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1. European Society of Cardiology quality indicators for the prevention and management of cancer therapy-related cardiovascular toxicity in cancer treatment:Cardio-oncology quality indicators

Author

Lee, G A, Aktaa, S, Baker, E, Gale, C P, Israa fadhil, Yaseen, Gulati, G, Asteggiano, R, Szmit, S, Cohen-Solal, A, Abdin, A, Jurczak, W, Garrido lopez, P, Sverdlov, A L, Tocchetti, C G, Barac, A, Parrini, I, Zamorano, P, Iakobishvili, Z, Pudil, R, Badimon, L, Kirby, A M, Blaes, A H, Farmakis, D, Curigliano, G, Stephens, R, Lyon, A R, and Lopez-Fernandez, T

Subjects
QUALITY INDICATORS, Cardio-Oncology
Abstract

Aims: To develop quality indicators (QIs) for the evaluation of the prevention and management of cancer therapy-related cardiovascular toxicity. Methods and results: We followed the European Society of Cardiology (ESC) methodology for QI development which comprises (i) identifying the key domains of care for the prevention and management of cancer therapy-related cardiovascular toxicity in patients on cancer treatment, (ii) performing a systematic review of the literature to develop candidate QIs, and (iii) selecting of the final set of QIs using a modified Delphi process. Work was undertaken in parallel with the writing of the 2022 ESC Guidelines on Cardio-Oncology and in collaboration with the European Haematology Association, the European Society for Therapeutic Radiology and Oncology and the International Cardio-Oncology Society. In total, 5 main and 9 secondary QIs were selected across five domains of care: (i) Structural framework, (ii) Baseline cardiovascular risk assessment, (iii) Cancer therapy related cardiovascular toxicity, (iv) Predictors of outcomes, and (v) Monitoring of cardiovascular complications during cancer therapy.Conclusion: We present the ESC Cardio-Oncology QIs with their development process and provide an overview of the scientific rationale for their selection. These indicators are aimed at quantifying and improving the adherence to guideline-recommended clinical practice and improving patient outcomes.

Published
2022
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2. European Society of Cardiology quality indicators for the prevention and management of cancer therapy-related cardiovascular toxicity in cancer treatment

Author

Lee, G A, primary, Aktaa, S, additional, Baker, E, additional, Gale, C P, additional, Yaseen, Israa F, additional, Gulati, G, additional, Asteggiano, R, additional, Szmit, S, additional, Cohen-Solal, A, additional, Abdin, A, additional, Jurczak, W, additional, Garrido Lopez, P, additional, Sverdlov, A L, additional, Tocchetti, C G, additional, Barac, A, additional, Parrini, I, additional, Zamorano, P, additional, Iakobishvili, Z, additional, Pudil, R, additional, Badimon, L, additional, Kirby, A M, additional, Blaes, A H, additional, Farmakis, D, additional, Curigliano, G, additional, Stephens, R, additional, Lyon, A R, additional, and Lopez-Fernandez, T, additional

Published
2022
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6. Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies

Author

Celutkiene, J., Pudil, R., Lopez-Fernandez, T., Grapsa, J., Nihoyannopoulos, P., Bergler-Klein, J., Cohen-Solal, A., Farmakis, D., Tocchetti, C. G., Haehling, S., Barberis, V., Flachskampf, F. A., Ceponlene, J., Haegler-Laube, E., Suter, T., Lapinskas, T., Prasad, S., Boer, R. A., Wechalekar, K., Anker, M. S., Iakobishvili, Z., Bucciarelli-Ducci, C., Schulz-Menger, J., Cosyns, B., Gaemperli, O., Belenkov, Y., Hulot, J-S, Galderisi, M., Lancellotti, P., Bax, J., Marwick, T. H., Chioncel, O., Jaarsma, T., Mullens, W., Piepoli, M., Thum, T., Heymans, S., Mueller, C., Moura, B., Ruschitzka, F., Zamorano, J. L., Rosano, G., Coats, A. J. S., Asteggiano, R., Seferovic, P., Thor Edvardsen, Lyon, A. R., Cardiovascular Centre (CVC), Hulot, Jean-Sebastien/0000-0001-5463-6117, Edvardsen, Thor/0000-0002-3800-765X, Bucciarelli-Ducci, Chiara/0000-0002-2515-0852, Clinical sciences, Cardio-vascular diseases, Cardiology, Cardiologie, MUMC+: MA Med Staf Spec Cardiologie (9), and RS: Carim - H02 Cardiomyopathy

Subjects
Vascular Endothelial Growth Factor A, Global longitudinal strain, SPECKLE-TRACKING ECHOCARDIOGRAPHY, Cardiac magnetic resonance, Cardiology, Antineoplastic Agents, Heart failure, ANTHRACYCLINE CARDIOTOXICITY, Imaging, LEFT-VENTRICULAR FUNCTION, Neoplasms, MAGNETIC-RESONANCE, BREAST-CANCER, Humans, AMERICAN SOCIETY, Computed tomography, Cardiotoxicity, MYOCARDIAL STRAIN, DIASTOLIC FUNCTION, Cardio-oncology, Radiology Nuclear Medicine and imaging, Echocardiography, oncology, Female, CHAMBER QUANTIFICATION, Cardiology and Cardiovascular Medicine, Nuclear imaging
Abstract

Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the ESC have evaluated the current evidence for the value of modern CV imaging in the cardio-oncology field. The most relevant echocardiographic parameters, including global longitudinal strain and three-dimensional ejection fraction, are proposed. The protocol for baseline pre-treatment evaluation and specific surveillance algorithms or pathways for anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor tyrosine kinase inhibitors, BCr-Abl tyrosine kinase inhibitors, proteasome inhibitors and immune checkpoint inhibitors are presented. The indications for CV imaging after completion of oncology treatment are considered. The typical consequences of radiation therapy and the possibility of their identification in the long term are also summarized. Special populations are discussed including female survivors planning pregnancy, patients with carcinoid disease, patients with cardiac tumours and patients with right heart failure. Future directions and ongoing CV imaging research in cardio-oncology are discussed. R.A.d.B. is supported by the Netherlands Heart Foundation (CVON DOSIS, grant 2014-40, CVON SHE-PREDICTS-HF, grant 2017-21, and CVON RED-CVD, grant 2017-11), and the European Research Council (ERC CoG 818715, SECRETE-HF). C.G.T. is supported by a Federico II University/Ricerca di Ateneo grant. Celutkiene, J (corresponding author), Vilnius Univ, Fac Med, Inst Clin Med, Clin Cardiac & Vasc Dis, Santariskiu 2, LT-08661 Vilnius, Lithuania. jelena.celutkiene@santa.lt

Published
2020

7. Cancer diagnosis in patients with heart failure

Author

Ameri, P, Canepa, M, Anker, MS, Belenkov, Y, Bergler-Klein, J, Cohen-Solal, A, Farmakis, D, López-Fernández, T, Lainscak, M, Pudil, R, Ruschitska, F, Seferovic, P, Filippatos, G, Coats, A, Suter, T, Von Haehling, S, Ciardiello, F, De Boer, RA, Lyon, AR, Tocchetti, CG, Heart Failure Association Cardio-Oncology Study Group of the European Society of Cardiology, Ameri, Pietro, Canepa, Marco, Anker, Markus S., Belenkov, Yury, Bergler-Klein, Jutta, Cohen-Solal, Alain, Farmakis, Dimitrio, López-Fernández, Teresa, Lainscak, Mitja, Pudil, Radek, Ruschitska, Frank, Seferovic, Petar, Filippatos, Gerasimo, Coats, Andrew, Suter, Thoma, Von Haehling, Stephan, Ciardiello, Fortunato, de Boer, Rudolf A., Lyon, Alexander R., and Tocchetti, Carlo G.

Subjects
Cardiac & Cardiovascular Systems, medicine.medical_treatment, Co-morbidity, Comorbidity, 030204 cardiovascular system & hematology, Global Health, Targeted therapy, Androgen deprivation therapy, Prostate cancer, 0302 clinical medicine, TARGETED THERAPY, RENAL-CELL CARCINOMA, Neoplasms, Epidemiology, INCREASED RISK, AMERICAN SOCIETY, Cancer, Heart failure, Prognosis, Therapy, Cardiology and Cardiovascular Medicine, ORAL ANTICOAGULANTS, Incidence (epidemiology), Incidence, Disease Management, 3. Good health, PROSTATE-CANCER, Survival Rate, PRACTICE GUIDELINES, 030220 oncology & carcinogenesis, Heart Failure Association Cardio-Oncology Study Group of the European Society of Cardiology, Life Sciences & Biomedicine, Diagnostic Imaging, medicine.medical_specialty, Prognosi, LONG-TERM, Malignancy, 1102 Cardiovascular Medicine And Haematology, 03 medical and health sciences, Breast cancer, medicine, Humans, BREAST-CANCER, Intensive care medicine, TERM-FOLLOW-UP, EUROPEAN ASSOCIATION, Science & Technology, business.industry, medicine.disease, MYOCARDIAL-INFARCTION, Cardiovascular System & Hematology, ATRIAL-FIBRILLATION, Cardiovascular System & Cardiology, ANDROGEN DEPRIVATION THERAPY, business
Abstract

Cancer and heart failure (HF) are common medical conditions with a steadily rising prevalence in industrialized countries, particularly in the elderly, and they both potentially carry a poor prognosis. A new diagnosis of malignancy in subjects with pre-existing HF is not infrequent, and challenges HF specialists as well as oncologists with complex questions relating to both HF and cancer management. An increased incidence of cancer in patients with established HF has also been suggested. This review paper summarizes the epidemiology and the prognostic implications of cancer occurrence in HF, the impact of pre-existing HF on cancer treatment decisions and the impact of cancer on HF therapeutic options, while providing some practical suggestions regarding patient care and highlighting gaps in knowledge.

Published
2018

9. European Society of Cardiology quality indicators for the prevention and management of cancer therapy-related cardiovascular toxicity in cancer treatment

Author

Lee, G A, Aktaa, S, Baker, E, Gale, C P, Yaseen, Israa F, Gulati, G, Asteggiano, R, Szmit, S, Cohen-Solal, A, Abdin, A, Jurczak, W, Garrido Lopez, P, Sverdlov, A L, Tocchetti, C G, Barac, A, Parrini, I, Zamorano, P, Iakobishvili, Z, Pudil, R, Badimon, L, Kirby, A M, Blaes, A H, Farmakis, D, Curigliano, G, Stephens, R, Lyon, A R, and Lopez-Fernandez, T

Published
2023
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11. Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)

Author

de Boer, R.A. Hulot, J.-S. Tocchetti, C.G. Aboumsallem, J.P. Ameri, P. Anker, S.D. Bauersachs, J. Bertero, E. Coats, A.J.S. Čelutkienė, J. Chioncel, O. Dodion, P. Eschenhagen, T. Farmakis, D. Bayes-Genis, A. Jäger, D. Jankowska, E.A. Kitsis, R.N. Konety, S.H. Larkin, J. Lehmann, L. Lenihan, D.J. Maack, C. Moslehi, J.J. Müller, O.J. Nowak-Sliwinska, P. Piepoli, M.F. Ponikowski, P. Pudil, R. Rainer, P.P. Ruschitzka, F. Sawyer, D. Seferovic, P.M. Suter, T. Thum, T. van der Meer, P. Van Laake, L.W. von Haehling, S. Heymans, S. Lyon, A.R. Backs, J.

Abstract

The co-occurrence of cancer and heart failure (HF) represents a significant clinical drawback as each disease interferes with the treatment of the other. In addition to shared risk factors, a growing body of experimental and clinical evidence reveals numerous commonalities in the biology underlying both pathologies. Inflammation emerges as a common hallmark for both diseases as it contributes to the initiation and progression of both HF and cancer. Under stress, malignant and cardiac cells change their metabolic preferences to survive, which makes these metabolic derangements a great basis to develop intersection strategies and therapies to combat both diseases. Furthermore, genetic predisposition and clonal haematopoiesis are common drivers for both conditions and they hold great clinical relevance in the context of personalized medicine. Additionally, altered angiogenesis is a common hallmark for failing hearts and tumours and represents a promising substrate to target in both diseases. Cardiac cells and malignant cells interact with their surrounding environment called stroma. This interaction mediates the progression of the two pathologies and understanding the structure and function of each stromal component may pave the way for innovative therapeutic strategies and improved outcomes in patients. The interdisciplinary collaboration between cardiologists and oncologists is essential to establish unified guidelines. To this aim, pre-clinical models that mimic the human situation, where both pathologies coexist, are needed to understand all the aspects of the bidirectional relationship between cancer and HF. Finally, adequately powered clinical studies, including patients from all ages, and men and women, with proper adjudication of both cancer and cardiovascular endpoints, are essential to accurately study these two pathologies at the same time. © 2020 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

Published
2020

12. Role of serum biomarkers in cancer patients receiving cardiotoxic cancer therapies: a position statement from the Cardio-Oncology Study Group of the Heart Failure Association and the Cardio-Oncology Council of the European Society of Cardiology

Author

Pudil, R. Mueller, C. Čelutkienė, J. Henriksen, P.A. Lenihan, D. Dent, S. Barac, A. Stanway, S. Moslehi, J. Suter, T.M. Ky, B. Štěrba, M. Cardinale, D. Cohen-Solal, A. Tocchetti, C.G. Farmakis, D. Bergler-Klein, J. Anker, M.S. Von Haehling, S. Belenkov, Y. Iakobishvili, Z. Maack, C. Ciardiello, F. Ruschitzka, F. Coats, A.J.S. Seferovic, P. Lainscak, M. Piepoli, M.F. Chioncel, O. Bax, J. Hulot, J.-S. Skouri, H. Hägler-Laube, E.S. Asteggiano, R. Fernandez, T.L. de Boer, R.A. Lyon, A.R.

