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2. Implementation of Low-Intensity Thrombolysis Monitoring Care in Routine Practice: Process Evaluation of the Optimal Post rtPA-IV Monitoring in Acute Ischemic Stroke Study in the USA

Author

Ouyang, Menglu, primary, González, Francisca, additional, Montalbano, Michelle, additional, Pruski, April, additional, Jan, Stephen, additional, Wang, Xia, additional, Johnson, Brenda, additional, Summers, Debbie V., additional, Khatri, Pooja, additional, Malavera, Alejandra, additional, Iacobelli, Michael, additional, Faigle, Roland, additional, Munoz-Venturelli, Paula, additional, Urrutia Goldsack, Francisca, additional, Day, Diana, additional, Robinson, Thompson G., additional, Durham, Alice C., additional, Ebraimo, Ahtasam, additional, Song, Lili, additional, Sui, Yi, additional, Wan Zaidi, Wan Asyraf, additional, Lindley, Richard I., additional, Delcourt, Candice, additional, Urrutia, Victor Cruz, additional, Anderson, Craig S., additional, and Liu, Hueiming, additional

Published
2024
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8. Abstract WMP13: Implementation Issues Arising From Less-intense Monitoring In Routine Care: Process Evaluation Of The Optimial Post Rtpa-iv Monitoring In Acute Ischemic Stroke (OPTIMISTmain) Study

Author

Ouyang, Menglu, primary, Gonzalez, Francisca, additional, Montalbano, Michelle, additional, Pruski, April, additional, Iacobelli, Michael, additional, Wang, Xia, additional, Faigle, Roland R, additional, Johnson, Brenda J, additional, Summers, Debbie, additional, Jan, Stephen, additional, Urrutia, Victor C, additional, Anderson, Craig S, additional, and Liu, Hueiming, additional

Published
2023
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13. List of Contributors

