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17 results on '"Princic, Elija"'

5. Use of bedaquiline in spinal osteomyelitis and soft tissue abscess caused by multidrug-resistant Mycobacterium tuberculosis: A case report

Author

De Vito,Andrea, Fiore,Vito, Urru,Valentina, Bozzi,Elena, Geremia,Nicholas, Princic,Elija, Canu,Donatella, Molicotti,Paola, Are,Riccardo, Babudieri,Sergio, and Madeddu,Giordano

Subjects
Hard to treat infection, Bedaquiline, MDR, Tuberculosis, Osteomyelitis, Bone infection
Abstract

Introduction Spinal Tuberculosis (STB) represents between 1% and 2% of total tuberculosis cases. STB management remains challenging; the first-line approach consists of medical treatment, while surgery is reserved for patients with complications. No data regarding STB treatment with bedaquiline-containing regimens are available in the literature. Case description Herein, we report the case of a 21-year-old man from Côte d'Ivoire with a multidrug resistance STB with subcutaneous abscess. After approval of the hospital off-label drug committee, we started bedaquiline 400 mg daily for two weeks, followed by 200 mg three times per week, for 22 weeks, associated with linezolid 600 mg daily, rifabutin 450 mg daily, and amikacin 750 mg daily (interrupted after eight weeks). During treatment, we performed a weekly EKG. No QT prolongation was shown, but inverted T waves appeared, requiring several cardiological consultations and cardiac MRI, but no cardiac dysfunction was found. After 24 weeks, bedaquiline was replaced with moxifloxacin 400 mg daily. The patient continued treatment for another year. We performed another computer tomography at the end of treatment, confirming the cure. Discussion A salvage regimen containing bedaquiline proved effective in treating multidrug-resistance tuberculosis spinal infection without causing severe adverse effects. However, further studies are needed to evaluate better bedaquiline bone penetration and the correct duration of treatment with bedaquiline in MDR spinal tuberculosis.

Published
2022

6. HCV treatment in Sardinian HIV-HCV coinfected patients: a real-life perspective study on safety, efficacy, and immune reconstitution

Author

Pes, Francesco, primary, Onali, Simona, additional, Balestrieri, Cinzia, additional, Angioni, Goffredo, additional, Ortu, Francesco, additional, Piano, Paola, additional, Lucia, Barca, additional, Scioscia, Rosetta, additional, Princic, Elija, additional, Bolliri, Anna Chiara, additional, Casale, Michele, additional, Cola, Alessandra, additional, Conti, Maria, additional, Peddis, Lorenza, additional, Serra, Giancarlo, additional, Vacca, Stefano, additional, Loi, Martina, additional, Urru, Enrico, additional, Murru, Claudia, additional, Matta, Laura, additional, Del Giacco, Stefano, additional, Babudieri, Sergio, additional, Maida, Ivana, additional, and Chessa, Luchino, additional

Published
2022
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7. Use of bedaquiline in spinal osteomyelitis and soft tissue abscess caused by multidrug-resistant Mycobacterium tuberculosis: A case report

Author

De Vito, Andrea, primary, Fiore, Vito, additional, Urru, Valentina, additional, Bozzi, Elena, additional, Geremia, Nicholas, additional, Princic, Elija, additional, Canu, Donatella, additional, Molicotti, Paola, additional, Are, Riccardo, additional, Babudieri, Sergio, additional, and Madeddu, Giordano, additional

Published
2022
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11. Early treatment with low-molecular-weight heparin reduces mortality rate in SARS-CoV-2 patients

Author

DE VITO, Andrea, primary, SADERI, Laura, additional, FIORE, Vito, additional, GEREMIA, Nicholas, additional, PRINCIC, Elija, additional, FANELLI, Chiara, additional, MUREDDA, Alberto A., additional, PANU NAPODANO, Catello, additional, MOI, Giulia, additional, MAIDA, Ivana, additional, FOIS, Alessandro G., additional, SOTGIU, Giovanni, additional, MADEDDU, Giordano, additional, and BABUDIERI, Sergio, additional

Published
2022
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16. Modifiable and non-modifiable risk factors for surgical site infection after colorectal surgery: a single-center experience.

