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7. Sepultura !

Author

Bureau, C., Moulonguet Doleris, L., Bidegain, F., Seidowsky, A., Trad, S., Prinseau, J., Hanslik, T., and Schmied, E.

Published
2013
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21. Elle suit le courant…

Author

Tnani, N., primary, Maillard, E., additional, Prinseau, J., additional, Baglin, A., additional, and Hanslik, T., additional

Published
2005
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45. Diurétiques, inhibiteurs de l'enzyme de conversion et anomalies électrolytiques chez les personnes âgées. Étude multicentrique lors de l'entrée à l'hôpital de 631 patients âgés de 70 ans et plus

Author

Baglin, A., primary, Prinseau, J., additional, Aegerter, Ph., additional, Piette, A.M., additional, Mornet, P., additional, Goupil, M., additional, Lesur, G., additional, Gayno, J.P., additional, Bournerias, F., additional, and Remy, J.M., additional

Published
1991
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46. Diurétiques, inhibiteurs de l'enzyme de conversion et anomalies électrolytiques chez les personnes âgées. Étude multicentrique lors de l'entrée à l'hôpital de 631 patients âgés de 70 ans et plus

Author

J.P. Gayno, Mornet P, AC Baglin, Goupil M, A.M. Piette, Ph. Aegerter, J.M. Remy, Lesur G, F. Bournerias, and Prinseau J

Subjects
Gynecology, Pediatrics, medicine.medical_specialty, Side effect, business.industry, Gastroenterology, Internal Medicine, medicine, business
Abstract

Electrolytic side effect of antihypertensive drugs were studied in 631 elderly patients. 4% of 337 patients without these drugs had a natremia lower than 130 mmol/l (HN) and 12% a kaliemia lower than 3.5 mmol/l (HK). With thiazides, HN and HK were more frequent (12% and 20% respectively), especially in women.

Published
1991
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47. Plasma free and sulfoconjugated catecholamines in healthy men.

Author

Cuche, J.-L., Prinseau, J., Ruget, G., Selz, F., Tual, J.-L., Baglin, A., Guedon, J., and Fritel, D.

Abstract

Plasma free and sulfoconjugated catecholamines were measured 28 times in 19 healthy men who had been in a recumbent position for at least 60 min (mean ± s.e.m., pg/ml): free dopamine = 36 ± 8, sulfoconjugated dopamine = 5568 ± 544, free norepinephrine = 178 ± 11, sulfoconjugated norepinephrine = 645± 29, free epinephrine = 37 ± 4, and sulfoconjugated epinephrine = 451 ± 26. They were also measured during passive and active upright posture, during extracellular volume expansion induced by an intravenous infusion of sodium chloride, and during recumbency, as a control, to investigate whether the free sulfoconjugated relationship might have a physiological role. Data obtained do not support such a hypothesis, even during episodes of orthostatic hypotension. In the control group, there was a progressive decrease of sulfoconjugated catecholamines during recumbency, between 8 a.m. and 12 noon. [ABSTRACT FROM PUBLISHER]

Published
1982
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49. Influence of food on the absorption of theophylline administered in the form of sustained release tablet and microgranules

Author

Flouvat B, Delhotal-Landes B, Prinseau J, Boutin Ms, and Karpouzas I

Subjects
Adult, Male, medicine.drug_class, Cmax, Administration, Oral, Biological Availability, Pharmaceutical Science, Absorption (skin), Pharmacology, Animal science, Theophylline, Bronchodilator, medicine, Humans, Sustained Release Tablet, Pharmacology (medical), Meal, Chemistry, General Medicine, Bioavailability, Kinetics, Intestinal Absorption, Food, Delayed-Action Preparations, Dietary Proteins, Absorption rate constant, medicine.drug
Abstract

Two sustained-release formulations of theophylline, tablets (T) and microgranules (MG) forms, were administered in a randomized order to 8 healthy subjects in fasting or with a high-protein test meal (50 per cent). Blood was collected for 32h post-dose. In fasting subjects, absorption of theophylline was significantly faster for T (tmax 5 h) as compared with MG (tmax 8 h, p less than 0.05), but Cmax and AUC were comparable; intersubject variability was higher with T. Administration of a high-protein test meal with T produced a significant decrease of the zero-order absorption rate constant of theophylline (K omicron 37.8 +/- 9.1 mgh-1 after meal versus 58.8 +/- 13 mgh-1 in fasting, p = 0.01), tmax was doubled to 10 h, and Cmax increased by 25 per cent (6.33 +/- 2.16 mgl-1 versus 5.04 +/- 1.28 mgl-1, p less than 0.02); with MG, tmax were the same (8 h), Cmax were not significantly increased (4.79 +/- 0.84 mgl-1 versus 4.55 +/- 0.67 mgl-1), absorption was delayed (lag-time 1.28 +/- 0.58 h) and the absorption was slightly accelerated (K omicron 50.4 +/- 10.4 mgh-1 versus 42.3 +/- 11.9 mgh-1, NS). For each form bioavailability was not significantly modified by food. This study demonstrated that food rich in protein modifies the absorption rate of theophylline in a sustained-release tablet formulation but is without influence in a pH-independent, sustained-release microgranule formulation.

Published
1988
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50. Oral load of tyrosine or L-dopa and plasma levels of free and sulfoconjugated catecholamines in healthy men

Author

Fritel D, M Devoisin, J. Guedon, L Reingeissen, F Selz, J. L. Tual, Baglin A, Cuche Jl, G Ruget, and Prinseau J

Subjects
Male, medicine.medical_specialty, Chemistry, Phenylalanine, Administration, Oral, Levodopa, Norepinephrine, Catecholamines, Endocrinology, Epinephrine, Dopamine, Carbidopa, Internal medicine, Internal Medicine, medicine, Catecholamine, Humans, Tyrosine, Ingestion, Metanephrine, medicine.drug
Abstract

The levels of free and sulfoconjugated catecholamines were measured in the plasma of fasting, recumbent normal subjects before and after an oral load of the catecholamine precursors tyrosine or L-dopa. Basal values of sulfoconjugated catecholamines, measured in plasma samples diluted 1:100 were 7998 +/- 540 pg/ml for dopamine sulfate, 2938 +/- 281 pg/ml for norepinephrine sulfate, and 2958 +/- 288 pg/ml for epinephrine sulfate (n = 37 tests in 15 men); these basal values are higher than those reported previously. Neither free nor sulfoconjugated catecholamine concentrations were changed by a tyrosine load (100 mg/kg) that induced a doubling of the plasma tyrosine level or by a meal low in phenylalanine and tyrosine (but otherwise supplying constituents of normal nourishment) that induced a greater than 50% reduction in the plasma tyrosine concentration. After an oral load of L-dopa (125 mg) the following were observed. (1) An extremely large increase (greater than 100-fold) in dopamine sulfate levels was noted, an increase that was less marked in the same subjects given L-dopa (125 mg) plus the peripheral dopa-decarboxylase inhibitor carbidopa (12.5 mg); as expected, free dopamine concentration also was increased. (2) Neither free nor sulfoconjugated norepinephrine concentrations were altered. (3) Epinephrine sulfate but not free epinephrine concentration was increased (more than ten-fold) after L-dopa ingestion alone; this result was unexpected and has to be confirmed before considering its physiological meaning, if any.

Published
1985
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