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2. Letter to the editor: Risk of false newborn screening after intra-uterine exposure to ETI

Author

Longziekten patientenzorg, Child Health, De Wachter, E., Davies, J. C., Simmonds, N. J., Castellani, C., de Winter-de Groot, K. M., Munck, A., Proesmans, M., Southern, K. W., Barben, J., Longziekten patientenzorg, Child Health, De Wachter, E., Davies, J. C., Simmonds, N. J., Castellani, C., de Winter-de Groot, K. M., Munck, A., Proesmans, M., Southern, K. W., and Barben, J.

Published
2024

4. Optimizing care for children with difficult-to-treat and severe asthma through specialist paediatric asthma centres:expert practical experience and advice

Author

Pijnenburg, M. W., Rubak, S., Skjerven, H. O., Verhulst, S., Elenius, V., Hugen, C., Jauhola, O., Kempeneers, C., Melén, E., Reier Nilsen, T., Rutjes, N. W., Ruotsalainen, M., Schaballie, H., Zwitserloot, A. M., Proesmans, M., Mäkelä, M. J., Pijnenburg, M. W., Rubak, S., Skjerven, H. O., Verhulst, S., Elenius, V., Hugen, C., Jauhola, O., Kempeneers, C., Melén, E., Reier Nilsen, T., Rutjes, N. W., Ruotsalainen, M., Schaballie, H., Zwitserloot, A. M., Proesmans, M., and Mäkelä, M. J.

Abstract

Severe asthma in children carries an unacceptable treatment burden, yet its rarity means clinical experience in treating it is limited, even among specialists. Practical guidance is needed to support clinical decision-making to optimize treatment for children with this condition. This modified Delphi convened 16 paediatric pulmonologists and allergologists from northern Europe, all experienced in treating children with severe asthma. Informed by interviews with stakeholders involved in the care of children with severe asthma (including paediatricians, nurses and carers), and an analysis of European guidelines, the experts built a consensus focused on the gaps in existing guidance. Explored were considerations for optimizing care for patients needing biologic treatment, and for selecting home or hospital delivery of biologics. This consensus is aimed at clinicians in specialist centres, as well as general paediatricians, paediatric allergologists and paediatric pulmonologists who refer children with the most severe asthma to specialist care. Consensus is based on expert opinion and is intended for use alongside published guidelines. Our discussions revealed three key facets to optimizing care. Firstly, early asthma detection in children presenting with wheezing and/or dyspnoea is vital, with a low threshold for referral from primary to specialist care. Secondly, children who may need biologics should be referred to and managed by specialist paediatric asthma centres; we define principles for the specialist team members, tests, and expertise necessary at such centres, as well as guidance on when homecare biologics delivery is and is not appropriate. Thirdly, shared decision-making is essential at all stages of the patient’s journey: clear, concise treatment plans are vital for patient/carer self-management, and structured processes for transition from paediatric to adult services are valuable. The experts identified the potential for specialist paediatric asthma nu

Published
2024

5. The impact of chest computed tomography and chest radiography on clinical management of cystic fibrosis lung disease

Author

Belessis, Y., Bremont, F., Bui, S., Casciaro, R., Cavicchi, M.C., Cox, D.M., Da Dalt, L., De Gregorio, F., Dubus, J.C., Gartner, S., Geerdink, M., Hansen, C.R., Honková, L., Jenkins, L.E., Jung, A., Karpati, F., Mainguy, C., Möller, A., Neri, A.S., Pressler, T., Proesmans, M., Raia, V., Reid, A.J.M., Rietschel, E., Robinson, P.D., Robinson, P.J., Rossi, P., Rovira, S., Schultz, A., Sepe, O., Skalická, V., Stick, S., Švabe, V., Tai, A., Tosco, A., Vazquez, C., Bortoluzzi, Carla F., Pontello, Eleonora, Pintani, Emily, de Winter-de Groot, Karin M., D'Orazio, Ciro, Assael, Baroukh M., Hunink, M.G. Myriam, Tiddens, Harm A.W.M., and Caudri, Daan

Published
2020
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7. EPS6.05 A phase 3b study of the effects of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) on cough and physical activity in people with cystic fibrosis (CF)