Author

Silvestri, Marta, Dobrinja, Chiara, Scomersi, Serena, Giudici, Fabiola, Turoldo, Angelo, Princic, Elija, Luzzati, Roberto, de Manzini, Nicolò, and Bortul, Marina

Subjects
SURGICAL site infections, PROCTOLOGY, PEOPLE with diabetes, MULTIVARIATE analysis, LENGTH of stay in hospitals, DISEASE risk factors
Abstract

Purpose: Surgical site infection (SSI) is the most common complication of colorectal surgery, resulting in significant burden in terms of morbidity and length of hospital stay. The aims of this study were to establish the incidence of SSI in patients undergoing colorectal surgeries and to identify potentially modifiable risk factors to reduce overall SSI rates.Methods: This retrospective study analyzed patients who underwent colorectal resection at our Department. Patients were identified using a prospective SSI database. Univariate and multivariate analyses were used to identify risk factors.Results: A total of 687 patients were enrolled in the study and the overall SSI rate was 19.9% (137 patients). Superficial incisional surgical site infections (SSSIs) developed in 52 (7.6%) patients, deep incisional surgical site infections (DSSIs) developed in 15 (2.2%), and organ/space infections (OSIs) developed in 70 (10.1%). Univariate and multivariate analyses confirmed that age, diabetes, emergency surgery, and a high infection risk index are risk factors for SSI.Conclusions: There are some modifiable and non-modifiable risk factors for SSI. IRI and age are non-modifiable, whereas the timing of surgery and diabetes can be modulated by trying to defer some emergency procedures to elective ones and normalizing the glycemia of diabetic patients. [ABSTRACT FROM AUTHOR]

Published
2018
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17. Modifiable and non-modifiable risk factors for surgical site infection after colorectal surgery: a single-center experience

Author

Serena Scomersi, Marina Bortul, Marta Silvestri, Angelo Turoldo, Nicolò de Manzini, Elija Princic, Roberto Luzzati, Fabiola Giudici, Chiara Dobrinja, Silvestri, Marta, Dobrinja, Chiara, Scomersi, Serena, Giudici, Fabiola, Turoldo, Angelo, Princic, Elija, Luzzati, Roberto, de Manzini, Nicolò, and Bortul, Marina

Subjects
Male, medicine.medical_specialty, Multivariate analysis, Colon, Abdominal infections, Surgical site infection, Colorectal surgery, Single Center, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Surgical oncology, Internal medicine, Diabetes Mellitus, medicine, Humans, Surgical Wound Infection, Digestive System Surgical Procedures, Aged, Retrospective Studies, Aged, 80 and over, Analysis of Variance, business.industry, Incidence, Abdominal Infection, Incidence (epidemiology), Age Factors, Rectum, Retrospective cohort study, General Medicine, Abdominal infection, Middle Aged, Surgery, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Emergencies, Complication, business
Abstract

PURPOSE: Surgical site infection (SSI) is the most common complication of colorectal surgery, resulting in significant burden in terms of morbidity and length of hospital stay. The aims of this study were to establish the incidence of SSI in patients undergoing colorectal surgeries and to identify potentially modifiable risk factors to reduce overall SSI rates. METHODS: This retrospective study analyzed patients who underwent colorectal resection at our Department. Patients were identified using a prospective SSI database. Univariate and multivariate analyses were used to identify risk factors. RESULTS: A total of 687 patients were enrolled in the study and the overall SSI rate was 19.9% (137 patients). Superficial incisional surgical site infections (SSSIs) developed in 52 (7.6%) patients, deep incisional surgical site infections (DSSIs) developed in 15 (2.2%), and organ/space infections (OSIs) developed in 70 (10.1%). Univariate and multivariate analyses confirmed that age, diabetes, emergency surgery, and a high infection risk index are risk factors for SSI. CONCLUSIONS: There are some modifiable and non-modifiable risk factors for SSI. IRI and age are non-modifiable, whereas the timing of surgery and diabetes can be modulated by trying to defer some emergency procedures to elective ones and normalizing the glycemia of diabetic patients.

Published
2017

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