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164 results on '"Pruvo, J.P."'

2. Feasibility and usefulness of brain imaging in catatonia

Author

Magnat, Maeva, primary, Mastellari, Tomas, additional, Krystal, Sidney, additional, Hanafi, Riyad, additional, Mateos, Marjorie, additional, Hacein-Bey, Lotfi, additional, Haroche, Alexandre, additional, Rogers, Jonathan P., additional, Williams, Steven C.R., additional, Pruvo, J.P., additional, and Amad, Ali, additional

Published
2023
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3. Trial of Deferiprone in Parkinson's Disease

Author

Devos, D., Labreuche, J., Rascol, O., Corvol, J.C., Duhamel, A., Delannoy, P. Guyon, Poewe, W., Compta, Y., Pavese, N., Růžička, E., Dušek, P., Post, B., Bloem, B.R., Berg, D., Maetzler, W., Otto, M., Habert, M.O., Lehericy, S., Ferreira, J., Dodel, R., Tranchant, C., Eusebio, A., Thobois, S., Marques, A.R., Meissner, W.G., Ory-Magne, F., Walter, U., Bie, R.M. de, Gago, M., Vilas, D., Kulisevsky, J., Januario, C., Coelho, M.V.S., Behnke, S., Worth, P., Seppi, K., Ouk, T., Potey, C., Leclercq, C., Viard, R., Kuchcinski, G., Lopes, R., Pruvo, J.P., Pigny, P., Garçon, G., Simonin, O., Carpentier, J., Rolland, A.S., Nyholm, D., Scherfler, C., Mangin, J.F., Chupin, M., Bordet, R., Dexter, D.T., Fradette, C., Spino, M., Tricta, F., Ayton, S., Bush, A.I., Devedjian, J.C., Duce, J.A., Cabantchik, I., Defebvre, L., Deplanque, D., Moreau, C., Devos, D., Labreuche, J., Rascol, O., Corvol, J.C., Duhamel, A., Delannoy, P. Guyon, Poewe, W., Compta, Y., Pavese, N., Růžička, E., Dušek, P., Post, B., Bloem, B.R., Berg, D., Maetzler, W., Otto, M., Habert, M.O., Lehericy, S., Ferreira, J., Dodel, R., Tranchant, C., Eusebio, A., Thobois, S., Marques, A.R., Meissner, W.G., Ory-Magne, F., Walter, U., Bie, R.M. de, Gago, M., Vilas, D., Kulisevsky, J., Januario, C., Coelho, M.V.S., Behnke, S., Worth, P., Seppi, K., Ouk, T., Potey, C., Leclercq, C., Viard, R., Kuchcinski, G., Lopes, R., Pruvo, J.P., Pigny, P., Garçon, G., Simonin, O., Carpentier, J., Rolland, A.S., Nyholm, D., Scherfler, C., Mangin, J.F., Chupin, M., Bordet, R., Dexter, D.T., Fradette, C., Spino, M., Tricta, F., Ayton, S., Bush, A.I., Devedjian, J.C., Duce, J.A., Cabantchik, I., Defebvre, L., Deplanque, D., and Moreau, C.

Abstract

Item does not contain fulltext, BACKGROUND: Iron content is increased in the substantia nigra of persons with Parkinson's disease and may contribute to the pathophysiology of the disorder. Early research suggests that the iron chelator deferiprone can reduce nigrostriatal iron content in persons with Parkinson's disease, but its effects on disease progression are unclear. METHODS: We conducted a multicenter, phase 2, randomized, double-blind trial involving participants with newly diagnosed Parkinson's disease who had never received levodopa. Participants were assigned (in a 1:1 ratio) to receive oral deferiprone at a dose of 15 mg per kilogram of body weight twice daily or matched placebo for 36 weeks. Dopaminergic therapy was withheld unless deemed necessary for symptom control. The primary outcome was the change in the total score on the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS; range, 0 to 260, with higher scores indicating more severe impairment) at 36 weeks. Secondary and exploratory clinical outcomes at up to 40 weeks included measures of motor and nonmotor disability. Brain iron content measured with the use of magnetic resonance imaging was also an exploratory outcome. RESULTS: A total of 372 participants were enrolled; 186 were assigned to receive deferiprone and 186 to receive placebo. Progression of symptoms led to the initiation of dopaminergic therapy in 22.0% of the participants in the deferiprone group and 2.7% of those in the placebo group. The mean MDS-UPDRS total score at baseline was 34.3 in the deferiprone group and 33.2 in the placebo group and increased (worsened) by 15.6 points and 6.3 points, respectively (difference, 9.3 points; 95% confidence interval, 6.3 to 12.2; P<0.001). Nigrostriatal iron content decreased more in the deferiprone group than in the placebo group. The main serious adverse events with deferiprone were agranulocytosis in 2 participants and neutropenia in 3 participants. CONCLUSIONS: In parti

Published
2022

5. Spinal cord infarction: clinical and magnetic resonance imaging findings and short term outcome

Author

Masson, C., Pruvo, J.P., Meder, J.F., Cordonnier, C., Touze, E., Giroud, M., Mas, J.L., and Leys, D.

Subjects
Magnetic resonance imaging -- Methods, Infarction -- Development and progression, Infarction -- Patient outcomes, Central nervous system diseases -- Development and progression, Central nervous system diseases -- Causes of, Health, Psychology and mental health
Published
2004

27. Pulse-Triggered DTI Sequence with Reduced FOV and Coronal Acquisition at 3T for the Assessment of the Cervical Spinal Cord in Patients with Myelitis

Author

Hodel, J., primary, Besson, P., additional, Outteryck, O., additional, Zéphir, H., additional, Ducreux, D., additional, Monnet, A., additional, Chéchin, D., additional, Zins, M., additional, Rodallec, M., additional, Pruvo, J.P., additional, Vermersch, P., additional, and Leclerc, X., additional

Published
2012
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37. Erreurs en imagerie neurologique

Author

Méder, J.F., primary, Naggara, O., additional, Petkova, M., additional, Leclerc, X., additional, Méary, E., additional, Oppenheim, C., additional, and Pruvo, J.P., additional

Published
2008
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41. Exploration de l’ischemie cerebrale

Author

Oppenheim, C., primary, Petkova, M., additional, Charbonneau, F., additional, Marsico, R., additional, Rodrigo, S., additional, Trystram, D., additional, Leclerc, X., additional, Pruvo, J.P., additional, and Méder, J.F., additional

Published
2008
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42. Imagerie du syndrome confusionnel

Author

Brami-Zylberberg, F., primary, Charbonneau, F., additional, Naggara, O., additional, Rodrigo, S., additional, Oppenheim, C., additional, Pruvo, J.P., additional, and Meder, J.F., additional

Published
2008
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46. Imagerie du vieillissement cerebral

Author

Naggara, O., primary, Oppenheim, C., additional, Delmaire, C., additional, Rodrigo, S., additional, Pruvo, J.P., additional, Leclerc, X., additional, and Méder, J.F., additional

Published
2007
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47. Hemorragie sous-arachnoidienne

Author

Méder, J.F., primary, Taschner, C., additional, Trystram, D., additional, Godon-Hardy, S., additional, Oppenheim, C., additional, Leclerc, X., additional, and Pruvo, J.P., additional

Published
2007
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50. Imagerie vasculaire en 2007

Author

Leclerc, X., primary, Gauvrit, J.Y., additional, Trystram, D., additional, Oppenheim, C., additional, Meder, J.F., additional, and Pruvo, J.P., additional

Published
2007
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