1. Within-treatment frequency of use versus abstinence as a predictor of longitudinal post-treatment follow-up assessments of drug use.
- Author
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Fitzmaurice GM, Lipsitz SR, and Weiss RD
- Subjects
- Adult, Cocaine urine, Cocaine-Related Disorders urine, Cognitive Behavioral Therapy statistics & numerical data, Disulfiram therapeutic use, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Psychotherapy, Psychodynamic statistics & numerical data, Randomized Controlled Trials as Topic, Treatment Outcome, Cocaine-Related Disorders therapy, Outcome Assessment, Health Care methods, Psychotherapy statistics & numerical data
- Abstract
Background: Abstinence is a widely-used endpoint in clinical trials of stimulant use disorders. A quantitative measure of frequency of use may be a more sensitive endpoint; however, it is important to establish that it is associated with post-treatment drug use. We examine and compare how within-treatment abstinence and frequency of use are related to two post-treatment longitudinal measures of drug use., Methods: For each of three existing stimulant use disorder clinical trial datasets, we examined the association between within-treatment frequency of use (based on urine screens), within-treatment abstinence, and post-treatment follow-up assessments of drug use (urine screens and reported days of use). In joint analyses that simultaneously model the effects of within-treatment abstinence and frequency of use, it is possible to discern their relative importance as predictors of post-treatment drug use during the 12 months following the end of treatment., Results: Results indicate a quantitative measure of within-treatment frequency of use was associated with longitudinal post-treatment follow-up assessments of drug use. Results from joint analyses of post-treatment follow-up drug use assessed by urine screens suggest that within-treatment frequency of use, rather than abstinence per se, is predictive of post-treatment drug use. However, results from joint analyses of self-report of days of use are equivocal., Conclusion: Results lend support to the use of a quantitative measure of within-treatment drug use as an alternative to complete abstinence. They suggest that some within-treatment use that fall short of complete abstinence may potentially represent clinically important improvements given their association with post-treatment drug use., Competing Interests: Declaration of Competing Interest Dr. Weiss has served as a consultant to Janssen Pharmaceuticals and GW Pharmaceuticals. All other authors report no potential conflicts of interest., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
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