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6. Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients

Author

Waeijen-Smit, K, Crutsen, M, Keene, S, Miravitlles, M, Crisafulli, E, Torres, A, Mueller, C, Schuetz, P, Ringbæk, T, Fabbian, F, Mekov, E, Harries, T, Lun, C, Ergan, B, Esteban, C, Quintana Lopez, J, López-Campos, J, Chang, C, Hancox, R, Shafuddin, E, Ellis, H, Janson, C, Ulrik, C, Gudmundsson, G, Epstein, D, Dominguez, J, Lacoma, A, Osadnik, C, Alia, I, Spannella, F, Karakurt, Z, Mehravaran, H, Utens, C, de Kruif, M, San Ko, F, Trethewey, S, Turner, A, Bumbacea, D, Murphy, P, Vermeersch, K, Zilberman-Itskovich, S, Steer, J, Echevarria, C, Bourke, S, Lane, N, de Batlle, J, Sprooten, R, Russell, R, Faverio, P, Cross, J, Prins, H, Spruit, M, Simons, S, Houben-Wilke, S, Franssen, F, Waeijen-Smit K., Crutsen M., Keene S., Miravitlles M., Crisafulli E., Torres A., Mueller C., Schuetz P., Ringbæk T. J., Fabbian F., Mekov E., Harries T. H., Lun C. T., Ergan B., Esteban C., Quintana Lopez J. M., López-Campos J. L., Chang C. L., Hancox R. J., Shafuddin E., Ellis H., Janson C., Ulrik C. S., Gudmundsson G., Epstein D., Dominguez J., Lacoma A., Osadnik C., Alia I., Spannella F., Karakurt Z., Mehravaran H., Utens C., de Kruif M. D., San Ko F. W., Trethewey S. P., Turner A. M., Bumbacea D., Murphy P. B., Vermeersch K., Zilberman-Itskovich S., Steer J., Echevarria C., Bourke S. C., Lane N., de Batlle J., Sprooten R. T. M., Russell R., Faverio P., Cross J. L., Prins H. J., Spruit M. A., Simons S. O., Houben-Wilke S., Franssen F. M. E., Waeijen-Smit, K, Crutsen, M, Keene, S, Miravitlles, M, Crisafulli, E, Torres, A, Mueller, C, Schuetz, P, Ringbæk, T, Fabbian, F, Mekov, E, Harries, T, Lun, C, Ergan, B, Esteban, C, Quintana Lopez, J, López-Campos, J, Chang, C, Hancox, R, Shafuddin, E, Ellis, H, Janson, C, Ulrik, C, Gudmundsson, G, Epstein, D, Dominguez, J, Lacoma, A, Osadnik, C, Alia, I, Spannella, F, Karakurt, Z, Mehravaran, H, Utens, C, de Kruif, M, San Ko, F, Trethewey, S, Turner, A, Bumbacea, D, Murphy, P, Vermeersch, K, Zilberman-Itskovich, S, Steer, J, Echevarria, C, Bourke, S, Lane, N, de Batlle, J, Sprooten, R, Russell, R, Faverio, P, Cross, J, Prins, H, Spruit, M, Simons, S, Houben-Wilke, S, Franssen, F, Waeijen-Smit K., Crutsen M., Keene S., Miravitlles M., Crisafulli E., Torres A., Mueller C., Schuetz P., Ringbæk T. J., Fabbian F., Mekov E., Harries T. H., Lun C. T., Ergan B., Esteban C., Quintana Lopez J. M., López-Campos J. L., Chang C. L., Hancox R. J., Shafuddin E., Ellis H., Janson C., Ulrik C. S., Gudmundsson G., Epstein D., Dominguez J., Lacoma A., Osadnik C., Alia I., Spannella F., Karakurt Z., Mehravaran H., Utens C., de Kruif M. D., San Ko F. W., Trethewey S. P., Turner A. M., Bumbacea D., Murphy P. B., Vermeersch K., Zilberman-Itskovich S., Steer J., Echevarria C., Bourke S. C., Lane N., de Batlle J., Sprooten R. T. M., Russell R., Faverio P., Cross J. L., Prins H. J., Spruit M. A., Simons S. O., Houben-Wilke S., and Franssen F. M. E.

