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2. The Association of HIV Status with Triple-Negative Breast Cancer in South African Breast Cancer Patients

Author

Dubner, Jacob L., primary, Neugut, Alfred I., additional, Joffe, Maureen, additional, O’Neil, Daniel S., additional, Ayeni, Oluwatosin A., additional, Chen, Carl, additional, Buccimazza, Ines, additional, Čačala, Sharon R., additional, Stopforth, Laura W., additional, Farrow, Hayley A., additional, Nietz, Sarah, additional, Murugan, Nivashini, additional, Phakathi, Boitumelo, additional, Jacobson, Judith S., additional, Crew, Katherine, additional, McCormack, Valarie, additional, Ruff, Paul, additional, Cubasch, Herbert, additional, and Pumpalova, Yoanna S., additional

Published
2024
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6. Biochemical progression free and overall survival among Black men with stage IV prostate cancer in South Africa: Results from a prospective cohort study.

Author

Pumpalova, Yoanna S., Ramakrishnan, Adarsh, May, Michael, Pentz, Audrey, Minkowitz, Shauli, Doherty, Sean, Singh, Elvira, Chen, Wenlong Carl, Rebbeck, Timothy R., Neugut, Alfred I., and Joffe, Maureen

Subjects
*PROSTATE cancer, *PROGRESSION-free survival, *BLACK men, *SOUTH Africans, *ANDROGEN deprivation therapy, BLACK South Africans
Abstract

Background: Men of African descent are disproportionately affected by prostate cancer (PCa), and many have metastatic disease at presentation. In South Africa (SA), androgen deprivation therapy (ADT) is the first-line treatment for stage IV PCa. Objective: To identify predictors of overall survival (OS) in Black South African men with stage IV PCa treated with ADT. Design, Setting, and Participants: Men diagnosed with prostate cancer (3/22/2016–10/30/2020) at Chris Hani Baragwanath Academic Hospital in Soweto, Johannesburg, were recruited for the Men of African Descent with Cancer of the Prostate study. We included men with newly diagnosed stage IV PCa treated with ADT who had a prostate-specific antigen (PSA) level drawn prior to initiation of ADT and had ≥1 PSA drawn ≥12weeks after ADT start. Outcomes Measures and Statistical Analysis: We used Kaplan–Meier statistics to estimate OS and Cox regression models to identify predictors of OS. Results and Limitations: Of the 1097 men diagnosed with prostate cancer, we included 153 men with stage IV PCa who received ADT and met PSA requirements. The median age was 68.0 years (interquartile range 64–73 years). Median OS from time of ADT initiation was 3.39 years (95% confidence interval (CI): 3.14%–noncalculable), while biochemical progression-free survival was 2.36 years (95% CI: 2.03%–3.73%). Biochemical progression (HR 3.52, 95% CI: 1.85%–6.70%), PSA nadir level >4ng/mL (HR 3.77, 95% CI: 1.86%–7.62%), alkaline phosphatase level at diagnosis >150 IU/dL (HR 3.09, 95% CI: 1.64%– 5.83%), and hemoglobin at diagnosis <13.5 g/dL (HR 2.90, 95% CI: 1.28%–6.56%) were associated with worse OS. Conclusions: In this study, we identified factors associated with poor OS among Black South African men with stage IV PCa treated with ADT. These factors may be useful in identifying patients for upfront treatment escalation, including the use of docetaxel chemotherapy or escalation of therapy at the time of biochemical progression. Patient Summary: In this study, we found that high alkaline phosphatase level, anemia at diagnosis, and high PSA nadir after initiation of androgen deprivation therapy are associated with worse overall survival among Black South African men treated with androgen deprivation therapy for metastatic prostate cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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9. The Impact of HIV Infection on Neoadjuvant and Adjuvant Chemotherapy Relative Dose Intensity in South African Patients with Breast Cancer

Author

O’Neil, Daniel S, primary, Ayeni, Oluwatosin A, additional, Farrow, Hayley A, additional, Chen, Wenlong Carl, additional, Demetriou, Georgia, additional, Buccimazza, Ines, additional, Čačala, Sharon, additional, Stopforth, Laura W, additional, Joffe, Maureen, additional, Antoni, Michael H, additional, Lopes, Gilberto, additional, Pumpalova, Yoanna S, additional, Mapanga, Witness, additional, Jacobson, Judith S, additional, Crew, Katherine D, additional, Neugut, Alfred I, additional, Ruff, Paul, additional, and Cubasch, Herbert, additional

Published
2023
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10. Abstract P1-01-03: The Impact of Comorbid HIV infection on Neoadjuvant and Adjuvant Chemotherapy Relative Dose Intensity in South African Breast Cancer Patients

Author

O’Neil, Daniel S., primary, Ayeni, Oluwatosin A, additional, Woolridge, Hayley A. Farrow, additional, Chen, Wenlong Carl, additional, Demetriou, Georgia, additional, Buccimazza, Ines, additional, Cacala, Sharon, additional, Joffe, Maureen, additional, Antoni, Michael, additional, Lopes, Gilberto, additional, Pumpalova, Yoanna, additional, Mapanga, Witness, additional, Jacobson, Judith S., additional, Crew, Katherine D., additional, Neugut, Alfred I., additional, Ruff, Paul, additional, and Cubasch, Herbert, additional

Published
2023
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11. The Impact of HIV Infection on Neoadjuvant and Adjuvant Chemotherapy Relative Dose Intensity in South African Patients with Breast Cancer.

