401,102 results on '"Price, A"'
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2. The Famous Actress
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Price, Adam O’Fallon
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- 2023
- Full Text
- View/download PDF
3. Germinous Seeds: Hawthorne's Creative Influence on Melville
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Cook, Jonathan A., Olsen-Smith, Steven, Smith, Elisa Barney, Lambie, Remington, Price, Abby, and Tonkin, Hunter
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- 2022
- Full Text
- View/download PDF
4. Student Reports of Bullying: Results from the 2022 School Crime Supplement to the National Crime Victimization Survey. Web Tables. NCES 2024-109
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National Center for Education Statistics (NCES) (ED/IES), RTI International, E. Thomsen, M. Henderson, A. Moore, N. Price, and M. W. McGarrah
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The tables in this report provide national-level estimates of the extent to which students ages 12-18 enrolled in grades 6-12 experience bullying during school. The tables show how bullying victimization varies by student and school characteristics such as sex, race/ethnicity, grade, household income, region, school locale, school enrollment size, and the percentage of students eligible for free or reduced-price lunch. The tables also show how rates of bullying victimization vary by crime-related characteristics such as: the presence of gangs, guns, drugs, alcohol, and hate-related graffiti at school; selected school security measures; student criminal victimization; personal fear of attack or harm; avoidance behaviors; fighting; and the carrying of weapons to school.
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- 2024
5. Using a Critical Service-Learning Approach to Prepare Public Health Practitioners
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Meg Landfri, Lindsay Bau Savelli, Brittany Nicole Price, Liz Chen, and Dane Emmerling
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Training the next generation of public health practitioners to promote health equity requires public health graduate programs to cultivate students' skills in community partnership. The Council on Education for Public Health (CEPH) requires Master of Public Health (MPH) students to produce a high-quality written product as part of their culminating Integrative Learning Experience (ILE). Because CEPH recommends that ILE written products be useful to community partners, ILEs can draw lessons from the field of experiential education, especially the social justice aligned principles of critical service-learning (CSL). However, the current literature lacks descriptions of how to operationalize CSL's principles within graduate-level culminating experiences. To help fill this gap, we discuss a CSL ILE for MPH students, called Capstone. We describe CSL's key components and explain and assess how each is operationalized. We hope Capstone's model will help educators engage more deeply with CSL practices to advance health equity.
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- 2024
6. The More, the Merrier? A Phenomenological Investigation of Counselor-in-Training Simultaneous Supervision
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William B. Lane, Timothy J. Hakenewerth, Camille D. Frank, Tessa B. Davis-Price, David M. Kleist, and Steven J. Moody
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Interpretative phenomenological analysis was used to explore the simultaneous supervision experiences of counselors-in-training. Simultaneous supervision is when a supervisee receives clinical supervision from multiple supervisors. Sometimes this supervision includes a university supervisor and a site supervisor. Other times this supervision occurs when a student has multiple sites in one semester and receives supervision at each site. Counselors-in-training described their experiences with simultaneous supervision during the course of their education. Four superordinate themes emerged: making sense of multiple perspectives, orchestrating the process, supervisory relationship dynamics, and personal dispositions and characteristics. Results indicated that counselors-in-training experienced compounded benefits and challenges. Implications for supervisors, supervisees, and counselor education programs are provided.
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- 2024
7. Exploring the Implications of University Campuses as Intercultural Spaces through the Lens of Social Justice
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Fiona Price
- Abstract
The internationalisation of higher education presents an increasingly urgent need to explore how universities can become more welcoming places for all students. Top-down implementation of widening participation and the inclusion of a more diverse and less prepared student population in higher education have led to social and academic exclusion, with systems failing to accommodate this change to support the less prepared intakes. Academic and social/cultural drivers are the key areas for bottom-up implementation of internationalisation strategies to support this influx and change in student profile. However, institutionalised separation of home and international students for academic support and language development provision, and separation of this support from subject disciplines, have increased the obstacles that block inclusive practice. An internationalised campus involves both top-down institutionalised intervention and bottom-up intervention of the academic self, enabling the potential for intercultural construction within and between communities, and promoting agency of the self in connection with others to enact change. Viewing university campuses as intercultural spaces that all students and staff need to navigate and inhabit has implications that this article explores through the lens of social justice and from the bottom-up perspective of language development provision, within the field of English for Academic Purposes, in an arts-based university.
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- 2024
8. White Girl Wasted: Gender Performativity of Sexuality with Alcohol in National Panhellenic Conference Sorority Women
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Pietro A. Sasso, Amber Manning-Ouellette, Kim E. Bullington, and Shelley Price-Williams
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This narrative qualitative study explored how sorority members negotiated their identities within systems of hegemony with their student communities. Sorority members used women's empowerment discourse to rationalize how they consumed alcohol, engaged in frequent consensual sexual relationships, and navigated relationships with fraternity men and across their campus sorority/fraternity communities. Implications for practice included harm reduction, sex education, and supportive policies.
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- 2024
9. What Brought Us Together to Form a Community for Scholarship
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Carolyn J. Loveridge, Frances Docherty, Sarah Honeychurch, Nathalie Tasler, Linnea Soler, Lindsey Pope, Victoria E. Price, and Beth Dickson
- Abstract
We are a group of teaching-focused academics who share a passion for learning, teaching and the Scholarship of Teaching and Learning (SoTL) in Higher Education (HE). In order to understand how practitioners from a diversity of backgrounds and disciplines came to be in their present LTS (Learning, Teaching & Scholarship) academic roles, we embarked on a Collaborative Autoethnography (CAE). This approach allowed us to use our personal narratives to explore what it means to be a SoTL practitioner in HE, and to analyse these narratives by using textual analysis. This paper unpacks these narratives, focusing on three themes: our rich and diverse backgrounds, influences on our routes to our current academic roles, and how we are loud and proud to be on a teaching-focused career path. It will be of interest to academics who are on, or contemplating, a teaching focused contract. It will also be of relevance to senior staff in HE who wish to understand the nature of these roles, and who wish to consider how to provide appropriate institutional structures to support and nurture these staff.
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- 2024
10. The Knowledge Component Attribution Problem for Programming: Methods and Tradeoffs with Limited Labeled Data
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Yang Shi, Robin Schmucker, Keith Tran, John Bacher, Kenneth Koedinger, Thomas Price, Min Chi, and Tiffany Barnes
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Understanding students' learning of knowledge components (KCs) is an important educational data mining task and enables many educational applications. However, in the domain of computing education, where program exercises require students to practice many KCs simultaneously, it is a challenge to attribute their errors to specific KCs and, therefore, to model student knowledge of these KCs. In this paper, we define this task as the KC attribution problem. We first demonstrate a novel approach to addressing this task using deep neural networks and explore its performance in identifying expert-defined KCs (RQ1). Because the labeling process takes costly expert resources, we further evaluate the effectiveness of transfer learning for KC attribution, using more easily acquired labels, such as problem correctness (RQ2). Finally, because prior research indicates the incorporation of educational theory in deep learning models could potentially enhance model performance, we investigated how to incorporate learning curves in the model design and evaluated their performance (RQ3). Our results show that in a supervised learning scenario, we can use a deep learning model, code2vec, to attribute KCs with a relatively high performance (AUC > 75% in two of the three examined KCs). Further using transfer learning, we achieve reasonable performance on the task without any costly expert labeling. However, the incorporation of learning curves shows limited effectiveness in this task. Our research lays important groundwork for personalized feedback for students based on which KCs they applied correctly, as well as more interpretable and accurate student models.
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- 2024
11. The Influence of Emergency Remote Teaching on K-12 World Language Instruction
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Scott Kissau, Kristin Davin, Benjamin Ade-Thurow, Helga Haudeck, and Laura Price
- Abstract
The abrupt shift to online instruction that occurred in spring 2020, often referred to as emergency remote teaching (ERT), caught many world language educators off guard. To prepare for future disruptions to face-to-face learning and illustrate promising online teaching practices that emerged during this extended period of time that could serve to expand and enhance world language instruction, it is important to understand how ERT influenced K-12 world language programs around the world. To help the world language teaching community better understand how ERT influenced world language instruction, a team of researchers collected interview data from world language teachers and students in the United States and Germany. Results confirmed that instruction was negatively impacted by the sudden shift to online formats, explained how and why instruction was influenced, and identified promising practices exhibited by teachers to mitigate the negative impact of ERT. World language teachers, stakeholders, and school leaders may wish to consider the results of this study to lessen the impact of future disruptions to on campus learning and to enhance the growing presence of online learning in schools.
