Search

Your search keyword '"Puisieux, Alain"' showing total 762 results
Start Over Author "Puisieux, Alain"
762 results on '"Puisieux, Alain"'

1. A druggable copper-signalling pathway that drives inflammation

Author

Solier, Stéphanie, Müller, Sebastian, Cañeque, Tatiana, Versini, Antoine, Mansart, Arnaud, Sindikubwabo, Fabien, Baron, Leeroy, Emam, Laila, Gestraud, Pierre, Pantoș, G. Dan, Gandon, Vincent, Gaillet, Christine, Wu, Ting-Di, Dingli, Florent, Loew, Damarys, Baulande, Sylvain, Durand, Sylvère, Sencio, Valentin, Robil, Cyril, Trottein, François, Péricat, David, Näser, Emmanuelle, Cougoule, Céline, Meunier, Etienne, Bègue, Anne-Laure, Salmon, Hélène, Manel, Nicolas, Puisieux, Alain, Watson, Sarah, Dawson, Mark A., Servant, Nicolas, Kroemer, Guido, Annane, Djillali, and Rodriguez, Raphaël

Published
2023
Full Text
View/download PDF

3. Guidelines and definitions for research on epithelial–mesenchymal transition

Author

Yang, Jing, Antin, Parker, Berx, Geert, Blanpain, Cédric, Brabletz, Thomas, Bronner, Marianne, Campbell, Kyra, Cano, Amparo, Casanova, Jordi, Christofori, Gerhard, Dedhar, Shoukat, Derynck, Rik, Ford, Heide L, Fuxe, Jonas, García de Herreros, Antonio, Goodall, Gregory J, Hadjantonakis, Anna-Katerina, Huang, Ruby YJ, Kalcheim, Chaya, Kalluri, Raghu, Kang, Yibin, Khew-Goodall, Yeesim, Levine, Herbert, Liu, Jinsong, Longmore, Gregory D, Mani, Sendurai A, Massagué, Joan, Mayor, Roberto, McClay, David, Mostov, Keith E, Newgreen, Donald F, Nieto, M Angela, Puisieux, Alain, Runyan, Raymond, Savagner, Pierre, Stanger, Ben, Stemmler, Marc P, Takahashi, Yoshiko, Takeichi, Masatoshi, Theveneau, Eric, Thiery, Jean Paul, Thompson, Erik W, Weinberg, Robert A, Williams, Elizabeth D, Xing, Jianhua, Zhou, Binhua P, and Sheng, Guojun

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, 2.1 Biological and endogenous factors, Generic health relevance, Animals, Biomedical Research, Cell Movement, Cell Plasticity, Consensus, Developmental Biology, Epithelial-Mesenchymal Transition, Humans, Neoplasms, Terminology as Topic, EMT International Association, Medical and Health Sciences, Biological sciences, Biomedical and clinical sciences, Health sciences
Abstract

Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by 'the EMT International Association' (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT.

Published
2020

4. EMT-driven plasticity prospectively increases cell–cell variability to promote therapeutic adaptation in breast cancer.

Author

Muller, Lauriane, Fauvet, Frédérique, Chassot, Christelle, Angileri, Francesca, Coutant, Angèle, Dégletagne, Cyril, Tonon, Laurie, Saintigny, Pierre, Puisieux, Alain, Morel, Anne-Pierre, Ouzounova, Maria, and Martinez, Pierre

Subjects
TRIPLE-negative breast cancer, MEDICAL sciences, PHENOTYPIC plasticity, EPITHELIAL-mesenchymal transition, TRANSCRIPTOMES
Abstract