Abstract

Serum biomarkers are an important tool in the baseline risk assessment and diagnosis of cardiovascular disease in cancer patients receiving cardiotoxic cancer treatments. Increases in cardiac biomarkers including cardiac troponin and natriuretic peptides can be used to guide initiation of cardioprotective treatments for cancer patients during treatment and to monitor the response to cardioprotective treatments, and they also offer prognostic value. This position statement examines the role of cardiac biomarkers in the management of cancer patients. The Cardio-Oncology Study Group of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the Cardio-Oncology Council of the ESC have evaluated the current evidence for the role of cardiovascular biomarkers in cancer patients before, during and after cardiotoxic cancer therapies. The characteristics of the main two biomarkers troponin and natriuretic peptides are discussed, the link to the mechanisms of cardiovascular toxicity, and the evidence for their clinical use in surveillance during and after anthracycline chemotherapy, trastuzumab and HER2-targeted therapies, vascular endothelial growth factor inhibitors, proteasome inhibitors, immune checkpoint inhibitors, cyclophosphamide and radiotherapy. Novel surveillance clinical pathways integrating cardiac biomarkers for cancer patients receiving anthracycline chemotherapy or trastuzumab biomarkers are presented and future direction in cardio-oncology biomarker research is discussed. © 2020 European Society of Cardiology

Published
2020

13. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society

Author

Lyon, A.R. Dent, S. Stanway, S. Earl, H. Brezden-Masley, C. Cohen-Solal, A. Tocchetti, C.G. Moslehi, J.J. Groarke, J.D. Bergler-Klein, J. Khoo, V. Tan, L.L. Anker, M.S. von Haehling, S. Maack, C. Pudil, R. Barac, A. Thavendiranathan, P. Ky, B. Neilan, T.G. Belenkov, Y. Rosen, S.D. Iakobishvili, Z. Sverdlov, A.L. Hajjar, L.A. Macedo, A.V.S. Manisty, C. Ciardiello, F. Farmakis, D. de Boer, R.A. Skouri, H. Suter, T.M. Cardinale, D. Witteles, R.M. Fradley, M.G. Herrmann, J. Cornell, R.F. Wechelaker, A. Mauro, M.J. Milojkovic, D. de Lavallade, H. Ruschitzka, F. Coats, A.J.S. Seferovic, P.M. Chioncel, O. Thum, T. Bauersachs, J. Andres, M.S. Wright, D.J. López-Fernández, T. Plummer, C. Lenihan, D.

Abstract

This position statement from the Heart Failure Association of the European Society of Cardiology Cardio-Oncology Study Group in collaboration with the International Cardio-Oncology Society presents practical, easy-to-use and evidence-based risk stratification tools for oncologists, haemato-oncologists and cardiologists to use in their clinical practice to risk stratify oncology patients prior to receiving cancer therapies known to cause heart failure or other serious cardiovascular toxicities. Baseline risk stratification proformas are presented for oncology patients prior to receiving the following cancer therapies: anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor inhibitors, second and third generation multi-targeted kinase inhibitors for chronic myeloid leukaemia targeting BCR-ABL, multiple myeloma therapies (proteasome inhibitors and immunomodulatory drugs), RAF and MEK inhibitors or androgen deprivation therapies. Applying these risk stratification proformas will allow clinicians to stratify cancer patients into low, medium, high and very high risk of cardiovascular complications prior to starting treatment, with the aim of improving personalised approaches to minimise the risk of cardiovascular toxicity from cancer therapies. © 2020 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.

Published
2020

16. Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC)

Author

Čelutkienė, J. Pudil, R. López-Fernández, T. Grapsa, J. Nihoyannopoulos, P. Bergler-Klein, J. Cohen-Solal, A. Farmakis, D. Tocchetti, C.G. von Haehling, S. Barberis, V. Flachskampf, F.A. Čeponienė, I. Haegler-Laube, E. Suter, T. Lapinskas, T. Prasad, S. de Boer, R.A. Wechalekar, K. Anker, M.S. Iakobishvili, Z. Bucciarelli-Ducci, C. Schulz-Menger, J. Cosyns, B. Gaemperli, O. Belenkov, Y. Hulot, J.-S. Galderisi, M. Lancellotti, P. Bax, J. Marwick, T.H. Chioncel, O. Jaarsma, T. Mullens, W. Piepoli, M. Thum, T. Heymans, S. Mueller, C. Moura, B. Ruschitzka, F. Zamorano, J.L. Rosano, G. Coats, A.J.S. Asteggiano, R. Seferovic, P. Edvardsen, T. Lyon, A.R. and Čelutkienė, J. Pudil, R. López-Fernández, T. Grapsa, J. Nihoyannopoulos, P. Bergler-Klein, J. Cohen-Solal, A. Farmakis, D. Tocchetti, C.G. von Haehling, S. Barberis, V. Flachskampf, F.A. Čeponienė, I. Haegler-Laube, E. Suter, T. Lapinskas, T. Prasad, S. de Boer, R.A. Wechalekar, K. Anker, M.S. Iakobishvili, Z. Bucciarelli-Ducci, C. Schulz-Menger, J. Cosyns, B. Gaemperli, O. Belenkov, Y. Hulot, J.-S. Galderisi, M. Lancellotti, P. Bax, J. Marwick, T.H. Chioncel, O. Jaarsma, T. Mullens, W. Piepoli, M. Thum, T. Heymans, S. Mueller, C. Moura, B. Ruschitzka, F. Zamorano, J.L. Rosano, G. Coats, A.J.S. Asteggiano, R. Seferovic, P. Edvardsen, T. Lyon, A.R.

Abstract

Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the ESC have evaluated the current evidence for the value of modern CV imaging in the cardio-oncology field. The most relevant echocardiographic parameters, including global longitudinal strain and three-dimensional ejection fraction, are proposed. The protocol for baseline pre-treatment evaluation and specific surveillance algorithms or pathways for anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor tyrosine kinase inhibitors, BCr-Abl tyrosine kinase inhibitors, proteasome inhibitors and immune checkpoint inhibitors are presented. The indications for CV imaging after completion of oncology treatment are considered. The typical consequences of radiation therapy and the possibility of their identification in the long term are also summarized. Special populations are discussed including female survivors planning pregnancy, patients with carcinoid disease, patients with cardiac tumours and patients with right heart failure. Future directions and ongoing CV imaging research in cardio-oncology are discussed. © 2020 European Society of Cardiology

Published
2020

17. Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from theCardio-OncologyStudyGroup of theHeartFailureAssociation of theEuropeanSociety ofCardiology in collaboration with theInternationalCardio-OncologySociety

Author

Lyon, AR, Dent, S, Stanway, S, Earl, H, Brezden-Masley, C, Cohen-Solal, A, Tocchetti, CG, Moslehi, JJ, Groarke, JD, Bergler-Klein, J, Khoo, V, Tan, LL, Anker, MS, von Haehling, S, Maack, C, Pudil, R, Barac, A, Thavendiranathan, P, Ky, B, Neilan, TG, Belenkov, Y, Rosen, SD, Iakobishvili, Z, Sverdlov, AL, Hajjar, LA, Macedo, AVS, Manisty, C, Ciardiello, F, Farmakis, D, de Boer, RA, Skouri, H, Suter, TM, Cardinale, D, Witteles, RM, Fradley, MG, Herrmann, J, Cornell, RF, Wechelaker, A, Mauro, MJ, Milojkovic, D, de Lavallade, H, Ruschitzka, F, Coats, AJS, Seferovic, PM, Chioncel, O, Thum, T, Bauersachs, J, Andres, MS, Wright, DJ, Lopez-Fernandez, T, Plummer, C, Lenihan, D, Lyon, AR, Dent, S, Stanway, S, Earl, H, Brezden-Masley, C, Cohen-Solal, A, Tocchetti, CG, Moslehi, JJ, Groarke, JD, Bergler-Klein, J, Khoo, V, Tan, LL, Anker, MS, von Haehling, S, Maack, C, Pudil, R, Barac, A, Thavendiranathan, P, Ky, B, Neilan, TG, Belenkov, Y, Rosen, SD, Iakobishvili, Z, Sverdlov, AL, Hajjar, LA, Macedo, AVS, Manisty, C, Ciardiello, F, Farmakis, D, de Boer, RA, Skouri, H, Suter, TM, Cardinale, D, Witteles, RM, Fradley, MG, Herrmann, J, Cornell, RF, Wechelaker, A, Mauro, MJ, Milojkovic, D, de Lavallade, H, Ruschitzka, F, Coats, AJS, Seferovic, PM, Chioncel, O, Thum, T, Bauersachs, J, Andres, MS, Wright, DJ, Lopez-Fernandez, T, Plummer, C, and Lenihan, D

Abstract

This position statement from the Heart Failure Association of the European Society of Cardiology Cardio-Oncology Study Group in collaboration with the International Cardio-Oncology Society presents practical, easy-to-use and evidence-based risk stratification tools for oncologists, haemato-oncologists and cardiologists to use in their clinical practice to risk stratify oncology patients prior to receiving cancer therapies known to cause heart failure or other serious cardiovascular toxicities. Baseline risk stratification proformas are presented for oncology patients prior to receiving the following cancer therapies: anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor inhibitors, second and third generation multi-targeted kinase inhibitors for chronic myeloid leukaemia targeting BCR-ABL, multiple myeloma therapies (proteasome inhibitors and immunomodulatory drugs), RAF and MEK inhibitors or androgen deprivation therapies. Applying these risk stratification proformas will allow clinicians to stratify cancer patients into low, medium, high and very high risk of cardiovascular complications prior to starting treatment, with the aim of improving personalised approaches to minimise the risk of cardiovascular toxicity from cancer therapies.

Published
2020

18. Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the European Society of Cardiology (ESC)

Author

Celutkiene, J, Pudil, R, Lopez-Fernandez, T, Grapsa, J, Nihoyannopoulos, P, Bergler-Klein, J, Cohen-Solal, A, Farmakis, D, Tocchetti, CG, von Haehling, S, Barberis, V, Flachskampf, FA, Ceponiene, I, Haegler-Laube, E, Suter, T, Lapinskas, T, Prasad, S, de Boer, RA, Wechalekar, K, Anker, MS, Iakobishvili, Z, Bucciarelli-Ducci, C, Schulz-Menger, J, Cosyns, B, Gaemperli, O, Belenkov, Y, Hulot, J-S, Galderisi, M, Lancellotti, P, Bax, J, Marwick, TH, Chioncel, O, Jaarsma, T, Mullens, W, Piepoli, M, Thum, T, Heymans, S, Mueller, C, Moura, B, Ruschitzka, F, Zamorano, JL, Rosano, G, Coats, AJS, Asteggiano, R, Seferovic, P, Edvardsen, T, Lyon, AR, Celutkiene, J, Pudil, R, Lopez-Fernandez, T, Grapsa, J, Nihoyannopoulos, P, Bergler-Klein, J, Cohen-Solal, A, Farmakis, D, Tocchetti, CG, von Haehling, S, Barberis, V, Flachskampf, FA, Ceponiene, I, Haegler-Laube, E, Suter, T, Lapinskas, T, Prasad, S, de Boer, RA, Wechalekar, K, Anker, MS, Iakobishvili, Z, Bucciarelli-Ducci, C, Schulz-Menger, J, Cosyns, B, Gaemperli, O, Belenkov, Y, Hulot, J-S, Galderisi, M, Lancellotti, P, Bax, J, Marwick, TH, Chioncel, O, Jaarsma, T, Mullens, W, Piepoli, M, Thum, T, Heymans, S, Mueller, C, Moura, B, Ruschitzka, F, Zamorano, JL, Rosano, G, Coats, AJS, Asteggiano, R, Seferovic, P, Edvardsen, T, and Lyon, AR

Abstract

Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the ESC have evaluated the current evidence for the value of modern CV imaging in the cardio-oncology field. The most relevant echocardiographic parameters, including global longitudinal strain and three-dimensional ejection fraction, are proposed. The protocol for baseline pre-treatment evaluation and specific surveillance algorithms or pathways for anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor tyrosine kinase inhibitors, BCr-Abl tyrosine kinase inhibitors, proteasome inhibitors and immune checkpoint inhibitors are presented. The indications for CV imaging after completion of oncology treatment are considered. The typical consequences of radiation therapy and the possibility of their identification in the long term are also summarized. Special populations are discussed including female survivors planning pregnancy, patients with carcinoid disease, patients with cardiac tumours and patients with right heart failure. Future directions and ongoing CV imaging research in cardio-oncology are discussed.

Published
2020

19. Recent advances in cardio-oncology: a report from the ‘Heart Failure Association 2019 and World Congress on Acute Heart Failure 2019’

Author

Anker, M.S. Hadzibegovic, S. Lena, A. Belenkov, Y. Bergler-Klein, J. de Boer, R.A. Farmakis, D. von Haehling, S. Iakobishvili, Z. Maack, C. Pudil, R. Skouri, H. Cohen-Solal, A. Tocchetti, C.G. Coats, A.J.S. Seferović, P.M. Lyon, A.R. for the Heart Failure Association Cardio-Oncology Study Group of the European Society of Cardiology

Abstract

While anti-cancer therapies, including chemotherapy, immunotherapy, radiotherapy, and targeted therapy, are constantly advancing, cardiovascular toxicity has become a major challenge for cardiologists and oncologists. This has led to an increasing demand of cardio-oncology units in Europe and a growing interest of clinicians and researchers. The Heart Failure 2019 meeting of the Heart Failure Association of the European Society of Cardiology in Athens has therefore created a scientific programme that included four dedicated sessions on the topic along with several additional lectures. The major points that were discussed at the congress included the implementation and delivery of a cardio-oncology service, the collaboration among cardio-oncology experts, and the risk stratification, prevention, and early recognition of cardiotoxicity. Furthermore, sessions addressed the numerous different anti-cancer therapies associated with cardiotoxic effects and provided guidance on how to treat cancer patients who develop cardiovascular disease before, during, and after treatment. © 2019 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology

Published
2019

20. Modern-day cardio-oncology: a report from the ‘Heart Failure and World Congress on Acute Heart Failure 2018’

Author

Anker, M.S. Lena, A. Hadzibegovic, S. Belenkov, Y. Bergler-Klein, J. de Boer, R.A. Cohen-Solal, A. Farmakis, D. von Haehling, S. López-Fernández, T. Pudil, R. Suter, T. Tocchetti, C.G. Lyon, A.R. for the Heart Failure Association Cardio-Oncology Study Group of the European Society of Cardiology

Abstract

During the ‘Heart Failure and World Congress on Acute Heart Failure 2018’, many sessions and lectures focused on cardio-oncology. This important field of research is constantly growing, and therefore, a great amount of time during the congress focused on it. Prevention and early recognition of side effects is very important in cancer patients. One of the most common and potentially severe problems during antineoplastic therapy is cardiotoxicity. Hence, cardio-oncology is vital in managing cancer patients. This paper will summarize the topics discussed in three main sessions and many additional lectures throughout the ‘Heart Failure and World Congress on Acute Heart Failure 2018’. The covered topics included pathophysiological mechanisms in the development of heart failure, risk factors, and early signs of cardiotoxicity detectable with different circulating and imaging biomarkers, as well as cardioprotective treatments recommended by different guidelines and position papers. © 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