Abstract

Background Exacerbations of COPD (ECOPD) have a major impact on patients and healthcare systems across the world. Precise estimates of the global burden of ECOPD on mortality and hospital readmission are needed to inform policy makers and aid preventive strategies to mitigate this burden. The aims of the present study were to explore global in-hospital mortality, post-discharge mortality and hospital readmission rates after ECOPD-related hospitalisation using an individual patient data meta-analysis (IPDMA) design. Methods A systematic review was performed identifying studies that reported in-hospital mortality, postdischarge mortality and hospital readmission rates following ECOPD-related hospitalisation. Data analyses were conducted using a one-stage random-effects meta-analysis model. This study was conducted and reported in accordance with the PRISMA-IPD statement. Results Data of 65 945 individual patients with COPD were analysed. The pooled in-hospital mortality rate was 6.2%, pooled 30-, 90- and 365-day post-discharge mortality rates were 1.8%, 5.5% and 10.9%, respectively, and pooled 30-, 90- and 365-day hospital readmission rates were 7.1%, 12.6% and 32.1%, respectively, with noticeable variability between studies and countries. Strongest predictors of mortality and hospital readmission included noninvasive mechanical ventilation and a history of two or more ECOPD-related hospitalisations < 12 months prior to the index event. Conclusions This IPDMA stresses the poor outcomes and high heterogeneity of ECOPD-related hospitalisation across the world. Whilst global standardisation of the management and follow-up of ECOPD-related hospitalisation should be at the heart of future implementation research, policy makers should focus on reimbursing evidence-based therapies that decrease (recurrent) ECOPD.

Published
2024

12. Exposure and virologic outcomes of dolutegravir combined with ritonavir boosted darunavir in treatment-naive individuals enrolled in the Netherlands Cohort Study on Acute HIV infection (NOVA)

Author

Prins, H. A. B., Zino, L., Svensson, Elin M., Verbon, A., de Bree, G. J., Prins, J. M., Reiss, P., Burger, D. M., Rokx, C., Colbers, A., Team, NOVA Study, Prins, H. A. B., Zino, L., Svensson, Elin M., Verbon, A., de Bree, G. J., Prins, J. M., Reiss, P., Burger, D. M., Rokx, C., Colbers, A., and Team, NOVA Study

Abstract

To the authors' knowledge, there is currently no literature or guidance recommendation regard-ing whether the dose of dolutegravir (DTG) should be increased when co-administered with darunavir/ritonavir (DRV/r) in patients with acute human immunodeficiency virus infection (AHI). This study assessed the pharmacokinetics (PK) of twice-daily (BID) DTG and once-daily (QD) DRV/r, and com-pared this with DTG QD without DRV/r in patients with AHI. Forty-six participants initiated antiretro-viral therapy within < 24 h of enrolment: DTG 50 mg BID, DRV/r 80 0/10 0 mg QD, and two nucleoside reverse transcriptase inhibitors (NRTIs) for 4 weeks (Phase I); and DTG 50 mg QD with two NRTIs there-after (Phase II: reference). Total DTG trough concentration (Ctrough) and area under the concentration-time profile of 0-24 h (AUC0-24h) were predicted using a population PK model. DTG glucuronidation metabolic ratio (MR) and DTG free fraction were determined and compared per treatment phase using geometric mean ratio (GMR) and 90% confidence interval (CI). Participants had a predicted geometric mean steady-state DTG Ctrough of 2.83 [coefficient of variation (CV%) 30.3%] mg/L (Phase I) and 1.28 (CV% 52.4%) mg/L (Phase II), with GMR of 2.20 (90% CI 1.90-2.55). Total exposure during DTG BID increased but did not double [AUC0-24h GMR 1.65 (90% CI 1.50-1.81) h.mg/L]. DTG glucuronidation MR increased by approxi-mately 29% during Phase I. DTG Ctrough was above in-vivo EC90 (0.32 mg/L) during both phases, except in one participant during Phase I. At Week 8, 84% of participants had viral loads <= 40 copies/mL. The drug-drug interaction between DTG (BID) and DRV/r (QD) was due to induced glucuronidation, and is not clinically relevant in patients with AHI.(c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

