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7 results on '"Pritchett, Jamie"'

3. Maternal HIV-1 envelope–specific antibody responses and reduced risk of perinatal transmission

Author

Permar, Sallie R., Fong, Youyi, Vandergrift, Nathan, Fouda, Genevieve G., Gilbert, Peter, Parks, Robert, Jaeger, Frederick H., Pollara, Justin, Martelli, Amanda, Liebl, Brooke E., Lloyd, Krissey, Yates, Nicole L., Overman, R. Glenn, Shen, Xiaoying, Whitaker, Kaylan, Chen, Haiyan, Pritchett, Jamie, Solomon, Erika, Friberg, Emma, Marshall, Dawn J., Whitesides, John F., Gurley, Thaddeus C., Von Holle, Tarra, Martinez, David R., Cai, Fangping, Kumar, Amit, Xia, Shi-Mao, Lu, Xiaozhi, Louzao, Raul, Wilkes, Samantha, Datta, Saheli, Sarzotti-Kelsoe, Marcella, Liao, Hua-Xin, Ferrari, Guido, Alam, S. Munir, Montefiori, David C., Denny, Thomas N., Moody, M. Anthony, Tomaras, Georgia D., Gao, Feng, and Haynes, Barton F.

Published
2015
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4. Notes from the Field: Targeted Biomonitoring for GenX and Other Per- and Polyfluoroalkyl Substances Following Detection of Drinking Water Contamination — North Carolina, 2018

Author

Pritchett, Jamie R., primary, Rinsky, Jessica L., additional, Dittman, Beth, additional, Christensen, Ariel, additional, Langley, Rick, additional, Moore, Zack, additional, Fleischauer, Aaron T., additional, Koehler, Kate, additional, Calafat, Antonia M., additional, Rogers, Rachel, additional, Esters, Laconial, additional, Jenkins, Rodney, additional, Collins, Faye, additional, Conner, Debra, additional, and Breysse, Patrick, additional

Published
2019
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5. Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques

Author

Luo, Kan, primary, Liao, Hua-Xin, additional, Zhang, Ruijun, additional, Easterhoff, David, additional, Wiehe, Kevin, additional, Gurley, Thaddeus C., additional, Armand, Lawrence C., additional, Allen, Ashley A., additional, Von Holle, Tarra A., additional, Marshall, Dawn J., additional, Whitesides, John F., additional, Pritchett, Jamie, additional, Foulger, Andrew, additional, Hernandez, Giovanna, additional, Parks, Robert, additional, Lloyd, Krissey E., additional, Stolarchuk, Christina, additional, Sawant, Sheetal, additional, Peel, Jessica, additional, Yates, Nicole L., additional, Dunford, Erika, additional, Arora, Sabrina, additional, Wang, Amy, additional, Bowman, Cindy M., additional, Sutherland, Laura L., additional, Scearce, Richard M., additional, Xia, Shi-Mao, additional, Bonsignori, Mattia, additional, Pollara, Justin, additional, Edwards, R. Whitney, additional, Santra, Sampa, additional, Letvin, Norman L., additional, Tartaglia, James, additional, Francis, Donald, additional, Sinangil, Faruk, additional, Lee, Carter, additional, Kaewkungwal, Jaranit, additional, Nitayaphan, Sorachai, additional, Pitisuttithum, Punnee, additional, Rerks-ngarm, Supachai, additional, Michael, Nelson L., additional, Kim, Jerome H., additional, Alam, S. Munir, additional, Vandergrift, Nathan A., additional, Ferrari, Guido, additional, Montefiori, David C., additional, Tomaras, Georgia D., additional, Haynes, Barton F., additional, and Moody, M. Anthony, additional

Published
2016
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6. Immunoglobulin Gene Insertions and Deletions in the Affinity Maturation of HIV-1 Broadly Reactive Neutralizing Antibodies

Author

Kepler, Thomas B., primary, Liao, Hua-Xin, additional, Alam, S. Munir, additional, Bhaskarabhatla, Rekha, additional, Zhang, Ruijun, additional, Yandava, Chandri, additional, Stewart, Shelley, additional, Anasti, Kara, additional, Kelsoe, Garnett, additional, Parks, Robert, additional, Lloyd, Krissey E., additional, Stolarchuk, Christina, additional, Pritchett, Jamie, additional, Solomon, Erika, additional, Friberg, Emma, additional, Morris, Lynn, additional, Karim, Salim S. Abdool, additional, Cohen, Myron S., additional, Walter, Emmanuel, additional, Moody, M. Anthony, additional, Wu, Xueling, additional, Altae-Tran, Han R., additional, Georgiev, Ivelin S., additional, Kwong, Peter D., additional, Boyd, Scott D., additional, Fire, Andrew Z., additional, Mascola, John R., additional, and Haynes, Barton F., additional

Published
2014
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7. Immunoglobulin Gene Insertions and Deletions in the Affinity Maturation of HIV-1 Broadly Reactive Neutralizing Antibodies

Author

Kwong, Peter D., Alam, S. Munir, Kepler, Thomas B., Morris, Lynn, Lloyd, Krissey E., Bhaskarabhatla, Rekha, Fire, Andrew Z., Zhang, Ruijun, Wu, Xueling, Parks, Robert, Walter, Emmanuel, Cohen, Myron S., Kelsoe, Garnett, Pritchett, Jamie, Anasti, Kara, Stewart, Shelley, Karim, Salim S.Abdool, Solomon, Erika, Stolarchuk, Christina, Liao, Hua Xin, Friberg, Emma, Haynes, Barton F., Altae-Tran, Han R., Yandava, Chandri, Georgiev, Ivelin S., Boyd, Scott D., Mascola, John R., and Moody, M. Anthony

Subjects
food and beverages, 3. Good health
Abstract

Induction of HIV-1 broad neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development but has remained challenging partially due to unusual traits of bnAbs, including high somatic hypermutation (SHM) frequencies and in-frame insertions and deletions (indels). Here we examined the propensity and functional requirement for indels within HIV-1 bnAbs. High-throughput sequencing of the immunoglobulin (Ig) VHDJH genes in HIV-1 infected and uninfected individuals revealed that the indel frequency was elevated among HIV-1-infected subjects, with no unique properties attributable to bnAb-producing individuals. This increased indel occurrence depended only on the frequency of SHM point-mutations. Indel-encoded regions were generally proximal to antigen binding sites. Additionally, reconstruction of a HIV-1 CD4-binding site bnAb clonal lineage revealed that a large compound VHDJH indel was required for bnAb activity. Thus, vaccine development should focus on designing regimens targeted at sustained activation of bnAb lineages to achieve the required SHM and indel events.

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