Published
2018

21. Cancer diagnosis in patients with heart failure: epidemiology, clinical implications and gaps in knowledge

Author

Ameri, P. Canepa, M. Anker, M.S. Belenkov, Y. Bergler-Klein, J. Cohen-Solal, A. Farmakis, D. López-Fernández, T. Lainscak, M. Pudil, R. Ruschitska, F. Seferovic, P. Filippatos, G. Coats, A. Suter, T. Von Haehling, S. Ciardiello, F. de Boer, R.A. Lyon, A.R. Tocchetti, C.G. for the Heart Failure Association Cardio-Oncology Study Group of the European Society of Cardiology

Abstract

Cancer and heart failure (HF) are common medical conditions with a steadily rising prevalence in industrialized countries, particularly in the elderly, and they both potentially carry a poor prognosis. A new diagnosis of malignancy in subjects with pre-existing HF is not infrequent, and challenges HF specialists as well as oncologists with complex questions relating to both HF and cancer management. An increased incidence of cancer in patients with established HF has also been suggested. This review paper summarizes the epidemiology and the prognostic implications of cancer occurrence in HF, the impact of pre-existing HF on cancer treatment decisions and the impact of cancer on HF therapeutic options, while providing some practical suggestions regarding patient care and highlighting gaps in knowledge. © 2018 The Authors. European Journal of Heart Failure © 2018 European Society of Cardiology

Published
2018

22. Are hospitalized or ambulatory patients with heart failure treated in accordance with European Society of Cardiology guidelines? Evidence from 12 440 patients of the ESC Heart Failure Long-Term Registry