Cellular plasticity enables cancer cells to adapt non-genetically, thereby preventing therapeutic success. The epithelial-mesenchymal transition (EMT) is a type of plasticity linked to resistance and metastasis. However, its exact impact on population diversity and its dynamics under chemotherapy is unknown. We used single-cell transcriptomics to investigate phenotypic diversity dynamics upon treatment in two in vitro models of triple negative breast cancer (TNBC), where EMT-driven plasticity is either induced or spontaneously occurring. We report that EMT-driven plasticity confers higher phenotypic cell–cell variability (p < 0.001) while enriching for stem-like cells. Genetic and phenotypic cell–cell variability were not consistently correlated. High-plasticity populations displayed more pre-adapted cells before treatment (p = 0.03). In a population displaying spontaneous EMT and phenotypic variation, pre-adapted cells were a rare minority of high-scoring outliers whose expression patterns correlated with survival in TNBC patients subjected to chemotherapy (p = 0.03). Higher plasticity was not associated with a partial EMT status. Our results provide novel insights on how EMT-driven plasticity promotes a prospective diversification process increasing population phenotypic diversity, which can yield rare pre-adapted states before treatment. This highlights the need to tackle phenotypic diversity prior to treatment in high-plasticity tumours. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

5. Low level of Fibrillarin, a ribosome biogenesis factor, is a new independent marker of poor outcome in breast cancer

Author

Nguyen Van Long, Flora, Lardy-Cleaud, Audrey, Carène, Dimitri, Rossoni, Caroline, Catez, Frédéric, Rollet, Paul, Pion, Nathalie, Monchiet, Déborah, Dolbeau, Agathe, Martin, Marjorie, Simioni, Valentin, Bray, Susan, Le Beherec, Doris, Mosele, Fernanda, Bouakka, Ibrahim, Colombe-Vermorel, Amélie, Odeyer, Laetitia, Diot, Alexandra, Jordan, Lee B., Thompson, Alastair M., Jamen, Françoise, Dubois, Thierry, Chabaud, Sylvie, Michiels, Stefan, Treilleux, Isabelle, Bourdon, Jean-Christophe, Pérol, David, Puisieux, Alain, André, Fabrice, Diaz, Jean-Jacques, and Marcel, Virginie

Published
2022
Full Text
View/download PDF

10. EU-LIFE charter of independent life science research institutes

Author

Superti-Furga, Giulio, Agostinho, Marta, Bury, Jo, Cook, Simon, Durinx, Christine, Ender, Anita, van Luenen, Henri, Lund, Anders H, Medema, René H, Miączyńska, Marta, Nickel, Dorthe, Pelicci, Pier Giuseppe, Puisieux, Alain, Ripatti, Samuli, Sander, Maike, Schubeler, Dirk, Serrano, Luis, Sommer, Thomas, Sonne-Hansen, Katrine, Tomančák, Pavel, Vives, Joan, Vontas, John, Bettencourt-Dias, Mónica, Superti-Furga, Giulio, Agostinho, Marta, Bury, Jo, Cook, Simon, Durinx, Christine, Ender, Anita, van Luenen, Henri, Lund, Anders H, Medema, René H, Miączyńska, Marta, Nickel, Dorthe, Pelicci, Pier Giuseppe, Puisieux, Alain, Ripatti, Samuli, Sander, Maike, Schubeler, Dirk, Serrano, Luis, Sommer, Thomas, Sonne-Hansen, Katrine, Tomančák, Pavel, Vives, Joan, Vontas, John, and Bettencourt-Dias, Mónica

Abstract

The diverse range of organizations contributing to the global research ecosystem is believed to enhance the overall quality and resilience of its output. Mid-sized autonomous research institutes, distinct from universities, play a crucial role in this landscape. They often lead the way in new research fields and experimental methods, including those in social and organizational domains, which are vital for driving innovation. The EU-LIFE alliance was established with the goal of fostering excellence by developing and disseminating best practices among European biomedical research institutes. As directors of the 15 EU-LIFE institutes, we have spent a decade comparing and refining our processes. Now, we are eager to share the insights we've gained. To this end, we have crafted this Charter, outlining 10 principles we deem essential for research institutes to flourish and achieve ground-breaking discoveries. These principles, detailed in the Charter, encompass excellence, independence, training, internationality and inclusivity, mission focus, technological advancement, administrative innovation, cooperation, societal impact, and public engagement. Our aim is to inspire the establishment of new institutes that adhere to these principles and to raise awareness about their significance. We are convinced that they should be viewed a crucial component of any national and international innovation strategies.