Author

Ahmad, Christopher S., Aisen, Mindy, Allen, Jason, Alon, Gad, Aloni, Ronit, Amin, Mayur Jayant, Ang-Muñoz, Cynthia D., Argoff, Charles E., Atanelov, Levi (Levan), Ayyangar, Rita, Bach, John R., Bačkonja, Miroslav Misha, Baggett, Leela, Barr, Karen P., Barrett, J. Christian, Bartels, Matthew, Basford, Jeffrey R., Bastepe-Gray, Serap, Beheshti, Mahya, Benjamin, Scott E., Bergin, William A., Bhatti, Omar Maurice, Bhullar, Ravneet, Bialek, Amy, Boninger, Michael L., Borg-Stein, Joanne, Brady, Susan, Brooke, Marvin McClatchey, Brown, Scott E., Brown, Steven E., Bukovitz, Brandon, Cabahug, Philippines G., Carson, Benjamin S., Sr., Cassius, David A., Chan, Leighton, Chan, Stephanie, Cicone, Caitlin M., Cohen, Jeffrey, Cooper, Rory A., Corrales, Alberto G., Cowling, Matthew, Cuccurullo, Sara, Cymet, Tyler C., Delaney, Kate E., Delavaux, Laurent, Sena, Giampaolo de, DeStefano, Lisa, Devon, Rubin I., Dillingham, Timothy R., Donofrio, Peter Daniel, Dreher, Freda, Duarte, Andrew J., Tan Dy, Rochelle Coleen, Ellenberg, Maury Ruben, Falco, Frank J.E., Filatov, Sergey, Findley, Thomas, Finnegan, Mark, Flamm, Michael, Flanagan, Steven, Furman, Michael B., Gabriel, Vincent, Ganchoon, Filipinas G., Gellhorn, Alfred C., Gharibo, Christopher, Gillis, Theresa A., Gimigliano, Francesca, Goetz, Lance L., Goldberg, Gary, Goldberg, Stephen, Gonzalez-Fernandez, Marlis, Grant, Ryan A., Habibi, Behnum, Hakimi, Kevin, Harvey, Richard L., Heckman, Jeffrey T., Heinle, Edward W., III, Helms, Joseph M., Heruti, Rafi J., Hinderer, Steven R., Ho, Chun, Honce, Bethany, Howard, Ileana Michelle, Huang, DongFeng, Hurvitz, Edward A., Iafrate, Julia Louisa, Ibanez, Katarzyna, Imamura, Marta, Ito, Akiko, Jackson, Kristen, Jones, Paul Steven, Joyce, Nanette Cunningham, Kalva, Shailaja, Kane, Chelsea, Katz, Richard T., Kerrigan, Deidre Casey, Khalid, Ehtesham, Khan, Fary, Khurana, Seema, Kiekens, Carlotte, Kim, Charles, Kiprovski, Kiril, Kirby, R. Lee, Knudsen, Michael L., Kolessar, David J., König, Franchesca, Korth, Sarah A., Koutalianos, Evangeline P., Kowalske, Karen J., Lains, Jorge, Ledbetter, David H., Lehman, Jeffrey, Lehman, Yehoshua J., Leonard, James W., Levy, Charles Edward, Lew, Karen, Li, Leonard S.W., Limke, Janet C., Littell, Kyle, Lopez, Francis, Mastanduno, Samantha, McGunigal, Thomas, Meyers, Jeffrey Saul, Mitchkash, Matthew, Mojica, Jose Alvin, Moroz, Alex, Myers, Stanley J., Nally, Emma, Napier, Fabreena E., Rao, Noel, Nosek, Margaret A., Odderson, Ib R., O’Young, Bryan J., Parikh, Sagar, Pazionis, Theresa J.C., Perkash, Inder, Pignolo, Robert, Poliak-Tunis, Michelle A., Press, Joel M., Priebe, Michael, Pruente, Jessica, Pruski, April D., Raghavan, Preeti, Rashbaum, Ira G., Ratan, Rajiv R., Recio, Albert, Richardson, James P., Rizzo, John-Ross, Robinson, Lawrence R., Rodriguez, Gianna Maria, Rodriguez, Rosa, Rondinelli, Robert, Rossi, Roger P., Rowan, Jacob, Rudin, Nathan J., Rundorff, Robert, Roza, Ryan J., Ryan-Michailidis, Emily, Saulle, Michael Frederick, Schneck, Carson D., Schneider, Jeffrey C., Schultz, Shannon L., Schwartz, Robert G., Sfeir, Jad Georges, Shafshak, Tarek, Shah, Jay P., Shamberg, Shoshana, Shapiro, Jennifer, Dave, Shashank, Siddiqi, Asad Riaz, Silver, Kenneth H., Slotkin, Jonathan R., Smith, Cher, Soares, Bosco Francisco, Soroker, Nachum, Speckman, Rebecca A., Stecco, Antonio, Stecco, Carla, Stein, Joel, Stern, Michelle, Sturgeon, John A., Sthalekar, Ninad Durganand, Stiens, Beth, Stiens, Steven A., Stiens, Elizabeth A., Stineman, Margaret Grace, Stover, Gary, Jr., Strauss, Constance L., Strauss, Nancy, Strayer, Jonathan, Suputtitada, Areerat, Tepper, Mitchell S., Terzella, Matthew, Terzic, Carmen M., Thakral, Aakash, Thakur, Lokendra, Thomas, Peter, Tippett, Donna C., Trasolini, Robert G., Trovato, Melissa, Tunis, Justin G., Uustal, Heikki, de Walle, Naheed Asad-Van, Dien, Craig Van, Varlotta, Gerard P., Visco, Christopher J., Vivekanandan, Sheela, Wainapel, Stanley F., Wang, Ninghua, Westheimer, Ruth, Whiteson, Jonathan H., Williams, Marc S., Williams, Olajide, Wortman-Jutt, Susan, Wu, Sam S.H., York, Henry S., Young, Mark A., Young, Marlene, Young, Michael J., Yuan, Xiaoning (Jenny), Zaremski, Jason L., and Zorowitz, Richard D.