Author

O'Neil, Daniel S, Ayeni, Oluwatosin A, Farrow, Hayley A, Chen, Wenlong Carl, Demetriou, Georgia, Buccimazza, Ines, Čačala, Sharon, Stopforth, Laura W, Joffe, Maureen, Antoni, Michael H, Lopes, Gilberto, Pumpalova, Yoanna S, Mapanga, Witness, Jacobson, Judith S, Crew, Katherine D, Neugut, Alfred I, Ruff, Paul, and Cubasch, Herbert

Subjects
ADJUVANT chemotherapy, HIV infections, GRANULOCYTE-colony stimulating factor, REGRESSION analysis, CANCER patients, DESCRIPTIVE statistics, RESEARCH funding, COMBINED modality therapy, BREAST tumors, DOSE-response relationship in biochemistry, COMORBIDITY
Abstract

Introduction In the South African Breast Cancer and HIV Outcomes (SABCHO) study, we previously found that breast cancer patients living with HIV and treated with neoadjuvant chemotherapy achieve lower rates of complete pathologic response than patients without HIV. We now assess the impact of comorbid HIV on receipt of timely and complete neoadjuvant and adjuvant chemotherapy. Materials and Methods Since June 2015, the SABCHO study has collected data on women diagnosed with breast cancer at 6 South African hospitals. We selected a sample of participants with stages I-III cancer who received ≥2 doses of neoadjuvant or adjuvant chemotherapy. Data on chemotherapies prescribed and received, filgrastim receipt, and laboratory values measured during treatment were captured from patients' medical records. We calculated the mean relative dose intensity (RDI) for all prescribed chemotherapies. We tested for association between full regimen RDI and HIV status, using linear regression to control for demographic and clinical covariates, and for association of HIV with laboratory abnormalities. Results The 166 participants living with HIV and 159 without HIV did not differ in median chemotherapy RDI: 0.89 (interquartile range (IQR) 0.77-0.95) among those living with HIV and 0.87 (IQR 0.77-0.94) among women without HIV. Patients living with HIV experienced more grade 3+ anemia and leukopenia than those without HIV (anemia: 10.8% vs. 1.9%, P =.001; leukopenia: 8.4% vs. 1.9%, P =.008) and were more likely to receive filgrastim (24.7% vs. 10.7%, P =.001). Conclusions HIV status did not impact neoadjuvant or adjuvant chemotherapy RDI, although patients with breast cancer living with HIV experienced more myelotoxicity during treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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14. Prevalence of multimorbidity in men of African descent with and without prostate cancer in Soweto, South Africa

Author

Mapanga, Witness, primary, Norris, Shane A., additional, Craig, Ashleigh, additional, Pumpalova, Yoanna, additional, Ayeni, Oluwatosin A., additional, Chen, Wenlong Carl, additional, Jacobson, Judith S., additional, Neugut, Alfred I., additional, Muchengeti, Mazvita, additional, Pentz, Audrey, additional, Doherty, Sean, additional, Minkowitz, Shauli, additional, Haffejee, Mohammed, additional, Rebbeck, Tim, additional, and Joffe, Maureen, additional

Published
2022
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18. Impact of HIV infection on survival among women with stage I‐III breast cancer: Results from the South African breast cancer and HIV outcomes study

Author

Ayeni, Oluwatosin A., primary, O'Neil, Daniel S., additional, Pumpalova, Yoanna S., additional, Chen, Wenlong Carl, additional, Nietz, Sarah, additional, Phakathi, Boitumelo, additional, Buccimazza, Ines, additional, Čačala, Sharon, additional, Stopforth, Laura W., additional, Farrow, Hayley A., additional, Mapanga, Witness, additional, Joffe, Maureen, additional, Chirwa, Tobias, additional, McCormack, Valerie, additional, Jacobson, Judith S., additional, Crew, Katherine D., additional, Neugut, Alfred I., additional, Ruff, Paul, additional, and Cubasch, Herbert, additional

Published
2022
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22. The Impact of Breast Cancer Treatment Delays on Survival Among South African Women

Author

Pumpalova, Yoanna S, primary, Ayeni, Oluwatosin A, additional, Chen, Wenlong Carl, additional, Buccimazza, Ines, additional, Cačala, Sharon, additional, Stopforth, Laura W, additional, Farrow, Hayley A, additional, Mapanga, Witness, additional, Nietz, Sarah, additional, Phakathi, Boitumelo, additional, Joffe, Maureen, additional, McCormack, Valerie, additional, Jacobson, Judith S, additional, Crew, Katherine D, additional, Neugut, Alfred I, additional, Ruff, Paul, additional, Cubasch, Herbert, additional, and O’Neil, Daniel S, additional

Published
2022
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26. The impact of HIV infection on overall survival among women with stage IV breast cancer in South Africa.