Published
2024

12. PSL Chemical Biology Symposia: Recent Progress in Ferroptosis

Author

Pereira, Arthur, primary, Baron, Leeroy, additional, Bucci, Romain, additional, Plays, Marina, additional, Bonasegale, Giulia, additional, Picard–Bernes, Armel, additional, Bibrowski, Manuel, additional, Morris, Nolwenn, additional, Marynberg, Sacha, additional, Sindikubwabo, Fabien, additional, Cañeque, Tatiana, additional, Müller, Sebastian, additional, Colombeau, Ludovic, additional, Solier, Stéphanie, additional, Bono, Yannick, additional, Gaillet, Christine, additional, Johannes, Ludger, additional, Puisieux, Alain, additional, and Rodriguez, Raphaël, additional

Published
2024
Full Text
View/download PDF

13. Cooperative pro-tumorigenic adaptation to oncogenic RAS through epithelial-to-mesenchymal plasticity

Author

De Blander, Hadrien, primary, Tonon, Laurie, additional, Fauvet, Frédérique, additional, Pommier, Roxane M., additional, Lamblot, Christelle, additional, Benhassoun, Rahma, additional, Angileri, Francesca, additional, Gibert, Benjamin, additional, Rodriguez, Raphaël, additional, Ouzounova, Maria, additional, Morel, Anne-Pierre, additional, and Puisieux, Alain, additional

Published
2024
Full Text
View/download PDF

22. EU‐LIFE charter of independent life science research institutes.

Author

Superti‐Furga, Giulio, Agostinho, Marta, Bury, Jo, Cook, Simon, Durinx, Christine, Ender, Anita, van Luenen, Henri, Lund, Anders H., Medema, René H., Miączyńska, Marta, Nickel, Dorthe, Pelicci, Pier Giuseppe, Puisieux, Alain, Ripatti, Samuli, Sander, Maike, Schubeler, Dirk, Serrano, Luis, Sommer, Thomas, Sonne‐Hansen, Katrine, and Tomančák, Pavel

Subjects
LIFE sciences, RESEARCH institutes, CONSCIOUSNESS raising, TECHNOLOGICAL innovations, CHARTERS
Abstract

The diverse range of organizations contributing to the global research ecosystem is believed to enhance the overall quality and resilience of its output. Mid‐sized autonomous research institutes, distinct from universities, play a crucial role in this landscape. They often lead the way in new research fields and experimental methods, including those in social and organizational domains, which are vital for driving innovation. The EU‐LIFE alliance was established with the goal of fostering excellence by developing and disseminating best practices among European biomedical research institutes. As directors of the 15 EU‐LIFE institutes, we have spent a decade comparing and refining our processes. Now, we are eager to share the insights we've gained. To this end, we have crafted this Charter, outlining 10 principles we deem essential for research institutes to flourish and achieve ground‐breaking discoveries. These principles, detailed in the Charter, encompass excellence, independence, training, internationality and inclusivity, mission focus, technological advancement, administrative innovation, cooperation, societal impact, and public engagement. Our aim is to inspire the establishment of new institutes that adhere to these principles and to raise awareness about their significance. We are convinced that they should be viewed a crucial component of any national and international innovation strategies. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

24. Author Correction: Guidelines and definitions for research on epithelial–mesenchymal transition

Author

Yang, Jing, Antin, Parker, Berx, Geert, Blanpain, Cédric, Brabletz, Thomas, Bronner, Marianne, Campbell, Kyra, Cano, Amparo, Casanova, Jordi, Christofori, Gerhard, Dedhar, Shoukat, Derynck, Rik, Ford, Heide L., Fuxe, Jonas, García de Herreros, Antonio, Goodall, Gregory J., Hadjantonakis, Anna-Katerina, Huang, Ruby Y. J., Kalcheim, Chaya, Kalluri, Raghu, Kang, Yibin, Khew-Goodall, Yeesim, Levine, Herbert, Liu, Jinsong, Longmore, Gregory D., Mani, Sendurai A., Massagué, Joan, Mayor, Roberto, McClay, David, Mostov, Keith E., Newgreen, Donald F., Nieto, M. Angela, Puisieux, Alain, Runyan, Raymond, Savagner, Pierre, Stanger, Ben, Stemmler, Marc P., Takahashi, Yoshiko, Takeichi, Masatoshi, Theveneau, Eric, Thiery, Jean Paul, Thompson, Erik W., Weinberg, Robert A., Williams, Elizabeth D., Xing, Jianhua, Zhou, Binhua P., and Sheng, Guojun