Published
2023
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13. Behavioral responses of terrestrial mammals to COVID-19 lockdowns

Author

Tucker, M., Schipper, A., Adams, T., Attias, N., Avgar, T., Babic, N., Barker, K., Bastille-Rousseau, G., Behr, D., Belant, J., Beyer Jr, D., Blaum, N., Blount, D., Bockmühl, D., Pires Boulhosa, R. L., Brown, M., Buuveibaatar, B., Cagnacci, F., (0000-0003-0575-6408) Calabrese, J., Černe, R., Chamaillé-Jammes, S., Chan, A. N., Chase, M., Chaval, Y., Chenaux-Ibrahim, Y., Cherry, S., Ćirović, D., Çoban, E., Cole, E., Conlee, L., Courtemanch, A., Cozzi, G., Davidson, S., Debloois, D., Dejid, N., Denicola, V., Desbiez, A., Douglas-Hamilton, I., Drake, D., Egan, M., Eikelboom, J., Fagan, W., Farmer, M., Fennessy, J., Finnegan, S., Fleming, C., Fournier, B., Fowler, N., Gantchoff, M., Garnier, A., Gehr, B., Geremia, C., Goheen, J., Hauptfleisch, M., Hebblewhite, M., Heim, M., Hertel, A., Heurich, M., Hewison, M., Hodson, J., Hoffman, N., Hopcraft, G., Huber, D., Isaac, E., Janik, K., Ježek, M., Johansson, Ö., Jordan, N. R., Kaczensky, P., Kamaru, D., Kauffman, M., Kautz, T., Kays, R., Kelly, A., Kindberg, J., Krofel, M., Kusak, J., Lamb, C., Lasharr, T., Leimgruber, P., Leitner, H., Lierz, M., Linnell, J., Lkhagvaja, P., Long, R., López-Bao, J., Loretto, M.-C., Marchand, P., Martin, H., Martinez, L., Mcbride Jr, R., Mclaren, A., Meisingset, E., Melzheimer, J., Merrill, E., Middleton, A., Monteith, K., Moore, S., Moorter, B. V., Morellet, N., Morrison, T., Müller, R., Mysterud, A., Noonan, M., O’Connor, D., Olson, D., Olson, K., Ortega, A., Ossi, F., Panzacchi, M., Patchett, R., Patterson, B., Paula, R. C. D., Payne, J., Peters, W., Petroelje, T., Pitcher, B., Pokorny, B., Poole, K., Potočnik, H., Poulin, M.-P., Pringle, R., Prins, H., Ranc, N., Reljić, S., Robb, B., Röder, R., Rolandsen, C., Rutz, C., Salemgareyev, A., Samelius, G., Sayine-Crawford, H., Schooler, S., Şekercioğlu, Ç., Selva, N., Semenzato, P., Sergiel, A., Sharma, K., Shawler, A., Signer, J., Silovský, V., Silva, J., Simon, R., Smiley, R., Smith, D., Solberg, E., Soto, D., Spiegel, O., Stabach, J., Stacy-Dawes, J., Stahler, D., Stephenson, J., Stewart, C., Strand, O., Sunde, P., Svoboda, N., Swart, J., Thompson, J., Toal, K., Uiseb, K., Vanacker, M., Velilla, M., Verzuh, T., Wachter, B., Wagler, B., Whittington, J., Wikelski, M., Wilmers, C., Wittemyer, G., Young, J., Zięba, F., Zwijacz-Kozica, T., Huijbregts, M., Mueller, T., Tucker, M., Schipper, A., Adams, T., Attias, N., Avgar, T., Babic, N., Barker, K., Bastille-Rousseau, G., Behr, D., Belant, J., Beyer