Author

Van Braeckel, E., primary, De Wachter, E., additional, Mall, M., additional, McKone, E., additional, Proesmans, M., additional, Ramsey, B., additional, Santamaria, S.V., additional, Smith, D., additional, Tullis, E., additional, Taylor-Cousar, J., additional, Chin, A., additional, Conner, S., additional, Jennings, M., additional, Weinstock, T., additional, and Keating, D., additional

Published
2023
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12. 692 Importance of cystic fibrosis transmembrane conductance regulator messenger ribonucleic acid testing to uncover other variants in cystic fibrosis genotype that affect cystic fibrosis transmembrane conductance regulator expression

Author

Ramalho, A., primary, Cuyx, S., additional, Boon, M., additional, Proesmans, M., additional, Dupont, L., additional, Van Hoorenbeeck, K., additional, De Wachter, E., additional, Van Biervliet, S., additional, De Boeck, K., additional, and Vermeulen, F., additional

Published
2022
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14. The Management of Asymptomatic Congenital Pulmonary Airway Malformation: Results of a European Delphi Survey

Author

Kersten, C.M., Hermelijn, S.M., Mullassery, D., Muthialu, N., Cobanoglu, N., Gartner, S., Bagolan, P., Burgos, C. Mesas, Sgrò, A., Heyman, S., Till, H., Suominen, J., Schurink, M., Desender, L., Losty, P., Steyaert, H., Terheggen-Lagro, S., Metzelder, M., Bonnard, A., Sfeir, R., Singh, M., Yardley, I., Rikkers-Mutsaerts, N., Ent, C.K. van der, Qvist, N., Cox, D.W., Peters, R., Bannier, M., Wessel, L., Proesmans, M., Stanton, M., Hannon, E., Zampoli, M., Morini, F., Tiddens, H., Wijnen, R.M.H., Schnater, J.M., Kersten, C.M., Hermelijn, S.M., Mullassery, D., Muthialu, N., Cobanoglu, N., Gartner, S., Bagolan, P., Burgos, C. Mesas, Sgrò, A., Heyman, S., Till, H., Suominen, J., Schurink, M., Desender, L., Losty, P., Steyaert, H., Terheggen-Lagro, S., Metzelder, M., Bonnard, A., Sfeir, R., Singh, M., Yardley, I., Rikkers-Mutsaerts, N., Ent, C.K. van der, Qvist, N., Cox, D.W., Peters, R., Bannier, M., Wessel, L., Proesmans, M., Stanton, M., Hannon, E., Zampoli, M., Morini, F., Tiddens, H., Wijnen, R.M.H., and Schnater, J.M.

Abstract

Item does not contain fulltext, Consensus on the optimal management of asymptomatic congenital pulmonary airway malformation (CPAM) is lacking, and comparison between studies remains difficult due to a large variety in outcome measures. We aimed to define a core outcome set (COS) for pediatric patients with an asymptomatic CPAM. An online, three-round Delphi survey was conducted in two stakeholder groups of specialized caregivers (surgeons and non-surgeons) in various European centers. Proposed outcome parameters were scored according to level of importance, and the final COS was established through consensus. A total of 55 participants (33 surgeons, 22 non-surgeons) from 28 centers in 13 European countries completed the three rounds and rated 43 outcome parameters. The final COS comprises seven outcome parameters: respiratory insufficiency, surgical complications, mass effect/mediastinal shift (at three time-points) and multifocal disease (at two time-points). The seven outcome parameters included in the final COS reflect the diversity in priorities among this large group of European participants. However, we recommend the incorporation of these outcome parameters in the design of future studies, as they describe measurable and validated outcomes as well as the accepted age at measurement.