Author

Maggioni, Aldo P, Anker, Stefan D., Dahlström, Ulf, Filippatos, Gerasimos, Ponikowski, Piotr, Zannad, Faiez, Amir, Offer, Chioncel, Ovidiu, Leiro, Marisa Crespo, Drozdz, Jaroslaw, Erglis, Andrejs, Fazlibegovic, Emir, Fonseca, Candida, Fruhwald, Friedrich, Gatzov, Plamen, Goncalvesova, Eva, Hassanein, Mahmoud, Hradec, Jaromir, Kavoliuniene, Ausra, Lainscak, Mitja, Logeart, Damien, Merkely, Bela, Metra, Marco, Persson, Hans, Seferovic, Petar, Temizhan, Ahmet, Tousoulis, Dimitris, Tavazzi, Luigi, Andarala, M., Fiorucci, E., Folkesson, E., Glemot, M., Gracia, G., Konte, M., Laroche, C., Mcneill, P. a., Missiamenou, V., Taylor, C., Fruhwald, F., Eberl, Alexander, Heller, S., Dolze, T., Platzer, V., Ablasser, K., Auer, J., Poelzl, G., Moertl, D., Podczeck Schweighofer, A., Reiter, S., Pravdic, D., Fazlibegovic, E., Muslibegovic, A., Vitlianova, K., Katova, T., Kotirkov, K., Petrov, I., Velikov, T., Kurteva, T., Gatzov, P., Kamenova, D., Antova, M., Tisheva, S., Sirakova, V., Krejci, J., Spinar, J., Mikolaskova, M., Krupicka, J., Malek, F., Hegarova, M., Pudil, R., Monhart, Z., Lazarova, M., Reda, A., Khairy, T., Farag, N., Saleh, A., Said, K., Abdel Hamid, M., Halawa, S., Ibrahim, B., Hanna, R., Hassanein, M., Sobhy, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Aboleineen, W., Gouda, M., Youssef, A., Elbahry, A., Abdel, A., Ebeid, H., Nasr, G., Sobhy, H., Ashmawy, M., Lefol, C., Isnard, R., Hagege, A., Thevenin, S., Jondeau, G., Logeart, D., Codjia, R., Galinier, M., Bauer, F., Delahaye, F., Lamblin, N., Fertin, M., De Groote, P., Coisne, D., Le Marcis, V., Lequeux, B., J. F., Ly, Lotton, P., Donal, E., Le Moal, V., Basquin, A., Reynaud, A., Ridard, C., Thebault, C., Behar, N., Mascle, S., Schiele, F., Seronde, M. F., Morel, M., Meneveau, N., Luporsi, P., Bernard, Y., Pillot, M., Briand, F., Damy, T., Eicher, J. C., Avgeropoulou, C., Panagiotis, T., Tousoulis, D., Kotrogiannis, I., Stefanadis, C., Chrysohoou, C., Tsitsinakis, G., Dimitroula, T., Karavidas, A., Matzaraki, V., Terrovitis, J., Kapelios, C., Sfakianaki, T., Filippatos, G., Parissis, J. T., Ntai, K., Papadopoulou, A., Tziourganou, H., Douras, A., Ntertsas, K., Karotsaki, T., Nikoloulis, N., Tsaknakis, T., Patrianakos, A., Nyktari, E., Vardas, P., Soos, P., Nyolczas, N., Csaba Nagy, A., Halmosi, R., Nemeth, F., Amon, G., Dinnyes, J., Vazan Fuhrmann, A., Shotan, A., Alony, I., Elber, J., Olaru, A., Valenti, C., Reggianini, L., Modena, M. G., Copelli, S., Leuzzi, Concetta, Dei Cas, L., Carubelli, V., Lombardi, Cecilia, Bulgari, M., Tanghetti, E., Quinzani, F., Metra, M., Rovetta, R., Brasolin, B., Fedele, F., Sergi, Daniela, Romeo, F., Scarfò, I., Vellini, M., Fabris, E., Cinquetti, Martino, Stolfo, Davide, Sinagra, Gianfranco, Merlo, Marco, Fucili, A., Ferrari, R., Vassanelli, C., Torelli, F., Marchese, G., Zanolla, L., Cicoira, M., Anselmi, Manuel, Piccinino, C., Sartori, C., Di Ruocco, M. V., Marino, P. N., Giordano, A., Brognoli, S., Zanelli, E., Cosmi, F., Cadeddu, C., Bandino, S., Mercuro, G., Deidda, M., Salvemini, G., Correale, M., Di Biase, M., Musio, S., Passero, T., Italiano, Graziella, Agostoni, P., Salvioni, E., Schiavina, G., Squeri, CARLO ATTILIO, Bosi, S., Barbieri, A., Lemme, E., Penco, M., Marcon, S., Romano, S., Di Mauro, M., Frisinghelli, A., Veniani, M., Pieri, Pietro, Novo, S., Proclemer, Alessandro, Fresco, C., Miani, Daniela, Artico, Jessica, Gaita, F., Bergerone, S., Pirelli, SALVATORE DONATO, Di Tano, G., Cattaneo, Silvana, Gualco, A., Opasich, C., Priori, S. G., Iori, Elisa, Leci, E., Melandri, F., Voronina, N., Erglis, A., Kalnins, A., Kavoliuniene, A., Rumbinaite, E., Kazakauskaite, E., Petraskiene, I., Karaliute, R., Smalinskas, V., Tamakauskas, V., Petraskiene, D., Brazyte Ramanauskiene, R., Vysniauskas, V., Nowicka, A., Grabia, J., Dankowski, R., Szyszka, A., Szymanowska, K., Straburzynska Migaj, E., Kaluzna Oleksy, M., Grajek, S., Kasztelowicz, P., Orzel, T., Bednarczyk, G., Ruszkowski, P., Klimkiewicz, J., Majzner, A., Matusiak, A., Bylicka, E., Kwiatkowska, E., Kwiatkowska, K., Ochnio, M., Krzyzewska, T., Tarnowska, A., Komuda, K., Sobieszczanska Malek, M., Leszek, P., Rywik, T., Wisniewska, J., Kozar Kaminska, K., Piotrowska, M., Zielinski, T., Mamcarz, A., Welnicki, M., Folga, A., Kaplon Cieslicka, A., Opolski, G., Marchel, M., Balsam, P., Michalek, A., Pawlak, A., Byczkowska, K., Mozenska, O., Gil, K., Gil, R. J., Skrobowski, A., Uzieblo Zyczkowska, B., Piotrowicz, K., Krzesinski, P., Stanczyk, A., Ciurzynski, M., Bienias, P., Pruszczyk, P., Juszczyk, Z., Switala, P., Stankala, S., Polonski, L., Rozentryt, P., Gabryel, J., Lazorko Piega, M., Kardaszewicz, P., Poprawa, I., Komorowska, E., Lauko Rachocka, A., Abdulkarim, A. F., Dudzik Plocica, A., Zolbach, A., Sajnaga, D., Komorowska, K., Baczynska, K., Samcik, M., Wolniewicz, L., Wozakowska Kaplon, B., Sosnowska Pasiarska, B., Bartkowiak, R., Fiega, A., Serwicka, A., Szymczyk, A., Fitas, G., Zysko, D., Poliwczak, A., Broncel, M., Bala, A., Kasprzak, J. D., Jankowski, L., Rudzinska, M., Zycinski, P., Retwinski, A., Pietka, I., Drozdz, J., Wojtczak Soska, K., Jankowska, E., Ponikowski, P., Cichy, A., Kostka, A., Kaminski, L., Weglarz, J., Bodys, A., Flis, P., Kleinrok, A., Prokop Lewicka, G., Mosakowska, K., Rynkiewicz, A., Bellwon, J., Dabrowska Kugacka, A., Lewicka, E., Raczak, G., Skorek, E., Szabowski, S., Krysiak, W., Pietrzak, J., Gilewski, W., Sinkiewicz, W., Furman, A., Zalewski, J., Nessler, J., Bury, K., Grzegorzko, A., Zabojszcz, M., Mirek Bryniarska, E., Klys, J., Przybylska, K., Szulik, M., Kalarus, Z., Kuczaj, A., Nowalany Kozielska, E., Krzeminski, A., Ventosa, A., Tavares Aguiar, C., Moura, B., Cardoso, J. S., De Jesus, I., Chin, J., Faria, R., Pereira, S., Lima, Giuseppe, Oliveira Guimarães, T., Francisco, A. R., Brito, D., Placido, R., Martins, S., Fonseca, C., Marques, F., Araujo, I., Proenca, M., Cardiga, R., Andrade, A., Castro, Alessandra, Pereira, A., Queirós, C., Silva, P., Santos, R., Lourenço, C., Moreno, N., Almeida, F., Quelhas, I., Baptista, A., Ferreira, A., Magalhaes, P., Ferreira, Clara, Moreira, I., Durao, D., Severino, D., Ferreira Da Silva, G., Marta, L., Peres, Martina, Stanescu, C., Dan, A., Dan, G. A., Daha, I., Popescu, R., Vinereanu, D., Sinescu, C. J., Macarie, C., Radoi, M., Nechita, E., Christodorescu, R., Datcu, M., Craiu, E., Otasevic, P., Ristic, A. D., Simeunovic, D., Seferovic, P., Pencic, B., Andric, A., Stojcevski, B., Lebedinski, E., Suzic Lazic, J., Celic, V., Krotin, M., Radovanovic, Slavena, Iric Cupic, V., Milanov, S., Davidovic, G., Jovic, Masa, Radin, A., Mihajlovic, B., Stojiljkovic, J., Cankovic, M., Cemerlic Adic, N., Dodic, Sara, Kecojevic, S., Stojsic, S., Petrovic, D., Deljanin Ilic, M., Ilić, Saša, Stoickov, V., Antic, S., Stanojevic, D., Pavlovic, M., Atanaskovic, V., Mitic, Vanja, Kovar, F., Goncalvesova, E., Murin, J., Pernicky, M., Klabnik, A., Kmec, J., Rajtman, D., Kovac, D., Horvat, Sara, Krunic, B., Bombek, M., Krajnc, I., Losic, R., Glavic, T., Komel, Janja, Cernic Suligoj, N., Ravnikar, T., Letonja, M., Cencic, Vanja, Savnik Iskra, M., Strasek, M., Leskovar, B., Drnovsek, B., Klen, J., Marolt, A., Kladnik, M., Slemenik Pusnik, C., Pusnik Vrckovnik, M., Jug, Barbara, Fras, Z., Bartolic, Andrej, Melihen Bartolic, C., Valentincic, M., Winkler, R., Blanco Canosa, P., Grille Cancela, Z., Crespo Leiro, M., Paniagua Martin, M. J., Marzoa Rivas, R., Barge Caballero, E., Torres Calvo, F., Bravo Marques, R., Epelde Gonzalo, F., Recio Platero, A., De La Fuente Galan, L., Lopez Diaz, J., Goncalvez Ramirez, L. Renier, Cubero Gallego, H., Sliwiski Herrera, J. F., Bierge Valero, D., Salmeron, F. M., Gallego Page, J. C., Jose Fernandez, M., Sahuquillo, A., Garcia De La Villa, B., Castro Conde, A., Iniesta Manjavacas, A. M., Salvador Montanes, O., Gonzalez Gallarza, R. Dalmau, Ofelia Rosillo, S., Araujo, A., Briceno, A., Alonso Pulpon, L., Cobo, M., Soria, T., Gomez Bueno, M., Garcia Pavia, P., Gonzalez Segovia, A., Sayago, I., Segovia Cubero, J., Delgado Jiménez, J. F., Angel Gomez Sanchez, M., Escribano Subias, P., Barrios Garrido Lestache, E., Ruiz Cano, M. J., Vicente Hernandez, M., Puga Martinez, M., Lopez Moreno, E., Serrano Martinez, J. L., Fernandez Alvarez, M., Rivera Lopez, R., Lopez Fernandez, S., Alcade Martinez, V., Sanmartin, M., Pellicer Cabo, A., Garcia Escriva, D., Ridocci Soriano, F., Perez Silvestre, J., Facila Rubio, L., Garcia Gonzalez, P., Sanchez Lazaro, I. J., Almenar Bonet, L., Garcia Pinilla, J. M., Andres, Ulrike Julia, Bayes Genis, A., Roig, E., Mirabet, S., Mendez, A., Garcia Cosio, L., Garay, A., Muntane, G., Gonzalez Costello, J., Leon, V., Diaz Molina, B., Famara Hernandez, I., Lara Padron, A., Laynez Cerdena, I., Mateo, I., Quiles, J., Bertomeu, V., Elamrani, A., Angel Rodrigez Ortega, J., Martinez Abellan, R., Valero, R., Fernandez Vivancos, C., Sanz Julve, M., Perez Martinez, M. T., Pascual Figal, D. A., Martinez Martinez Espejo, M. D., Rosario Gracia Rodenas, M., Pastor Perez, F., Melin, M., Hägglund, E., Stenberg, A., Lindahl, I. M., Asserlund, B., Olsson, L., Dahlström, U., Afzelius, M., Karlström, P., Tengvall, L., Wiklund, P. A., Olsson, B., Temizhan, A., Kalayci, S., Bozkurt, M., Taraktas, M., Cavusoglu, Y., Gunes, H., Birhan Yilmaz, M., Demir, B., Gencer, E., Maggioni, Aldo P, Anker, Stefan D., Dahlström, Ulf, Filippatos, Gerasimo, Ponikowski, Piotr, Zannad, Faiez, Amir, Offer, Chioncel, Ovidiu, Leiro, Marisa Crespo, Drozdz, Jaroslaw, Erglis, Andrej, Fazlibegovic, Emir, Fonseca, Candida, Fruhwald, Friedrich, Gatzov, Plamen, Goncalvesova, Eva, Hassanein, Mahmoud, Hradec, Jaromir, Kavoliuniene, Ausra, Lainscak, Mitja, Logeart, Damien, Merkely, Bela, Metra, Marco, Persson, Han, Seferovic, Petar, Temizhan, Ahmet, Tousoulis, Dimitri, Tavazzi, Luigi, Andarala, M., Fiorucci, E., Folkesson, E., Glemot, M., Gracia, G., Konte, M., Laroche, C., Mcneill, P. a., Missiamenou, V., Taylor, C., Fruhwald, F., Eberl, Alexander, Heller, S., Dolze, T., Platzer, V., Ablasser, K., Auer, J., Poelzl, G., Moertl, D., Podczeck Schweighofer, A., Reiter, S., Pravdic, D., Fazlibegovic, E., Muslibegovic, A., Vitlianova, K., Katova, T., Kotirkov, K., Petrov, I., Velikov, T., Kurteva, T., Gatzov, P., Kamenova, D., Antova, M., Tisheva, S., Sirakova, V., Krejci, J., Spinar, J., Mikolaskova, M., Krupicka, J., Malek, F., Hegarova, M., Pudil, R., Monhart, Z., Lazarova, M., Reda, A., Khairy, T., Farag, N., Saleh, A., Said, K., Abdel Hamid, M., Halawa, S., Ibrahim, B., Hanna, R., Hassanein, M., Sobhy, M., El Messiry, F., El Shazly, A. H., Elrakshy, Y., Aboleineen, W., Gouda, M., Youssef, A., Elbahry, A., Abdel, A., Ebeid, H., Nasr, G., Sobhy, H., Ashmawy, M., Lefol, C., Isnard, R., Hagege, A., Thevenin, S., Jondeau, G., Logeart, D., Codjia, R., Galinier, M., Bauer, F., Delahaye, F., Lamblin, N., Fertin, M., De Groote, P., Coisne, D., Le Marcis, V., Lequeux, B., Ly, J. F., Lotton, P., Donal, E., Le Moal, V., Basquin, A., Reynaud, A., Ridard, C., Thebault, C., Behar, N., Mascle, S., Schiele, F., Seronde, M. F., Morel, M., Meneveau, N., Luporsi, P., Bernard, Y., Pillot, M., Briand, F., Damy, T., Eicher, J. C., Avgeropoulou, C., Panagiotis, T., Tousoulis, D., Kotrogiannis, I., Stefanadis, C., Chrysohoou, C., Tsitsinakis, G., Dimitroula, T., Karavidas, A., Matzaraki, V., Terrovitis, J., Kapelios, C., Sfakianaki, T., Filippatos, G., Parissis, J. T., Ntai, K., Papadopoulou, A., Tziourganou, H., Douras, A., Ntertsas, K., Karotsaki, T., Nikoloulis, N., Tsaknakis, T., Patrianakos, A., Nyktari, E., Vardas, P., Soos, P., Nyolczas, N., Csaba Nagy, A., Halmosi, R., Nemeth, F., Amon, G., Dinnyes, J., Vazan Fuhrmann, A., Shotan, A., Alony, I., Elber, J., Olaru, A., Valenti, C., Reggianini, L., Modena, M. G., Copelli, S., Leuzzi, Concetta, Dei Cas, L., Carubelli, V., Lombardi, Cecilia, Bulgari, M., Tanghetti, E., Quinzani, F., Metra, M., Rovetta, R., Brasolin, B., Fedele, F., Sergi, Daniela, Romeo, F., Scarfò, I., Vellini, M., Fabris, E., Cinquetti, Martino, Stolfo, Davide, Sinagra, Gianfranco, Merlo, Marco, Fucili, A., Ferrari, R., Vassanelli, C., Torelli, F., Marchese, G., Zanolla, L., Cicoira, M., Anselmi, Manuel, Piccinino, C., Sartori, C., Di Ruocco, M. V., Marino, P. N., Giordano, A., Brognoli, S., Zanelli, E., Cosmi, F., Cadeddu, C., Bandino, S., Mercuro, G., Deidda, M., Salvemini, G., Correale, M., Di Biase, M., Musio, S., Passero, T., Italiano, Graziella, Agostoni, P., Salvioni, E., Schiavina, G., Squeri, CARLO ATTILIO, Bosi, S., Barbieri, A., Lemme, E., Penco, M., Marcon, S., Romano, S., Di Mauro, M., Frisinghelli, A., Veniani, M., Pieri, Pietro, Novo, S., Proclemer, Alessandro, Fresco, C., Miani, Daniela, Artico, Jessica, Gaita, F., Bergerone, S., Pirelli, SALVATORE DONATO, Di Tano, G., Cattaneo, Silvana, Gualco, A., Opasich, C., Priori, S. G., Iori, Elisa, Leci, E., Melandri, F., Voronina, N., Erglis, A., Kalnins, A., Kavoliuniene, A., Rumbinaite, E., Kazakauskaite, E., Petraskiene, I., Karaliute, R., Smalinskas, V., Tamakauskas, V., Petraskiene, D., Brazyte Ramanauskiene, R., Vysniauskas, V., Nowicka, A., Grabia, J., Dankowski, R., Szyszka, A., Szymanowska, K., Straburzynska Migaj, E., Kaluzna Oleksy, M., Grajek, S., Kasztelowicz, P., Orzel, T., Bednarczyk, G., Ruszkowski, P., Klimkiewicz, J., Majzner, A., Matusiak, A., Bylicka, E., Kwiatkowska, E., Kwiatkowska, K., Ochnio, M., Krzyzewska, T., Tarnowska, A., Komuda, K., Sobieszczanska Malek, M., Leszek, P., Rywik, T., Wisniewska, J., Kozar Kaminska, K., Piotrowska, M., Zielinski, T., Mamcarz, A., Welnicki, M., Folga, A., Kaplon Cieslicka, A., Opolski, G., Marchel, M., Balsam, P., Michalek, A., Pawlak, A., Byczkowska, K., Mozenska, O., Gil, K., Gil, R. J., Skrobowski, A., Uzieblo Zyczkowska, B., Piotrowicz, K., Krzesinski, P., Stanczyk, A., Ciurzynski, M., Bienias, P., Pruszczyk, P., Juszczyk, Z., Switala, P., Stankala, S., Polonski, L., Rozentryt, P., Gabryel, J., Lazorko Piega, M., Kardaszewicz, P., Poprawa, I., Komorowska, E., Lauko Rachocka, A., Abdulkarim, A. F., Dudzik Plocica, A., Zolbach, A., Sajnaga, D., Komorowska, K., Baczynska, K., Samcik, M., Wolniewicz, L., Wozakowska Kaplon, B., Sosnowska Pasiarska, B., Bartkowiak, R., Fiega, A., Serwicka, A., Szymczyk, A., Fitas, G., Zysko, D., Poliwczak, A., Broncel, M., Bala, A., Kasprzak, J. D., Jankowski, L., Rudzinska, M., Zycinski, P., Retwinski, A., Pietka, I., Drozdz, J., Wojtczak Soska, K., Jankowska, E., Ponikowski, P., Cichy, A., Kostka, A., Kaminski, L., Weglarz, J., Bodys, A., Flis, P., Kleinrok, A., Prokop Lewicka, G., Mosakowska, K., Rynkiewicz, A., Bellwon, J., Dabrowska Kugacka, A., Lewicka, E., Raczak, G., Skorek, E., Szabowski, S., Krysiak, W., Pietrzak, J., Gilewski, W., Sinkiewicz, W., Furman, A., Zalewski, J., Nessler, J., Bury, K., Grzegorzko, A., Zabojszcz, M., Mirek Bryniarska, E., Klys, J., Przybylska, K., Szulik, M., Kalarus, Z., Kuczaj, A., Nowalany Kozielska, E., Krzeminski, A., Ventosa, A., Tavares Aguiar, C., Moura, B., Cardoso, J. S., De Jesus, I., Chin, J., Faria, R., Pereira, S., Lima, Giuseppe, Oliveira Guimarães, T., Francisco, A. R., Brito, D., Placido, R., Martins, S., Fonseca, C., Marques, F., Araujo, I., Proenca, M., Cardiga, R., Andrade, A., Castro, Alessandra, Pereira, A., Queirós, C., Silva, P., Santos, R., Lourenço, C., Moreno, N., Almeida, F., Quelhas, I., Baptista, A., Ferreira, A., Magalhaes, P., Ferreira, Clara, Moreira, I., Durao, D., Severino, D., Ferreira Da Silva, G., Marta, L., Peres, Martina, Stanescu, C., Dan, A., Dan, G. A., Daha, I., Popescu, R., Vinereanu, D., Sinescu, C. J., Macarie, C., Radoi, M., Nechita, E., Christodorescu, R., Datcu, M., Craiu, E., Otasevic, P., Ristic, A. D., Simeunovic, D., Seferovic, P., Pencic, B., Andric, A., Stojcevski, B., Lebedinski, E., Suzic Lazic, J., Celic, V., Krotin, M., Radovanovic, Slavena, Iric Cupic, V., Milanov, S., Davidovic, G., Jovic, Masa, Radin, A., Mihajlovic, B., Stojiljkovic, J., Cankovic, M., Cemerlic Adic, N., Dodic, Sara, Kecojevic, S., Stojsic, S., Petrovic, D., Deljanin Ilic, M., Ilić, Saša, Stoickov, V., Antic, S., Stanojevic, D., Pavlovic, M., Atanaskovic, V., Mitic, Vanja, Kovar, F., Goncalvesova, E., Murin, J., Pernicky, M., Klabnik, A., Kmec, J., Rajtman, D., Kovac, D., Horvat, Sara, Krunic, B., Bombek, M., Krajnc, I., Losic, R., Glavic, T., Komel, Janja, Cernic Suligoj, N., Ravnikar, T., Letonja, M., Cencic, Vanja, Savnik Iskra, M., Strasek, M., Leskovar, B., Drnovsek, B., Klen, J., Marolt, A., Kladnik, M., Slemenik Pusnik, C., Pusnik Vrckovnik, M., Jug, Barbara, Fras, Z., Bartolic, Andrej, Melihen Bartolic, C., Valentincic, M., Winkler, R., Blanco Canosa, P., Grille Cancela, Z., Crespo Leiro, M., Paniagua Martin, M. J., Marzoa Rivas, R., Barge Caballero, E., Torres Calvo, F., Bravo Marques, R., Epelde Gonzalo, F., Recio Platero, A., De La Fuente Galan, L., Lopez Diaz, J., Goncalvez Ramirez, L. Renier, Cubero Gallego, H., Sliwiski Herrera, J. F., Bierge Valero, D., Salmeron, F. M., Gallego Page, J. C., Jose Fernandez, M., Sahuquillo, A., Garcia De La Villa, B., Castro Conde, A., Iniesta Manjavacas, A. M., Salvador Montanes, O., Gonzalez Gallarza, R. Dalmau, Ofelia Rosillo, S., Araujo, A., Briceno, A., Alonso Pulpon, L., Cobo, M., Soria, T., Gomez Bueno, M., Garcia Pavia, P., Gonzalez Segovia, A., Sayago, I., Segovia Cubero, J., Delgado Jiménez, J. F., Angel Gomez Sanchez, M., Escribano Subias, P., Barrios Garrido Lestache, E., Ruiz Cano, M. J., Vicente Hernandez, M., Puga Martinez, M., Lopez Moreno, E., Serrano Martinez, J. L., Fernandez Alvarez, M., Rivera Lopez, R., Lopez Fernandez, S., Alcade Martinez, V., Sanmartin, M., Pellicer Cabo, A., Garcia Escriva, D., Ridocci Soriano, F., Perez Silvestre, J., Facila Rubio, L., Garcia Gonzalez, P., Sanchez Lazaro, I. J., Almenar Bonet, L., Garcia Pinilla, J. M., Andres, Ulrike Julia, Bayes Genis, A., Roig, E., Mirabet, S., Mendez, A., Garcia Cosio, L., Garay, A., Muntane, G., Gonzalez Costello, J., Leon, V., Diaz Molina, B., Famara Hernandez, I., Lara Padron, A., Laynez Cerdena, I., Mateo, I., Quiles, J., Bertomeu, V., Elamrani, A., Angel Rodrigez Ortega, J., Martinez Abellan, R., Valero, R., Fernandez Vivancos, C., Sanz Julve, M., Perez Martinez, M. T., Pascual Figal, D. A., Martinez Martinez Espejo, M. D., Rosario Gracia Rodenas, M., Pastor Perez, F., Melin, M., Hägglund, E., Stenberg, A., Lindahl, I. M., Asserlund, B., Olsson, L., Dahlström, U., Afzelius, M., Karlström, P., Tengvall, L., Wiklund, P. A., Olsson, B., Temizhan, A., Kalayci, S., Bozkurt, M., Taraktas, M., Cavusoglu, Y., Gunes, H., Birhan Yilmaz, M., Demir, B., and Gencer, E.