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- 2024
12. The Unschooling of the Well-educated Negro
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Price, Allen
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- 2021
13. Benchmarking the design of the cryogenics system for the underground argon in DarkSide-20k
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Collaboration, DarkSide-20k, Acerbi, F., Adhikari, P., Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Amaudruz, P., Angiolilli, M., Aprile, E., Ardito, R., Corona, M. Atzori, Auty, D. J., Ave, M., Avetisov, I. C., Azzolini, O., Back, H. O., Balmforth, Z., Olmedo, A. Barrado, Barrillon, P., Batignani, G., Bhowmick, P., Blua, S., Bocci, V., Bonivento, W., Bottino, B., Boulay, M. G., Buchowicz, A., Bussino, S., Busto, J., Cadeddu, M., Cadoni, M., Calabrese, R., Camillo, V., Caminata, A., Canci, N., Capra, A., Caravati, M., Cárdenas-Montes, M., Cargioli, N., Carlini, M., Castellani, A., Castello, P., Cavalcante, P., Cebrian, S., Ruiz, J. Cela, Chashin, S., Chepurnov, A., Cifarelli, L., Cintas, D., Citterio, M., Cleveland, B., Coadou, Y., Cocco, V., Colaiuda, D., Vilda, E. Conde, Consiglio, L., Costa, B. S., Czubak, M., D'Aniello, M., D'Auria, S., Rolo, M. D. Da Rocha, Darbo, G., Davini, S., De Cecco, S., De Guido, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Ludovico, A., Di Noto, L., Di Stefano, P., Dias, L. K., Mairena, D. Díaz, Ding, X., Dionisi, C., Dolganov, G., Dordei, F., Dronik, V., Elersich, A., Ellingwood, E., Erjavec, T., Diaz, M. Fernandez, Ficorella, A., Fiorillo, G., Franchini, P., Franco, D., Gatti, H. Frandini, Frolov, E., Gabriele, F., Gahan, D., Galbiati, C., Galiński, G., Gallina, G., Gallus, G., Garbini, M., Abia, P. Garcia, Gawdzik, A., Gendotti, A., Ghisi, A., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Grandi, L., Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hallin, A., Hamer, A., Haranczyk, M., Harrop, B., Hessel, T., Hill, S., Horikawa, S., Hu, J., Hubaut, F., Hucker, J., Hugues, T., Hungerford, E. V., Ianni, A., Ippolito, V., Jamil, A., Jillings, C., Jois, S., Kachru, P., Keloth, R., Kemmerich, N., Kemp, A., Kendziora, C. L., Kimura, M., Kish, A., Kondo, K., Korga, G., Kotsiopoulou, L., Koulosousas, S., Kubankin, A., Kunzé, P., Kuss, M., Kuźniak, M., Kuzwa, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Leoni, A., Lidey, L., Lissia, M., Luzzi, L., Lychagina, O., Macfadyen, O., Machulin, I. N., Manecki, S., Manthos, I., Mapelli, L., Marasciulli, A., Mari, S. M., Mariani, C., Maricic, J., Martinez, M., Martoff, C. J., Matteucci, G., Mavrokoridis, K., McDonald, A. B., Mclaughlin, J., Merzi, S., Messina, A., Milincic, R., Minutoli, S., Mitra, A., Moharana, A., Moioli, S., Monroe, J., Moretti, E., Morrocchi, M., Mroz, T., Muratova, V. N., Murphy, M., Murra, M., Muscas, C., Musico, P., Nania, R., Nessi, M., Nieradka, G., Nikolopoulos, K., Nikoloudaki, E., Nowak, J., Olchanski, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Papi, D., Pastuszak, G., Paternoster, G., Peck, A., Pegoraro, P. A., Pelczar, K., Pellegrini, L. A., Perez, R., Perotti, F., Pesudo, V., Piacentini, S. I., Pino, N., Plante, G., Pocar, A., Poehlmann, M., Pordes, S., Pralavorio, P., Price, D., Puglia, S., Bazetto, M. Queiroga, Ragusa, F., Ramachers, Y., Ramirez, A., Ravinthiran, S., Razeti, M., Renshaw, A. L., Rescigno, M., Retiere, F., Rignanese, L. P., Rivetti, A., Roberts, A., Roberts, C., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Rudik, D., Sabia, M., Salomone, P., Samoylov, O., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Santos, E. M., Savarese, C., Scapparone, E., Schillaci, G., Schuckman II, F. G., Scioli, G., Semenov, D. A., Shalamova, V., Sheshukov, A., Simeone, M., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Smirnova, T., Smith, B., Sotnikov, A., Spadoni, F., Spangenberg, M., Stefanizzi, R., Steri, A., Stornelli, V., Stracka, S., Sulis, S., Sung, A., Sunny, C., Suvorov, Y., Szelc, A. M., Taborda, O., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thompson, A., Thorpe, T. N., Tonazzo, A., Torres-Lara, S., Tricomi, A., Unzhakov, E. V., Vallivilayil, T. J., Van Uffelen, M., Velazquez-Fernandez, L., Viant, T., Viel, S., Vishneva, A., Vogelaar, R. B., Vossebeld, J., Vyas, B., Wada, M., Walczak, M. B., Wang, H., Wang, Y., Westerdale, S., Williams, L., Wojaczyński, R., Wojcik, M., Wojcik, M. M., Wright, T., Xiao, X., Xie, Y., Yang, C., Yin, J., Zabihi, A., Zakhary, P., Zani, A., Zhang, Y., Zhu, T., Zichichi, A., Zuzel, G., and Zykova, M. P.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
DarkSide-20k (DS-20k) is a dark matter detection experiment under construction at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy. It utilises ~100 t of low radioactivity argon from an underground source (UAr) in its inner detector, with half serving as target in a dual-phase time projection chamber (TPC). The UAr cryogenics system must maintain stable thermodynamic conditions throughout the experiment's lifetime of >10 years. Continuous removal of impurities and radon from the UAr is essential for maximising signal yield and mitigating background. We are developing an efficient and powerful cryogenics system with a gas purification loop with a target circulation rate of 1000 slpm. Central to its design is a condenser operated with liquid nitrogen which is paired with a gas heat exchanger cascade, delivering a combined cooling power of >8 kW. Here we present the design choices in view of the DS-20k requirements, in particular the condenser's working principle and the cooling control, and we show test results obtained with a dedicated benchmarking platform at CERN and LNGS. We find that the thermal efficiency of the recirculation loop, defined in terms of nitrogen consumption per argon flow rate, is 95 % and the pressure in the test cryostat can be maintained within $\pm$(0.1-0.2) mbar. We further detail a 5-day cool-down procedure of the test cryostat, maintaining a cooling rate typically within -2 K/h, as required for the DS-20k inner detector. Additionally, we assess the circuit's flow resistance, and the heat transfer capabilities of two heat exchanger geometries for argon phase change, used to provide gas for recirculation. We conclude by discussing how our findings influence the finalisation of the system design, including necessary modifications to meet requirements and ongoing testing activities., Comment: 45 pages, 24 figures
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- 2024
14. Spectral Guarantees for Adversarial Streaming PCA
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Price, Eric and Xun, Zhiyang
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Computer Science - Data Structures and Algorithms ,Computer Science - Machine Learning - Abstract
In streaming PCA, we see a stream of vectors $x_1, \dotsc, x_n \in \mathbb{R}^d$ and want to estimate the top eigenvector of their covariance matrix. This is easier if the spectral ratio $R = \lambda_1 / \lambda_2$ is large. We ask: how large does $R$ need to be to solve streaming PCA in $\widetilde{O}(d)$ space? Existing algorithms require $R = \widetilde{\Omega}(d)$. We show: (1) For all mergeable summaries, $R = \widetilde{\Omega}(\sqrt{d})$ is necessary. (2) In the insertion-only model, a variant of Oja's algorithm gets $o(1)$ error for $R = O(\log n \log d)$. (3) No algorithm with $o(d^2)$ space gets $o(1)$ error for $R = O(1)$. Our analysis is the first application of Oja's algorithm to adversarial streams. It is also the first algorithm for adversarial streaming PCA that is designed for a spectral, rather than Frobenius, bound on the tail; and the bound it needs is exponentially better than is possible by adapting a Frobenius guarantee., Comment: FOCS 2024
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- 2024
15. Segue 2 Recently Collided with the Cetus-Palca Stream: New Opportunities to Constrain Dark Matter in an Ultra-Faint Dwarf
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Foote, Hayden R., Besla, Gurtina, Garavito-Camargo, Nicolás, Patel, Ekta, Thomas, Guillaume F., Bonaca, Ana, Price-Whelan, Adrian M., Peter, Annika H. G., Zaritsky, Dennis, and Conroy, Charlie
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Astrophysics - Astrophysics of Galaxies - Abstract
Stellar streams in the Milky Way are promising detectors of low-mass dark matter (DM) subhalos predicted by $\Lambda$CDM. Passing subhalos induce perturbations in streams that indicate the presence of the subhalos. Understanding how known DM-dominated satellites impact streams is a crucial step towards using stream perturbations to constrain the properties of dark perturbers. Here, we cross-match a $\textit{Gaia}$ EDR3 and SEGUE member catalog of the Cetus-Palca stream (CPS) with H3 for additional radial velocity measurements and fit the orbit of the CPS using this 6-D data. We demonstrate for the first time that the ultra-faint dwarf Segue 2 had a recent (77$\pm$5 Myr ago) close flyby (within the stream's 2$\sigma$ width) with the CPS. This interaction enables constraints on Segue 2's mass and density profile at larger radii ($\mathcal{O}(1)$ kpc) than are probed by its stars ($\mathcal{O}(10)$ pc). While Segue 2 is not expected to strongly affect the portion of the stream covered by our 6-D data, we predict that if Segue 2's mass within $\sim 6$ kpc is $5\times 10^9\,M_\odot$, the CPS's velocity dispersion will be $\sim 40$ km/s larger ahead of the impact site than behind it. If no such heating is detected, Segue 2's mass cannot exceed $10^9\,M_\odot$ within $\sim 6$ kpc. The proper motion distribution of the CPS near the impact site is mildly sensitive to the shape of Segue 2's density profile. This study presents a critical test for frameworks designed to constrain properties of dark subhalos from stream perturbations., Comment: 33 pages, 14 figures, 6 tables. Submitted to ApJ, comments welcome
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- 2024
16. A Timeline of the M81 Group: Properties of the Extended Structures of M82 and NGC 3077
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Velguth, Benjamin N., Bell, Eric F., Smercina, Adam, Price, Paul, Gozman, Katya, Monachesi, Antonela, D'Souza, Richard, Bailin, Jeremy, De Jong, Roelof S., Jang, In Sung, and Slater, Colin T.
