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23 results on '"Prisant, Nadia"'

4. Genetic causes of macrozoospermia and proposal for an optimized genetic diagnosis strategy based on sperm parameters

Author

Coudert, Alicia, primary, Cazin, Caroline, additional, Amiri-Yekta, Amir, additional, Ben Mustapha, Selima Fourati, additional, Zouari, Raoudha, additional, Bessonat, Julien, additional, Zoghmar, Abdelali, additional, Clergeau, Antoine, additional, Metzler-Guillemain, Catherine, additional, Triki, Chema, additional, Lejeune, Hervé, additional, Sermondade, Nathalie, additional, Pipiras, Eva, additional, Prisant, Nadia, additional, Cedrin, Isabelle, additional, Koscinski, Isabelle, additional, Keskes, Leila, additional, Lestrade, Florence, additional, Hesters, Laetitia, additional, Rives, Nathalie, additional, Dorphin, Béatrice, additional, Guichet, Agnes, additional, Patrat, Catherine, additional, Dulioust, Emmanuel, additional, Feraille, Aurélie, additional, Robert, François, additional, Brouillet, Sophie, additional, Morel, Frédéric, additional, Perrin, Aurore, additional, Rougier, Nathalie, additional, Bieth, Eric, additional, Sorlin, Arthur, additional, Siffroi, Jean-Pierre, additional, Ben Khelifa, Mariem, additional, Boiterelle, Florence, additional, Hennebicq, Sylvianne, additional, Satre, Veronique, additional, Arnoult, Christophe, additional, Coutton, Charles, additional, Barbotin, Anne-Laure, additional, Thierry-Mieg, Nicolas, additional, Kherraf, Zine-Eddine, additional, and Ray, Pierre F., additional

Published
2023
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12. The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population

Author

Dieterich, Klaus, Zouari, Raoudha, Harbuz, Radu, Vialard, François, Martinez, Delphine, Bellayou, Hanane, Prisant, Nadia, Zoghmar, Abdelali, Guichaoua, Marie Roberte, Koscinski, Isabelle, Kharouf, Mahmoud, Noruzinia, Mehrdad, Nadifi, Sellama, Sefiani, Abdelaziz, Lornage, Jacqueline, Zahi, Mohamed, Viville, Stéphane, Sèle, Bernard, Jouk, Pierre-Simon, Jacob, Marie-Christine, Escalier, Denise, Nikas, Yorgos, Hennebicq, Sylviane, Lunardi, Joël, and Ray, Pierre F.

Published
2009

14. Zika virus in the female genital tract

Author

Prisant, Nadia, primary, Bujan, Louis, additional, Benichou, Hélène, additional, Hayot, Pierre-Humbert, additional, Pavili, Lynda, additional, Lurel, Sylvia, additional, Herrmann, Cecile, additional, Janky, Eustase, additional, and Joguet, Guillaume, additional

Published
2016
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15. European regulation REACH and the assessment of testicular toxicity

Author

Perrard, Marie-Hélène, Grenet, Christophe, Prisant, Nadia, Geoffroy-Siraudin, Cendrine, Segretain, Dominique, Guichaoua, Marie-Roberte, Pointis, Georges, Durand, Philippe, Institut de Génomique Fonctionnelle de Lyon (IGFL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Lyon (ENS Lyon), Centre méditérannéen de médecine moléculaire (C3M), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance Publique - Hôpitaux de Marseille (APHM), Université Paris Descartes - Paris 5 (UPD5), École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Université Nice Sophia Antipolis (1965 - 2019) (UNS)

Subjects
[SDV]Life Sciences [q-bio], MALADIE TESTICULAIRE, [INFO]Computer Science [cs]
Abstract