Subjects
Registrie, Male, ACE inhibitors, Angiotensin-Converting Enzyme Inhibitors, Nitrate, Beta-blockers, Ambulatory Care, Medicine, Registries, Diuretics, Mineralocorticoid Receptor Antagonists, Angiotensin Receptor Antagonist, Middle Aged, Defibrillators, Implantable, Clinical Practice, Europe, Hospitalization, Ambulatory, MRAs, Practice Guidelines as Topic, MRA, Cardiology, CRT, Female, Guideline Adherence, Implantable, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, Cardiotonic Agents, cardiology and cardiovascular mediciney, Mineralocorticoid Antagonists, Adrenergic beta-Antagonists, Heart failure, ICD, Aged, Angiotensin Receptor Antagonists, Heart Failure, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Nitrates, Platelet Aggregation Inhibitors, Drug treatment, ACE inhibitor, Internal medicine, Diuretic, Cardiotonic Agent, In patient, Beta-blocker, Mineralocorticoid Receptor Antagonist, business.industry, Platelet Aggregation Inhibitor, beta-blockers, heart failure, adrenergic beta-antagonists, aged, ambulatory care, angiotensin receptor antagonists, angiotensin-converting enzyme inhibitors, cardiology, cardiotonic agents, defibrillators, implantable, diuretics, europe, female, guideline adherence, hospitalization, humans, hydroxymethylglutaryl-coa reductase inhibitors, male, middle aged, mineralocorticoid receptor antagonists, nitrates, platelet aggregation inhibitors, practice guidelines as topic, registries, Adrenergic beta-Antagonist, Angiotensin-Converting Enzyme Inhibitor, Guideline, medicine.disease, Observational study, Hydroxymethylglutaryl-CoA Reductase Inhibitor, business, Defibrillators
Abstract

AimsTo evaluate how recommendations of European guidelines regarding pharmacological and non-pharmacological treatments for heart failure (HF) are adopted in clinical practice.Methods and resultsThe ESC-HF Long-Term Registry is a prospective, observational study conducted in 211 Cardiology Centres of 21 European and Mediterranean countries, members of the European Society of Cardiology (ESC). From May 2011 to April 2013, a total of 12 440 patients were enrolled, 40.5% with acute HF and 59.5% with chronic HF. Intravenous treatments for acute HF were heterogeneously administered, irrespective of guideline recommendations. In chronic HF, with reduced EF, renin-angiotensin system (RAS) blockers, beta-blockers, and mineralocorticoid antagonists (MRAs) were used in 92.2, 92.7, and 67.0% of patients, respectively. When reasons for non-adherence were considered, the real rate of undertreatment accounted for 3.2, 2.3, and 5.4% of the cases, respectively. About 30% of patients received the target dosage of these drugs, but a documented reason for not achieving the target dosage was reported in almost two-thirds of them. The more relevant reasons for non-implantation of a device, when clinically indicated, were related to doctor uncertainties on the indication, patient refusal, or logistical/cost issues.ConclusionThis pan-European registry shows that, while in patients with acute HF, a large heterogeneity of treatments exists, drug treatment of chronic HF can be considered largely adherent to recommendations of current guidelines, when the reasons for non-adherence are taken into account. Observations regarding the real possibility to adhere fully to current guidelines in daily clinical practice should be seriously considered when clinical practice guidelines have to be written. © 2013 Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2013. For permissions please email: journals.permissions@oup.com

Published
2013

23. Poster session 2: Thursday 4 December 2014, 08:30-12:30Location: Poster area

Author

Domingos, J, Augustine, D, Leeson, P, Noble, J, Doan, HL, Boubrit, L, Cheikh-Khalifa, R, Laveau, F, Djebbar, M, Pousset, F, Isnard, R, Hammoudi, N, Lisi, M, Cameli, M, Di Tommaso, C, Curci, V, Reccia, R, Maccherini, M, Henein, MY, Mondillo, S, Leitman, M, Vered, Z, Rashid, H, Yalcin, MU, Gurses, KM, Kocyigit, D, Evranos, B, Yorgun, H, Sahiner, L, Kaya, B, Aytemir, K, Ozer, N, Bertella, E, Petulla', M, Baggiano, A, Mushtaq, S, Russo, E, Gripari, P, Innocenti, E, Andreini, D, Tondo, C, Pontone, G, Necas, J, Kovalova, S, Hristova, K, Shiue, I, Bogdanva, V, Teixido Tura, G, Sanchez, V, Rodriguez-Palomares, J, Gutierrez, L, Gonzalez-Alujas, T, Garcia-Dorado, D, Forteza, A, Evangelista, A, Timoteo, AT, Aguiar Rosa, S, Cruz Ferreira, R, Campbell, R, Carrick, D, Mccombe, C, Tzemos, N, Berry, C, Sonecki, P, Noda, M, Setoguchi, M, Ikenouchi, T, Nakamura, T, Yamamoto, Y, Murakami, T, Katou, Y, Usui, M, Ichikawa, K, Isobe, M, Kwon, B, Roh, J, Kim, H, Ihm, S, Barron, AJ, Francis, D, Mayet, J, Wensel, R, Kosiuk, J, Dinov, B, Bollmann, A, Hindricks, G, Breithardt, O, Rio, P, Moura Branco, L, Galrinho, A, Cacela, D, Pinto Teixeira, P, Afonso Nogueira, M, Pereira-Da-Silva, T, Abreu, J, Teresa Timoteo, A, Pavlyukova, E, Tereshenkova, E, Karpov, R, Piatkowski, R, Kochanowski, J, Opolski, G, Barbier, P, Mirea, O, Guglielmo, M, Savioli, G, Cefalu, C, Pudil, R, Horakova, L, Rozloznik, M, Balestra, C, Rimbas, R, Enescu, O, Calin, S, Vinereanu, D, Karsenty, C, Hascoet, S, Hadeed, K, Semet, F, Dulac, Y, Alacoque, X, Leobon, B, Acar, P, Dharma, S, Sukmawan, R, Soesanto, A, Vebiona, K, Firdaus, I, Danny, S, Driessen, MM, Sieswerda, G, Post, M, Snijder, R, Van Dijk, A, Leiner, T, Meijboom, F, Chrysohoou, C, Tsitsinakis, G, Tsiachris, D, Aggelis, A, Herouvim, E, Vogiatzis, I, Pitsavos, C, Koulouris, G, Stefanadis, C, Erdei, T, Edwards, J, Braim, D, Yousef, Z, Fraser, A, Avenatti, E, Magnino, C, Omede', P, Presutti, D, Moretti, C, Iannaccone, A, Ravera, A, Gaita, F, Milan, A, Veglio, F, Scali, M, Simioniuc, A, Fusini, L, Dini, F, Okura, H, Murata, E, Kataoka, T, Mikaelpoor, A, Ojaghi Haghighi, S, Alizadeasl, A, Sharifi-Zarchi, A, Zaroui, A, Ben Halima, M, Mourali, M, Mechmeche, R, Rodriguez Palomares, JF, Maldonado, G, Garcia, G, Otaegui, I, Garcia Del Blanco, B, Teixido, G, Gonzalez Alujas, M, Garcia Dorado, D, Godinho, AR, Correia, A, Rangel, I, Rocha, A, Rodrigues, J, Araujo, V, Almeida, P, Macedo, F, Maciel, M, Rekik, B, Mghaieth, F, Aloui, H, Boudiche, S, Jomaa, M, Ayari, J, Tabebi, N, Farhati, A, Mourali, S, Dekleva, M, Markovic-Nikolic, N, Zivkovic, M, Stankovic, A, Boljevic, D, Korac, N, Beleslin, B, Arandjelovic, A, Ostojic, M, Galli, E, Guirette, Y, Auffret, V, Daudin, M, Fournet, M, Mabo, P, Donal, E, Chin, CW, Luo, E, Hwan, J, White, A, Newby, D, Dweck, M, Carstensen, HG, Larsen, LH, Hassager, C, Kofoed, KF, Jensen, JS, Mogelvang, R, Kowalczyk, M, Debska, M, Kolesnik, A, Dangel, J, Kawalec, W, Migliore, R, Adaniya, M, Barranco, M, Miramont, G, Gonzalez, S, Tamagusuku, H, Davidsen, ES, Kuiper, KK, Matre, K, Gerdts, E, Igual Munoz, B, Maceira Gonzalez, A, Erdociain Perales, M, Estornell Erill, J, Valera Martinez, F, Miro Palau, V, Piquer Gil, M, Sepulveda Sanchez, P, Cervera Zamora, A, Montero Argudo, A, Placido, R, Silva Marques, J, Magalhaes, A, Guimaraes, T, Nobre E Menezes, M, Goncalves, S, Ramalho, A, Robalo Martins, S, Almeida, A, Nunes Diogo, A, Abid, L, Ben Kahla, S, Charfeddine, S, Abid, D, Kammoun, S, Tounsi, A, Hammami, R, Triki, F, Akrout, M, Mallek, S, Hentati, M, Sirbu, CF, Berrebi, A, Huber, A, Folliguet, T, Yang, LT, Shih, J, Liu, Y, Li, Y, Tsai, L, Luo, C, Tsai, W, Babukov, R, Bartosh, F, Bazilev, V, Muraru, D, Cavalli, G, Addetia, K, Miglioranza, M, Veronesi, F, Mihaila, S, Tadic, M, Cucchini, U, Badano, L, Lang, R, Miyazaki, S, Slavich, M, Miyazaki, T, Figini, F, Lativ, A, Chieffo, A, Montrfano, M, Alfieri, O, Colombo, A, Agricola, E, Liu, D, Hu, K, Herrmann, S, Stoerk, S, Kramer, B, Ertl, G, Bijnens, B, Weidemann, F, Brand, M, Butz, T, Tzikas, S, Van Bracht, M, Roeing, J, Wennemann, R, Christ, M, Grett, M, Trappe, HJ, Scherzer, S, Geroldinger, A, Krenn, L, Roth, C, Gangl, C, Maurer, G, Rosenhek, R, Neunteufl, T, Binder, T, Bergler-Klein, J, Martins, E, Pinho, T, Leite, S, Azevedo, O, Belo, A, Campelo, M, Amorim, S, Rocha-Goncalves, F, Goncalves, L, Silva-Cardoso, J, Ahn, H, Kim, K, Jeon, H, Youn, H, Haland, T, Saberniak, J, Leren, I, Edvardsen, T, Haugaa, K, Ziolkowska, L, Boruc, A, Turska-Kmiec, A, Zubrzycka, M, Monivas Palomero, V, Mingo Santos, S, Goirigolzarri Artaza, J, Rodriguez Gonzalez, E, Rivero Arribas, B, Castro Urda, V, Dominguez Rodriguez, F, Mitroi, C, Gracia Lunar, I, Fernadez Lozano, I, Palecek, T, Masek, M, Kuchynka, P, Fikrle, M, Spicka, I, Rysava, R, Linhart, A, Hasselberg, N, Borgquist, R, Platonov, P, Ancona, R, Comenale Pinto, S, Caso, P, Coopola, M, Arenga, F, Rapisarda, O, D'onofrio, A, Sellitto, V, Calabro, R, Rosca, M, Popescu, B, Calin, A, Mateescu, A, Beladan, C, Jalba, M, Rusu, E, Zilisteanu, D, Ginghina, C, Pressman, G, Cepeda-Valery, B, Romero-Corral, A, Moldovan, R, Saenz, A, Orban, M, Samuel, S, Fijalkowski, M, Fijalkowska, M, Gilis-Siek, N, Blaut, K, Galaska, R, Sworczak, K, Gruchala, M, Nowak, R, Ikonomidis, I, Triantafyllidi, H, Trivilou, P, Tzortzis, S, Papadopoulos, C, Pavlidis, G, Paraskevaidis, I, Lekakis, J, Padiyath, A, Li, L, Xiao, Y, Danford, D, Kutty, S, Kaymaz, C, Aktemur, T, Poci, N, Ozturk, S, Akbal, O, Yilmaz, F, Tokgoz Demircan, H, Kirca, N, Tanboga, I, Ozdemir, N, Greiner, S, Jud, A, Aurich, M, Hess, A, Hilbel, T, Hardt, S, Katus, H, D'ascenzi, F, Alvino, F, Focardi, M, Solari, M, Bonifazi, M, Konopka, M, Krol, W, Klusiewicz, A, Burkhard, K, Chwalbinska, J, Pokrywka, A, Dluzniewski, M, Braksator, W, King, GJ, Coen, K, Gannon, S, Fahy, N, Kindler, H, Clarke, J, Iliuta, L, Rac-Albu, M, Cortez-Dias, N, Francisco, A, Silva, G, Kyu, K, Kong, W, Songco, G, Galupo, M, Castro, M, Shin Hnin, W, Ronald Lee, C, Poh, K, Milazzo, V, Di Stefano, C, Tosello, F, Leone, D, Sabia, L, Sobrero, G, Maule, S, Jamiel, AM, Ahmed, AM, Farah, I, Al-Mallah, MH, Petroni, R, Magnano, R, Bencivenga, S, Di Mauro, M, Petroni, S, Altorio, S, Romano, S, Penco, M, Kumor, M, Lipczynska, M, Klisiewicz, A, Wojcik, A, Konka, M, Kozuch, K, Szymanski, P, Hoffman, P, Rimbas, M, Reynaud, A, Lund, L, Persson, H, Hage, C, Oger, E, Linde, C, Daubert, J, Maria Oliveira Lima, M, Costa, H, Gomes Da Silva, M, Noman Alencar, M, Carmo Pereira Nunes, M, Costa Rocha, M, Siala, A, Ozawa, K, Funabashi, N, Takaoka, H, Kobayashi, Y, Matsumura, Y, Wada, M, Hirakawa, D, Yasuoka, Y, Morimoto, N, Takeuchi, H, Kitaoka, H, Sugiura, T, Lakkas, L, Naka, K, Ntounousi, E, Gkirdis, I, Koutlas, V, Bechlioulis, A, Pappas, K, Katsouras, C, Siamopoulos, K, Michalis, L, Evangelou, D, Kalaitzidis, R, Tzeltzes, G, Nakas, G, Generati, G, Bandera, F, Pellegrino, M, Labate, V, Alfonzetti, E, Guazzi, M, Zagatina, A, Zhuravskaya, N, Al-Mallah, M, Alsaileek, A, Qureshi, W, Peyre, M, Amadieu, R, Yamanaka, Y, Sotomi, Y, Iwakura, K, Inoue, K, Toyoshima, Y, Tanaka, K, Oka, T, Tanaka, N, Orihara, Y, Fujii, K, Soulat-Dufour, L, Lang, S, Boyer-Chatenet, L, Van Der Vynckt, C, Ederhy, S, Adavane, S, Haddour, N, Boccara, F, Cohen, A, Huitema, M, Boerman, S, Vorselaars, V, Grutters, J, Gopal, AS, Saha, S, Toole, R, Kiotsekoglou, A, Cao, J, Reichek, N, Meyer, CG, Altiok, E, Al Ateah, G, Lehrke, M, Becker, M, Lotfi, S, Autschbach, R, Marx, N, Hoffmann, R, Frick, M, Nemes, A, Sepp, R, Kalapos, A, Domsik, P, Forster, T, Caro Codon, J, Blazquez Bermejo, Z, Lopez Fernandez, T, Valbuena Lopez, SC, Iniesta Manjavacas, AM, De Torres Alba, F, Dominguez Melcon, F, Pena Conde, L, Moreno Yanguela, M, Lopez-Sendon, JL, Lengyel, C, Orosz, A, Varkonyi, T, Rendon, J, Saldarriaga, CI, Duarte, N, Foldeak, D, Borbenyi, Z, Hamdy, A, Fereig, H, Nabih, M, Abdel-Aziz, A, Ali, A, Broyd, C, Wielandts, JY, De Buck, S, Michielsen, K, Louw, R, Garweg, C, Nuyts, J, Ector, J, Maes, F, Heidbuchel, H, Gillis, K, Bala, G, Tierens, S, Cosyns, B, Maurovich-Horvat, P, Horvath, T, Jermendy, A, Celeng, C, Panajotu, A, Bartykowszki, A, Karolyi, M, Tarnoki, A, Jermendy, G, and Merkely, B

