effect on opioid prescribing has predominantly been studied in the emergency department setting. Objective: The purpose of this study is to describe the development of an enterprise-wide opioid scorecard, the architecture of its implementation, and plans for future research on its effects. Methods: Using data generated by the author's enterprise vendor–based electronic health record, the enterprise analytics software, and expertise from a dedicated group of informaticists, physicians, and analysts, the authors developed an opioid scorecard that was released on a quarterly basis via email to all opioid prescribers at our institution. These scorecards compare providers' opioid prescribing habits on the basis of established metrics to those of their peers within their specialty throughout the enterprise. Results: At the time of this study's completion, 2034 providers have received at least 1 scorecard over a 5-quarter period ending in September 2021. Poisson regression demonstrated a 1.6% quarterly reduction in opioid prescribing, and chi-square analysis demonstrated pre-post reductions in the proportion of prescriptions longer than 5 days' duration and a morphine equivalent daily dose of >50. Conclusions: To our knowledge, this is the first peer comparison effort with high-quality evidence-based metrics of this scale published in the literature. By sharing this process for designing the metrics and the process of distribution, the authors hope to influence other health systems to attempt to curb the opioid pandemic through peer comparison. Future research examining the effects of this intervention could demonstrate significant reductions in opioid prescribing, thus potentially reducing the progression of individual patients to opioid use disorder and the associated increased risk of morbidity and mortality. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Postoperative diplopia after medial–inferior orbital wall decompression in patients with thyroid eye disease

Author

Armache, Maria, primary, McKnight, Tory, additional, Parsel, Sean M, additional, Chitguppi, Chandala, additional, Toskala, Elina, additional, Rosen, Marc, additional, Watson, Alison, additional, Pribitkin, Edmund, additional, Rabinowitz, Michael, additional, Rabinowitz, Mindy, additional, Bilyk, Jurij, additional, and Nyquist, Gurston, additional

Published
2023
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10. Orbital resection by intranasal technique (ORBIT): A new classification system for reporting endoscopically resectable primary benign orbital tumors

Author

Jafari, Aria, primary, Adappa, Nithin D., additional, Anagnos, Vincent J., additional, Campbell, Raewyn G., additional, Castelnuovo, Paolo, additional, Chalian, Ara, additional, Chambers, Christopher B., additional, Chitguppi, Chandala, additional, Dallan, Iacopo, additional, El Rassi, Edward, additional, Freitag, Suzanne K., additional, Fernandez Miranda, Juan C., additional, Ferreira, Manuel, additional, Gardner, Paul A., additional, Gudis, David A., additional, Harvey, Richard J., additional, Huang, Qian, additional, Humphreys, Ian M., additional, Kennedy, David W., additional, Lee, John Y.K., additional, Lehmann, Ashton E., additional, Locatelli, Davide, additional, McKinney, Kibwei A., additional, Moreau, Annie, additional, Nyquist, Gurston, additional, Palmer, James N., additional, Prepageran, Narayanan, additional, Pribitkin, Edmund A., additional, Rabinowitz, Mindy R., additional, Rosen, Marc R., additional, Sacks, Raymond, additional, Sharma, Dhruv, additional, Snyderman, Carl H., additional, Tonya Stefko, S., additional, Stokken, Janalee K., additional, Wang, Eric W., additional, Workman, Alan D., additional, Wu, Arthur W., additional, Yu, Jen Y., additional, Zhang, Matthew M., additional, Zhou, Bing, additional, and Bleier, Benjamin S., additional

Published
2023
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13. Laser Facial Resurfacing

Author

Pribitkin, Edmund A., Stucker, Fred J., editor, de Souza, Chris, editor, Kenyon, Guy S., editor, Lian, Timothy S., editor, Draf, Wolfgang, editor, and Schick, Bernhard, editor

Published
2009
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22. Using ultrasonic preoperative thyroid volume to determine incision length for minimally invasive thyroid surgery

Author

Daly, Austin P., Romanelli-Gobbi, Massi, Miller, Jeffrey L., Rosen, David, Cognetti, David M., and Pribitkin, Edmund A.

Subjects
Methods, Diagnostic ultrasonography -- Methods, Thyroidectomy -- Methods, Preoperative care -- Methods, Minimally invasive surgery -- Methods, Diagnosis, Ultrasonic -- Methods
Abstract

The determination of the volume of a diseased thyroid lobe or an entire gland by preoperative ultrasonography may enable surgeons to select candidates for a minimally invasive approach to thyroid [...]

Published
2015

33. The evolving etiology of bilateral vocal fold immobility

Author

Feehery, John M., Pribitkin, Edmund A., Heffelfinger, Ryan N., Lacombe, Victor G., Lee, Daniel, Lowry, Louis D., Keane, William M., and Sataloff, Robert T.

Subjects
Diagnosis, Statistics, Causes of, Vocal cord paralysis -- Diagnosis -- Statistics, Vocal cords -- Paralysis
Abstract

Summary: In the past, bilateral vocal fold immobility (BVFI) occurred most commonly after thyroidectomy. However, no large series documenting the etiology of adult BVFI has been published within the past [...]

Published
2003

36. Laryngeal sarcoidosis

Author

Dean, Carole M., Sataloff, Robert Thayer, Hawkshaw, Mary J., and Pribitkin, Edmund

Subjects
Practice, Diseases, Physiological aspects, Usage, Case studies, Causes of, Autoimmune diseases -- Case studies -- Physiological aspects, Larynx -- Diseases -- Case studies -- Physiological aspects, Otolaryngology -- Practice -- Case studies -- Physiological aspects, Hoarseness -- Causes of -- Case studies -- Physiological aspects, Steroids (Drugs) -- Case studies -- Usage -- Physiological aspects, Sarcoidosis -- Physiological aspects -- Case studies, Inhalers -- Case studies -- Usage -- Physiological aspects
Abstract

Summary: Sarcoidosis is a chronic granulomatous disease that tends to involve the lungs, hilar and mediastinal lymph nodes, liver, eyes, skin, bones, and nervous system. Sarcoidosis involves the larynx less [...]

Published
2002

42. Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities

Author

Mainland, Joel D, primary, Barlow, Linda A, additional, Munger, Steven D, additional, Millar, Sarah E, additional, Vergara, M Natalia, additional, Jiang, Peihua, additional, Schwob, James E, additional, Goldstein, Bradley J, additional, Boye, Shannon E, additional, Martens, Jeffrey R, additional, Leopold, Donald A, additional, Bartoshuk, Linda M, additional, Doty, Richard L, additional, Hummel, Thomas, additional, Pinto, Jayant M, additional, Trimmer, Casey, additional, Kelly, Christine, additional, Pribitkin, Edmund A, additional, and Reed, Danielle R, additional

Published
2020
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46. Pathology Quiz Case 1

Author

Van Abel, Kathryn M., Bilyk, Jurij R., Bourne, Scott E., Ezzat, Waleed H., Finden, Steven G., and Pribitkin, Edmund A.

Published
2010

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