Published
2024
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14. Implementation of a Framework for Telerehabilitation in Clinical Care Across the Continuum During COVID-19 and Beyond

Author

Kim, Soo Yeon, primary, Daley, Kelly, additional, Pruski, April D., additional, AlFarra, Tariq, additional, Azola, Alba, additional, Gonzalez Fernandez, Marlis, additional, Keszler, Mary S., additional, Friedel, Stacey, additional, Haaf, Hayley, additional, Segall, Harrison, additional, Lien, Peiting, additional, Cypher, Jacklyn, additional, Mazariegos, Julia, additional, and Raghavan, Preeti, additional

Published
2021
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15. Managing the Rehabilitation Wave: Rehabilitation Services for COVID-19 Survivors

Author

Kim, Soo Y., primary, Kumble, Sowmya, additional, Patel, Bhavesh, additional, Pruski, April D., additional, Azola, Alba, additional, Tatini, Anisa L., additional, Nadendla, Kavita, additional, Richards, Laryssa, additional, Keszler, Mary S., additional, Kott, Margaret, additional, Friedman, Michael, additional, Friedlander, Tracy, additional, Silver, Kenneth, additional, Hoyer, Erik H., additional, Celnik, Pablo, additional, Lavezza, Annette, additional, and González-Fernández, Marlís, additional

Published
2020
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21. Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as safe anti-inflammatory, analgesic, antipyretic, antioxidant prodrugs.

Author

Chattopadhyay, Mitali, Velazquez, Carlos A, Pruski, April, Nia, Kamran V, Abdellatif, Khaled R, Keefer, Larry K, and Kashfi, Khosrow

Abstract

Chronic inflammation is an underlying etiological factor in carcinogenesis; nonsteroidal anti-inflammatory drugs (NSAIDs) and their chemically modified NO-releasing prodrugs (NO-NSAIDs) are promising chemopreventive agents. The aim of this study was to conduct a head-to-head comparison between two NO-ASAs possessing different NO donor groups, an organic nitrate [3-nitrooxyphenyl acetylsalicylate (NO-ASA; NCX-4016)] and an N-diazeniumdiolate [NONO-ASA, O(2)- (acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA; CVM-01)], as antiulcerogenic, analgesic, anti-inflammatory, and antipyretic agents. All drugs were administered orally at equimolar doses. For antiulcerogenic study, 6 h after administration, the number and size of hemorrhagic lesions in stomachs from euthanized animals were counted. Tissue samples were frozen for prostaglandin E(2) (PGE(2)), superoxide dismutase (SOD), and malondialdehyde determination. For anti-inflammatory study, 1 h after drug administration, the volume of carrageenan-induced rat paw edemas was measured for 6 h. For antipyretic study, 1 h after dosing, fever was induced by intraperitoneal LPS, and body core temperatures measured for 5 h. For analgesic study, time-dependent analgesic effect of prodrugs was evaluated by carrageenan-induced hyperalgesia. Drugs were administered 30 min after carrageenan. NO-ASA and NONO-ASA were equipotent as analgesic and anti-inflammatory agents but were better than aspirin. Despite a drastic reduction of PGE(2) in stomach tissue, both prodrugs were devoid of gastric side effects. Lipid peroxidation induced by aspirin was higher than that observed by prodrugs. SOD activity induced by both prodrugs was similar, but approximately 2-fold higher than that induced by aspirin. CVM-01 is as effective as NCX-4016 in anti-inflammatory, analgesic, and antipyretic assays in vivo, and it showed an equivalent safety profile in the stomach. These results underscore the use of N-diazeniumdiolate moieties in drug design.

Published
2010
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22. Implementation of low-intensity thrombolysis monitoring care in routine practice: process evaluation of the Optimal Post rtPA-IV Monitoring in Acute Ischemic Stroke (OPTIMISTmain) study in the United States.