Subjects
medicine.medical_specialty, biology, Early Repolarization Pattern, business.industry, Athletes, Physical therapy, medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine, business, biology.organism_classification
Published
2014

25. Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial

Author

Nicholls, Stephen J., Kastelein, John J. P., Schwartz, Gregory G., Bash, Dianna, Rosenson, Robert S., Cavender, Matthew A., Brennan, Danielle M., Koenig, Wolfgang, Jukema, J. Wouter, Nambi, Vijay, Wright, R. Scott, Menon, Venu, Lincoff, A. Michael, Nissen, Hennekens C, Steven E., Brown, Wv, Demets, D, Pfeffer, M, Roleau, J, Abraham, J, Gebel, J, Huff, C, Katzan, I, Shishehbor, M, Rassi, A, Uchino, K, Vest, A, Zishiri, E, Heckman, Mj, Balog, C, Dart, A, Amerena, J, Prasad, C, Farshid, A, Gunalingam, B, Thompson, P, Collins, N, Arstall, M, van Gaal, W, Aroney, C, Mahar, L, Youssef, G, Horowitz, J, Anand, D, Rodes-Cabau, J, Polasek, P, Lai, C, Huynh, T, Hubacek, J, Kokis, A, Paradis, Jm, Mukherjee, A, Senaratne, M, Constance, C, Gosselin, G, Lavi, S, Parker, J, Zadra, R, Abramson, B, Della-Siega, A, Spinar, J, Pudil, R, Motovska, Z, Maly, M, Hutyra, M, Pleva, L, Mayer, O, Semenka, J, Klimovic, T, Horak, D, Cervinka, P, Klimsa, Z, Hulinsky, V, Reichert, P, Monhart, Z, Rotterova, H, Kobulia, B, Shaburishvili, T, Mamatsashvili, M, Chapidze, G, Chumburidze, V, Megreladze, I, Khintibidze, I, Leithäuser, B, Voehringer, Hf, Wachter, R, Nogai, K, Lapp, H, Haltern, G, Gielen, S, Dorsel, T, Möllmann, H, Stellbrink, C, Hengstenberg, C, Dengler, T, Heuer, H, Kreuzer, J, Leschke, M, Mudra, H, Werner, N, Braun-Dullaeus, R, Rosenberg, M, Frey, N, Koenig, W, Strasser, R, Genth-Zotz, S, Kiss, R, Nagy, A, Kovacs, Z, Csapo, K, Edes, I, Sereg, M, Vertes, A, Ronaszeki, A, Kancz, S, Benczur, B, Polgar, P, Muller, G, Simonyi, G, Dezsi, C, Merkely, B, Dinnyes, J, Lupkovics, G, Kahali, D, Banker, D, Trivedi, S, Rajput, R, Premchand, R, Dani, S, Vadaganelli, P, Gupta, S, Chandra, S, Fulwani, M, Chawla, K, Parikh, K, Prati, F, Speciale, G, Valgimigli, M, Suriano, P, Sangiorgi, G, Fineschi, M, Merenda, R, Marenzi, G, Berti, S, Corrada, E, Cuccia, C, Testa, R, Moretti, L, Mennuni, M, Biasucci, Lm, Lioy, E, Auguadro, C, Magagnini, E, Fedele, F, Piscione, F, Azar, R, Trip, Md, Liem, A, den Hartoog, M, Lenderink, T, van de Wetering ML, Lok, D, Oei, F, Tans, Jg, Ilmer, B, Keijzers, M, Monraats, P, Kedhi, E, Breedveld, Rw, Herrman, J, van Wijk, L, Ronner, E, Nierop, P, Bosschaert, M, Hermans, W, Doevendans, P, Troquay, R, van der Heijden, R, Veen, G, Bokern, Mj, Bronzwaer, Pn, Kie, Sh, Den Hartog, F, Elliott, J, Wilkins, G, Hart, H, Devlin, G, Harding, S, Ponikowski, P, Madej, A, Kochmanski, M, Witkowski, A, Pluta, W, Bronisz, M, Kornacewicz-Jach, Z, Wysokinski, A, Ujda, M, Drozdz, J, Derlaga, B, Gessek, J, Dabrowski, M, Miekus, P, Kozlowski, A, Gniot, J, Musial, W, Dobrzycki, S, Rynkiewicz, A, Psuja, P, Rekosz, J, Drzewiecki, A, Kuznetsov, V, Gordeev, I, Goloshchekin, B, Markov, V, Barbarich, V, Belenky, D, Mikhin, V, Volkova, E, Timofeev, A, Ermoshkina, L, Barbarash, O, Klein, G, Libis, R, Vishnevsky, A, Linev, K, Khaisheva, L, Ruda, M, Dovgalevskiy, Y, Shvarts, Y, Zateyshchikov, D, Kostenko, V, Shalnev, V, Simanenkov, V, Arkhipov, M, Ovcharenko, E, Guseva, G, Akhunova, S, Ortiz, Ai, Navarro, Mj, Romero, Aj, Goya, Il, Peñaranda, As, Cendon, Aa, Rubio, Am, Zubiri, Jj, Soriano, Fr, Sanz, Rr, Genís, Ab, Lago, Vn, Fernández, Jd, Romo, Ai, Franco, Sn, Martin, Ih, Montero, Js, Martin Mde, M, González, Mj, Antolin, Jm, Areses, El, Miranda, Jm, Alonso-Pulpón, L, Esquivias, Gb, Jarne, Ef, Cortés, Jm, Pérez, Mb, Gormaz, Cl, Alegret, Jm, Nava, Js, Ingelmo, Jm, Urbano, Rh, Sanmartín, M, Katerenchuk, O, Vakaliuk, I, Karpenko, O, Prokhorov, O, Koval, O, Faynyk, A, Kopytsya, M, Karpenko, Y, Kraiz, I, Feskov, O, Rudenko, L, Kozhukhov, S, Goloborodko, B, Rivera, E, Broadwater, S, Crowley, S, Vijay, N, Goswami, R, Ferrier, L, Blanchard, A, Mccullum, K, Chernick, R, Bertolet, B, Battaglia, J, Richardson, J, Lochridge, S, Lieberman, S, Amkieh, A, Cavender, Jb, Denning, S, Treasure, C, Kmetzo, J, Stillabower, M, Brilakis, E, Schwartz, G, Acheatel, R, Kukuy, E, Ashchi, M, Skelding, K, Martin, L, Gillespie, E, French, W, Pollock, S, Polk, D, Black, R, Drenning, D, Anderson, J, Sanz, M, Korban, E, Wiley, M, Rezkalla, S, Minisi, A, Shah, A, Silverman, P, Amlani, M, Eaton, G, Brown, A, Jay, D, Loussararian, A, Lamas, G, Lauer, M, Williams, J, Asfour, A, Runquist, L, Robertson, R, Blonder, R, Davies, C, Downes, T, Chronos, N, Marso, S, Haldis, T, Eich, D, Ahmed, M, East, C, Macdonald, L, Seigel, P, White, M, Camp, A, Kleiman, N, Burtt, D, Strain, J, Go, B, Henry, P, Sultan, P, Delafontaine, P, Kashou, H, Lambert, C, Movahed, M, Saucedo, J, Thadani, U, Chandrashekhar, Y, Lu, D, Chandna, H, Mann, J, Ramaswamy, G, Browne, K, Janik, M, Cannon, K, Tolerico, P., Berni, Andrea, ACS - Amsterdam Cardiovascular Sciences, Vascular Medicine, and Cardiology

Subjects
Male, Indoles, Acetates, Acute Coronary Syndrome, Aged, Angina, Unstable, Atherosclerosis, Double-Blind Method, Early Termination of Clinical Trials, Female, Heptanoic Acids, Humans, Middle Aged, Phospholipases A, Phospholipases A2, Secretory, Pyrroles, Risk, Stroke, Survival Analysis, Treatment Outcome, Myocardial Infarction, law.invention, chemistry.chemical_compound, Randomized controlled trial, law, Atorvastatin, Clinical endpoint, Medicine (all), General Medicine, Angina, Keto Acids, medicine.medical_specialty, Acute coronary syndrome, Placebo, Unstable, Internal medicine, Multicenter trial, medicine, Atorvastatin Calcium, Unstable angina, business.industry, Secretory, medicine.disease, Interim analysis, Surgery, Phospholipases A2, chemistry, Varespladib, business
Abstract

Importance Secretory phospholipase A 2 (sPLA 2 ) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA 2 inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes is unknown. Objective To determine the effects of sPLA 2 inhibition with varespladib on cardiovascular outcomes. Design, Setting, and Participants A double-blind, randomized, multicenter trial at 362 academic and community hospitals in Europe, Australia, New Zealand, India, and North America of 5145 patients randomized within 96 hours of presentation of an acute coronary syndrome (ACS) to either varespladib (n = 2572) or placebo (n = 2573) with enrollment between June 1, 2010, and March 7, 2012 (study termination on March 9, 2012). Interventions Participants were randomized to receive varespladib (500 mg) or placebo daily for 16 weeks, in addition to atorvastatin and other established therapies. Main Outcomes and Measures The primary efficacy measure was a composite of cardiovascular mortality, nonfatal myocardial infarction (MI), nonfatal stroke, or unstable angina with evidence of ischemia requiring hospitalization at 16 weeks. Six-month survival status was also evaluated. Results At a prespecified interim analysis, including 212 primary end point events, the independent data and safety monitoring board recommended termination of the trial for futility and possible harm. The primary end point occurred in 136 patients (6.1%) treated with varespladib compared with 109 patients (5.1%) treated with placebo (hazard ratio [HR], 1.25; 95% CI, 0.97-1.61; log-rank P = .08). Varespladib was associated with a greater risk of MI (78 [3.4%] vs 47 [2.2%]; HR, 1.66; 95% CI, 1.16-2.39; log-rank P = .005). The composite secondary end point of cardiovascular mortality, MI, and stroke was observed in 107 patients (4.6%) in the varespladib group and 79 patients (3.8%) in the placebo group (HR, 1.36; 95% CI, 1.02-1.82; P = .04). Conclusions and Relevance In patients with recent ACS, varespladib did not reduce the risk of recurrent cardiovascular events and significantly increased the risk of MI. The sPLA 2 inhibition with varespladib may be harmful and is not a useful strategy to reduce adverse cardiovascular outcomes after ACS. Trial Registration clinicaltrials.gov Identifier:NCT01130246

Published
2014

27. Use of multiple biomarkers for evaluation of anthracycline-induced cardiotoxicity in patients with acute myeloid leukemia

Author

Horacek, J. M., Tichy, M., Jebavy, L., Pudil, R., Ulrychova, M., and Jaroslav Malý

Subjects
Uncategorized
Abstract

To assess cardiac toxicity of anthracycline treatment with six biomarkers of cardiac injury: myoglobin, creatine kinase MB (CK-MB mass), cardiac troponin T (cTnT), cardiac troponin I (cTnI), heart-type fatty acid binding protein (H-FABP), glycogen phosphorylase BB (GPBB). Methods: We evaluated anthracycline-induced cardiotoxicity in 12 acute myeloid leukemia patients (mean age 51.3 ± 10.7 years, 7 females). All biomarkers were measured at the baseline, after first chemotherapy (CT) with anthracyclines, after last CT with anthracyclines (total cumulative dose 479.8 ± 106.2 mg/m2) and 6 months thereafter. Values above the reference range were considered elevated. Results: GPBB increased above the cut-off (7.30 µg/L) in 2 (16.7%) patients after first CT, in 3 (25.0%) patients after last CT and remained elevated in 2 (16.7%) patients within 6 months after CT. CTnI became elevated (above 0.40 µg/L) in 1 (8.3%) patient after first and last CT and within 6 months after CT. CTnT remained negative (below 0.01 µg/L) during CT in all patients. Six months after CT, delayed cTnT positivity was found in 1 (8.3%) patient. All patients with cTnI or cTnT positivity had elevated GPBB. Other biomarkers (myoglobin, CK-MB mass, H-FABP) remained within the reference range in all patients. Conclusion: Our preliminary results suggest that GPBB could be a new promising marker for detection of anthracycline-related cardiotoxicity and probably superior to cardiac troponins. The predictive value for development of cardiomyopathy in the future is not clear and will be evaluated during a prospective follow-up. Цель: провести оценку кардиотоксичности, вызываемой антрациклином, с помощью ряда биомаркеров поражения сердца: миоглобина, креатин-киназы MB (CK-MB mass), кардиального тропонина T (cTnT), кардиального тропонина I (cTnI), белка, связывающего жирные кислоты (H-FABP), и гликогенфосфорилазы BB (GPBB). Методы: оценку кардиотоксичности проводили у 12 больных острой миелоидной лейкемией (средний возраст — 51,3 ± 10,7 года, 7 женщин). Измерены начальные показатели всех биомаркеров, а также таковые после проведения первой и последней химиотерапии (ХT) антрациклинами (общая накопленная доза — 479,8 ± 106,2 мг/м2 ) и через 6 мес после завершения терапии. Значения выше начальных рассматривали как повышенные. Результаты: уровень GPBB превысил норму (7,30 µg/L) у 2 больных (16,7%) после первой ХT, у 3 (25,0%) — после последней ХT и оставался повышенным у 2 больных (16,7%) и через 6 мес после ХT. Уровень CTnI повысился (более 0,40 µg/L) у 1 больного (8,3%) после первой и последней ХT, а также и через 6 мес после ХT. Значения CTnT оставались в пределах нормы (ниже 0,01 µg/L) во время проведения CT у всех пациентов. Через 6 мес после ХT отдаленная положительная реакция на cTnT выявлена у 1 больного (8,3%). У всех пациентов с положительными cTnI или cTnT установлен повышенный уровень GPBB. Другие биомаркеры (миоглобин, CK-MB, H-FABP) оставались в пределах нормы у всех больных. Выводы: предварительные результаты, полученные в данном исследовании, позволяют предположить, что GPBB можно рассматривать как новый перспективный маркер для выявления кардиотоксичности, вызванной антрациклинами, и, возможно, превосходит предложенные ранее тропонины. Возможная прогностическая ценность этого маркера при развитии кардиомиопатии пока не установлена.