Jr, D., Blaum, N., Blount, D., Bockmühl, D., Pires Boulhosa, R. L., Brown, M., Buuveibaatar, B., Cagnacci, F., (0000-0003-0575-6408) Calabrese, J., Černe, R., Chamaillé-Jammes, S., Chan, A. N., Chase, M., Chaval, Y., Chenaux-Ibrahim, Y., Cherry, S., Ćirović, D., Çoban, E., Cole, E., Conlee, L., Courtemanch, A., Cozzi, G., Davidson, S., Debloois, D., Dejid, N., Denicola, V., Desbiez, A., Douglas-Hamilton, I., Drake, D., Egan, M., Eikelboom, J., Fagan, W., Farmer, M., Fennessy, J., Finnegan, S., Fleming, C., Fournier, B., Fowler, N., Gantchoff, M., Garnier, A., Gehr, B., Geremia, C., Goheen, J., Hauptfleisch, M., Hebblewhite, M., Heim, M., Hertel, A., Heurich, M., Hewison, M., Hodson, J., Hoffman, N., Hopcraft, G., Huber, D., Isaac, E., Janik, K., Ježek, M., Johansson, Ö., Jordan, N. R., Kaczensky, P., Kamaru, D., Kauffman, M., Kautz, T., Kays, R., Kelly, A., Kindberg, J., Krofel, M., Kusak, J., Lamb, C., Lasharr, T., Leimgruber, P., Leitner, H., Lierz, M., Linnell, J., Lkhagvaja, P., Long, R., López-Bao, J., Loretto, M.-C., Marchand, P., Martin, H., Martinez, L., Mcbride Jr, R., Mclaren, A., Meisingset, E., Melzheimer, J., Merrill, E., Middleton, A., Monteith, K., Moore, S., Moorter, B. V., Morellet, N., Morrison, T., Müller, R., Mysterud, A., Noonan, M., O’Connor, D., Olson, D., Olson, K., Ortega, A., Ossi, F., Panzacchi, M., Patchett, R., Patterson, B., Paula, R. C. D., Payne, J., Peters, W., Petroelje, T., Pitcher, B., Pokorny, B., Poole, K., Potočnik, H., Poulin, M.-P., Pringle, R., Prins, H., Ranc, N., Reljić, S., Robb, B., Röder, R., Rolandsen, C., Rutz, C., Salemgareyev, A., Samelius, G., Sayine-Crawford, H., Schooler, S., Şekercioğlu, Ç., Selva, N., Semenzato, P., Sergiel, A., Sharma, K., Shawler, A., Signer, J., Silovský, V., Silva, J., Simon, R., Smiley, R., Smith, D., Solberg, E., Soto, D., Spiegel, O., Stabach, J., Stacy-Dawes, J., Stahler, D., Stephenson, J., Stewart, C., Strand, O., Sunde, P., Svoboda, N., Swart, J., Thompson, J., Toal, K., Uiseb, K., Vanacker, M., Velilla, M., Verzuh, T., Wachter, B., Wagler, B., Whittington, J., Wikelski, M., Wilmers, C., Wittemyer, G., Young, J., Zięba, F., Zwijacz-Kozica, T., Huijbregts, M., and Mueller, T.

