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15 results on '"Przybylska‐Piech, Anna"'

5. Seasonal changes in activity of hypothalamic thyroid hormone system in different winter phenotypes of Djungarian hamster (Phodopus sungorus).

Author

Przybylska-Piech, Anna S., Diedrich, Victoria, and Herwig, Annika

Subjects
*THYROTROPIN releasing factor, *HYPOTHALAMIC hormones, *MONOCARBOXYLATE transporters, *GENE expression, *THYROID hormones
Abstract

Although the Djungarian hamster (Phodopus sungorus) is a seasonality model, it presents substantial variability in winter acclimation. In response to short photoperiod, some individuals express a suite of winter traits such as low body mass, regressed gonads, white fur, and daily torpor, while others develop only some adjustments or maintain a summer phenotype. Despite comprehensive research, the mechanisms underlying polymorphism of winter phenotype are still unknown. We compared key elements of the hypothalamic thyroid hormone system, as well as the tanycyte architecture in hamsters of both sexes. Individuals presented different responses to short photoperiod characterized either as phenotypes (non-responder, partial-responder and full-responder) or photoresponsive index. We measured the expression of genes coding iodothyronine deiodinase 2 and 3, monocarboxylate transporter 8, thyrotropin-releasing hormone, and somatostatin in 40 individuals and counted the number of immunolabeled tanycyte processes in standardized regions of interest around the third ventricle in 30 individuals. Animals acclimated to short photoperiod presented a downregulation of diodinase 2 and somatostatin and an upregulation of deiodinase 3, as well as a decreased number of tanycyte processes, compared to long photoperiod-exposed individuals. Although phenotypes did not differ in gene expression, the higher the photoresponsive index, the lower was the deiodinase 2 expression and the higher the deiodinase 3 expression. Partial-responders and full-responders had less tanycyte processes than non-responders, and the number of tanycyte processes correlated with the photoresponsive index. Sexes differed neither in their seasonal response, nor hypothalamic gene expression, but females had more tanycyte processes. Our results are in accordance with studies emphasizing the pivotal role of thyroid hormones in seasonal response. We suggest that the whole spectrum of winter phenotypes exists within the population of Djungarian hamsters and that it is reflected also at the level of neuroendocrine regulation. However, the neuroendocrine underpinnings of winter phenotype polymorphism require further investigation. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Solving the conundrum of intra‐specific variation in metabolic rate: A multidisciplinary conceptual and methodological toolkit

Author

Metcalfe, Neil B., primary, Bellman, Jakob, additional, Bize, Pierre, additional, Blier, Pierre U., additional, Crespel, Amélie, additional, Dawson, Neal J., additional, Dunn, Ruth E., additional, Halsey, Lewis G., additional, Hood, Wendy R., additional, Hopkins, Mark, additional, Killen, Shaun S., additional, McLennan, Darryl, additional, Nadler, Lauren E., additional, Nati, Julie J.H., additional, Noakes, Matthew J., additional, Norin, Tommy, additional, Ozanne, Susan E., additional, Peaker, Malcolm, additional, Pettersen, Amanda K., additional, Przybylska‐Piech, Anna, additional, Rathery, Alann, additional, Récapet, Charlotte, additional, Rodríguez, Enrique, additional, Salin, Karine, additional, Stier, Antoine, additional, Thoral, Elisa, additional, Westerterp, Klaas R., additional, Westerterp‐Plantenga, Margriet S., additional, Wojciechowski, Michał S., additional, and Monaghan, Pat, additional

Published
2023
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10. Solving the conundrum of intra‐specific variation in metabolic rate: A multidisciplinary conceptual and methodological toolkit

Author

Metcalfe, Neil B., Bellman, Jakob, Bize, Pierre, Blier, Pierre U., Crespel, Amélie, Dawson, Neal J., Dunn, Ruth E., Halsey, Lewis G., Hood, Wendy R., Hopkins, Mark, Killen, Shaun S., Mclennan, Darryl, Nadler, Lauren E., Nati, Julie J.h., Noakes, Matthew J., Norin, Tommy, Ozanne, Susan E., Peaker, Malcolm, Pettersen, Amanda K., Przybylska‐piech, Anna, Rathery, Alann, Récapet, Charlotte, Rodríguez, Enrique, Salin, Karine, Stier, Antoine, Thoral, Elisa, Westerterp, Klaas R., Westerterp‐plantenga, Margriet S., Wojciechowski, Michał S., Monaghan, Pat, Metcalfe, Neil B., Bellman, Jakob, Bize, Pierre, Blier, Pierre U., Crespel, Amélie, Dawson, Neal J., Dunn, Ruth E., Halsey, Lewis G., Hood, Wendy R., Hopkins, Mark, Killen, Shaun S., Mclennan, Darryl, Nadler, Lauren E., Nati, Julie J.h., Noakes, Matthew J., Norin, Tommy, Ozanne, Susan E., Peaker, Malcolm, Pettersen, Amanda K., Przybylska‐piech, Anna, Rathery, Alann, Récapet, Charlotte, Rodríguez, Enrique, Salin, Karine, Stier, Antoine, Thoral, Elisa, Westerterp, Klaas R., Westerterp‐plantenga, Margriet S., Wojciechowski, Michał S., and Monaghan, Pat

Abstract

Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in metabolic rate found among and within individual animals of the same species. Research in this area has been hampered by differences in approach, terminology and methodology, and the context in which measurements are made. Recent advances provide important opportunities to identify and address the key questions in the field. By bringing together researchers from different areas of biology and biomedicine, we describe and evaluate these developments and the insights they could yield, highlighting the need for more standardisation across disciplines. We conclude with a list of important questions that can now be addressed by developing a common conceptual and methodological toolkit for studies on metabolic variation in animals.