Author

Ouyang M, González F, Montalbano M, Pruski A, Jan S, Wang X, Johnson B, Summers DV, Khatri P, Malavera A, Iacobelli M, Faigle R, Munoz-Venturelli P, Urrutia Goldsack F, Day D, Robinson TG, Durham AC, Ebraimo A, Song L, Sui Y, Wan Zaidi WA, Lindley RI, Delcourt C, Urrutia VC, Anderson CS, and Liu H

Abstract

Introduction: The ongoing OPTIMISTmain study, an international, multicenter, stepped-wedge cluster randomized trial, aims to determine effectiveness and safety of low-intensity versus standard monitoring in thrombolysis-treated patients with mild-to-moderate acute ischemic stroke (AIS). An embedded process evaluation explored integration and impact of the intervention on care processes at participating US sites., Methods: A mixed-methods approach with quantitative and qualitative data were collected between September 2021 and November 2022. Implementer surveys were undertaken at pre- and post-intervention phases to understand the perceptions of low-intensity monitoring strategy. A sample of stroke care nurses were invited to participate in semi-structured interviews at an early stage of post-intervention. Qualitative data were analyzed deductively using the normalization process theory; quantitative data were tabulated., Results: Interviews with 21 nurses at 8 hospitals have shown low-intensity monitoring was well accepted, as there were less time constraints and reduced workload for each patient. There were initial safety concerns over missing deteriorating patients and difficulties in changing established routines. Proper training, education, and communication, and changing the habits and culture of care, were key elements to successfully adopting the new monitoring care into routine practice. Similar results were found in the post-intervention survey (42 nurses from 13 hospitals). Nurses reported time being freed up to provide patient education (56%), daily living care (50%), early mobilization (26%), mood/cognition assessment (44%), and other aspects (i.e. communication, family support)., Conclusions: Low-intensity monitoring for patients with mild-to-moderate acute ischemic stroke, facilitated by appropriate education and organizational support, appears feasible and acceptable at US hospitals., (S. Karger AG, Basel.)

Published
2024
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23. Acquisition and retention of motor sequences: the effects of time of the day and sleep.

Author

Kvint S, Bassiri B, Pruski A, Nia J, Nemet I, Lopresti M, Perfetti B, Moisello C, Tononi G, and Ghilardi MF

Subjects
Adolescent, Analysis of Variance, Biomechanical Phenomena, Female, Humans, Male, Motor Skills physiology, Neuropsychological Tests, Reaction Time, Serial Learning physiology, Time Factors, Young Adult, Circadian Rhythm physiology, Movement physiology, Retention, Psychology physiology, Sleep physiology, Wakefulness physiology
Abstract

Study Objectives: We used a sequence-learning task to assess whether: 1. The time interval between awakening and training equally affects the rate of acquisition of sequence order, a declarative component, and the kinematic optimization process, an implicit component; 2. Sleep enhances the retention of both these aspects of sequence learning., Design: For aim 1, we compare the acquisition rate of a new motor sequence in a group trained in the morning and another in the evening. For aim 2., we tested retention of the same motor sequence twelve hours later, either without sleep (normal day activity or a night of sleep deprivation) or with interposed sleep (afternoon napping or regular full night sleep)., Setting: Training and Testing were performed in a controlled laboratory setting., Participants: Thirty-six right-handed normal subjects (age range 18-24 years; 16 women)., Results: During the training, acquisition rate of the sequence order was significantly higher in the AM-trained than in the PM-trained group, without differences in the kinematic optimization processes. Both declarative and implicit learning indices were significantly higher in the subjects tested after sleep compared to those tested without interposed sleep., Conclusion: The best time for fast and efficient acquisition of new declarative material is the morning, while the kinematic aspects of skill acquisition are not sensitive to the time of day. However, better retention of both declarative material and motor skills requires two conditions: a period of post-training sleep and the achievement of performance saturation during training.

Published
2011
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