Published
2021
Full Text
View/download PDF

26. Figure S8 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas

Author

Sertier, Anne-Sophie, primary, Ferrari, Anthony, primary, Pommier, Roxane M., primary, Treilleux, Isabelle, primary, Boyault, Sandrine, primary, Devouassoux-Shisheboran, Mojgan, primary, Kielbassa, Janice, primary, Thomas, Emilie, primary, Tonon, Laurie, primary, Le Texier, Vincent, primary, Charreton, Amandine, primary, Morel, Anne-Pierre, primary, Floquet, Anne, primary, Joly, Florence, primary, Berton-Rigaud, Dominique, primary, Ferron, Gwenaël, primary, Arnould, Laurent, primary, Croce, Sabrina, primary, Bataillon, Guillaume, primary, Saintigny, Pierre, primary, Mery-Lamarche, Eliane, primary, Sagan, Christine, primary, Senaratne, Aruni P., primary, Gut, Ivo G., primary, Calvo, Fabien, primary, Viari, Alain, primary, Ouzounova, Maria, primary, Ray-Coquard, Isabelle, primary, and Puisieux, Alain, primary

Published
2023
Full Text
View/download PDF

27. Supplementary Table 3 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas

Author

Sertier, Anne-Sophie, primary, Ferrari, Anthony, primary, Pommier, Roxane M., primary, Treilleux, Isabelle, primary, Boyault, Sandrine, primary, Devouassoux-Shisheboran, Mojgan, primary, Kielbassa, Janice, primary, Thomas, Emilie, primary, Tonon, Laurie, primary, Le Texier, Vincent, primary, Charreton, Amandine, primary, Morel, Anne-Pierre, primary, Floquet, Anne, primary, Joly, Florence, primary, Berton-Rigaud, Dominique, primary, Ferron, Gwenaël, primary, Arnould, Laurent, primary, Croce, Sabrina, primary, Bataillon, Guillaume, primary, Saintigny, Pierre, primary, Mery-Lamarche, Eliane, primary, Sagan, Christine, primary, Senaratne, Aruni P., primary, Gut, Ivo G., primary, Calvo, Fabien, primary, Viari, Alain, primary, Ouzounova, Maria, primary, Ray-Coquard, Isabelle, primary, and Puisieux, Alain, primary

Published
2023
Full Text
View/download PDF

28. FIGURE 3 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas

Author

Sertier, Anne-Sophie, primary, Ferrari, Anthony, primary, Pommier, Roxane M., primary, Treilleux, Isabelle, primary, Boyault, Sandrine, primary, Devouassoux-Shisheboran, Mojgan, primary, Kielbassa, Janice, primary, Thomas, Emilie, primary, Tonon, Laurie, primary, Le Texier, Vincent, primary, Charreton, Amandine, primary, Morel, Anne-Pierre, primary, Floquet, Anne, primary, Joly, Florence, primary, Berton-Rigaud, Dominique, primary, Ferron, Gwenaël, primary, Arnould, Laurent, primary, Croce, Sabrina, primary, Bataillon, Guillaume, primary, Saintigny, Pierre, primary, Mery-Lamarche, Eliane, primary, Sagan, Christine, primary, Senaratne, Aruni P., primary, Gut, Ivo G., primary, Calvo, Fabien, primary, Viari, Alain, primary, Ouzounova, Maria, primary, Ray-Coquard, Isabelle, primary, and Puisieux, Alain, primary