Published
2023
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11. Solving the conundrum of intra‐specific variation in metabolic rate:A multidisciplinary conceptual and methodological toolkit: New technical developments are opening the door to an understanding of why metabolic rate varies among individual animals of a species

Author

Metcalfe, Neil B., Bellman, Jakob, Bize, Pierre, Blier, Pierre U., Crespel, Amélie, Dawson, Neal J., Dunn, Ruth E., Halsey, Lewis G., Hood, Wendy R., Hopkins, Mark, Killen, Shaun S., McLennan, Darryl, Nadler, Lauren E., Nati, Julie J.H., Noakes, Matthew J., Norin, Tommy, Ozanne, Susan E., Peaker, Malcolm, Pettersen, Amanda K., Przybylska‐Piech, Anna, Rathery, Alann, Récapet, Charlotte, Rodríguez, Enrique, Salin, Karine, Stier, Antoine, Thoral, Elisa, Westerterp, Klaas R., Westerterp‐Plantenga, Margriet S., Wojciechowski, Michał S., Monaghan, Pat, Metcalfe, Neil B., Bellman, Jakob, Bize, Pierre, Blier, Pierre U., Crespel, Amélie, Dawson, Neal J., Dunn, Ruth E., Halsey, Lewis G., Hood, Wendy R., Hopkins, Mark, Killen, Shaun S., McLennan, Darryl, Nadler, Lauren E., Nati, Julie J.H., Noakes, Matthew J., Norin, Tommy, Ozanne, Susan E., Peaker, Malcolm, Pettersen, Amanda K., Przybylska‐Piech, Anna, Rathery, Alann, Récapet, Charlotte, Rodríguez, Enrique, Salin, Karine, Stier, Antoine, Thoral, Elisa, Westerterp, Klaas R., Westerterp‐Plantenga, Margriet S., Wojciechowski, Michał S., and Monaghan, Pat

Abstract

Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in metabolic rate found among and within individual animals of the same species. Research in this area has been hampered by differences in approach, terminology and methodology, and the context in which measurements are made. Recent advances provide important opportunities to identify and address the key questions in the field. By bringing together researchers from different areas of biology and biomedicine, we describe and evaluate these developments and the insights they could yield, highlighting the need for more standardisation across disciplines. We conclude with a list of important questions that can now be addressed by developing a common conceptual and methodological toolkit for studies on metabolic variation in animals.

Published
2023

12. Solving the conundrum of intra-specific variation in metabolic rate: A multidisciplinary conceptual and methodological toolkit:New technical developments are opening the door to an understanding of why metabolic rate varies among individual animals of a species

Author

Metcalfe, Neil B., Bellman, Jakob, Bize, Pierre, Blier, Pierre U., Crespel, Amélie, Dawson, Neal J., Dunn, Ruth E., Halsey, Lewis G., Hood, Wendy R., Hopkins, Mark, Killen, Shaun S., McLennan, Darryl, Nadler, Lauren E., Nati, Julie J.H., Noakes, Matthew J., Norin, Tommy, Ozanne, Susan E., Peaker, Malcolm, Pettersen, Amanda K., Przybylska-Piech, Anna, Rathery, Alann, Récapet, Charlotte, Rodríguez, Enrique, Salin, Karine, Stier, Antoine, Thoral, Elisa, Westerterp, Klaas R., Westerterp-Plantenga, Margriet S., Wojciechowski, Michał S., Monaghan, Pat, Metcalfe, Neil B., Bellman, Jakob, Bize, Pierre, Blier, Pierre U., Crespel, Amélie, Dawson, Neal J., Dunn, Ruth E., Halsey, Lewis G., Hood, Wendy R., Hopkins, Mark, Killen, Shaun S., McLennan, Darryl, Nadler, Lauren E., Nati, Julie J.H., Noakes, Matthew J., Norin, Tommy, Ozanne, Susan E., Peaker, Malcolm, Pettersen, Amanda K., Przybylska-Piech, Anna, Rathery, Alann, Récapet, Charlotte, Rodríguez, Enrique, Salin, Karine, Stier, Antoine, Thoral, Elisa, Westerterp, Klaas R., Westerterp-Plantenga, Margriet S., Wojciechowski, Michał S., and Monaghan, Pat

Abstract

Researchers from diverse disciplines, including organismal and cellular physiology, sports science, human nutrition, evolution and ecology, have sought to understand the causes and consequences of the surprising variation in metabolic rate found among and within individual animals of the same species. Research in this area has been hampered by differences in approach, terminology and methodology, and the context in which measurements are made. Recent advances provide important opportunities to identify and address the key questions in the field. By bringing together researchers from different areas of biology and biomedicine, we describe and evaluate these developments and the insights they could yield, highlighting the need for more standardisation across disciplines. We conclude with a list of important questions that can now be addressed by developing a common conceptual and methodological toolkit for studies on metabolic variation in animals.

Published
2023

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