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Astrophysics - Astrophysics of Galaxies - Abstract
Mergers of and interactions between galaxies imprint a wide diversity of morphological, dynamical, and chemical characteristics in stellar halos and tidal streams. Measuring these characteristics elucidates aspects of the progenitors of the galaxies we observe today. The M81 group is the perfect galaxy group to understand the past, present, and future of a group of galaxies in the process of merging. Here we measure the end of star formation (t$_{90}$) and metallicity ([M/H]) of the stellar halo of M82 and the eastern tidal stream of NGC 3077 to: 1) test the idea that M82 possesses a genuine stellar halo, formed before any interaction with M81, 2) determine if NGC 3077's tidal disruption is related to the star formation history in its tails, and 3) create a timeline of the assembly history of the central trio in the M81 group. We argue that M82 possesses a genuine, metal poor ([M/H] ~ -1.62 dex) stellar halo, formed from the merger of a small satellite galaxy roughly 6.6 Gyr ago. We also find that the stars present in NGC 3077's tails formed before tidal disruption with M81, and possesses a roughly uniform metallicity as shown in Okamoto et. al. 2023 implying that NGC 3077's progenitor had significant population gradients. Finally, we present a timeline of the central trio's merger/interaction history., Comment: 17 pages, 12 figures, 1 table, accepted for publication in ApJ
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- 2024
17. The UNCOVER Survey: First Release of Ultradeep JWST/NIRSpec PRISM spectra for ~700 galaxies from z~0.3-13 in Abell 2744
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Price, Sedona H., Bezanson, Rachel, Labbe, Ivo, Furtak, Lukas J., de Graaff, Anna, Greene, Jenny E., Kokorev, Vasily, Setton, David J., Suess, Katherine A., Brammer, Gabriel, Cutler, Sam E., Leja, Joel, Pan, Richard, Wang, Bingjie, Weaver, John R., Whitaker, Katherine E., Atek, Hakim, Burgasser, Adam J., Chemerynska, Iryna, Dayal, Pratika, Feldmann, Robert, Schreiber, Natascha M. Förster, Fudamoto, Yoshinobu, Fujimoto, Seiji, Glazebrook, Karl, Goulding, Andy D., Khullar, Gourav, Kriek, Mariska, Marchesini, Danilo, Maseda, Michael V., Miller, Tim B., Muzzin, Adam, Nanayakkara, Themiya, Nelson, Erica, Oesch, Pascal A., Shipley, Heath, Smit, Renske, Taylor, Edward N., van Dokkum, Pieter, Williams, Christina C., and Zitrin, Adi
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Astrophysics - Astrophysics of Galaxies - Abstract
We present the design and observations of low resolution JWST/NIRSpec PRISM spectroscopy from the Ultradeep NIRSpec and NIRCam ObserVations before the Epoch of Reionization (UNCOVER) Cycle 1 JWST Treasury program. Targets are selected using JWST/NIRCam photometry from UNCOVER and other programs, and cover a wide range of categories and redshifts to ensure the legacy value of the survey. These categories include the first galaxies at $z\gtrsim10$, faint galaxies during the Epoch of Reionization ($z\sim6-8$), high redshift AGN ($z\gtrsim6$), Population III star candidates, distant quiescent and dusty galaxies ($1\lesssim z \lesssim 6$), and filler galaxies sampling redshift--color--magnitude space from $z\sim 0.1-13$. Seven NIRSpec MSA masks across the extended Abell 2744 cluster were observed, along with NIRCam parallel imaging in 8 filters (F090W, F115W, F150W, F200W, F277W, F356W, F410M, F444W, F480M) over a total area of ~26 arcmin$^2$, overlapping existing HST coverage from programs including the Hubble Frontier Fields and BUFFALO. We successfully observed 553 objects down to $m_{\mathrm{F444W}}\sim30\mathrm{AB}$, and by leveraging mask overlaps, we reach total on-target exposure times ranging from 2.4-16.7h. We demonstrate the success rate and distribution of confirmed redshifts, and also highlight the rich information revealed by these ultradeep spectra for a subset of our targets. An updated lens model of Abell 2744 is also presented, including 14 additional spectroscopic redshifts and finding a total cluster mass of $M_{\mathrm{SL}}=(2.1\pm0.3)\times10^{15}\,\mathrm{M}_{\odot}$. We publicly release reduced 1D and 2D spectra for all objects observed in Summer 2023 along with a spectroscopic redshift catalog and the updated lens model of the cluster (https://jwst-uncover.github.io/DR4.html)., Comment: 19 pages, 9 figures, 4 tables, submitted to ApJ, comments welcome! Data available at: https://jwst-uncover.github.io/DR4.html (v2: figure format correction)
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- 2024
18. JADES Ultra-red Flattened Objects: Morphologies and Spatial Gradients in Color and Stellar Populations
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Gibson, Justus L., Nelson, Erica, Williams, Christina C., Price, Sedona H., Whitaker, Katherine E., Suess, Katherine A., de Graaff, Anna, Johnson, Benjamin D., Bunker, Andrew J., Baker, William M., Bhatawdekar, Rachana, Boyett, Kristan, Charlot, Stephane, Curtis-Lake, Emma, Eisenstein, Daniel J., Hainline, Kevin, Hausen, Ryan, Maiolino, Roberto, Rieke, George, Rieke, Marcia, Robertson, Brant, Tacchella, Sandro, and Willott, Chris
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Astrophysics - Astrophysics of Galaxies - Abstract
One of the more surprising findings after the first year of JWST observations is the large number of spatially extended galaxies (ultra-red flattened objects, or UFOs) among the optically-faint galaxy population otherwise thought to be compact. Leveraging the depth and survey area of the JADES survey, we extend observations of the optically-faint galaxy population to an additional 112 objects, 56 of which are well-resolved in F444W with effective sizes, $R_e > 0.25''$, more than tripling previous UFO counts. These galaxies have redshifts around $2 < z < 4$, high stellar masses ($\mathrm{log(M_*/M_{\odot})} \sim 10-11$), and star-formation rates around $\sim 100-1000 \mathrm{M_{\odot}/yr}$. Surprisingly, UFOs are red across their entire extents which spatially resolved analysis of their stellar populations shows is due to large values of dust attenuation (typically $A_V > 2$ mag even at large radii). Morphologically, the majority of our UFO sample tends to have low S\'ersic indices ($n \sim 1$) suggesting these large, massive, optically faint galaxies have little contribution from a bulge in F444W. Further, a majority have axis-ratios between $0.2 < q < 0.4$, which Bayesian modeling suggests that their intrinsic shapes are consistent with being a mixture of inclined disks and prolate objects with little to no contribution from spheroids. While kinematic constraints will be needed to determine the true intrinsic shapes of UFOs, it is clear that an unexpected population of large, disky or prolate objects contributes significantly to the population of optically faint galaxies., Comment: 24 pages, 13 figures; accepted for publication in The Astrophysical Journal
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- 2024
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19. Observational Signatures of Circumbinary Discs II: Kinematic Signatures in Velocity Residuals
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Calcino, Josh, Norfolk, Brodie, Price, Daniel J., Hilder, Thomas, Speedie, Jessica, Pinte, Christophe, Garg, Himanshi, Teague, Richard, Hall, Cassandra, and Stadler, Jochen
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Kinematic studies of protoplanetary discs are a valuable method for uncovering hidden companions. In the first paper of this series, we presented five morphological and kinematic criteria that aid in asserting the binary nature of a protoplanetary disc. In this work we study the kinematic signatures of circumbinary discs in the residuals of their velocity maps. We show that Doppler-flips, spiral arms, eccentric gas motion, fast flows inside of the cavity, and vortex-like kinematic signatures are commonly observed. Unlike in the planetary mass companion case, Doppler-flips in circumbinary discs are not necessarily centred on a companion, and can extend towards the cavity edge. We then compare the kinematic signatures in our simulations with observations and see similarities to the Doppler-flip signal in HD 100546 and the vortex-like kinematic signatures in HD 142527. Our analysis also reveals kinematic evidence for binarity in several protoplantary disks typically regarded as circumstellar rather than circumbinary, including AB Aurigae and HD 100546., Comment: 15 pages, 12 Figures. Submitted to MNRAS, revised version. Comments welcomed and appreciated!
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- 2024
20. DESI Massive Post-Starburst Galaxies at $\mathbf{z\sim1.2}$ have compact structures and dense cores
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Zhang, Yunchong, Setton, David J., Price, Sedona H., Bezanson, Rachel, Khullar, Gourav, Newman, Jeffrey A., Aguilar, Jessica Nicole, Ahlen, Steven, Andrews, Brett H., Brooks, David, Claybaugh, Todd, de la Macorra, Axel, Dey, Biprateep, Doel, Peter, Gaztañaga, Enrique, Gontcho, Satya Gontcho A, Greene, Jenny E., Juneau, Stephanie, Kehoe, Robert, Kisner, Theodore, Kriek, Mariska, Leja, Joel, Manera, Marc, Meisner, Aaron, Miquel, Ramon, Moustakas, John, Prada, Francisco, Rossi, Graziano, Sanchez, Eusebio, Schubnell, Michael, Siudek, Małgorzata, Spilker, Justin, Sprayberry, David, Suess, Katherine A., Tarlé, Gregory, and Zou, Hu
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Astrophysics - Astrophysics of Galaxies - Abstract
Post-starburst galaxies (PSBs) are young quiescent galaxies that have recently experienced a rapid decrease in star formation, allowing us to probe the fast-quenching period of galaxy evolution. In this work, we obtained HST WFC3/F110W imaging to measure the sizes of 171 massive ($\mathrm{log(M_{*}/M_{\odot})\sim\,11)}$ spectroscopically identified PSBs at $1
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- 2024
21. An Earth-sized Planet on the Verge of Tidal Disruption
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Dai, Fei, Howard, Andrew W., Halverson, Samuel, Orell-Miquel, Jaume, Palle, Enric, Isaacson, Howard, Fulton, Benjamin, Price, Ellen M., Plotnykov, Mykhaylo, Rogers, Leslie A., Valencia, Diana, Paragas, Kimberly, Greklek-McKeon, Michael, Barrientos, Jonathan Gomez, Knutson, Heather A., Petigura, Erik A., Weiss, Lauren M., Lee, Rena, Brinkman, Casey L., Huber, Daniel, Steffansson, Gudmundur, Masuda, Kento, Giacalone, Steven, Lu, Cicero X., Kite, Edwin S., Hu, Renyu, Gaidos, Eric, Zhang, Michael, Rubenzahl, Ryan A., Winn, Joshua N., Han, Te, Beard, Corey, Holcomb, Rae, Householder, Aaron, Gilbert, Gregory J., Lubin, Jack, Ong, J. M. Joel, Polanski, Alex S., Saunders, Nicholas, Van Zandt, Judah, Yee, Samuel W., Zhang, Jingwen, Zink, Jon, Holden, Bradford, Baker, Ashley, Brodheim, Max, Crossfield, Ian J. M., Deich, William, Edelstein, Jerry, Gibson, Steven R., Hill, Grant M., Jelinsky, Sharon R, Kassis, Marc, Laher, Russ R., Lanclos, Kyle, Lilley, Scott, Payne, Joel N., Rider, Kodi, Robertson, Paul, Roy, Arpita, Schwab, Christian, Shaum, Abby P., Sirk, Martin M., Smith, Chris, Vandenberg, Adam, Walawender, Josh, Wang, Sharon X., Shin-Ywan, Wang, Wishnow, Edward, Wright, Jason T., Yeh, Sherry, Caballero, Jos. A., Morales, Juan C., Murgas, Felipe, Nagel, Evangelos, Reiners, Ansgar, Schweitzer, Andreas, Tabernero, Hugo M., Zechmeister, Mathias, Spencer, Alton, Ciardi, David R., Clark, Catherine A., Lund, Michael B., Caldwell, Douglas A., Collins, Karen A., Schwarz, Richard P., Barkaoui, Khalid, Watkins, Cristilyn N., Shporer, Avi, Narita, Norio, Fukui, Akihiko, Srdoc, Gregor, Latham, David W., Jenkins, Jon M., Ricker, George R., Seager, Sara, and Vanderspek, Roland
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Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
TOI-6255~b (GJ 4256) is an Earth-sized planet (1.079$\pm0.065$ $R_\oplus$) with an orbital period of only 5.7 hours. With the newly commissioned Keck Planet Finder (KPF) and CARMENES spectrographs, we determined the planet's mass to be 1.44$\pm$0.14 $M_{\oplus}$. The planet is just outside the Roche limit, with $P_{\rm orb}/P_{\rm Roche}$ = 1.13 $\pm0.10$. The strong tidal force likely deforms the planet into a triaxial ellipsoid with a long axis that is $\sim$10\% longer than the short axis. Assuming a reduced stellar tidal quality factor $Q_\star^\prime \approx10^7$, we predict that tidal orbital decay will cause TOI-6255 to reach the Roche limit in roughly 400 Myr. Such tidal disruptions may produce the possible signatures of planet engulfment that have been on stars with anomalously high refractory elemental abundances compared to its conatal binary companion. TOI-6255 b is also a favorable target for searching for star-planet magnetic interactions, which might cause interior melting and hasten orbital decay. TOI-6255 b is a top target (Emission Spectroscopy Metric of about 24) for phase curve observations with the James Webb Space Telescope., Comment: 18 pages, 7 figures, 5 tables, accepted to AAS Journals. The first RV mass measurement from the Keck Planet Finder
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- 2024
22. Carbon enrichment in APOGEE disk stars as evidence of mass transfer in binaries
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Foster, Steve, Schiavon, Ricardo P., de Castro, Denise B., Lucatello, Sara, Daher, Christine, Penoyre, Zephyr, Price-Whelan, Adrian, Badenes, Carles, Fernández-Trincado, JJ. G., García-Hernández, D. A., Holtzman, Jon, Jönsson, Henrik, and Shetrone, Matthew
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Carbon abundances in first-ascent giant stars are usually lower than those of their main-sequence counterparts. At moderate metallicities, stellar evolution of single stars cannot account for the existence of red-giant branch stars with enhanced carbon abundances. The phenomenon is usually interpreted as resulting from past mass transfer from an evolved binary companion now in the white dwarf evolutionary stage. Aims: We aim to confirm the links between [C/O] enhancement, s-process element enhancement and binary fraction using large-scale catalogues of stellar abundances and probable binary stars. Methods: We use a large data set from the 17 data release of the SDSS-IV/APOGEE~2 survey to identify carbon-enhanced stars in the Galactic disk. We identify a continuum of carbon enrichment throughout three different sub-populations of disk stars and explore links between the degree of carbon enrichment and binary frequency, metallicity and chemical compositions. Results: We verify a clear correlation between binary frequency and enhancement in the abundances of both carbon and cerium, lending support to the scenario whereby carbon-enhanced stars are the result of mass transfer by an evolved binary companion. In addition, we identify clustering in the carbon abundances of high-$\alpha$ disk stars, suggesting that those on the high metallicity end are likely younger, in agreement with theoretical predictions for the presence of a starburst population following the gas-rich merger of the Gaia-Enceladus/Sausage system., Comment: 20 pages
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- 2024
23. The Extreme Low-mass End of the Mass-Metallicity Relation at $z\sim7$
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Chemerynska, Iryna, Atek, Hakim, Dayal, Pratika, Furtak, Lukas J., Feldmann, Robert, Greene, Jenny E., Maseda, Michael V., Nanayakkara, Themiya, Oesch, Pascal A., Labbe, Ivo, Bezanson, Rachel, Brammer, Gabriel, Cutler, Sam E., Leja, Joel, Pan, Richard, Price, Sedona H., Wang, Bingjie, Weaver, John R., and Whitaker, Katherine E.
