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14. ChemInform Abstract: Separation of Phthalideisoquinoline Alkaloids and Products of Their Semisynthetic Transformation by Capillary Zone Electrophoresis

Author

A. Proksova and Proksa B

Subjects
Transformation (genetics), Capillary electrophoresis, Chromatography, biology, Chemistry, Papaver, General Medicine, biology.organism_classification
Abstract

The aim of this paper was to study the separation of phthalideisoquinoline and secoisoquinoline alkaloids of Papaver somniferum and stereoisomers of their transformation products by CZE

Published
2010
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42. Identification and determination of organic acids in cultivation medium of Penicillium vermiculatum dang.

Author

Proksa, B., Adamcová, J., Liptaj, T., Prónayová, N., and Fuska, J.

Abstract

Copyright of Chemical Monthly / Monatshefte für Chemie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1994
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43. Synthesis of 2-acetyl-3-methyl-4 H-1,4-benzothiazine and its derivatives.

Author

Steiner, B., Koóš, M., Matulová, M., and Proksa, B.

Abstract

Copyright of Chemical Monthly / Monatshefte für Chemie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
1993
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44. Regulation of biosynthesis of thiolutin and aureothricin in Streptomyces kasugaensis.

Author

Šturdíková, M., Proksa, B., Uhrín, D., and Fuska, J.

Abstract

l-Methionine and dl-ethionine decreased production of thiolutin and aureothricin in Streptomyces kasugaensis. In the presence of l-methionine the culture also produced 3-methylthioacrylic acid, 3-methylthiopropionic acid and 3,6-bis-(2-methylthioethyl)-2,5-dioxopiperazine. Production of the metabolites depended on the concentration of l-methionine in the medium. [ABSTRACT FROM AUTHOR]

Published
1990
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48. Depsides and Depsidones as Inhibitors of HIV-1 Integrase:  Discovery of Novel Inhibitors through 3D Database Searching

Author

Neamati, N., Hong, H., Mazumder, A., Wang, S., Sunder, S., Nicklaus, M. C., Milne, G. W. A., Proksa, B., and Pommier, Y.

Abstract

Seventeen lichen acids comprising depsides, depsidones, and their synthetic derivatives have been examined for their inhibitory activity against HIV-1 integrase, and two pharmacophores associated with inhibition of this enzyme have been identified. A search of the NCI 3D database of approximately 200 000 structures yielded some 800 compounds which contain one or the other pharmacophore. Forty-two of these compounds were assayed for HIV-1 integrase inhibition, and of these, 27 had inhibitory IC50 values of less than 100 μM; 15 were below 50 μM. Several of these compounds were also examined for their activity against HIV-2 integrase and mammalian topoisomerase I.

Published
1997

50. OR-1—a mixture of esters of glyceric acid produced by Penicillium funiculosum and its antitrypsin activity.

Author

Lešová, K., Šturdíková, M., Proksa, B., Pigoš, M., and Liptaj, T.

Abstract

A mixture of related metabolites (denoted OR-1) was isolated from the fermentation broth of Penicillium funiculosum together with mitorubrinic acid. Structurally OR-1 is glyceric acid esterified with C14−C18 fatty acids. Steady-state studies revealed that OR-1 behaved like an uncompetitive trypsin inhibitor with K i 17.6 μmol/L. [ABSTRACT FROM AUTHOR]

Published
2001
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