Published
2008

29. Varespladib and cardiovascular events in patients with an acute coronary syndrome: The VISTA-16 randomized clinical trial

Author

Nicholls, SJ, Kastelein, JJP, Schwartz, GG, Bash, D, Rosenson, RS, Cavender, MA, Brennan, DM, Koenig, W, Jukema, JW, Nambi, V, Wright, RS, Menon, V, Lincoff, AM, Nissen, SE, Hennekens, C, Brown, WV, DeMets, D, Pfeffer, M, Roleau, J, Abraham, J, Gebel, J, Huff, C, Katzan, I, Shishehbor, M, Rassi, A, Uchino, K, Vest, A, Zishiri, E, Heckman, MJ, Balog, C, Dart, A, Amerena, John, Prasad, C, Farshid, A, Gunalingam, B, Thompson, P, Collins, N, Arstall, M, van Gaal, W, Aroney, C, Mahar, L, Youssef, G, Horowitz, J, Anand, D, Rodes-Cabau, J, Polasek, P, Lai, C, Huynh, T, Hubacek, J, Kokis, A, Paradis, JM, Mukherjee, A, Senaratne, M, Constance, C, Gosselin, G, Lavi, S, Parker, J, Zadra, R, Abramson, B, Della-Siega, A, Spinar, J, Pudil, R, Motovska, Z, Maly, M, Hutyra, M, Pleva, L, Mayer, O, Semenka, J, Klimovic, T, Horak, D, Cervinka, P, Klimsa, Z, Hulinsky, V, Reichert, P, Monhart, Z, Rotterova, H, Kobulia, B, Shaburishvili, T, Mamatsashvili, M, Chapidze, G, Chumburidze, V, Megreladze, I, Khintibidze, I, Leithäuser, B, Voehringer, HF, Wachter, R, Nogai, K, Lapp, H, Haltern, G, Gielen, S, Dorsel, T, Möllmann, H, Stellbrink, C, Hengstenberg, C, Dengler, T, Heuer, H, Kreuzer, J, Leschke, M, Mudra, H, Werner, N, Nicholls, SJ, Kastelein, JJP, Schwartz, GG, Bash, D, Rosenson, RS, Cavender, MA, Brennan, DM, Koenig, W, Jukema, JW, Nambi, V, Wright, RS, Menon, V, Lincoff, AM, Nissen, SE, Hennekens, C, Brown, WV, DeMets, D, Pfeffer, M, Roleau, J, Abraham, J, Gebel, J, Huff, C, Katzan, I, Shishehbor, M, Rassi, A, Uchino, K, Vest, A, Zishiri, E, Heckman, MJ, Balog, C, Dart, A, Amerena, John, Prasad, C, Farshid, A, Gunalingam, B, Thompson, P, Collins, N, Arstall, M, van Gaal, W, Aroney, C, Mahar, L, Youssef, G, Horowitz, J, Anand, D, Rodes-Cabau, J, Polasek, P, Lai, C, Huynh, T, Hubacek, J, Kokis, A, Paradis, JM, Mukherjee, A, Senaratne, M, Constance, C, Gosselin, G, Lavi, S, Parker, J, Zadra, R, Abramson, B, Della-Siega, A, Spinar, J, Pudil, R, Motovska, Z, Maly, M, Hutyra, M, Pleva, L, Mayer, O, Semenka, J, Klimovic, T, Horak, D, Cervinka, P, Klimsa, Z, Hulinsky, V, Reichert, P, Monhart, Z, Rotterova, H, Kobulia, B, Shaburishvili, T, Mamatsashvili, M, Chapidze, G, Chumburidze, V, Megreladze, I, Khintibidze, I, Leithäuser, B, Voehringer, HF, Wachter, R, Nogai, K, Lapp, H, Haltern, G, Gielen, S, Dorsel, T, Möllmann, H, Stellbrink, C, Hengstenberg, C, Dengler, T, Heuer, H, Kreuzer, J, Leschke, M, Mudra, H, and Werner, N