National audience; Several studies suggest that exposure to environmental pollutants is partly responsible for testicular pathologies that have considerably increased over the last decades (cryptorchidism, hypospadias, cancer, decrease in the number of ejaculated spermatozoa). However, the cellular and molecular mechanisms involved in this reprotoxicity remain mostly unknown. One of the challenges of the european regulation REACH is to improve the knowledge on the chemical, toxic and ecotoxic properties of substances used in everyday life. As for the testicular toxicity, the few in vivo models used are not always the most appropriate for mechanistic studies. Our laboratory has developed and validated on a physiological point of view, coculture systems of germ cells in bicameral chambers, which reproduce a blood-testis barrier, allowing the determination of the mechanisms responsible for the toxicity of organic or mineral compounds on spermatogenesis, while reducing greatly the number of animals required.; Un des enjeux de la réglementation européenne REACH est l'amélioration des connaissances des propriétés chimiques, toxiques et écotoxiques des substances utilisées dans la vie courante. Concernant la toxicité testiculaire, nous manquons de modèles pertinents et les rares modèles in vivo utilisés ne sont pas toujours appropriés pour des études mécanistiques. Notre laboratoire a développé des systèmes de culture des cellules germinales mâles, en chambre bicamérale, qui reproduisent une barrière hématotesticulaire et permettent d'étudier le mécanisme d'action des régulateurs physiologiques et les effets d'une substance toxique sur la spermatogenèse, tout en réduisant le nombre d'animaux requis.

Published
2010

17. Analyse de la spermatogenèseex vivo

Author

Perrard, Marie-Hélène, primary, Grenet, Christophe, additional, Prisant, Nadia, additional, Geoffroy-Siraudin, Cendrine, additional, Segretain, Dominique, additional, Guichaoua, Marie-Roberte, additional, Pointis, Georges, additional, and Durand, Philippe, additional

Published
2010
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22. Analysis of the intratesticular control of spermatogenesis by ex-vivo approaching.

Author

Perrard, Marie-Hélene, Prisant, Nadia, Geoffroy-Siraudin, Cendrine, Segretain, Dominique, Pointis, Georges, Guichaoua, Marie-Roberte, and Durand, Philippe

Subjects
SPERMATOGENESIS, TESTIS, MALE reproductive organs, GERM cells, HEREDITY
Abstract

Spermatogenesis involves the realization of a particular genetic program which requires a specific environment ("niche"). Multiplication, differentiation and apoptosis of male germ cells are finely regulated by pituitary hormones (mainly LH and FSH), and by a complex network of factors originating from both the somatic cells and the germ cells of the testis. It is becoming clear that hormones and intra-testicular regulatory factors can compensate, at least in part, for the absence of some hormones or factors including FSH and LH or androgen receptors. Since, most of the growth factors, cytokines and neurotrophins produced within the testis are widely expressed in the organism, the attempts to understand their role in spermatogenesis by "classical" knock-out strategies have been often disappointing. Therefore an important aspect of our previous work was to settle and characterize carefully two systems of cocultures of testicular germ cells with somatic cells in bicameral chambers. For instance, we showed for the first time that the whole meiotic step could be performed in vitro in a mammalian species (the rat). Moreover, all our data indicate that our co-culture systems enable to highlight mechanisms pertinent to the physiological processes. Sperm parameters have been deteriorated considerably during the past 4-5 decades. There is now evidence that chemical exposure is at least partly responsible for these testicular diseases. If a large number of environmental pollutants are able to affect male fertility and to exert carcinogenic effects, their cellular and molecular mechanisms are still unidentified. The cultures in bicameral chambers that we settled can be used to study the effects of a toxicant when added in the basal compartment of the culture chamber, which appears relevant to the in vivo situation. Taken together our results indicate that our in vitro culture systems, which allow screening for the effect of biological activity of different physiological factors, can be also helpful to study that of any chemicals on both survival and multiplication/differentiation of somatic and/or spermatogenic cells on a relatively long time period. [ABSTRACT FROM AUTHOR]

Published
2009
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23. Analyse de la spermatogenèse ex vivo

Author

Perrard, Marie-Hélène, Grenet, Christophe, Prisant, Nadia, Geoffroy-Siraudin, Cendrine, Segretain, Dominique, Guichaoua, Marie-Roberte, Pointis, Georges, and Durand, Philippe

Abstract

Un des enjeux de la réglementation européenne REACH est l’amélioration des connaissances des propriétés chimiques, toxiques et écotoxiques des substances utilisées dans la vie courante. Concernant la toxicité testiculaire, nous manquons de modèles pertinents et les rares modèles in vivoutilisés ne sont pas toujours appropriés pour des études mécanistiques. Notre laboratoire a développé des systèmes de culture des cellules germinales mâles, en chambre bicamérale, qui reproduisent une barrière hématotesticulaire et permettent d’étudier le mécanisme d’action des régulateurs physiologiques et les effets d’une substance toxique sur la spermatogenèse, tout en réduisant le nombre d’animaux requis.

Published
2010
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