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59 results on '"Proteasome Endopeptidase Complex deficiency"'

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1. Stem cell transplantation as treatment for major histocompatibility class I deficiency.

2. PSMD9 ribosomal protein network maintains nucleolar architecture and WT p53 levels.

3. Impairment of Proteasome Function in Podocytes Leads to CKD.

4. Macrophage pyroptosis is mediated by immunoproteasome subunit β5i (LMP7) in abdominal aortic aneurysm.

5. REGγ controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells.

6. The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells.

7. Heart-Specific Immune Responses in an Animal Model of Autoimmune-Related Myocarditis Mitigated by an Immunoproteasome Inhibitor and Genetic Ablation.

8. The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling.

9. Age-Dependent Effects of Immunoproteasome Deficiency on Mouse Adenovirus Type 1 Pathogenesis.

10. Proteasome activator REGγ promotes inflammation in Leydig cells via IkBε signaling.

11. Colonic Proteome Signature in Immunoproteasome-Deficient Stressed Mice and Its Relevance for Irritable Bowel Syndrome.

12. Proteasome Biology Is Compromised in White Matter After Asphyxic Cardiac Arrest in Neonatal Piglets.

13. LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins.

14. REGγ deficiency suppresses tumor progression via stabilizing CK1ε in renal cell carcinoma.

15. The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire.

16. Immunoproteasome subunit ß5i/LMP7-deficiency in atherosclerosis.

17. Quantitative Proteomics Reveals Extensive Changes in the Ubiquitinome after Perturbation of the Proteasome by Targeted dsRNA-Mediated Subunit Knockdown in Drosophila.

18. Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice.

19. Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-κB activation.

20. Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer.

21. Differentiation of preadipocytes and mature adipocytes requires PSMB8.

22. Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia.

23. Immunoproteasome subunit LMP7 Deficiency Improves Obesity and Metabolic Disorders.

24. Proteasome function is not impaired in healthy aging of the lung.

25. Assembly mechanisms of specialized core particles of the proteasome.

26. Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.

27. The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy.

28. REGγ deficiency promotes premature aging via the casein kinase 1 pathway.

29. β5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma.

30. Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice.

31. Corneal wound healing is compromised by immunoproteasome deficiency.

32. Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice.

33. Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation.

34. Gankyrin gene deletion followed by proteomic analysis: insight into the roles of Gankyrin in tumorigenesis and metastasis.

35. Proteomic analysis of hepatitis C virus (HCV) core protein transfection and host regulator PA28γ knockout in HCV pathogenesis: a network-based study.

36. Priming of Leishmania-reactive CD8+ T cells in vivo does not require LMP7-containing immunoproteasomes.

37. The proteasome system in infection: impact of β5 and LMP7 on composition, maturation and quantity of active proteasome complexes.

38. A critical role for the inducible proteasomal subunits LMP7 and MECL1 in cytokine production by activated murine splenocytes.

39. Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks.

40. The antiviral immune response in mice devoid of immunoproteasome activity.

41. Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.

42. PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo.

43. Diverse polyubiquitin chains accumulate following 26S proteasomal dysfunction in mammalian neurones.

44. Immunoproteasome-deficiency has no effects on NK cell education, but confers lymphocytes into targets for NK cells in infected wild-type mice.

45. Prevention of experimental colitis by a selective inhibitor of the immunoproteasome.

46. Unexpected role for the immunoproteasome subunit LMP2 in antiviral humoral and innate immune responses.

47. Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence.

48. Screening for OST deficiencies in unsolved CDG-I patients.

49. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans.

50. Negative regulation of MAVS-mediated innate immune response by PSMA7.

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