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443 results on '"Przepiorka, D."'

24. Characteristics of human dendritic cells generated in a microgravity analog culture system

Author

Savary, C. A, Grazziuti, M. L, Przepiorka, D, Tomasovic, S. P, McIntyre, B. W, Woodside, D. G, Pellis, N. R, Pierson, D. L, Rex, J. H, and McIntire, L. V

Subjects
Life Sciences (General)
Abstract

Generation of an effective immune response requires that antigens be processed and presented to T lymphocytes by antigen-presenting cells, the most efficient of which are dendritic cells (DC). Because of their influence on both the innate and the acquired arms of immunity, a defect in DC would be expected to result in a broad impairment of immune function, not unlike that observed in astronauts during or after space flight. In the study reported here, we investigated whether DC generation and function are altered in a culture environment that models microgravity, i.e., the rotary-cell culture system (RCCS). We observed that RCCS supported the generation of DC identified by morphology, phenotype (HLA-DR+ and lacking lineage-associated markers), and function (high allostimulatory activity). However, the yield of DC from RCCS was significantly lower than that from static cultures. RCCS-generated DC were less able to phagocytose Aspergillus fumigatus conidia and expressed a lower density of surface HLA-DR. The proportion of DC expressing CD80 was also significantly reduced in RCCS compared to static cultures. When exposed to fungal antigens, RCCS-generated DC produced lower levels of interleukin-12 and failed to upregulate some costimulatory/adhesion molecules involved in antigen presentation. These data suggest that DC generation, and some functions needed to mount an effective immune response to pathogens, may be disturbed in the microgravity environment of space.

Published
2001
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31. Long-term outcome of a Phase II study of BM transplants, partially depleted ex-vivo of CD5-positive and CD8-positive T-lymphocytes in unrelated and related donor 1 antigen mismatched recipients

Author

Gajewski, J.L., Nimer, S., Saliba, R.M., Thomas, M., Przepiorka, D., Giralt, S., von Besien, K., Mehra, R., Andersson, B., Chan, K.W., Ippoliti, C., Warkinten, D., Feigs, S., Territo, M., Schiller, G., Lebkowski, J., Moseley, A.M., Lloyd, K., von Hoeff, M., Okarma, T., and Champlin, R.

Published
1999
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33. The Midlatitude Trough and the Plasmapause in the Nighttime Ionosphere Simultaneously Observed by DEMETER During 2006–2009.

Author

Chen, C. Y., Liu, Tiger J. Y., Lee, I. T., Rothkaehl, H., Przepiorka, D., Chang, Loren C., Matyjasiak, B., Ryu, K., and Oyama, K.‐I.

Abstract

Abstract: This paper concurrently investigates the midlatitude trough and the plasmapause positions in the ionosphere by colocated measurements of the electron density, electron temperature, and whistler count probed by DEMETER (Detection of Electro‐Magnetic Emissions Transmitted from Earthquake Regions) satellite in the nighttime at 2230 LT (local time; 1900–0100 MLT, magnetic local time, mainly in the premidnight period) during the 4‐year period of 2006–2009. More than 13,000 Detection of Electro‐Magnetic Emissions Transmitted from Earthquake Regions orbits of the electron density and the electron temperature are used to search the trough position, while the same amount of the whistler count is employed to determine the plasmapause position at the satellite altitude. The plasmapause is more sensitive to solar activity, which moves equatorward 1.0–1.2° form the low to high solar activity of the study period. On the other hand, the midlatitude trough is more sensitive to seasonal variation, which shifts poleward 1.7–2.5° from the winter to summer month in the study period. The midlatitude trough usually appears in the poleward side of the plasmapause during the study period. Both of the midlatitude trough and the plasmapause move equatorward during the magnetic disturbed condition. For the magnetic disturbed Kp ≥ 6−, the midlatitude trough can appear in the equatorward side of the plasmapause. [ABSTRACT FROM AUTHOR]

Published
2018
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34. Allogeneic stem cell transplantation for agnogenic myeloid metaplasia: a European Group for Blood and Marrow Transplantation, Société Française de Greffe de Moelle, Gruppo Italiano per il Trapianto del Midollo Osseo, and Fred Hutchinson Cancer Research Center Collaborative Study

Author

Guardiola, P, Anderson, J, Bandini, G, Cervantes, F, Runde, V, Arcese, W, Bacigalupo, A, Przepiorka, D, O'Donnell, M, Polchi, P, Buzyn, A, Sutton, L, Cazals Hatem, D, Sale, G, de Witte, T, Deeg, H, and Gluckman, E

Subjects
Homologous, Adult, Male, Transplantation, Time Factors, Histocompatibility Testing, Hematopoietic Stem Cell Transplantation, Graft vs Host Disease, Survival Analysis, United States, Hematopoiesis, Europe, Primary Myelofibrosis, Multivariate Analysis, Splenectomy, Humans, Female, Erythrocyte Transfusion, Settore MED/15 - Malattie del Sangue, Probability, Transplantation, Homologous, Follow-Up Studies
Published
1999

50. Hyper-CVAD and high-dose methotrexate/cytarabine followed by stem-cell transplantation: an active regimen for aggressive mantle-cell lymphoma.

Author

Khouri, I F, primary, Romaguera, J, additional, Kantarjian, H, additional, Palmer, J L, additional, Pugh, W C, additional, Korbling, M, additional, Hagemeister, F, additional, Samuels, B, additional, Rodriguez, A, additional, Giralt, S, additional, Younes, A, additional, Przepiorka, D, additional, Claxton, D, additional, Cabanillas, F, additional, and Champlin, R, additional

Published
1998
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