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Astrophysics - Astrophysics of Galaxies - Abstract
The mass-metallicity relation (MZR) provides crucial insights into the baryon cycle in galaxies and provides strong constraints on galaxy formation models. We use JWST NIRSpec observations from the UNCOVER program to measure the gas-phase metallicity in a sample of eight galaxies during the epoch of reionization at $z=6-8$. Thanks to strong lensing of the galaxy cluster Abell 2744, we are able to probe extremely low stellar masses between $10^{6}$ and $10^{8} M_{\odot}$. Using strong lines diagnostics and the most recent JWST calibrations, we derive extremely-low oxygen abundances ranging from 12+log(O/H)=6.7 to 7.8. By combining this sample with more massive galaxies at similar redshifts, we derive a best-fit relation of 12+{\rm log(O/H)}=$0.39_{-0.02}^{+0.02} \times$ log(\mstar) $+ 4.52_{-0.17}^{+0.17}$, which is steeper than determinations at $z \sim 3$. Our results show a clear redshift evolution in the overall normalization of the relation, galaxies at higher redshift having significantly lower metallicities at a given mass. A comparison with theoretical models provides important constraints on which physical processes, such as metal mixing, star formation or feedback recipes, are important in reproducing the observations. Additionally, these galaxies exhibit star formation rates that are higher by a factor of a few to tens compared to extrapolated relations at similar redshifts or theoretical predictions of main-sequence galaxies, pointing to a recent burst of star formation. All these observations are indicative of highly stochastic star formation and ISM enrichment, expected in these low-mass systems, suggesting that feedback mechanisms in high-$z$ dwarf galaxies might be different from those in place at higher masses., Comment: Submitted to ApJL
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- 2024
24. Chemical tracers of a highly eccentric AGB-main sequence star binary
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Danilovich, T., Malfait, J., Van de Sande, M., Montargès, M., Kervella, P., De Ceuster, F., Coenegrachts, A., Millar, T. J., Richards, A. M. S., Decin, L., Gottlieb, C. A., Pinte, C., De Beck, E., Price, D. J., Wong, K. T., Bolte, J., Menten, K. M., Baudry, A., de Koter, A., Etoka, S., Gobrecht, D., Gray, M., Herpin, F., Jeste, M., Lagadec, E., Maes, S., McDonald, I., Marinho, L., Müller, H. S. P., Pimpanuwat, B., Plane, J. M. C., Sahai, R., Wallström, S. H. J., Yates, J., and Zijlstra, A.
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Astrophysics - Solar and Stellar Astrophysics - Abstract
Binary interactions have been proposed to explain a variety of circumstellar structures seen around evolved stars, including asymptotic giant branch (AGB) stars and planetary nebulae. Studies resolving the circumstellar envelopes of AGB stars have revealed spirals, discs and bipolar outflows, with shaping attributed to interactions with a companion. For the first time, we have used a combined chemical and dynamical analysis to reveal a highly eccentric and long-period orbit for W Aquilae, a binary system containing an AGB star and a main sequence companion. Our results are based on anisotropic SiN emission, the first detections of NS and SiC towards an S-type star, and density structures observed in the CO emission. These features are all interpreted as having formed during periastron interactions. Our astrochemistry-based method can yield stringent constraints on the orbital parameters of long-period binaries containing AGB stars, and will be applicable to other systems., Comment: This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature's AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41550-023-02154-y
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- 2024
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25. On shock capturing in smoothed particle hydrodynamics
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Price, Daniel J.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
For the past 20 years, our approach to shock capturing in smoothed particle hydrodynamics (SPH) has been to use artificial viscosity and conductivity terms supplemented by switches to control excess dissipation away from shocks (Monaghan 1997; Morris & Monaghan 1997). This approach has been demonstrated to be superior to approximate Riemann solvers in a recent comparison (Puri & Ramachandran 2014). The Cullen & Dehnen (2010) switch is regarded as the state of the art. But are we missing something? I will present a novel approach to shock capturing in SPH that utilises the philosophy of approximate Riemann solvers but provides a direct improvement on the ability to reduce excess dissipation away from shocks while preserving the fidelity of the shock itself., Comment: 6 pages, 12 figures, proceedings of 2019 international SPHERIC workshop, Exeter UK. Despite what I said in these proceedings, I later concluded that switches are indeed better, because one can ensure positive definite entropy increase, which is not the case with reconstruction (see Price & Laibe 2020; arXiv:2005.06562)
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- 2024
26. The ALMA-CRISTAL survey: Dust temperature and physical conditions of the interstellar medium in a typical galaxy at z=5.66
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Villanueva, V., Herrera-Camus, R., Gonzalez-Lopez, J., Aravena, M., Assef, R. J., Baeza-Garay, Mauricio, Barcos-Muñoz, L., Bovino, S., Bowler, R. A. A., da Cunha, E., De Looze, I., Diaz-Santos, T., Ferrara, A., Foerster-Schreiber, N., Algera, H., Iked, R., Killi, M., Mitsuhashi, I., Naab, T., Relano, M., Spilker, J., Solimano, M., Palla, M., Price, S. H., Posses, A., Tadaki, K., Telikova, K., and Übler, H.
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Astrophysics - Astrophysics of Galaxies - Abstract
We present new $\lambda_{\rm rest}=77$ $\mu$m dust continuum observations from the ALMA of HZ10 (CRISTAL-22), a dusty main-sequence galaxy at $z$=5.66 as part of the [CII] Resolved Ism in STar-forming Alma Large program, CRISTAL. The high angular resolution of the ALMA Band 7 and new Band 9 data($\sim{0}''.4$) reveals the complex structure of HZ10, which comprises two main components (HZ10-C and HZ10-W) and a bridge-like dusty emission between them (the Bridge). We model the dust spectral energy distribution (SED) to constrain the physical conditions of the interstellar medium (ISM) and its variations among the different components identified in HZ10. We find that HZ10-W (the more UV-obscured component) has an SED dust temperature of $T_{\rm SED}$$\sim$51.2$\pm13.1$ K; this is $\sim$5 K higher (although still consistent) than that of the central component and previous global estimations for HZ10. Our new ALMA data allow us to reduce by a factor of $\sim$2.3 the uncertainties of global $T_{\rm SED}$ measurements compared to previous studies. Interestingly, HZ10-W shows a lower [CII]/FIR ratio compared to the other two components (although still within the uncertainties), suggesting a harder radiation field destroying polycyclic aromatic hydrocarbon associated with [CII] emission (e.g., active galactic nuclei or young stellar populations). While HZ10-C appears to follow the tight IRX-$\beta_{\rm UV}$ relation seen in local UV-selected starburst galaxies and high-$z$ star-forming galaxies, we find that both HZ10-W and the Bridge depart from this relation and are well described by dust-screen models with holes in front of a hard UV radiation field. This suggests that the UV emission (likely from young stellar populations) is strongly attenuated in the more dusty components of the HZ10 system.
