242 results on '"Procko, Erik"'
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2. A computationally designed ACE2 decoy has broad efficacy against SARS-CoV-2 omicron variants and related viruses in vitro and in vivo
3. Multiple mechanisms of self-association of chemokine receptors CXCR4 and CCR5 demonstrated by deep mutagenesis
4. A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions
5. Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection
6. TAPBPR employs a ligand-independent docking mechanism to chaperone MR1 molecules
7. The substrate import mechanism of the human serotonin transporter
8. Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants
9. An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2
10. Engineering Proteins by Combining Deep Mutational Scanning and Yeast Display
11. TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap
12. Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits
13. Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy
14. Sequence basis for selectivity of ephrin-B2 ligand for Eph receptors and pathogenic henipavirus G glycoproteins
15. Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy
16. Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex
17. An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry
18. A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions
19. Xeno-interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes
20. The Sequence Basis for Selectivity of Ephrin-B2 Ligand for Eph Receptors and Pathogenic Henipavirus G Glycoproteins
21. Multiple mechanisms of self-association of chemokine receptors CXCR4 and CCR5 demonstrated by deep mutagenesis
22. Intracellular Delivery System for Antibody–Peptide Drug Conjugates
23. The Sequence Basis for Selectivity of Ephrin-B2 Ligand for Eph Receptors and Pathogenic Henipavirus G Glycoproteins: Selective Ephrin-B2 Decoys for Nipah and Hendra Virus
24. Machine Learning Guided Design of High-Affinity ACE2 Decoys for SARS-CoV-2 Neutralization
25. Abstract 1393: The Sequence Basis for Selectivity of Ephrin B2 for its Receptors and Henipaviral G Proteins
26. A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
27. Computational Design of a Protein-Based Enzyme Inhibitor
28. Deep mutagenesis in the study of COVID-19: a technical overview for the proteomics community
29. A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions
30. An engineered ACE2 decoy receptor can be administered by inhalation and potently targets the BA.1 and BA.2 omicron variants of SARS-CoV-2
31. Structural Rearrangement of the Serotonin Transporter Intracellular Gate Induced by Thr276 Phosphorylation
32. Motif-Driven Design of Protein–Protein Interfaces
33. The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans
34. Combining simulations and deep mutagenesis to elucidate structural dynamics of monoamine transporters
35. A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions
36. Computationally engineered ACE2 decoy binds with nanomolar affinity with the SARS-CoV-2 spike protein
37. Machine learning guided design of high affinity ACE2 decoys for SARS-CoV-2 neutralization
38. Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants
39. Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes
40. Antigen processing and presentation: TAPping into ABC transporters
41. Structural and energetic basis of folded--protein transport by the FimD usher
42. Abstract 12355: An Engineered High-Affinity ACE2 Peptide Therapeutically Alleviates Lung Vascular Endothelial Injury and Mortality Induced by Distinct SARS-CoV-2 Variants
43. Structural rearrangement of the intracellular gate of the serotonin transporter induced by Thr276 phosphorylation
44. Computationally Designed ACE2 Decoy Receptor Binds SARS-CoV-2 Spike (S) Protein with Tight Nanomolar Affinity
45. A Tethered Ligand Assay to Probe SARS-CoV-2:ACE2 Interactions
46. A Tethered Ligand Assay to Probe SARS-CoV-2:ACE2 Interactions
47. The Ankyrin Repeats of TRPV1 Bind Multiple Ligands and Modulate Channel Sensitivity
48. ACE2‐based decoy receptors for SARS coronavirus 2
49. Deep Mutagenesis of a Transporter for Uptake of a Non-Native Substrate Identifies Conformationally Dynamic Regions
50. Deep Mutational Scanning of Viral Glycoproteins and Their Host Receptors
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