Published
2022

23. Varicella paediatric hospitalisations in Belgium: a 1-year national survey

Author

Blumental, Sophie, Sabbe, Martine, Lepage, Philippe, Asscherickx, W., Audiens, H., Azou, M., Baten, E., Bertrand, Th., Beullens, B., Bouteiller, A-S, Bruylants, B., Candi, B., Cavatorta, E., Corthouts, I., Croisier, C., Delbushaye, J., De Lille, L., Deman, S., Demeester, A., Denoncin, C., De Roeck, J-P., De Schutter, I., De Schynkel, K., de Selys, A., Desimpel, H., De Temmerman, D., Duvivier, B., Eerdekens, K., Elyahyioui, M., Fedora, L., Franckx, J., Frère, J., Lerusse, C., Garmyn, K., Genin, C., Gielen, ML., Gueulette, E., Guzganu, L., Hemelsoet, N., Henckens, F., Jaumotte, J., Jeannin, Ph., Joachim, L., Jonckheer, T., Khalil, T., Kreitz, S., Lemay, P., Lemmens, F., Lenga, E., Levy, J., Lubrez, A., Maka, M., Matthijs, I., Michel, M., Naert, M., Naudts, K., Nica, A-M, Nobre-Machado, A., Oosterlynck, L., Peeters, S., Persyn, J., Pletincx, M., Proesmans, M., Vermeulen, F., Quaegebeur, K., Questiaux, J-F., Raes, M., Ramet, J., Renders, F., Rentmeesters, A-M., Saive, N., Sauer, K., Schelstraete, P., Segers, K., Seghaye, M-C., Sercu, E., Slaouti, T., Snoeck, L., Stalens, J-Ph., Thijs, J., Nikolaas, AZ, Tshibuabua, G., Tuerlinckx, D., Vandecasteele, G., Van den Berghe, L., Vandenbossche, L., Vandenbroeck, P., Vandenbussche, E., Vander Auwera, A., Vanderbruggen, K., Van der Linden, D., Van Eldere, S., Van Genechten, T., Vlemincx, I., Van Hauthem, H., Van Lierde, B., Van Lierde, S., Van Oort, M., Van Steirteghem, S., Verbeeck, P., Verdonck, L., Verghote, M., Verniest, R., Versteegh, Ch., Vincke, P., and Watillon, Ph.

Published
2016
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28. ERS International Congress 2020: highlights from the Paediatric Assembly

Author

Ardura-Garcia, C, Cuevas-Ocaña, Sara, Freitag, Nadine, Kampouras, Asterios, King, J, Kouis, Panayiotis, Mensink-Bout, SM, Whitehouse, A, Williams, E, Dassios, T, Duijts, Liesbeth, Ersu, R, Gaillard, EA, Horsley, AR, Proesmans, M, Rottier, Robbert, Schramm, Dirk, Moeller, A, Pijnenburg, Marielle, Ardura-Garcia, C, Cuevas-Ocaña, Sara, Freitag, Nadine, Kampouras, Asterios, King, J, Kouis, Panayiotis, Mensink-Bout, SM, Whitehouse, A, Williams, E, Dassios, T, Duijts, Liesbeth, Ersu, R, Gaillard, EA, Horsley, AR, Proesmans, M, Rottier, Robbert, Schramm, Dirk, Moeller, A, and Pijnenburg, Marielle

Abstract

In this review, the Paediatric Assembly of the European Respiratory Society (ERS) presents a summary of the highlights and most relevant findings in the field of paediatric respiratory medicine presented at the virtual ERS International Congress 2020. Early Career Members of the ERS and Chairs of the different Groups comprising the Paediatric Assembly discuss a selection of the presented research. These cover a wide range of research areas, including respiratory physiology and sleep, asthma and allergy, cystic fibrosis, respiratory infection and immunology, neonatology and intensive care, epidemiology, bronchology and lung and airway development. Specifically, we describe the long-term effect in lung function of premature birth, mode of delivery and chronic respiratory conditions such as cystic fibrosis. In paediatric asthma, we present risk factors, phenotypes and their progression with age, and the challenges in diagnosis. We confirm the value of the lung clearance index to detect early lung changes in cystic fibrosis. For bronchiectasis treatment, we highlight the importance of identifying treatable traits. The use of biomarkers and genotypes to identify infants at risk of long-term respiratory morbidity is also discussed. We present the long-term impact on respiratory health of early life and fetal exposures to maternal obesity and intrauterine hypoxia, mechanical ventilation hyperoxia, aeroallergens, air pollution, vitamin A deficient intake and bronchitis. Moreover, we report on the use of metabolomics and genetic analysis to understand the effect of these exposures on lung growth and alveolar development. Finally, we stress the need to establish multidisciplinary teams to treat complex airway pathologies.