Published
2023
Full Text
View/download PDF

29. FIGURE 2 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas

Author

Sertier, Anne-Sophie, primary, Ferrari, Anthony, primary, Pommier, Roxane M., primary, Treilleux, Isabelle, primary, Boyault, Sandrine, primary, Devouassoux-Shisheboran, Mojgan, primary, Kielbassa, Janice, primary, Thomas, Emilie, primary, Tonon, Laurie, primary, Le Texier, Vincent, primary, Charreton, Amandine, primary, Morel, Anne-Pierre, primary, Floquet, Anne, primary, Joly, Florence, primary, Berton-Rigaud, Dominique, primary, Ferron, Gwenaël, primary, Arnould, Laurent, primary, Croce, Sabrina, primary, Bataillon, Guillaume, primary, Saintigny, Pierre, primary, Mery-Lamarche, Eliane, primary, Sagan, Christine, primary, Senaratne, Aruni P., primary, Gut, Ivo G., primary, Calvo, Fabien, primary, Viari, Alain, primary, Ouzounova, Maria, primary, Ray-Coquard, Isabelle, primary, and Puisieux, Alain, primary

Published
2023
Full Text
View/download PDF

30. FIGURE 4 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas

Author

Sertier, Anne-Sophie, primary, Ferrari, Anthony, primary, Pommier, Roxane M., primary, Treilleux, Isabelle, primary, Boyault, Sandrine, primary, Devouassoux-Shisheboran, Mojgan, primary, Kielbassa, Janice, primary, Thomas, Emilie, primary, Tonon, Laurie, primary, Le Texier, Vincent, primary, Charreton, Amandine, primary, Morel, Anne-Pierre, primary, Floquet, Anne, primary, Joly, Florence, primary, Berton-Rigaud, Dominique, primary, Ferron, Gwenaël, primary, Arnould, Laurent, primary, Croce, Sabrina, primary, Bataillon, Guillaume, primary, Saintigny, Pierre, primary, Mery-Lamarche, Eliane, primary, Sagan, Christine, primary, Senaratne, Aruni P., primary, Gut, Ivo G., primary, Calvo, Fabien, primary, Viari, Alain, primary, Ouzounova, Maria, primary, Ray-Coquard, Isabelle, primary, and Puisieux, Alain, primary

Published
2023
Full Text
View/download PDF

31. FIGURE 1 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas

Author

Sertier, Anne-Sophie, primary, Ferrari, Anthony, primary, Pommier, Roxane M., primary, Treilleux, Isabelle, primary, Boyault, Sandrine, primary, Devouassoux-Shisheboran, Mojgan, primary, Kielbassa, Janice, primary, Thomas, Emilie, primary, Tonon, Laurie, primary, Le Texier, Vincent, primary, Charreton, Amandine, primary, Morel, Anne-Pierre, primary, Floquet, Anne, primary, Joly, Florence, primary, Berton-Rigaud, Dominique, primary, Ferron, Gwenaël, primary, Arnould, Laurent, primary, Croce, Sabrina, primary, Bataillon, Guillaume, primary, Saintigny, Pierre, primary, Mery-Lamarche, Eliane, primary, Sagan, Christine, primary, Senaratne, Aruni P., primary, Gut, Ivo G., primary, Calvo, Fabien, primary, Viari, Alain, primary, Ouzounova, Maria, primary, Ray-Coquard, Isabelle, primary, and Puisieux, Alain, primary

Published
2023
Full Text
View/download PDF

32. Data from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas

Author

Sertier, Anne-Sophie, primary, Ferrari, Anthony, primary, Pommier, Roxane M., primary, Treilleux, Isabelle, primary, Boyault, Sandrine, primary, Devouassoux-Shisheboran, Mojgan, primary, Kielbassa, Janice, primary, Thomas, Emilie, primary, Tonon, Laurie, primary, Le Texier, Vincent, primary, Charreton, Amandine, primary, Morel, Anne-Pierre, primary, Floquet, Anne, primary, Joly, Florence, primary, Berton-Rigaud, Dominique, primary, Ferron, Gwenaël, primary, Arnould, Laurent, primary, Croce, Sabrina, primary, Bataillon, Guillaume, primary, Saintigny, Pierre, primary, Mery-Lamarche, Eliane, primary, Sagan, Christine, primary, Senaratne, Aruni P., primary, Gut, Ivo G., primary, Calvo, Fabien, primary, Viari, Alain, primary, Ouzounova, Maria, primary, Ray-Coquard, Isabelle, primary, and Puisieux, Alain, primary