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- 2024
27. SPIN: Hierarchical Segmentation with Subpart Granularity in Natural Images
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Myers-Dean, Josh, Reynolds, Jarek, Price, Brian, Fan, Yifei, and Gurari, Danna
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Hierarchical segmentation entails creating segmentations at varying levels of granularity. We introduce the first hierarchical semantic segmentation dataset with subpart annotations for natural images, which we call SPIN (SubPartImageNet). We also introduce two novel evaluation metrics to evaluate how well algorithms capture spatial and semantic relationships across hierarchical levels. We benchmark modern models across three different tasks and analyze their strengths and weaknesses across objects, parts, and subparts. To facilitate community-wide progress, we publicly release our dataset at https://joshmyersdean.github.io/spin/index.html., Comment: Accepted at ECCV 2024
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- 2024
28. Scattering transforms on the sphere, application to large scale structure modelling
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Mousset, Louise, Allys, Erwan, Price, Matthew A., Aumont, Jonathan, Delouis, Jean-Marc, Montier, Ludovic, and McEwen, Jason D.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Scattering transforms are a new type of summary statistics recently developed for the study of highly non-Gaussian processes, which have been shown to be very promising for astrophysical studies. In particular, they allow one to build generative models of complex non-linear fields from a limited amount of data. In the context of upcoming cosmological surveys, the extension of these tools to spherical data is necessary. We develop scattering transforms on the sphere and focus on the construction of maximum-entropy generative models of astrophysical fields. The quality of the generative models, both statistically and visually, is very satisfying, which therefore open up a wide range of new applications for future cosmological studies., Comment: Contribution to the 2024 Cosmology session of the 58th Rencontres de Moriond. For details, please refer to the full article arXiv:2407.07007
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- 2024
29. Dust formation during the interaction of binary stars by common envelope
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Bermúdez-Bustamante, Luis C., De Marco, Orsola, Siess, Lionel, Price, Daniel J., González-Bolívar, Miguel, Lau, Mike Y. M., Mu, Chunliang, Hirai, Ryosuke, Danilovich, Taïssa, and Kasliwal, Mansi
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Astrophysics - Solar and Stellar Astrophysics ,Astrophysics - Astrophysics of Galaxies - Abstract
We performed numerical simulations of the common envelope (CE) interaction between two intermediate-mass asymptotic giant branch (AGB) stars and their low-mass companions. For the first time, formation and growth of dust in the envelope is calculated explicitly. We find that the first dust grains appear as early as $\sim$1-3 yrs after the onset of the CE, and are smaller than grains formed later. As the simulations progress, a high-opacity dusty shell forms, resulting in the CE photosphere being up to an order of magnitude larger than it would be without the inclusion of dust. At the end of the simulations, the total dust yield is $0.0082~M_{\odot}$ ($0.022~M_{\odot}$) for a CE with a $1.7~M_{\odot}$ ($3.7~M_{\odot}$) AGB star. Dust formation does not substantially lead to more mass unbinding or substantially alter the orbital evolution., Comment: 6 pages, 6 figures, contributed talk to the Proceedings IAU Symposium No. 384
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- 2024
30. Iron Snails: non-equilibrium dynamics and spiral abundance patterns
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Frankel, Neige, Hogg, David W., Tremaine, Scott, Price-Whelan, Adrian, and Shen, Jeff
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Astrophysics - Astrophysics of Galaxies - Abstract
Galaxies are not in a dynamical steady state. They continually undergo perturbations, e.g., from infalling dwarf galaxies and dark-matter substructure. After a dynamical perturbation, stars phase mix towards a new steady state; in so doing they generally form spiral structures, such as spiral density waves in galaxy disks and the Gaia Snail observed in the vertical phase-space density in the solar neighborhood. Structures in phase-space density can be hard to measure accurately, because spatially varying selection effects imprint their own patterns on the density. However, stellar labels such as metallicity, or other element abundances, or stellar masses and ages, can be measured even in the face of complex or unknown spatial selection functions. We show that if the equilibrium galaxy has phase-space gradients in these labels, any perturbation that could raise a spiral wave in the phase-space density will raise a spiral wave in the distribution of labels as well. We work out the relationship between the spiral patterns in the density and in the labels. As an example, we analyze the Gaia Snail and show that its amplitude and dynamical age as derived from elemental abundances (mainly [Mg/Fe]) follow similar patterns to those derived from the phase-space density. Our best model dates the Snail's perturbation to about 400 Myr ago although we find significant variations with angular momentum in the best-fit age. Conceptually, the ideas presented here are related to Orbital Torus Imaging, chemical tagging, and other methods that use stellar labels to trace dynamics., Comment: Submitted to ApJ, comments are welcome
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- 2024
31. Generative models of astrophysical fields with scattering transforms on the sphere
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Mousset, Louise, Allys, Erwan, Price, Matthew A., Aumont, Jonathan, Delouis, Jean-Marc, Montier, Ludovic, and McEwen, Jason D.
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Scattering transforms are a new type of summary statistics recently developed for the study of highly non-Gaussian processes, which have been shown to be very promising for astrophysical studies. In particular, they allow one to build generative models of complex non-linear fields from a limited amount of data, and have also been used as the basis of new statistical component separation algorithms. In the context of upcoming cosmological surveys, such as LiteBIRD for the cosmic microwave background polarization or Rubin-LSST and Euclid for study of the large scale structures of the Universe, the extension of these tools to spherical data is necessary. We develop scattering transforms on the sphere and focus on the construction of maximum-entropy generative models of several astrophysical fields. We construct, from a single target field, generative models of homogeneous astrophysical and cosmological fields, whose samples are quantitatively compared to the target fields using common statistics (power spectrum, pixel probability density function and Minkowski functionals). Our sampled fields agree well with the target fields, both statistically and visually. These generative models therefore open up a wide range of new applications for future astrophysical and cosmological studies; particularly those for which very little simulated data is available. We make our code available to the community so that this work can be easily reproduced and developed further., Comment: submitted to A&A, 13 pages, 10 figures, code available at https://github.com/astro-informatics/s2scat
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- 2024
32. DarkSide-20k sensitivity to light dark matter particles
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Collaboration, DarkSide-20k, Acerbi, F., Adhikari, P., Agnes, P., Ahmad, I., Albergo, S., Albuquerque, I. F. M., Alexander, T., Alton, A. K., Amaudruz, P., Angiolilli, M., Aprile, E., Ardito, R., Corona, M. Atzori, Auty, D. J., Ave, M., Avetisov, I. C., Azzolini, O., Back, H. O., Balmforth, Z., Olmedo, A. Barrado, Barrillon, P., Batignani, G., Bhowmick, P., Blua, S., Bocci, V., Bonivento, W., Bottino, B., Boulay, M. G., Buchowicz, A., Bussino, S., Busto, J., Cadeddu, M., Cadoni, M., Calabrese, R., Camillo, V., Caminata, A., Canci, N., Capra, A., Caravati, M., Cárdenas-Montes, M., Cargioli, N., Carlini, M., Castellani, A., Castello, P., Cavalcante, P., Cebrian, S., Ruiz, J. M. Cela, Chashin, S., Chepurnov, A., Cifarelli, L., Cintas, D., Citterio, M., Cleveland, B., Coadou, Y., Cocco, V., Colaiuda, D., Vilda, E. Conde, Consiglio, L., Costa, B. S., Czubak, M., D'Aniello, M., D'Auria, S., Rolo, M. D. Da Rocha, Darbo, G., Davini, S., De Cecco, S., De Guido, G., Dellacasa, G., Derbin, A. V., Devoto, A., Di Capua, F., Di Ludovico, A., Di Noto, L., Di Stefano, P., Dias, L. K., Mairena, D. Díaz, Ding, X., Dionisi, C., Dolganov, G., Dordei, F., Dronik, V., Elersich, A., Ellingwood, E., Erjavec, T., Diaz, M. Fernandez, Ficorella, A., Fiorillo, G., Franchini, P., Franco, D., Gatti, H. Frandini, Frolov, E., Gabriele, F., Gahan, D., Galbiati, C., Galiński, G., Gallina, G., Gallus, G., Garbini, M., Abia, P. Garcia, Gawdzik, A., Gendotti, A., Ghisi, A., Giovanetti, G. K., Casanueva, V. Goicoechea, Gola, A., Grandi, L., Grauso, G., di Cortona, G. Grilli, Grobov, A., Gromov, M., Guerzoni, M., Gulino, M., Guo, C., Hackett, B. R., Hallin, A., Hamer, A., Haranczyk, M., Harrop, B., Hessel, T., Hill, S., Horikawa, S., Hu, J., Hubaut, F., Hucker, J., Hugues, T., Hungerford, E. V., Ianni, A., Ippolito, V., Jamil, A., Jillings, C., Jois, S., Kachru, P., Keloth, R., Kemmerich, N., Kemp, A., Kendziora, C. L., Kimura, M., Kondo, K., Korga, G., Kotsiopoulou, L., Koulosousas, S., Kubankin, A., Kunzé, P., Kuss, M., Kuźniak, M., Kuzwa, M., La Commara, M., Lai, M., Guirriec, E. Le, Leason, E., Leoni, A., Lidey, L., Lissia, M., Luzzi, L., Lychagina, O., Macfadyen, O., Machulin, I. N., Manecki, S., Manthos, I., Mapelli, L., Marasciulli, A., Mari, S. M., Mariani, C., Maricic, J., Martinez, M., Martoff, C. J., Matteucci, G., Mavrokoridis, K., McDonald, A. B., Mclaughlin, J., Merzi, S., Messina, A., Milincic, R., Minutoli, S., Mitra, A., Moioli, S., Monroe, J., Moretti, E., Morrocchi, M., Mroz, T., Muratova, V. N., Murphy, M., Murra, M., Muscas, C., Musico, P., Nania, R., Nessi, M., Nieradka, G., Nikolopoulos, K., Nikoloudaki, E., Nowak, J., Olchanski, K., Oleinik, A., Oleynikov, V., Organtini, P., de Solórzano, A. Ortiz, Pallavicini, M., Pandola, L., Pantic, E., Paoloni, E., Papi, D., Pastuszak, G., Paternoster, G., Peck, A., Pegoraro, P. A., Pelczar, K., Pellegrini, L. A., Perez, R., Perotti, F., Pesudo, V., Piacentini, S. I., Pino, N., Plante, G., Pocar, A., Poehlmann, M., Pordes, S., Pralavorio, P., Price, D., Puglia, S., Bazetto, M. Queiroga, Ragusa, F., Ramachers, Y., Ramirez, A., Ravinthiran, S., Razeti, M., Renshaw, A. L., Rescigno, M., Retiere, F., Rignanese, L. P., Rivetti, A., Roberts, A., Roberts, C., Rogers, G., Romero, L., Rossi, M., Rubbia, A., Rudik, D., Sabia, M., Salomone, P., Samoylov, O., Sandford, E., Sanfilippo, S., Santone, D., Santorelli, R., Santos, E. M., Savarese, C., Scapparone, E., Schillaci, G., Schuckman II, F. G., Scioli, G., Semenov, D. A., Shalamova, V., Sheshukov, A., Simeone, M., Skensved, P., Skorokhvatov, M. D., Smirnov, O., Smirnova, T., Smith, B., Sotnikov, A., Spadoni, F., Spangenberg, M., Stefanizzi, R., Steri, A., Stornelli, V., Stracka, S., Sulis, S., Sung, A., Sunny, C., Suvorov, Y., Szelc, A. M., Taborda, O., Tartaglia, R., Taylor, A., Taylor, J., Tedesco, S., Testera, G., Thieme, K., Thompson, A., Tonazzo, A., Torres-Lara, S., Tricomi, A., Unzhakov, E. V., Vallivilayil, T. J., Van Uffelen, M., Velazquez-Fernandez, L., Viant, T., Viel, S., Vishneva, A., Vogelaar, R. B., Vossebeld, J., Vyas, B., Walczak, M. B., Wang, Y., Wang, H., Westerdale, S., Williams, L., Wojaczyński, R., Wojcik, M., Wojcik, M. M., Wright, T., Xie, Y., Yang, C., Yin, J., Zabihi, A., Zakhary, P., Zani, A., Zhang, Y., Zhu, T., Zichichi, A., Zuzel, G., and Zykova, M. P.