Published
2021

31. Pulmonary function testing in children's interstitial lung disease

Author

Ring A, Carlens J, Bush A, Castillo-Corullon S, Fasola S, Gaboli M, Griese M, Koucky V, La Grutta S, Lombardi E, Proesmans M, Schwerk N, Snijders D, Nielsen K, and Buchvald F

Abstract

The use of pulmonary function tests (PFTs) has been widely described in airway diseases like asthma and cystic fibrosis, but for children's interstitial lung disease (chILD), which encompasses a broad spectrum of pathologies, the usefulness of PFTs is still undetermined, despite widespread use in adult interstitial lung disease. A literature review was initiated by the COST/Enter chILD working group aiming to describe published studies, to identify gaps in knowledge and to propose future research goals in regard to spirometry, whole-body plethysmography, infant and pre-school PFTs, measurement of diffusing capacity, multiple breath washout and cardiopulmonary exercise tests in chILD. The search revealed a limited number of papers published in the past three decades, of which the majority were descriptive and did not report pulmonary function as the main outcome. PFTs may be useful in different stages of management of children with suspected or confirmed chILD, but the chILD spectrum is diverse and includes a heterogeneous patient group in all ages. Research studies in well-defined patient cohorts are needed to establish which PFT and outcomes are most relevant for diagnosis, evaluation of disease severity and course, and monitoring individual conditions both for improvement in clinical care and as end-points in future randomised controlled trials.

Published
2020

32. ERS International Congress, Madrid, 2019: highlights from the Paediatric Assembly

Author

Nenna, R, Slaats, M, Ersu, R, Lo, D, Seglani, S, Nissenbaum, C, Horsley, AR, Proesmans, M, Petrarca, L, Williams, E, Dassios, T, Ardura-Garcia, C, Duijts, Liesbeth, Marczak, H, Snijders, D, Rottier, Robbert, Chao, CM, Pijnenburg, Marielle, Grigg, J, Nenna, R, Slaats, M, Ersu, R, Lo, D, Seglani, S, Nissenbaum, C, Horsley, AR, Proesmans, M, Petrarca, L, Williams, E, Dassios, T, Ardura-Garcia, C, Duijts, Liesbeth, Marczak, H, Snijders, D, Rottier, Robbert, Chao, CM, Pijnenburg, Marielle, and Grigg, J

Published
2020

41. The impact of chest computed tomography and chest radiography on clinical management of cystic fibrosis lung disease

Author

Bortoluzzi, Carla F., primary, Pontello, Eleonora, additional, Pintani, Emily, additional, de Winter-de Groot, Karin M., additional, D'Orazio, Ciro, additional, Assael, Baroukh M., additional, Hunink, M.G. Myriam, additional, Tiddens, Harm A.W.M., additional, Caudri, Daan, additional, Belessis, Y., additional, Bremont, F., additional, Bui, S., additional, Casciaro, R., additional, Cavicchi, M.C., additional, Cox, D.M., additional, Da Dalt, L., additional, De Gregorio, F., additional, Dubus, J.C., additional, Gartner, S., additional, Geerdink, M., additional, Hansen, C.R., additional, Honková, L., additional, Jenkins, L.E., additional, Jung, A., additional, Karpati, F., additional, Mainguy, C., additional, Möller, A., additional, Neri, A.S., additional, Pressler, T., additional, Proesmans, M., additional, Raia, V., additional, Reid, A.J.M., additional, Rietschel, E., additional, Robinson, P.D., additional, Robinson, P.J., additional, Rossi, P., additional, Rovira, S., additional, Schultz, A., additional, Sepe, O., additional, Skalická, V., additional, Stick, S., additional, Švabe, V., additional, Tai, A., additional, Tosco, A., additional, and Vazquez, C., additional

Published
2020
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42. WS11.5 Evaluation of combinations of the CFTR potentiator dirocaftor, corrector posenacaftor and amplifier nesolicaftor in cystic fibrosis subjects with two copies of the F508del mutation

Author

Downey, D. G, primary, Fajac, I., additional, Flume, P., additional, O’Carroll, M., additional, Pressler, T., additional, Proesmans, M., additional, Quon, B., additional, Schwarz, C., additional, Sutharsan, S., additional, Jiang, J., additional, and Gilmartin, G., additional

Published
2020
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