Published
2023
Full Text
View/download PDF

33. Supplementary Table 2 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas

Author

Sertier, Anne-Sophie, primary, Ferrari, Anthony, primary, Pommier, Roxane M., primary, Treilleux, Isabelle, primary, Boyault, Sandrine, primary, Devouassoux-Shisheboran, Mojgan, primary, Kielbassa, Janice, primary, Thomas, Emilie, primary, Tonon, Laurie, primary, Le Texier, Vincent, primary, Charreton, Amandine, primary, Morel, Anne-Pierre, primary, Floquet, Anne, primary, Joly, Florence, primary, Berton-Rigaud, Dominique, primary, Ferron, Gwenaël, primary, Arnould, Laurent, primary, Croce, Sabrina, primary, Bataillon, Guillaume, primary, Saintigny, Pierre, primary, Mery-Lamarche, Eliane, primary, Sagan, Christine, primary, Senaratne, Aruni P., primary, Gut, Ivo G., primary, Calvo, Fabien, primary, Viari, Alain, primary, Ouzounova, Maria, primary, Ray-Coquard, Isabelle, primary, and Puisieux, Alain, primary

Published
2023
Full Text
View/download PDF

34. Supplementary Table 1 from Dissecting the Origin of Heterogeneity in Uterine and Ovarian Carcinosarcomas

Author

Sertier, Anne-Sophie, primary, Ferrari, Anthony, primary, Pommier, Roxane M., primary, Treilleux, Isabelle, primary, Boyault, Sandrine, primary, Devouassoux-Shisheboran, Mojgan, primary, Kielbassa, Janice, primary, Thomas, Emilie, primary, Tonon, Laurie, primary, Le Texier, Vincent, primary, Charreton, Amandine, primary, Morel, Anne-Pierre, primary, Floquet, Anne, primary, Joly, Florence, primary, Berton-Rigaud, Dominique, primary, Ferron, Gwenaël, primary, Arnould, Laurent, primary, Croce, Sabrina, primary, Bataillon, Guillaume, primary, Saintigny, Pierre, primary, Mery-Lamarche, Eliane, primary, Sagan, Christine, primary, Senaratne, Aruni P., primary, Gut, Ivo G., primary, Calvo, Fabien, primary, Viari, Alain, primary, Ouzounova, Maria, primary, Ray-Coquard, Isabelle, primary, and Puisieux, Alain, primary

Published
2023
Full Text
View/download PDF

35. Spatial transcriptomics reveal pitfalls and opportunities for the detection of rare high-plasticity breast cancer subtypes

Author

Coutant, Angele, primary, Cockenpot, Vincent, additional, Muller, Lauriane, additional, Degletagne, Cyril, additional, Pommier, Roxane, additional, Tonon, Laurie, additional, Ardin, Maude, additional, Michallet, Marie-Cecile, additional, Caux, Christophe, additional, Laurent, Marie, additional, Morel, Anne-Pierre, additional, Saintigny, Pierre, additional, Puisieux, Alain, additional, Ouzounova, Maria, additional, and Martinez, Pierre, additional

Published
2023
Full Text
View/download PDF

36. Dissecting the origin of heterogeneity in uterine and ovarian carcinosarcomas

Author

Sertier, Anne-Sophie, primary, Ferrari, Anthony, additional, Pommier, Roxane M., additional, Treilleux, Isabelle, additional, Boyault, Sandrine, additional, Devouassoux-Shisheboran, Mojgan, additional, Kielbassa, Janice, additional, Thomas, Emilie, additional, Tonon, Laurie, additional, Le Texier, Vincent, additional, Charreton, Amandine, additional, Morel, Anne-Pierre, additional, Floquet, Anne, additional, Joly, Florence, additional, Berton-Rigaud, Dominique, additional, Ferron, Gwenaël, additional, Arnould, Laurent, additional, Croce, Sabrina, additional, Bataillon, Guillaume, additional, Saintigny, Pierre, additional, Mery-Lamarche, Eliane, additional, Sagan, Christine, additional, Senaratne, Aruni P., additional, Gut, Ivo G., additional, Calvo, Fabien, additional, Viari, Alain, additional, Ouzounova, Maria, additional, Ray-Coquard, Isabelle, additional, and Puisieux, Alain, additional