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High Energy Physics - Experiment ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The dual-phase liquid argon time projection chamber is presently one of the leading technologies to search for dark matter particles with masses below 10 GeV/c$^2$. This was demonstrated by the DarkSide-50 experiment with approximately 50 kg of low-radioactivity liquid argon as target material. The next generation experiment DarkSide-20k, currently under construction, will use 1,000 times more argon and is expected to start operation in 2027. Based on the DarkSide-50 experience, here we assess the DarkSide-20k sensitivity to models predicting light dark matter particles, including Weakly Interacting Massive Particles (WIMPs) and sub-GeV/c$^2$ particles interacting with electrons in argon atoms. With one year of data, a sensitivity improvement to dark matter interaction cross-sections by at least one order of magnitude with respect to DarkSide-50 is expected for all these models. A sensitivity to WIMP--nucleon interaction cross-sections below $1\times10^{-42}$ cm$^2$ is achievable for WIMP masses above 800 MeV/c$^2$. With 10 years exposure, the neutrino fog can be reached for WIMP masses around 5 GeV/c$^2$., Comment: submitted to Nature Communications
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- 2024
33. Future Events as Backdoor Triggers: Investigating Temporal Vulnerabilities in LLMs
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Price, Sara, Panickssery, Arjun, Bowman, Sam, and Stickland, Asa Cooper
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Computer Science - Cryptography and Security ,Computer Science - Computation and Language ,Computer Science - Machine Learning - Abstract
Backdoors are hidden behaviors that are only triggered once an AI system has been deployed. Bad actors looking to create successful backdoors must design them to avoid activation during training and evaluation. Since data used in these stages often only contains information about events that have already occurred, a component of a simple backdoor trigger could be a model recognizing data that is in the future relative to when it was trained. Through prompting experiments and by probing internal activations, we show that current large language models (LLMs) can distinguish past from future events, with probes on model activations achieving 90% accuracy. We train models with backdoors triggered by a temporal distributional shift; they activate when the model is exposed to news headlines beyond their training cut-off dates. Fine-tuning on helpful, harmless and honest (HHH) data does not work well for removing simpler backdoor triggers but is effective on our backdoored models, although this distinction is smaller for the larger-scale model we tested. We also find that an activation-steering vector representing a model's internal representation of the date influences the rate of backdoor activation. We take these results as initial evidence that, at least for models at the modest scale we test, standard safety measures are enough to remove these backdoors.
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- 2024
34. Spacetime-topological events
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Feis, Joshua, Weidemann, Sebastian, Sheppard, Tom, Price, Hannah M., and Szameit, Alexander
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Physics - Optics - Abstract
Time is, figuratively and literally, becoming the new dimension for crystalline matter. As such, rapid recent progress on time-varying media gave rise to the notion of temporal and spatiotemporal crystals. Fundamentally rethinking the role of time, which, in contrast to space exhibits a unique unidirectionality often referred to as the arrow of time, promises a new dimension also for topological physics. Here, we enter the new realm of time and spacetime topology: Firstly, we implement a time-topological time interface state. Secondly, we propose and observe a spacetime-topological event and demonstrate unique features like its limited collapse under disorder and causality-suppressed coupling. The new paradigms of time and spacetime topology unveil a distinctive role of causality and non-Hermiticity in topology and pave the way towards topological spatiotemporal wave control with unique robustness.
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- 2024
35. Carbon and Iron Deficiencies in Quiescent Galaxies at z=1-3 from JWST-SUSPENSE: Implications for the Formation Histories of Massive Galaxies
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Beverage, Aliza G., Slob, Martje, Kriek, Mariska, Conroy, Charlie, Barro, Guillermo, Bezanson, Rachel, Brammer, Gabriel, Cheng, Chloe M., de Graaff, Anna, Schreiber, Natascha M. Förster, Franx, Marijn, Lorenz, Brian, Piña, Pavel E. Mancera, Marchesini, Danilo, Muzzin, Adam, Newman, Andrew B., Price, Sedona H., Shapley, Alice E., Stefanon, Mauro, Suess, Katherine A., van Dokkum, Pieter, Weinberg, David, and Weisz, Daniel R.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We present the stellar metallicities and multi-element abundances (C, Mg, Si, Ca, Ti, Cr, and Fe) of 15 massive (log M/M$_\odot$=10.2-11.2) quiescent galaxies at z=1-3, derived from ultradeep JWST-SUSPENSE spectra. Compared to quiescent galaxies at z~0, these galaxies exhibit a deficiency of 0.25 dex in [C/H], 0.16 dex in [Fe/H], and 0.07 dex in [Mg/H], implying rapid formation and quenching before significant enrichment from asymptotic giant branch stars and Type Ia supernovae. Additionally, we find that galaxies that form at higher redshift have higher [Mg/Fe] and lower [Fe/H] and [Mg/H], irrespective of their observed redshift. The evolution in [Fe/H] and [C/H] is therefore primarily explained by lower redshift samples naturally including galaxies with longer star-formation timescales. On the other hand, the lower [Mg/H] can be explained by galaxies forming at earlier epochs expelling larger gas reservoirs during their quenching phase. Consequently, the mass-metallicity relation, primarily reflecting [Mg/H], is also lower at z=1-3 compared to the lower redshift relation, though the slopes are similar. Finally, we compare our results to standard stellar population modeling approaches employing solar abundance patterns and non-parametric star-formation histories (using Prospector). Our SSP-equivalent ages agree with the mass-weighted ages from Prospector, while the metallicities disagree significantly. Nonetheless, the metallicities better reflect [Fe/H] than total [Z/H]. We also find that star-formation timescales inferred from elemental abundances are significantly shorter than those from Prospector, and we discuss the resulting implications for the early formation of massive galaxies., Comment: Submitted to ApJ; 18 pages, 6 figures, 1 table
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- 2024
36. Evaluating Exposure to Coastal Hazards in the Supervised Offender Population Using Social Disorganization Theory
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Price, Ashleigh, Cochran, David M., Raber, George, and Hill, Joshua
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- 2020
- Full Text
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37. Testing the Effects of a Utility Value Intervention in an Online Research Methods Course: A Conceptual Replication of Hulleman Et Al. (2017, Study 2)
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Paul C. Price, Kiana Crisosto, Anthony Carvalho, Constance J. Jones, Meaghan McCready, Amber Shaver, and Andrea N. Wiemann
- Abstract
Background: Utility-value (UV) classroom interventions typically involve students completing assignments that involve writing about the usefulness of the course material. They are widely recommended and have received some empirical support. Objective: This study tested the effectiveness of a UV intervention in an online research methods course. It was a conceptual replication of a study by Hulleman et al. (2017, Study 2). Method: Students (N = 264) were randomly assigned to complete three assignments that required them to write about the usefulness of course material or three assignments that required them to summarize course material. The groups were compared in terms of their scores on a research methods knowledge test, their final papers, their final exams, and their final point totals, along with measures of the interestingness and usefulness of the course material. Results: There were no differences between conditions on any of the outcome variables. Conclusion: The UV intervention was ineffective. Further research is needed to establish the conditions under which such interventions are and are not effective. Teaching Implications: UV interventions do not necessarily improve student performance. Instructors who use them should consider doing so in a way that allows for an assessment of their effect in their local context.
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- 2024
- Full Text
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38. Middle and High School LGBTQ Students Report What Makes School LGBTQ-Affirming across Race/Ethnicity and Gender Identity, a Topic Modeling Method
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Myeshia N. Price, Wilson Y. Lee, J. N. Hobbs, Jonah P. DeChants, and Carrie K. Davis
- Abstract
BACKGROUND: Affirming spaces have been associated with improved mental health outcomes for lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ) adolescents. METHODS: With data from adolescents currently enrolled in middle or high school across the United States, this study used topic modeling methods to examine students' reports of what they were looking for in LGBTQ-affirming schools and, separately, the association of LGBTQ-affirming schools with suicide risk reduction. RESULTS: Topic models demonstrated consistent themes in how students determined that their school was affirming, such as LGBTQ clubs, teachers requesting pronouns, pride flags, and accepting peers. Students of color uniquely looked for actionable responses in addressing LGBTQ issues. Transgender and nonbinary students required explicit mention of support for transgender issues. Quantitatively, LGBTQ students who reported that their school was LGBTQ-affirming had 20% lower odds of attempting suicide in the past year (adjusted odds ratio = 0.80). CONCLUSIONS: These findings suggest that schools must be safe for all youth and implementing policies that make LGBTQ students feel seen and supported in their identities is a protective factor for mental health. IMPLICATIONS: School policies must ensure that youth have access to supportive people, symbols of support, and LGBTQ clubs and that they are also salient to LGBTQ students of color and transgender and nonbinary students.
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- 2024
- Full Text
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39. Interprofessional Education on Autism and Intellectual Disabilities: Program Description and Initial Evaluation
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Johanna R. Price, Karena Cooper-Duffy, Billy T. Ogletree, Jonathan M. Campbell, Amy J. Rose, Machelle Cathey, and Kong Chen
- Abstract
Project INTERprofessional Autism Collaborative Training (INTERACT) is an interprofessional education program designed to prepare graduate students in psychology, special education, and speech-language pathology to work with autistic children with moderate to severe intellectual disabilities. The rising prevalence of autism, coupled with increased appreciation for interprofessional approaches to service delivery, indicates the need for university training programs to prepare graduate students to work interprofessionally with this population; yet descriptions of such programs and their effectiveness are not reported in the literature. In this article, we explain the process through which an interprofessional faculty team developed Project INTERACT, describe the sequence of coursework and team-based clinical experiences that comprise the program, and present preliminary data regarding its effectiveness. Twenty-four graduate students in psychology, special education, and speech-language pathology participated in this quantitative study. We report results from three rating scales that participants completed at program entry, midpoint, and program exit. Participants endorsed positive attitudes toward interprofessional practice and demonstrated high levels of knowledge about autism. Self-rated knowledge and abilities in interprofessional practice increased significantly by program exit. Project INTERACT scholars developed knowledge and skills related to understanding, assessing, and treating autistic children with intellectual disabilities, through the lens of team-based interprofessional collaboration. We discuss implications for practice with Project INTERACT.
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- 2024
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40. Birth of protein folds and functions in the virome
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Nomburg, Jason, Doherty, Erin E, Price, Nathan, Bellieny-Rabelo, Daniel, Zhu, Yong K, and Doudna, Jennifer A
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Biochemistry and Cell Biology ,Medical Microbiology ,Biomedical and Clinical Sciences ,Biological Sciences ,Genetics ,Immunization ,Biodefense ,Infectious Diseases ,Emerging Infectious Diseases ,1.1 Normal biological development and functioning ,2.2 Factors relating to the physical environment ,Infection ,Generic health relevance ,General Science & Technology - Abstract
The rapid evolution of viruses generates proteins that are essential for infectivity and replication but with unknown functions, due to extreme sequence divergence1. Here, using a database of 67,715 newly predicted protein structures from 4,463 eukaryotic viral species, we found that 62% of viral proteins are structurally distinct and lack homologues in the AlphaFold database2,3. Among the remaining 38% of viral proteins, many have non-viral structural analogues that revealed surprising similarities between human pathogens and their eukaryotic hosts. Structural comparisons suggested putative functions for up to 25% of unannotated viral proteins, including those with roles in the evasion of innate immunity. In particular, RNA ligase T-like phosphodiesterases were found to resemble phage-encoded proteins that hydrolyse the host immune-activating cyclic dinucleotides 3',3'- and 2',3'-cyclic GMP-AMP (cGAMP). Experimental analysis showed that RNA ligase T homologues encoded by avian poxviruses similarly hydrolyse cGAMP, showing that RNA ligase T-mediated targeting of cGAMP is an evolutionarily conserved mechanism of immune evasion that is present in both bacteriophage and eukaryotic viruses. Together, the viral protein structural database and analyses presented here afford new opportunities to identify mechanisms of virus-host interactions that are common across the virome.
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- 2024
41. High-throughput genetics enables identification of nutrient utilization and accessory energy metabolism genes in a model methanogen.