Published
2014

34. Abstracts

Author

Barthelemy, O., primary, Silvain, J., additional, Brieger, D., additional, Bellemain-Appaix, A., additional, Cayla, G., additional, Beygui, F., additional, Lancar, R., additional, Collet, J. P., additional, Mercadier, A., additional, Montalescot, G., additional, Cha, K. S., additional, Nam, Y. H., additional, Kim, J. H., additional, Park, S. Y., additional, Park, T. H., additional, Kim, M. H., additional, Kim, Y. D., additional, Lee, H. C., additional, Ahn, M. S., additional, Hong, T. J., additional, Blanco, R., additional, Blanco, F., additional, Szarfer, J., additional, Garcia Escudero, A., additional, Gigena, G., additional, Gagliardi, J., additional, Rodriguez, A., additional, Sarmiento, R., additional, Affatatto, S., additional, Riccitelli, M., additional, Petris, A., additional, Datcu, M. D., additional, Pop, C., additional, Radoi, M., additional, Arsenescu-Georgescu, C., additional, Petrescu, I., additional, Petrescu, L., additional, Serban, L., additional, Nechita, E., additional, Tatu-Chitoiu, G., additional, Dorobantu, M., additional, Benedek, I., additional, Craiu, E., additional, Sinescu, C., additional, Ionescu, D. D., additional, Ginghina, C., additional, Minescu, B., additional, Izzo, A., additional, Mantovani, P., additional, Tomasi, L., additional, Dall'oglio, L., additional, Bonatti, S., additional, Rosiello, R., additional, Romano, M., additional, Agostini, F., additional, Zanini, R., additional, Zhao, Z. Y., additional, Wu, Y. J., additional, Li, J. J., additional, Yany, Y. J., additional, Qian, H. Y., additional, Tang, Y. D., additional, Timoteo, A. T., additional, Toste, A., additional, Lousinha, A., additional, Ramos, R., additional, Oliveira, J. A., additional, Ferreira, M. L., additional, Ferreira, R. C., additional, Cabades, C., additional, Diez Gil, J. L., additional, Aguar, P., additional, Sanmiguel, D., additional, Lopez-March, A., additional, Marmol, R., additional, Guerra, L., additional, Girbes, V., additional, Ferrando, J., additional, Rincon De Arellano, A., additional, Patricio, L., additional, Blondal, M., additional, Ainla, T., additional, Marandi, T., additional, Eha, J., additional, Oliveira, M. M., additional, Silva, M. N., additional, Cunha, P. S., additional, Feliciano, J., additional, Silva, S., additional, Kanovsky, J., additional, Kala, P., additional, Parenica, J., additional, Poloczek, M., additional, Prymusova, K., additional, Kubkova, L., additional, Spinar, J., additional, Olinic, D., additional, Homorodean, C., additional, Ober, M., additional, Olinic, M., additional, Andrioaia, C., additional, Condac, A., additional, Masmoudi, M., additional, Berdaoui, B., additional, Labidi, S., additional, Tapia Ballesteros, C., additional, Hernandez Luis, C., additional, Sandin, M. G., additional, Vegas, J. M., additional, Andion, R., additional, Martinez, N., additional, Gonzalez, I. A., additional, Alvarado, M., additional, Amat, I. J., additional, San Roman, J. A., additional, Garcia Gonzalez, M. J., additional, Arroyo Ucar, E., additional, Hernandez Garcia, C., additional, Dorta Martin, M., additional, Marrero Rodriguez, F., additional, Dragu, R., additional, Kapeliovich, M., additional, Hammerman, H., additional, Silva, D., additional, Cortez-Dias, N., additional, Jorge, C., additional, Silva Marques, J., additional, Carilho Ferreira, P., additional, Robalo Martins, S., additional, Almeida Ribeiro, M., additional, Calisto, C., additional, Fiuza, M., additional, Lopes, M. G., additional, Milicevic, P., additional, Panic, M., additional, Stankovic, I., additional, Milicevic, D., additional, Kalezic, T., additional, Kafedzic, S., additional, Ilic, I., additional, Cerovic, M., additional, Putnikovic, B., additional, Neskovic, A., additional, Rott, D., additional, Leibowitz, D., additional, Monhart, Z., additional, Reissigova, J., additional, Grunfeldova, H., additional, Jansky, P., additional, Valente, B., additional, Villanueva Benito, I., additional, Solla, I., additional, Paredes, E., additional, Diaz Castro, O., additional, Calvo, F., additional, Baz, J. A., additional, Iniguez, A., additional, Aleksova, A., additional, Gerloni, R., additional, Belfiore, R., additional, Carriere, C., additional, Barbati, G., additional, Fabris, E., additional, Possa, F., additional, Nait, D., additional, Milo, M., additional, Sinagra, G., additional, Marques, N., additional, Mimoso, J., additional, Gomes, V., additional, Agra Bermejo, R. M., additional, Emad Abu Assi, E. A. A., additional, Sergio Raposeiras Roubin, S. R. R., additional, Pilar Cabanas Grandio, P. C. G., additional, Carlos Pena Gil, C. P. G., additional, Jose Maria Garcia Acuna, J. M. G. A., additional, Jose Ramon Gonzalez Juanatey, J. R. G. J., additional, Daly, M. J., additional, Scott, P., additional, Owens, C. G., additional, Tomlin, A., additional, Smith, B., additional, Adgey, A. A. J., additional, Alvarez-Contreras, L. R., additional, Juarez, U., additional, Altamirano, A., additional, Arias, A., additional, Alvarez-San Gabriel, A., additional, Gonzalez-Pacheco, H., additional, Martinez-Sanchez, C., additional, Rahnavardi, M., additional, Keshtkar-Jahromi, M., additional, Vakili, H., additional, Gholamin, S., additional, Razavi, S. M., additional, Gilis-Januszewski, T., additional, Mellwig, K.- P., additional, Wiemer, M., additional, Gilis-Januszewski, J., additional, Peterschroeder, A., additional, Koerfer, J., additional, Horstkotte, D., additional, Vrsalovic, M., additional, Getaldic, B., additional, Vrkic, N., additional, Pintaric, H., additional, Khan, S., additional, Wasan, B., additional, Moretti, L., additional, Grossi, P., additional, Silenzi, S., additional, Testa, M., additional, Candelori, L., additional, Clementi, L. N., additional, Forlini, M., additional, Lando, L., additional, Pezzuoli, M. L., additional, Corradetti, P., additional, Leurent, G., additional, Pennec, P. Y., additional, Filippi, E., additional, Moquet, B., additional, Hacot, J. P., additional, Druelles, P., additional, Rialan, A., additional, Rouault, G., additional, Coudert, I., additional, Le Breton, H., additional, Gevaert, S., additional, Tromp, F., additional, Vandecasteele, E., additional, De Somer, F., additional, Van Belleghem, Y., additional, Bouchez, S., additional, Martens, F., additional, Herck, I., additional, De Pauw, M., additional, Ludka, O., additional, Sepsi, M., additional, Miklik, R., additional, Dusek, L., additional, Tomcikova, D., additional, Garcia-Acuna, J. M., additional, Aguiar-Souto, P., additional, Raposeiras Roubin, S., additional, Agra-Bermejo, R., additional, Jacquet, M., additional, Abu-Assi, E., additional, Gonzalez-Juanatey, J. R., additional, Ibatov, A., additional, Labrova, R., additional, Karlik, R., additional, Lokaj, P., additional, She, Q., additional, Deng, S. B., additional, Huang, S. H., additional, Gu, L. J., additional, Rong, J. I. A. N., additional, Wu, Z. K., additional, Li, Y., additional, Zhang, J., additional, Parascan, L., additional, Campanile, A., additional, Spinelli, L., additional, Santulli, G., additional, Ciccarelli, M., additional, De Gennaro, S., additional, Assante Di Panzillo, E., additional, Trimarco, B., additional, Iaccarino, G., additional, Bobescu, E., additional, Datcu, G., additional, Dobreanu, D., additional, Doka, B., additional, Charniot, J.- C., additional, Cosson, C., additional, Albertini, J. P., additional, Bittar, R., additional, Giral, P., additional, Cherfils, C., additional, Guillerm, E., additional, Bonnefont-Rousselot, D., additional, Rusali, A., additional, Cojocaru, L., additional, Parepa, I., additional, Koizumi, T., additional, Iida, S., additional, Sato, J., additional, Kikutani, T., additional, Muramatsu, T., additional, Nishimura, S., additional, Komiyama, N., additional, Lee, W. P., additional, Ong, B. B., additional, Haralambos, K., additional, Townsend, D., additional, Rees, J. A. 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L., additional, Ishibashi, Y., additional, Yamauchi, M., additional, Akashi, Y., additional, Musha, H., additional, Miyake, F., additional, Hnatek, T., additional, Kamenik, L., additional, Sedlon, P., additional, Luxova, J., additional, Steuerova, B., additional, Skvaril, J., additional, Cernohous, M., additional, Zavoral, M., additional, Ratkovic, N., additional, Nemanja Djenic, N. R., additional, Aleksandra Jovelic, A. J., additional, Slobodan Obradovic, S. O., additional, Branko Gligic, B. G., additional, Kletsiou, E., additional, Giannakopoulou, M., additional, Bozas, E., additional, Iliodromitis, E. K., additional, Papathanassoglou, E. D. E., additional, Anton, M., additional, Anton, G., additional, Muraru, M., additional, Salinger Martinovic, S., additional, Radosavljevic, M., additional, Stanojevic, D., additional, Zivkovic, M., additional, Pessoa, T., additional, Aspromonte, N., additional, Ronco, C., additional, Tubaro, M., additional, Santini, M., additional, Colivicchi, F., additional, Aiello, A., additional, Cruz, D., additional, Anzoletti Boscolo, A., additional, Vianello, G., additional, Valle, R., additional, Parspour, A., additional, Watkins, S., additional, Datta, D., additional, Nikishin, A. G., additional, Pirnazarov, M. M., additional, Nurbaev, T. A., additional, Motovska, Z., additional, Fischerova, M., additional, Osmancik, P., additional, Maly, M., additional, Widimsky, P., additional, Pavli, E., additional, Dibra, A., additional, Mehilli, J., additional, Dibra, L., additional, Schoemig, A., additional, Kastrati, A., additional, Carmo, P., additional, Almeida, M., additional, Teles, R., additional, Goncalves, P., additional, Brito, J., additional, D'ascenzo, F., additional, Gonella, A., additional, Longo, G., additional, Pullara, A., additional, Moretti, C., additional, Sciuto, F., additional, Omede', P., additional, Biondi Zoccai, G., additional, Trevi, G. P., additional, Sheiban, I., additional, Cafe, H. M., additional, Pereira, D., additional, Freitas, D., additional, Ortiz Berbel, D., additional, Rabasa Baraibar, J. M., additional, Leone, A. M., additional, De Caterina, A., additional, Aurelio, A., additional, Sciahbasi, A., additional, Lioy, E., additional, Trani, C., additional, Burzotta, F., additional, Porto, I., additional, Rebuzzi, A. G., additional, Trusinskis, K., additional, Juhnevica, D., additional, Strenge, K., additional, Sondore, D., additional, Kumsars, I., additional, Jegere, S., additional, Narbute, I., additional, Grave, A., additional, Zakke, I., additional, Erglis, A., additional, Ferrari, C., additional, Bartorelli, A. L., additional, Saeed, M., additional, Cozma, D., additional, Pescariu, S., additional, Dragulescu, S. I., additional, Kamal, H. S., additional, Abdelfattah, A., additional, Abdelbary, A. M., additional, Elassar, H., additional, Naggar, A., additional, Khaled, M., additional, Fareed, A. M., additional, Pernes, J. M., additional, Gaux, J. C., additional, Prull, M. W., additional, Sasko, B., additional, Wirdemann, H., additional, Bittlinsky, A., additional, Butz, T., additional, Trappe, H. J., additional, Perazzolo Marra, M., additional, Cacciavillani, L., additional, Marzari, A., additional, De Lazzari, M., additional, Turri, R., additional, China, P., additional, Corbetti, F., additional, Iliceto, S., additional, Stazhadze, L. L., additional, Spiridonova, E. A., additional, Bulanova, N. A., additional, Ermolaev, A. A., additional, Savic, L., additional, Mrdovic, I., additional, Krljanac, G., additional, Perunicic, J., additional, Asanin, M., additional, Lasica, R., additional, Matic, M., additional, Vasiljevic, Z., additional, Ostojic, M., additional, Tichy, M., additional, Andrys, C., additional, Conti, A., additional, Poggioni, C., additional, Viviani, G., additional, Bulletti, F., additional, Boni, V., additional, Luzzi, M., additional, Vicidomini, S., additional, Donati, M., additional, Del Taglia, B., additional, Pini, R., additional, Sousa, O., additional, Fontes-Carvalho, R., additional, Caeiro, D., additional, Dias Ferreira, N., additional, Silva, G., additional, Pereira, E., additional, Ribeiro, J., additional, Albuquerque, A., additional, Gama Ribeiro, V., additional, Murai, M., additional, Takeda, Y., additional, Shinmyo, T., additional, Tanigawa, J., additional, Hazui, H., additional, Nakakohji, T., additional, Ohishi, Y., additional, Hoshiga, M., additional, Ishihara, T., additional, Hanafusa, T., additional, Belohlavek, J., additional, Rohn, V., additional, Kunstyr, J., additional, Lips, M., additional, Semrad, M., additional, Mlejnsky, F., additional, Tosovsky, J., additional, Linhart, A., additional, Lindner, J., additional, Sablik, Z., additional, Samborska-Sablik, A., additional, Drozdz, J., additional, Gaszynski, W., additional, Izquierdo-Gomez, M. M., additional, Juarez-Prera, R., additional, Blanco-Palacios, G., additional, Lakhdar, R., additional, Drissa, M., additional, Jedaida, B., additional, Drissa, H., additional, Sampaio, F., additional, Hsin, H.- T., additional, Huang, J.- H., additional, Chiu, K.- M., additional, Chen, Z.- S., additional, Lin, P.- C., additional, Chen, L.- Y., additional, Chu, S.- H., additional, Efthimiadis, I., additional, Skendros, P., additional, Sarantopoulos, A., additional, Boura, P., additional, Van Der Laan, A. M., additional, Van Der Vleuten, P. A., additional, Klees, M., additional, Tijssen, J. G. P., additional, Backus, B. E., additional, Six, A. J., additional, Kelder, J. H., additional, Mosterd, A., additional, Mast, E. G., additional, Mast, T. P., additional, Braam, R., additional, Tio, R., additional, Veldkamp, R., additional, Doevendans, P. A., additional, Paarup Dridi, N., additional, Holmvang, L., additional, Engstroem, T., additional, Rekik, S., additional, Brunet, J., additional, Hager, F. X., additional, Bayet, G., additional, Meille, L., additional, Quatre, J. M., additional, Sainsous, J., additional, Chu, P.- H., additional, Tang, C.- H., additional, Pogosova, N., additional, Koltunov, I. E., additional, Sapunova, I. D., additional, Vigodin, V. A., additional, Uhliar, R., additional, Schmidt, A., additional, Brockmeyer, B., additional, Suzuki, A., additional, Eki, Y., additional, Higuchi, H., additional, Yukawa, A., additional, Yamauchi, R., additional, Sato, Y., additional, Endo, Y., additional, Salazar Mendigucha Garcia, J., additional, Homs Vila, S., additional, Cequier Fillat, A., additional, Andion Ogando, R., additional, Sandin Fuentes, M., additional, Vegas Valle, J. M., additional, Gonzalez Garcia, I. A., additional, Duro Aguado, I. A., additional, Palomino Doza, A. J., additional, Gomez Salvador, I., additional, San Roman Calvar, J. A., additional, Mamarasulov, T. M., additional, Todorovic, L., additional, Cherneva, Z. C. H., additional, Denchev, S. D., additional, Heltai, K., additional, Boytsov, A., additional, Nikulina, N. N., additional, Zanna, D., additional, Marangelli, V., additional, Caiati, C., additional, Picon Heras, R., additional, Loureiro, M. J., additional, Urazovskaya, I., additional, Vinogradova, D., additional, Vasilieva, E., additional, Shpektor, A., additional, Conti, E., additional, Musumeci, M. B., additional, Lauri, F. M., additional, Dito, E., additional, De Giusti, M., additional, Lallo, A., additional, Fusco, D., additional, Davoli, M., additional, Volpe, M., additional, Autore, C., additional, Gamra, H., additional, Dridi, Z., additional, Hassine, M., additional, Addad, F., additional, Gherissi, I., additional, Reda, A., additional, Mahjoub, M., additional, Bouraoui, S., additional, Abdennadher, M., additional, Betbout, F., additional, Mota, P. M. F. P., additional, Silva, J. D., additional, Jankovic Tomasevic, R., additional, Djordjevic, V., additional, Djordjevic Radojkovic, D., additional, Scafa Udriste, A., additional, Fruntelata, A., additional, Gainoiu, E., additional, Bogdan, S., additional, Zamfir, D., additional, Teodorescu, C., additional, Guran, M., additional, Constantinescu, D., additional, Konopka, A., additional, Banaszewski, M., additional, Wojtkowska, I., additional, Stepinska, J., additional, Vidergold, J. V., additional, Osipova, I. V., additional, Tavrovskaya, T. V., additional, Galkina, J. V., additional, Timofeev, A. V., additional, Vorobyov, R. I., additional, Vorobyova, E. N., additional, Matos, L., additional, Carvalho, A. C. C., additional, Oliveira, W., additional, Cintra, F., additional, Poyares, D., additional, Andersen, M., additional, Martins, R., additional, Tufik, S., additional, Ostadal, P., additional, Brada, J., additional, Horakova, S., additional, Mlcek, M., additional, Hrachovina, V., additional, Kittnar, O., additional, Gorudko, I. V., additional, Buko, I. V., additional, Cherenkevich, S. N., additional, Polonetsky, L. Z., additional, Plotkin, V. Y., additional, Timoshina, M. A., additional, Azanchevskaya, S. V., additional, Chromov-Borisov, N. N., additional, Vorlat, A., additional, Snoep, L., additional, Claeys, M. J., additional, Vrints, C. J., additional, Palazzuoli, A., additional, Caputo, M., additional, Quatrini, I., additional, Calabro, A., additional, Antonelli, G., additional, Campagna, M. S., additional, Franci, B., additional, Nuti, R., additional, Maisel, A., additional, Negrini, M., additional, Minora, T., additional, Marino, P., additional, Seregni, R., additional, Tavlueva, E., additional, Barbarash, O., additional, Barbarash, L., additional, Janota, T., additional, Kudlicka, J., additional, Malik, K., additional, Wichterle, D., additional, Hradec, J., additional, Body, R., additional, Carley, S. D., additional, Mcdowell, G., additional, Nuttall, M., additional, Wibberley, C., additional, France, M., additional, Cruickshank, J. K., additional, Mackway-Jones, K., additional, Leon, M., additional, Cozma, C., additional, Mitu, F., additional, Almeida, D. R., additional, Dias, C. B., additional, Burazor, I., additional, Burazor, M., additional, Krstic, M., additional, Lazovic, M., additional, Vukmanovic, M., additional, Djordjevic, J., additional, Radovanovic, Z., additional, Ilic, D., additional, Bosnjakovic, P., additional, Ferreira, A. C., additional, Mateus, P. S., additional, Fontes, P., additional, Teixeira, T., additional, Conte, G., additional, Menozzi, A., additional, Solinas, E., additional, Bolognesi, M. G., additional, Tadonio, I., additional, Mantovani, F., additional, Cattabiani, A., additional, Vignali, L., additional, Ardissino, D., additional, Tautu, O., additional, Alexandrescu, A., additional, Niculescu, R., additional, Jankovic, R., additional, Bozinovic, N., additional, Santos, C., additional, Costa, F., additional, Cardoso, G., additional, Correia, I., additional, Fountoulaki, K., additional, Kastellanos, S., additional, Voltirakis, E., additional, Kokotos, A., additional, Michalakeas, C., additional, Kontsas, K., additional, Hasioti, K., additional, Iliodromitis, E. T., additional, Sandin Fuentes, M. G., additional, Zatarain Nicolas, E., additional, Martinez Uruena, N., additional, Alvarado Montes De Oca, M., additional, Dytrych, V., additional, Kovarnik, T., additional, Smid, O., additional, Kral, A., additional, Aroutunov, A. G., additional, Intwala, S., additional, Jegere, I., additional, Shaalan, H. S. H., additional, Pagava, Z., additional, Agladze, R., additional, Shakarishvili, R., additional, Sharashidze, N., additional, Gujejiani, L., additional, Saatashvili, G., additional, Katova, T. Z., additional, Kostova, V., additional, Simova, Y., additional, Vukotic, S., additional, Rafajlovski, S., additional, Romanovic, R., additional, Antonijevic, N., additional, Gligic, B., additional, Hutyra, M., additional, Skala, T., additional, Horak, D., additional, Vindis, D., additional, Taborsky, M., additional, Contine, A., additional, Del Pinto, M., additional, Angeli, F., additional, Verdecchia, P., additional, Borgognoni, F., additional, Grikstaite, E., additional, Pantano, P., additional, Ambrosio, G., additional, Cavallini, C., additional, Bonanad, C., additional, Sanchis, J., additional, Bodi, V., additional, Nunez, J., additional, Bosch, X., additional, Heras, M., additional, Pellicer, M., additional, Llacer, A., additional, Adao, L., additional, Oliveira, M., additional, Goncalves, H., additional, Primo, J., additional, Gama, V., additional, Lombardi, C., additional, Metra, M., additional, Bugatti, S., additional, Pasotti, E., additional, Quinzani, F., additional, Adamo, M., additional, Villa, C., additional, Rovetta, R., additional, Manerba, A., additional, Mariani, M., additional, Dushpanova, A., additional, Baroni, M., additional, Cerone, E., additional, Nardelli, A., additional, Gianetti, J., additional, Berti, S., additional, Feliciano, F., additional, Soares, R., additional, Santos, S., additional, Kruger, A., additional, Vondrakova, D., additional, Herget, J., additional, Navarro, C., additional, Cromie, N. A., additional, Adgey, J. A. A., additional, Caeiro Pereira, D., additional, Braga, P., additional, Fontes Carvalho, R., additional, Rodrigues, A., additional, Goncalves, M., additional, Simoes, L., additional, and Borisov, K. V., additional

Published
2010
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46. N-terminální pro BNP a echokardiografické parametry u pacientů s neobstruktivní hypertrofickou kardiomyopatií.

Author

Pudil, R., Horáková, L., Vašatová, M., Karešová, I., Fučíková, A., Praus, R., and Palička, V.

Abstract

Objective: To assess plasma N-terminal pro brain natriuretic peptide (NT-proBNP) concentration in patients with nonobstructive cardiomyopathy (HCM) and try to find an association with morphological and functional echocardiographic parameters. Design of the study: observational study. Settings: 1st Department of Internal Medicine - Cardioangiology, University Hospital Hradec Králové, Czech Republic. Methods: 21 patients with HCM was enrolled into the study. Echo and catheterization were performed before enrolment into the study. We analysed plasma NT-proBNP concentrations and their association with morphological and functional parameters. Results: Compared to control group, plasma NT-proBNP was significantly increased (377.7 ± 317.5 ng/L vs. 91.3 ± 76.6 ng/L, p = 0.005). We observed significant association of NT-proBNP and left ventricular ejection fraction (r = -0.48, p = 0.03), left ventricular fractional shortening (r = -0.44, p = 0.05) and left ventricle mass index (r = 0.52, p = 0.02). Conclusions: Hypertrophic cardiomyopathy is associated with increased plasma NT-proBNP concentration. The increase of NT-proBNP is determined by left ventricle mass and systolic function. We assume that assessment of these parameters could be useful in diagnosis and risk stratification in these patients. [ABSTRACT FROM AUTHOR]

Published
2015

47. Hyperbarická medicína v České republice - aktuální pohled.

Author

Hájek, M., Pudil, R., Rozložník, M., Chmelař, D., Beran, V., Novomeský, F., Sázel, M., and Hrnčíř, E.

Abstract

Hyperbaric medicine is a medical specialty, which includes the issue of hyperbaric oxygen therapy and diving medicine. The authors of the article devote attention mainly to hyperbaric oxygen therapy. Theoretical principles are mentioned as well as some important aspects and issues related to scientific evidence benefits of hyperbaric therapy for selected indications. They discussed the issue of availability of this therapy, particularly difficulties in ensuring systematic treatment of intensive care patients as well as practical aspects of treatment. Also the current situation in the training of medical personnel in the segment is mentioned. The use of hyperbaric oxygen therapy is important in modern medicine, it brings better functional outcomes, reduce morbidity, mortality and alleviate neurological sequelae of many pathological conditions, especially accident and infectious etiology in the current financial cost-efficiency in the health system. [ABSTRACT FROM AUTHOR]

Published
2015

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