Published
2023
Full Text
View/download PDF

39. In Vivo Characterization of the Toxicological Properties of DPhP, One of the Main Degradation Products of Aryl Phosphate Esters

Author

Selmi-Ruby, Samia, Marin-Saez, Jesus, Fildier, Aurelie, Bulete, Audrey, Abdallah, Myriam, Garcia, Jessica, Deverchere, Julie, Spinner, Loic, Giroud, Barbara, Ibanez, Sebastien, Granjon, Thierry, Bardel, Claire, Puisieux, Alain, Fervers, Beatrice, Vulliet, Emmanuelle, Payen, Lea, and Vigneron, Arnaud M.

Subjects
Chemical properties, Research, Health aspects, Phosphates -- Health aspects -- Chemical properties, Toxicological chemistry -- Research, Aromatic amines -- Chemical properties, Plasticizers -- Chemical properties -- Health aspects, Medical research, Medicine, Experimental
Abstract

Introduction Diphenyl phosphate (DPhP) has been used as a main biomarker for assessing exposure to aryl phosphate esters (APEs), especially triphenyl phosphate (TPhP), a molecule suspected of presenting human health [...], Background: Aryl phosphate esters (APEs) are widely used and commonly present in the environment. Health hazards associated with these compounds remain largely unknown and the effects of diphenyl phosphate (DPhP), one of their most frequent derivatives, are poorly characterized. Objective: Our aim was to investigate whether DPhP per se may represent a more relevant marker of exposure to APEs than direct assessment of their concentration and determine its potential deleterious biological effects in chronically exposed mice. Methods: Conventional animals (FVB mice) were acutely or chronically exposed to relevant doses of DPhP or to triphenyl phosphate (TPhP), one of its main precursors. Both molecules were measured in blood and other tissues by liquid chromatography-mass spectrometry (LC-MS). Effects of chronic DPhP exposure were addressed through liver multi-omics analysis to determine the corresponding metabolic profile. Deep statistical exploration was performed to extract correlated information, guiding further physiological analyses. Results: Multi-omics analysis confirmed the existence of biological effects of DPhP, even at a very low dose of 0.1mg/mL in drinking water. Chemical structural homology and pathway mapping demonstrated a clear reduction of the fatty acid catabolic processes centered on acylcarnitine and mitochondrial [beta]-oxidation in mice exposed to DPhP in comparison with those treated with vehicle. An interesting finding was that in mice exposed to DPhP, mRNA, expression of genes involved in lipid catabolic processes and regulated by peroxisome proliferator-activated receptor alpha (PPAR[alpha]) was lower than that in vehicle-treated mice. Immunohistochemistry analysis showed a specific down- regulation of HMGCS2, a kernel target gene of PPAR[alpha]. Overall, DPhP absorption disrupted body weight-gain processes. Conclusions: Our results suggest that in mice, the effects of chronic exposure to DPhP, even at a low dose, are not negligible. Fatty acid metabolism in the liver is essential for controlling fast and feast periods, with adverse consequences on the overall physiology. Therefore, the impact of DPhP on circulating fat, cardiovascular pathologies and metabolic disease incidence deserves, in light of our results, further investigations. https://doi.org/10.1289/EHP6826

Published
2020
Full Text
View/download PDF

40. Supplemental Figure 4 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
Full Text
View/download PDF

41. Supplemental Patient Information from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
Full Text
View/download PDF

42. Data from Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells

Author

Paquet-Fifield, Sophie, primary, Koh, Shir Lin, primary, Cheng, Lesley, primary, Beyit, Laura M., primary, Shembrey, Carolyn, primary, Mølck, Christina, primary, Behrenbruch, Corina, primary, Papin, Marina, primary, Gironella, Meritxell, primary, Guelfi, Sophie, primary, Nasr, Ramona, primary, Grillet, Fanny, primary, Prudhomme, Michel, primary, Bourgaux, Jean-Francois, primary, Castells, Antoni, primary, Pascussi, Jean-Marc, primary, Heriot, Alexander G., primary, Puisieux, Alain, primary, Davis, Melissa J., primary, Pannequin, Julie, primary, Hill, Andrew F., primary, Sloan, Erica K., primary, and Hollande, Frédéric, primary