Abstract

COVID-19 lockdowns in early 2020 reduced human mobility, providing an opportunity to disentangle its effects on animals from those of landscape modifications. Using GPS data, we compared movements and road avoidance of 2300 terrestrial mammals (43 species) during the lockdowns to the same period in 2019. Individual responses were variable with no change in average movements or road avoidance behavior, likely due to variable lockdown conditions. However, under strict lockdowns 10-day 95th percentile displacements increased by 73%, suggesting increased landscape permeability. Animals’ 1-hour 95th percentile displacements declined by 12% and animals were 36% closer to roads in areas of high human footprint, indicating reduced avoidance during lockdowns. Overall, lockdowns rapidly altered some spatial behaviors, highlighting variable but substantial impacts of human mobility on wildlife worldwide.

Published
2023

14. Forces Underlying Sustainability Transition Practices Among Organic Farmers in the Netherlands: Experiences in Transition and Beyond

Author

Prins, H. and Prins, H.

Abstract

In recent years, the multiple effects of food, feed and bio-based systems on the environment have been in the research spotlight. According to other literature, agriculture plays a big role in the food industry, especially in the Netherlands. Whereas conventional farming is still regarded as the most common way of farming, organic farming is increasing to grow and gain attention. Since organic farming is not solely focused on productivity and revenue, but also on the environmental and ecological consequences, it is usually already more sustainable than conventional farming. However, it is still quite unclear which forces exactly drive and oppose these sustainability transitions among organic farmers in the Netherlands, making it this paper’s main goal to find an answer to that question. Previous research on organic agriculture and the motivations to become an organic farmer by adopting sustainable practices identified several forces already, but this study seeks to investigate the exact intrinsic and extrinsic driving and opposing forces at play during these sustainability transitions among farmers in the Netherlands, to gain a deeper and more sophisticated understanding of this. Through qualitative interviews conducted with 9 Dutch organic farmers or Dutch farmers in transition to organic farming, the data analysis revealed that 16 driving forces as well as 16 opposing forces were found. Among these forces, 5 were found to simultaneously drive and oppose sustainability transition practices.

Published
2023

15. Exposure and virologic outcomes of dolutegravir combined with ritonavir boosted darunavir in treatment-naïve individuals enrolled in the Netherlands Cohort Study on Acute HIV infection (NOVA)

Author

Prins, H. A.B., Zino, L., Svensson, E. M., Verbon, A., de Bree, G. J., Prins, J. M., Reiss, P., Burger, D. M., Rokx, C., Colbers, A., Prins, H. A.B., Zino, L., Svensson, E. M., Verbon, A., de Bree, G. J., Prins, J. M., Reiss, P., Burger, D. M., Rokx, C., and Colbers, A.

Abstract

To the authors’ knowledge, there is currently no literature or guidance recommendation regarding whether the dose of dolutegravir (DTG) should be increased when co-administered with darunavir/ritonavir (DRV/r) in patients with acute human immunodeficiency virus infection (AHI). This study assessed the pharmacokinetics (PK) of twice-daily (BID) DTG and once-daily (QD) DRV/r, and compared this with DTG QD without DRV/r in patients with AHI. Forty-six participants initiated antiretroviral therapy within <24 h of enrolment: DTG 50 mg BID, DRV/r 800/100 mg QD, and two nucleoside reverse transcriptase inhibitors (NRTIs) for 4 weeks (Phase I); and DTG 50 mg QD with two NRTIs thereafter (Phase II: reference). Total DTG trough concentration (Ctrough) and area under the concentration–time profile of 0–24 h (AUC0–24h) were predicted using a population PK model. DTG glucuronidation metabolic ratio (MR) and DTG free fraction were determined and compared per treatment phase using geometric mean ratio (GMR) and 90% confidence interval (CI). Participants had a predicted geometric mean steady-state DTG Ctrough of 2.83 [coefficient of variation (CV%) 30.3%] mg/L (Phase I) and 1.28 (CV% 52.4%) mg/L (Phase II), with GMR of 2.20 (90% CI 1.90–2.55). Total exposure during DTG BID increased but did not double [AUC0–24h GMR 1.65 (90% CI 1.50–1.81) h.mg/L]. DTG glucuronidation MR increased by approximately 29% during Phase I. DTG Ctrough was above in-vivo EC90 (0.32 mg/L) during both phases, except in one participant during Phase I. At Week 8, 84% of participants had viral loads ≤40 copies/mL. The drug–drug interaction between DTG (BID) and DRV/r (QD) was due to induced glucuronidation, and is not clinically relevant in patients with AHI.