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Day, Leslie A, Carlson, Hans K, Fonseca, Dallas R, Arkin, Adam P, Price, Morgan N, Deutschbauer, Adam M, and Costa, Kyle C
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Microbiology ,Biological Sciences ,Ecology ,Genetics ,1.1 Normal biological development and functioning ,Generic health relevance ,archaea ,transposons ,metabolism ,Biochemistry and cell biology ,Medical microbiology - Abstract
Archaea are widespread in the environment and play fundamental roles in diverse ecosystems; however, characterization of their unique biology requires advanced tools. This is particularly challenging when characterizing gene function. Here, we generate randomly barcoded transposon libraries in the model methanogenic archaeon Methanococcus maripaludis and use high-throughput growth methods to conduct fitness assays (RB-TnSeq) across over 100 unique growth conditions. Using our approach, we identified new genes involved in nutrient utilization and response to oxidative stress. We identified novel genes for the usage of diverse nitrogen sources in M. maripaludis including a putative regulator of alanine deamination and molybdate transporters important for nitrogen fixation. Furthermore, leveraging the fitness data, we inferred that M. maripaludis can utilize additional nitrogen sources including ʟ-glutamine, ᴅ-glucuronamide, and adenosine. Under autotrophic growth conditions, we identified a gene encoding a domain of unknown function (DUF166) that is important for fitness and hypothesize that it has an accessory role in carbon dioxide assimilation. Finally, comparing fitness costs of oxygen versus sulfite stress, we identified a previously uncharacterized class of dissimilatory sulfite reductase-like proteins (Dsr-LP; group IIId) that is important during growth in the presence of sulfite. When overexpressed, Dsr-LP conferred sulfite resistance and enabled use of sulfite as the sole sulfur source. The high-throughput approach employed here allowed for generation of a large-scale data set that can be used as a resource to further understand gene function and metabolism in the archaeal domain.IMPORTANCEArchaea are widespread in the environment, yet basic aspects of their biology remain underexplored. To address this, we apply randomly barcoded transposon libraries (RB-TnSeq) to the model archaeon Methanococcus maripaludis. RB-TnSeq coupled with high-throughput growth assays across over 100 unique conditions identified roles for previously uncharacterized genes, including several encoding proteins with domains of unknown function (DUFs). We also expand on our understanding of carbon and nitrogen metabolism and characterize a group IIId dissimilatory sulfite reductase-like protein as a functional sulfite reductase. This data set encompasses a wide range of additional conditions including stress, nitrogen fixation, amino acid supplementation, and autotrophy, thus providing an extensive data set for the archaeal community to mine for characterizing additional genes of unknown function.
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- 2024
42. High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage
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Lai, Yunjia, Koelmel, Jeremy P, Walker, Douglas I, Price, Elliott J, Papazian, Stefano, Manz, Katherine E, Castilla-Fernández, Delia, Bowden, John A, Nikiforov, Vladimir, David, Arthur, Bessonneau, Vincent, Amer, Bashar, Seethapathy, Suresh, Hu, Xin, Lin, Elizabeth Z, Jbebli, Akrem, McNeil, Brooklynn R, Barupal, Dinesh, Cerasa, Marina, Xie, Hongyu, Kalia, Vrinda, Nandakumar, Renu, Singh, Randolph, Tian, Zhenyu, Gao, Peng, Zhao, Yujia, Froment, Jean, Rostkowski, Pawel, Dubey, Saurabh, Coufalíková, Kateřina, Seličová, Hana, Hecht, Helge, Liu, Sheng, Udhani, Hanisha H, Restituito, Sophie, Tchou-Wong, Kam-Meng, Lu, Kun, Martin, Jonathan W, Warth, Benedikt, Pollitt, Krystal J Godri, Klánová, Jana, Fiehn, Oliver, Metz, Thomas O, Pennell, Kurt D, Jones, Dean P, and Miller, Gary W
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Medical Biochemistry and Metabolomics ,Analytical Chemistry ,Biomedical and Clinical Sciences ,Chemical Sciences ,Bioengineering ,2.5 Research design and methodologies (aetiology) ,Generic health relevance ,Good Health and Well Being ,Humans ,Mass Spectrometry ,Exposome ,Metabolomics ,Proteomics ,Environmental Exposure ,exposome ,toxicants ,high-resolutionmass spectrometry ,chromatography ,non-targetedanalysis ,environmentalexposures ,chemical space ,metabolomics ,environmental exposures ,high-resolution mass spectrometry ,non-targeted analysis ,Environmental Sciences - Abstract
In the modern "omics" era, measurement of the human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics and metabolomics, has emerged as a leading technology to broadly profile chemical exposure agents and related biomolecules for accurate mass measurement, high sensitivity, rapid data acquisition, and increased resolution of chemical space. Non-targeted approaches are increasingly accessible, supporting a shift from conventional hypothesis-driven, quantitation-centric targeted analyses toward data-driven, hypothesis-generating chemical exposome-wide profiling. However, HRMS-based exposomics encounters unique challenges. New analytical and computational infrastructures are needed to expand the analysis coverage through streamlined, scalable, and harmonized workflows and data pipelines that permit longitudinal chemical exposome tracking, retrospective validation, and multi-omics integration for meaningful health-oriented inferences. In this article, we survey the literature on state-of-the-art HRMS-based technologies, review current analytical workflows and informatic pipelines, and provide an up-to-date reference on exposomic approaches for chemists, toxicologists, epidemiologists, care providers, and stakeholders in health sciences and medicine. We propose efforts to benchmark fit-for-purpose platforms for expanding coverage of chemical space, including gas/liquid chromatography-HRMS (GC-HRMS and LC-HRMS), and discuss opportunities, challenges, and strategies to advance the burgeoning field of the exposome.
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- 2024
43. Minimal Residual Disease using a Plasma-Only Circulating Tumor DNA Assay to Predict Recurrence of Metastatic Colorectal Cancer Following Curative Intent Treatment.
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Parikh, Aparna, Chee, Bryant, Tsai, Jill, Rich, Thereasa, Price, Kristin, Patel, Sonia, Zhang, Li, Ibrahim, Faaiz, Esquivel, Mikaela, Van Seventer, Emily, Jarnagin, Joy, Raymond, Victoria, Corvera, Carlos, Hirose, Kenzo, Nakakura, Eric, Corcoran, Ryan, Van Loon, Katherine, and Atreya, Chloe
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Humans ,Colorectal Neoplasms ,Circulating Tumor DNA ,Neoplasm ,Residual ,Female ,Male ,Neoplasm Recurrence ,Local ,Middle Aged ,Aged ,Biomarkers ,Tumor ,Prognosis ,Adult ,Neoplasm Metastasis ,Aged ,80 and over - Abstract
PURPOSE: Minimal residual disease (MRD) detection can identify the recurrence in patients with colorectal cancer (CRC) following definitive treatment. We evaluated a plasma-only MRD assay to predict recurrence and survival in patients with metastatic CRC who underwent curative intent procedures (surgery and/or radiotherapy), with or without (neo)adjuvant chemotherapy. The primary objective of this study was to assess the correlation of postprocedure tumor cell-free DNA detection status with radiographic disease recurrence. EXPERIMENTAL DESIGN: Preprocedure and postprocedure longitudinal samples were collected from 53 patients and analyzed with a multiomic MRD assay detecting circulating tumor DNA (ctDNA) from genomic and epigenomic signals. Preprocedure and postprocedure ctDNA detection correlated with recurrence-free and overall survival (OS). RESULTS: From 52 patients, 230/233 samples were successfully analyzed. At the time of data cutoff, 36 (69.2%) patients recurred with median follow-up of 31 months. Detectable ctDNA was observed in 19/42 patients (45.2%) with ctDNA analyzed 3 weeks postprocedure. ctDNA detection 3 weeks postprocedure was associated with shorter median recurrence-free survival (RFS; HR, 5.27; 95% CI, 2.31-12.0; P < 0.0001) and OS (HR, 12.83; 95% CI, 3.6-45.9; P < 0.0001). Preprocedure ctDNA detection status was not associated with RFS but was associated with improved OS (HR, 4.65; 95% CI, 1.4-15.2; P = 0.0111). Undetectable ctDNA preprocedure had notable long-term OS, >90% 3 years postprocedure. CONCLUSIONS: In this cohort of oligometastatic CRC, detection of ctDNA preprocedure or postprocedure was associated with inferior outcomes even after accounting for known prognostic clinicopathologic variables. This suggests ctDNA may enhance current risk stratification methods helping the evaluation of novel treatments and surveillance strategies toward improving patient outcomes.
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- 2024
44. Fickian Insights Using Probability Theory as Logic
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Price Jr, Peter E.