Published
2023
Full Text
View/download PDF

43. Supplemental Figure 3 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
Full Text
View/download PDF

44. Supplemental Table S4 from Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells

Author

Paquet-Fifield, Sophie, primary, Koh, Shir Lin, primary, Cheng, Lesley, primary, Beyit, Laura M., primary, Shembrey, Carolyn, primary, Mølck, Christina, primary, Behrenbruch, Corina, primary, Papin, Marina, primary, Gironella, Meritxell, primary, Guelfi, Sophie, primary, Nasr, Ramona, primary, Grillet, Fanny, primary, Prudhomme, Michel, primary, Bourgaux, Jean-Francois, primary, Castells, Antoni, primary, Pascussi, Jean-Marc, primary, Heriot, Alexander G., primary, Puisieux, Alain, primary, Davis, Melissa J., primary, Pannequin, Julie, primary, Hill, Andrew F., primary, Sloan, Erica K., primary, and Hollande, Frédéric, primary

Published
2023
Full Text
View/download PDF

45. Supplemental Figure 5 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
Full Text
View/download PDF

46. Supplemental Table 1 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
Full Text
View/download PDF

47. Supplemental Figure 2 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
Full Text
View/download PDF

48. Supplemental Figures - Legends - Methods from Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells

Author

Paquet-Fifield, Sophie, primary, Koh, Shir Lin, primary, Cheng, Lesley, primary, Beyit, Laura M., primary, Shembrey, Carolyn, primary, Mølck, Christina, primary, Behrenbruch, Corina, primary, Papin, Marina, primary, Gironella, Meritxell, primary, Guelfi, Sophie, primary, Nasr, Ramona, primary, Grillet, Fanny, primary, Prudhomme, Michel, primary, Bourgaux, Jean-Francois, primary, Castells, Antoni, primary, Pascussi, Jean-Marc, primary, Heriot, Alexander G., primary, Puisieux, Alain, primary, Davis, Melissa J., primary, Pannequin, Julie, primary, Hill, Andrew F., primary, Sloan, Erica K., primary, and Hollande, Frédéric, primary

Published
2023
Full Text
View/download PDF

49. Supplementary Data from EMT Transcription Factor ZEB1 Represses the Mutagenic POLθ-Mediated End-Joining Pathway in Breast Cancers

Author

Prodhomme, Mélanie K., primary, Pommier, Roxane M., primary, Franchet, Camille, primary, Fauvet, Frédérique, primary, Bergoglio, Valérie, primary, Brousset, Pierre, primary, Morel, Anne-Pierre, primary, Brunac, Anne-Cécile, primary, Devouassoux-Shisheboran, Mojgan, primary, Petrilli, Virginie, primary, Moyret-Lalle, Caroline, primary, Hoffmann, Jean-Sébastien, primary, Puisieux, Alain, primary, and Tissier, Agnès, primary

Published
2023
Full Text
View/download PDF

50. Supplemental Table 2 from Genomic Copy Number Profiling Using Circulating Free Tumor DNA Highlights Heterogeneity in Neuroblastoma

Author

Chicard, Mathieu, primary, Boyault, Sandrine, primary, Colmet Daage, Leo, primary, Richer, Wilfrid, primary, Gentien, David, primary, Pierron, Gaelle, primary, Lapouble, Eve, primary, Bellini, Angela, primary, Clement, Nathalie, primary, Iacono, Isabelle, primary, Bréjon, Stéphanie, primary, Carrere, Marjorie, primary, Reyes, Cécile, primary, Hocking, Toby, primary, Bernard, Virginie, primary, Peuchmaur, Michel, primary, Corradini, Nadège, primary, Faure-Conter, Cécile, primary, Coze, Carole, primary, Plantaz, Dominique, primary, Defachelles, Anne Sophie, primary, Thebaud, Estelle, primary, Gambart, Marion, primary, Millot, Frédéric, primary, Valteau-Couanet, Dominique, primary, Michon, Jean, primary, Puisieux, Alain, primary, Delattre, Olivier, primary, Combaret, Valérie, primary, and Schleiermacher, Gudrun, primary

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results