1. Associations of Body Mass Index, Smoking, and Alcohol Consumption With Prostate Cancer Mortality in the Asia Cohort Consortium
- Author
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Ichiro Tsuji, Norie Sawada, Waka Ohishi, Betsy Rolland, Daehee Kang, Yoshikazu Nishino, Kotaro Ozasa, Chien-Jen Chen, Shao Yuan Chuang, Habibul Ahsan, Jung Eun Lee, Mangesh S. Pednekar, Masako Kakizaki, Dongfeng Gu, Lesley M. Butler, Prakash C. Gupta, Shoichiro Tsugane, Paolo Boffetta, San Lin You, Wei Zheng, Rashmi Sinha, Yu Chen, Hideo Tanaka, Yong-Bing Xiang, Jiang He, Dong Hyun Kim, Dale McLerran, Keun-Young Yoo, Mark D. Thornquist, Ziding Feng, Yumi Sugawara, Jay H. Fowke, Wen-Harn Pan, Manami Inoue, Sue K. Park, Faruque Parvez, Akiko Tamakoshi, Renwei Wang, Kunnambath Ramadas, John D. Potter, Woon-Puay Koh, Eric J. Grant, Yoon Ok Ahn, Isao Oze, Yasutake Tomata, Xiao-Ou Shu, Catherine Sauvaget, Jian-Min Yuan, Fowke, J.H., McLerran, D.F., Gupta, P.C., He, J., Shu, X.-O., Ramadas, K., Tsugane, S., Inoue, M., Tamakoshi, A., Koh, W.-P., Nishino, Y., Tsuji, I., Ozasa, K., Yuan, J.-M., Tanaka, H., Ahn, Y.-O., Chen, C.-J., Sugawara, Y., Yoo, K.-Y., Ahsan, H., Pan, W.-H., Pednekar, M., Gu, D., Xiang, Y.-B., Sauvaget, C., Sawada, N., Wang, R., Kakizaki, M., Tomata, Y., Ohishi, W., Butler, L.M., Oze, I., Kim, D.-H., You, S.-L., Park, S.K., Parvez, F., Chuang, S.-Y., Chen, Y., Lee, J.E., Grant, E., Rolland, B., Thornquist, M., Feng, Z., Zheng, W., Boffetta, P., Sinha, R., Kang, D., and Potter, J.D.
- Subjects
Gynecology ,Male ,medicine.medical_specialty ,Alcohol Drinking ,Epidemiology ,business.industry ,Original Contributions ,Hazard ratio ,Smoking ,Prostatic Neoplasms ,medicine.disease ,Body Mass Index ,Prostate-specific antigen ,Prostate cancer ,Prostate cancer screening ,Cohort ,Medicine ,Humans ,Obesity ,business ,Prospective cohort study ,Body mass index ,Demography ,Cause of death ,Prostate cancer - body mass - alcohol consumption - Abstract
Many potentially modifiable risk factors for prostate cancer are also associated with prostate cancer screening, which may induce a bias in epidemiologic studies. We investigated the associations of body mass index (weight (kg)/height (m)2), smoking, and alcohol consumption with risk of fatal prostate cancer in Asian countries where prostate cancer screening is not widely utilized. Analysis included 18 prospective cohort studies conducted during 1963-2006 across 6 countries in southern and eastern Asia that are part of the Asia Cohort Consortium. Body mass index, smoking, and alcohol intake were determined by questionnaire at baseline, and cause of death was ascertained through death certificates. Analysis included 522,736 men aged 54 years, on average, at baseline. During 4.8 million person-years of follow-up, there were 634 prostate cancer deaths (367 prostate cancer deaths across the 11 cohorts with alcohol data). In Cox proportional hazards analyses of all cohorts in the Asia Cohort Consortium, prostate cancer mortality was not significantly associated with obesity (body mass index >25: hazard ratio (HR) = 1.08, 95% confidence interval (CI): 0.85, 1.36), ever smoking (HR = 1.00, 95% CI: 0.84, 1.21), or heavy alcohol intake (HR = 1.00, 95% CI: 0.74, 1.35). Differences in prostate cancer screening and detection probably contribute to differences in the association of obesity, smoking, or alcohol intake with prostate cancer risk and mortality between Asian and Western populations and thus require further investigation. © The Author 2015. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health.
- Published
- 2015