1. Asthma phenotypes in Turkey: a multicenter cross-sectional study in adult asthmatics; PHENOTURK study
- Author
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Yildiz, F. and Mungan, D. and Gemicioglu, B. and Yorgancioglu, A. and Dursun, B. and Oner Erkekol, F. and Ogus, C. and Turktas, H. and Bogatekin, G. and Topcu, F. and Deveci, F. and Bayram, H. and Tor, M. and Kalyoncu, A.F., Pulmonary Diseases Department, Kocaeli University School of MedicineKocaeli, Turkey, Department of Allergy, Ankara University School of Medicine, Ankara, Turkey, Pulmonary Diseases Department, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey, Pulmonary Diseases Department, Celal Bayar University School of Medicine, Manisa, Turkey, Pulmonary Diseases Department, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey, Department of Allergy, Ataturk Chest Diseases and Thoracic Surgery Research Hospital, Ankara, Turkey, Pulmonary Diseases Department, Akdeniz University School of Medicine, Antalya, Turkey, Pulmonary Diseases Department, Gazi University School of Medicine, Ankara, Turkey, Diyarbakir State Hospital, Diyarbakir, Turkey, Pulmonary Diseases Department, Dicle University School of Medicine, Diyarbakir, Turkey, Pulmonary Diseases Department, Firat University School of Medicine, Elazig, Turkey, Pulmonary Diseases Department, Gaziantep University School of Medicine, Gaziantep, Turkey, Pulmonary Diseases Department, Bulent Ecevit University School of Medicine, Zonguldak, Turkey, and Department of Allergy, Hacettepe University School of Medicine, Ankara, Turkey
- Abstract
Background and Aims: To evaluate asthma phenotypes in patients with asthma from different regions of Turkey. Methods: A total of 1400 adult asthmatic patients (mean (SD) age: 44.0 (13.9) years, 75% females) from 14 centers across Turkey were included in this study and a standard questionnaire was applied between the time period of February 2011–January 2012. Results: The disease onset ≥ 40 years of age was higher percentage in obese vs. normal/overweight patients and nonallergic vs. allergic patients (P < 0.01). The percentage of patients who had FEV1 values over 80% was higher in allergic than nonallergic and normal/overweight than obese patients (P < 0.01). Uncontrolled asthmatics have more severe disease (P < 0.01). There were more frequent hospital admissions in nonallergic and uncontrolled asthmatics (P < 0.01). Chronic rhino-sinusitis was the leading comorbid disorder in normal/overweight and allergic asthma, while gastroesophageal reflux disorder was more frequent in nonallergic and uncontrolled asthma (P < 0.01). Asthma control rate was the highest (39.0%) in patients from Marmara region among all geographical regions (P < 0.05). Conclusion: In conclusion, our findings revealed existence of clinical/trigger related phenotypes based on BMI, allergic status, control level and geographical region with more frequent respiratory dysfunction and/or adverse health outcomes in uncontrolled, obese and nonallergic phenotypes. © 2015 John Wiley & Sons Ltd
- Published
- 2017