Published
2023

16. Laparoscopic peritoneal lavage or sigmoidectomy for perforated diverticulitis with purulent peritonitis: a multicentre, parallel-group, randomised, open-label trial

Author

Hop, W C, Opmeer, B C, Reitsma, J B, Scholte, R A, Waltmann, E W H, Legemate, D A, Bartelsman, J F, Meijer, D W, de Brouwer, M, van Dalen, J, Durbridge, M, Geerdink, M, Ilbrink, G J, Mehmedovic, S, Middelhoek, P, Di Saverio, Salomone, Boom, M J, Consten, E C J, van der Bilt, J D W, van Olden, G D J, Stam, M A W, Verweij, M S, Busch, O R C, Buskens, C J, El-Massoudi, Y, Kluit, A B, van Rossem, C C, Schijven, M P, Tanis, P J, Unlu, C, Gerhards, M F, Karsten, T M, de Nes, L C, Rijna, H, van Wagensveld, B A, Koffeman, G I, Steller, E P, Tuynman, J B, Bruin, S C, van der Peet, D L, Blanken-Peeters, C F J M, Cense, H A, Jutte, E, Crolla, R M P H, van der Schelling, G P, van Zeeland, M, de Graaf, E J R, Groenendijk, R P R, Vermaas, M, Schouten, O, de Vries, M R, Prins, H A, Lips, D J, Bosker, R J I, van der Hoeven, J A B, Diks, J, Plaisier, P W, Kruyt, P M, Sietses, C, Stommel, M W J, Nienhuijs, S W, de Hingh, I H J T, Luyer, M D P, van Montfort, G, Ponten, E H, Smulders, J F, van Duyn, E B, Klaase, J M, Swank, D J, Ottow, R T, Stockmann, H B A C, Vermeulen, J, Vuylsteke, R J C L M, Belgers, H J, Fransen, S, von Meijenfeldt, E M, Sosef, M N, van Geloven, A A W, Hendriks, E R, ter Horst, B, Leeuwenburgh, M M N, van Ruler, O, Vogten, J M, Vriens, E J C, Westerterp, M, Eijsbouts, Q A J, Bentohami, A, Bijlsma, T S, de Korte, N, Nio, D, Govaert, M J P M, Joosten, J J A, Tollenaar, R A E M, Stassen, L P S, Wiezer, M J, Hazebroek, E J, Smits, A B, van Westreenen, H L, Lange, J F, Brandt, A, Nijboer, W N, Toorenvliet, B R, Weidema, W F, Coene, P P L O, Mannaerts, G H H, den Hartog, D, de Vos, R J, Zengerink, J F, Hoofwijk, A G M, Hulsewé, K W E, Melenhorst, J, Stoot, J H M B, Steup, W H, Huijstee, P J, Merkus, J W S, Wever, J J, Maring, J K, Heisterkamp, J, van Grevenstein, W M U, Vriens, M R, Besselink, M G H, Borel Rinkes, I H M, Witkamp, A J, Slooter, G D, Konsten, J L M, Engel, A F, Pierik, E G J M, Frakking, T G, van Geldere, D, Patijn, G A, D'Hoore, A J L, de Buck van Overstraeten, A, Miserez, M, Terrasson, I, Wolthuis, A, De Blasiis, M G, Vennix, Sandra, Musters, Gijsbert D, Mulder, Irene M, Swank, Hilko A, Consten, Esther C, Belgers, Eric H, van Geloven, Anna A, Gerhards, Michael F, Govaert, Marc J, van Grevenstein, Wilhelmina M, Hoofwijk, Anton G, Kruyt, Philip M, Nienhuijs, Simon W, Boermeester, Marja A, Vermeulen, Jefrey, van Dieren, Susan, Lange, Johan F, and Bemelman, Willem A

Published
2015
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31. Macromonitor Nationaal Programma Onderwijs mbo en ho: Eerste tussenrapportage

Author

Broek, J.F.L.H. van den, Cuppen, J., Hendrix, M., Muja, A., Wolbers, M.H.J., Helvoirt, D. van, Leest, C.M.B., Bisschop, P., Eijkern, I. van, Prins, H., Ven, K. van der, Abbink, H.H.B., Bijlsma, I., Cörvers, F., Vermeulen, S., Lubberman, J., Broek, J.F.L.H. van den, Cuppen, J., Hendrix, M., Muja, A., Wolbers, M.H.J., Helvoirt, D. van, Leest, C.M.B., Bisschop, P., Eijkern, I. van, Prins, H., Ven, K. van der, Abbink, H.H.B., Bijlsma, I., Cörvers, F., Vermeulen, S., and Lubberman, J.

Abstract

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Published
2022

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