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Condensed Matter - Statistical Mechanics ,Condensed Matter - Soft Condensed Matter - Abstract
In Clearing Up Mysteries -- The Original Goal (Maximum Entropy and Bayesian Methods: Cambridge, England, 1988 Springer, pp. 1-27) Jaynes derived Fick's Law for a dilute binary solution from Bayes' Theorem by considering, probabilistically, the motion of dilute solute molecules. Modifying Jaynes' prior, changing the frame of reference, and allowing for multicomponent systems, one can follow Jaynes' logic to arrive at several expressions for the diffusion coefficient that are widely used in application to solvent-polymer systems. These results, however, do not generally satisfy required conditions over the full concentration range. This limitation is resolved by considering the joint motion of all components in the solution with the inclusion of known physical constraints. Doing so, one arrives at a new set of constitutive equations for binary and multicomponent diffusion that include Darken's form as a limit and provide means to characterize inter-species correlations, removing the need for the ad hoc modifications of the thermodynamic term or substitution of bulk compositions with local compositions that have been proposed in the literature. In binary systems, the Bayesian expression for the mutual diffusion coefficient provides explicit limits on non-ideal mutual diffusion behavior, given component self-diffusion coefficients, that can be attributed to inter-species correlation versus stronger intra- and inter-species clustering. Applications of the model to published data for a set of binary systems are presented, along with pointers to further directions for research., Comment: 25 pages, 14 figures
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- 2024
45. Multistep Criticality Search and Power Shaping in Microreactors with Reinforcement Learning
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Radaideh, Majdi I., Tunkle, Leo, Price, Dean, Abdulraheem, Kamal, Lin, Linyu, and Elias, Moutaz
- Subjects
Electrical Engineering and Systems Science - Systems and Control ,Computer Science - Computational Engineering, Finance, and Science ,Computer Science - Machine Learning ,Statistics - Applications - Abstract
Reducing operation and maintenance costs is a key objective for advanced reactors in general and microreactors in particular. To achieve this reduction, developing robust autonomous control algorithms is essential to ensure safe and autonomous reactor operation. Recently, artificial intelligence and machine learning algorithms, specifically reinforcement learning (RL) algorithms, have seen rapid increased application to control problems, such as plasma control in fusion tokamaks and building energy management. In this work, we introduce the use of RL for intelligent control in nuclear microreactors. The RL agent is trained using proximal policy optimization (PPO) and advantage actor-critic (A2C), cutting-edge deep RL techniques, based on a high-fidelity simulation of a microreactor design inspired by the Westinghouse eVinci\textsuperscript{TM} design. We utilized a Serpent model to generate data on drum positions, core criticality, and core power distribution for training a feedforward neural network surrogate model. This surrogate model was then used to guide a PPO and A2C control policies in determining the optimal drum position across various reactor burnup states, ensuring critical core conditions and symmetrical power distribution across all six core portions. The results demonstrate the excellent performance of PPO in identifying optimal drum positions, achieving a hextant power tilt ratio of approximately 1.002 (within the limit of $<$ 1.02) and maintaining criticality within a 10 pcm range. A2C did not provide as competitive of a performance as PPO in terms of performance metrics for all burnup steps considered in the cycle. Additionally, the results highlight the capability of well-trained RL control policies to quickly identify control actions, suggesting a promising approach for enabling real-time autonomous control through digital twins., Comment: 15 pages, 3 figures, and 2 tables
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- 2024
46. First Measurement of Deeply Virtual Compton Scattering on the Neutron with Detection of the Active Neutron
- Author
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CLAS Collaboration, Hobart, A., Niccolai, S., Čuić, M., Kumerički, K., Achenbach, P., Alvarado, J. S., Armstrong, W. R., Atac, H., Avakian, H., Baashen, L., Baltzell, N. A., Barion, L., Bashkanov, M., Battaglieri, M., Benkel, B., Benmokhtar, F., Bianconi, A., Biselli, A. S., Boiarinov, S., Bondi, M., Booth, W. A., Bossù, F., Brinkmann, K. -Th., Briscoe, W. J., Brooks, W. K., Bueltmann, S., Burkert, V. D., Cao, T., Capobianco, R., Carman, D. S., Chatagnon, P., Ciullo, G., Cole, P. L., Contalbrigo, M., D'Angelo, A., Dashyan, N., De Vita, R., Defurne, M., Deur, A., Diehl, S., Dilks, C., Djalali, C., Dupre, R., Egiyan, H., Alaoui, A. El, Fassi, L. El, Elouadrhiri, L., Fegan, S., Filippi, A., Fogler, C., Gates, K., Gavalian, G., Gilfoyle, G. P., Glazier, D., Gothe, R. W., Gotra, Y., Guidal, M., Hafidi, K., Hakobyan, H., Hattawy, M., Hauenstein, F., Heddle, D., Holtrop, M., Ilieva, Y., Ireland, D. G., Isupov, E. L., Jiang, H., Jo, H. S., Joo, K., Kageya, T., Kim, A., Kim, W., Klimenko, V., Kripko, A., Kubarovsky, V., Kuhn, S. E., Lanza, L., Leali, M., Lee, S., Lenisa, P., Li, X., MacGregor, I. J. D., Marchand, D., Mascagna, V., Maynes, M., McKinnon, B., Meziani, Z. E., Migliorati, S., Milner, R. G., Mineeva, T., Mirazita, M., Mokeev, V., Camacho, C. Muñoz, Nadel-Turonski, P., Naidoo, P., Neupane, K., Niculescu, G., Osipenko, M., Pandey, P., Paolone, M., Pappalardo, L. L., Paremuzyan, R., Pasyuk, E., Paul, S. J., Phelps, W., Pilleux, N., Pokhrel, M., Rafael, S. Polcher, Poudel, J., Price, J. W., Prok, Y., Reed, T., Richards, J., Ripani, M., Ritman, J., Rossi, P., Golubenko, A. A., Salgado, C., Schadmand, S., Schmidt, A., Scott, Marshall B. C., Seroka, E. M., Sharabian, Y. G., Shirokov, E. V., Shrestha, U., Sparveris, N., Spreafico, M., Stepanyan, S., Strakovsky, I. I., Strauch, S., Tan, J. A., Trotta, N., Tyson, R., Ungaro, M., Vallarino, S., Venturelli, L., Tommaso, V., Voskanyan, H., Voutier, E., Watts, D. P, Wei, X., Williams, R., Wood, M. H., Xu, L., Zachariou, N., Zhang, J., Zhao, Z. W., and Zurek, M.
- Subjects
High Energy Physics - Experiment ,Nuclear Experiment - Abstract
Measuring Deeply Virtual Compton Scattering on the neutron is one of the necessary steps to understand the structure of the nucleon in terms of Generalized Parton Distributions (GPDs). Neutron targets play a complementary role to transversely polarized proton targets in the determination of the GPD $E$. This poorly known and poorly constrained GPD is essential to obtain the contribution of the quarks' angular momentum to the spin of the nucleon. DVCS on the neutron was measured for the first time selecting the exclusive final state by detecting the neutron, using the Jefferson Lab longitudinally polarized electron beam, with energies up to 10.6 GeV, and the CLAS12 detector. The extracted beam-spin asymmetries, combined with DVCS observables measured on the proton, allow a clean quark-flavor separation of the imaginary parts of the GPDs $H$ and $E$., Comment: 7 pages, 6 figures
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- 2024
47. Machine Learning Materials Properties with Accurate Predictions, Uncertainty Estimates, Domain Guidance, and Persistent Online Accessibility
- Author
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Jacobs, Ryan, Schultz, Lane E., Scourtas, Aristana, Schmidt, KJ, Price-Skelly, Owen, Engler, Will, Foster, Ian, Blaiszik, Ben, Voyles, Paul M., and Morgan, Dane
- Subjects
Condensed Matter - Materials Science - Abstract
One compelling vision of the future of materials discovery and design involves the use of machine learning (ML) models to predict materials properties and then rapidly find materials tailored for specific applications. However, realizing this vision requires both providing detailed uncertainty quantification (model prediction errors and domain of applicability) and making models readily usable. At present, it is common practice in the community to assess ML model performance only in terms of prediction accuracy (e.g., mean absolute error), while neglecting detailed uncertainty quantification and robust model accessibility and usability. Here, we demonstrate a practical method for realizing both uncertainty and accessibility features with a large set of models. We develop random forest ML models for 33 materials properties spanning an array of data sources (computational and experimental) and property types (electrical, mechanical, thermodynamic, etc.). All models have calibrated ensemble error bars to quantify prediction uncertainty and domain of applicability guidance enabled by kernel-density-estimate-based feature distance measures. All data and models are publicly hosted on the Garden-AI infrastructure, which provides an easy-to-use, persistent interface for model dissemination that permits models to be invoked with only a few lines of Python code. We demonstrate the power of this approach by using our models to conduct a fully ML-based materials discovery exercise to search for new stable, highly active perovskite oxide catalyst materials.
- Published
- 2024
48. Compaction during fragmentation and bouncing produces realistic dust grain porosities in protoplanetary discs
- Author
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Michoulier, Stéphane, Gonzalez, Jean-François, and Price, Daniel J.
- Subjects
Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Context: In protoplanetary discs, micron-sized dust grows to form millimetre- to centimetre-sized pebbles but encounters several barriers during its evolution. Collisional fragmentation and radial drift impede further dust growth to planetesimal size. Fluffy grains have been hypothesised to solve these problems. While porosity leads to faster grain growth, the implied porosity values obtained from previous simulations were larger than suggested by observations. Aims: In this paper, we study the influence of porosity on dust evolution taking into account growth, bouncing, fragmentation, compaction, rotational disruption and snow lines, in order to understand their impact on dust evolution. Methods: We develop a module for porosity evolution for the 3D Smoothed Particle Hydrodynamics (SPH) code Phantom that accounts for dust growth and fragmentation. This mono-disperse model is integrated into both a 1D code and the 3D code to capture the overall evolution of dust and gas. Results: We show that porosity helps dust growth and leads to the formation of larger solids than when considering compact grains, as predicted by previous work. Our simulations taking into account compaction during fragmentation show that large millimetre grains are still formed, but are 10 to 100 times more compact. Thus, mm sizes with typical filling factors of ~0.1 match the values measured on comets or via polarimetric observations of protoplanetary discs., Comment: 24 pages, 21 figures, accepted for publication in A&A
- Published
- 2024
- Full Text
- View/download PDF
49. The First Combined H$\alpha$ and Rest-UV Spectroscopic Probe of Galactic Outflows at High Redshift
- Author
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Kehoe, Emily, Shapley, Alice E., Schreiber, N. M Forster, Pahl, Anthony J., Topping, Michael W., Reddy, Naveen A., Genzel, Reinhard, Price, Sedona H., and Tacconi, L. J.
- Subjects
Astrophysics - Astrophysics of Galaxies - Abstract
We investigate the multi-phase structure of gas flows in galaxies. We study 80 galaxies during the epoch of peak star formation ($1.4\leq z\leq2.7$) using data from Keck/LRIS and VLT/KMOS. Our analysis provides a simultaneous probe of outflows using UV emission and absorption features and H$\alpha$ emission. With this unprecedented data set, we examine the properties of gas flows estimated from LRIS and KMOS in relation to other galaxy properties, such as star formation rate (SFR), star formation rate surface density ($\Sigma_{\rm SFR}$), stellar mass (M$_*$), and main sequence offset ($\Delta$MS). We find no strong correlations between outflow velocity measured from rest-UV lines and galaxy properties. However, we find that galaxies with detected outflows show higher averages in SFR, $\Sigma_{\rm SFR}$, and $\Delta$MS than those lacking outflow detections, indicating a connection between outflow and galaxy properties. Furthermore, we find a lower average outflow velocity than previously reported, suggesting greater absorption at the systemic redshift of the galaxy. Finally, we detect outflows in 49% of our LRIS sample and 30% in the KMOS sample, and find no significant correlation between outflow detection and inclination. These results may indicate that outflows are not collimated and that H$\alpha$ outflows have a lower covering fraction than low-ionization interstellar absorption lines. Additionally, these tracers may be sensitive to different physical scales of outflow activity. A larger sample size with a wider dynamic range in galaxy properties is needed to further test this picture., Comment: 20 pages, 9 figures, 5 tables, submitted to ApJ
- Published
- 2024
50. A Neck Orthosis with Multi-Directional Variable Stiffness for Persons with Dropped Head Syndrome
- Author
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Torrendell, Santiago Price, Kadone, Hideki, Hassan, Modar, Chen, Yang, Miura, Kousei, and Suzuki, Kenji
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Computer Science - Robotics - Abstract
Dropped Head Syndrome (DHS) causes a passively correctable neck deformation. Currently, there is no wearable orthopedic neck brace to fulfill the needs of persons suffering from DHS. Related works have made progress in this area by creating mobile neck braces that provide head support to mitigate deformation while permitting neck mobility, which enhances user-perceived comfort and quality of life. Specifically, passive designs show great potential for fully functional devices in the short term due to their inherent simplicity and compactness, although achieving suitable support presents some challenges. This work introduces a novel compliant mechanism that provides non-restrictive adjustable support for the neck's anterior and posterior flexion movements while enabling its unconstrained free rotation. The results from the experiments on non-affected persons suggest that the device provides the proposed adjustable support that unloads the muscle groups involved in supporting the head without overloading the antagonist muscle groups. Simultaneously, it was verified that the free rotation is achieved regardless of the stiffness configuration of the device., Comment: Accepted Manuscript
- Published
- 2024
- Full Text
- View/download PDF
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