Author

Pumpalova, Yoanna S, primary, Ayeni, Oluwatosin, additional, Chen, Wenlong Carl, additional, O'Neil, Daniel, additional, Nietz, Sarah, additional, Phakathi, Boitumelo, additional, Buccimazza, Ines, additional, Cacala, Sharon, additional, Stopforth, Laura, additional, Farrow, Hayley, additional, Joffe, Maureen, additional, Mapanga, Witness, additional, Jacobson, Judith, additional, Crew, Katherine D., additional, Cubasch, Herbert, additional, Ruff, Paul, additional, and Neugut, Alfred I., additional

Published
2021
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27. Mismatch Repair (MMR) Gene Alteration and BRAF V600E Mutation Are Potential Predictive Biomarkers of Immune Checkpoint Inhibitors in MMR-Deficient Colorectal Cancer

Author

Sahin, Ibrahim Halil, primary, Goyal, Subir, additional, Pumpalova, Yoanna, additional, Sonbol, Mohamad B., additional, Das, Satya, additional, Haraldsdottir, Sigurdis, additional, Ahn, Daniel, additional, Ciombor, Kristen K., additional, Chen, Zhengjia, additional, Draper, Amber, additional, Berlin, Jordan, additional, Bekaii-Saab, Tanios, additional, Lesinski, Gregory B., additional, El-Rayes, Bassel F., additional, and Wu, Christina, additional

Published
2021
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28. Impact of Breast Cancer Treatment Delays on Survival Among South African Women.

Author

Pumpalova, Yoanna S, Ayeni, Oluwatosin A, Chen, Wenlong Carl, Buccimazza, Ines, Cačala, Sharon, Stopforth, Laura W, Farrow, Hayley A, Mapanga, Witness, Nietz, Sarah, Phakathi, Boitumelo, Joffe, Maureen, McCormack, Valerie, Jacobson, Judith S, Crew, Katherine D, Neugut, Alfred I, Ruff, Paul, Cubasch, Herbert, and O'Neil, Daniel S

Subjects
BREAST tumor treatment, BREAST cancer prognosis, CONFIDENCE intervals, REGRESSION analysis, TREATMENT delay (Medicine), COMPARATIVE studies, CANCER patients, DESCRIPTIVE statistics, SOCIODEMOGRAPHIC factors, COMBINED modality therapy, WOMEN'S health, PROPORTIONAL hazards models
Abstract

Background In high-income settings, delays from breast cancer (BC) diagnosis to initial treatment worsen overall survival (OS). We examined how time to BC treatment initiation (TTI) impacts OS in South Africa (SA). Methods We evaluated women enrolled in the South African BC and HIV Outcomes study between July 1, 2015 and June 30, 2019, selecting women with stages I-III BC who received surgery and chemotherapy. We constructed a linear regression model estimating the impact of sociodemographic and clinical factors on TTI and separate multivariable Cox proportional hazard models by first treatment (surgery and neoadjuvant chemotherapy (NAC)) assessing the effect of TTI (in 30-day increments) on OS. Results Of 1260 women, 45.6% had upfront surgery, 54.4% had NAC, and 19.5% initiated treatment >90 days after BC diagnosis. Compared to the surgery group, more women in the NAC group had stage III BC (34.8% vs 81.5%). Living further away from a hospital and having hormone receptor positive (vs negative) BC was associated with longer TTI (8 additional days per 100 km, P =. 003 and 8 additional days, P =. 01, respectively), while Ki67 proliferation index >20 and upfront surgery (vs NAC) was associated with shorter TTI (12 and 9 days earlier; P =. 0001 and.007, respectively). Treatment initiation also differed among treating hospitals (P <. 0001). Additional 30-day treatment delays were associated with worse survival in the surgery group (HR 1.11 [95%CI 1.003-1.22]), but not in the NAC group. Conclusions Delays in BC treatment initiation are common in SA public hospitals and are associated with worse survival among women treated with upfront surgery. [ABSTRACT FROM AUTHOR]

Published
2022
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31. Clinical and molecular markers of immune checkpoint inhibitor (ICI) response in dMMR colorectal cancer (CRC) patients (pts).

Author

Sahin, Ibrahim Halil, primary, Goyal, Subir, additional, Pumpalova, Yoanna S, additional, Sonbol, Mohamad Bassam, additional, Das, Satya, additional, Haraldsdottir, Sigurdis, additional, Chen, Zhengjia, additional, Akce, Mehmet, additional, Alese, Olatunji B., additional, Shaib, Walid Labib, additional, Ahn, Daniel H., additional, Ciombor, Kristen Keon, additional, Berlin, Jordan, additional, Bekaii-Saab, Tanios S., additional, Draper, Amber, additional, Lesinski, Gregory B., additional, El-Rayes, Bassel F., additional, and Wu, Christina, additional

Published
2020
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32. Immune-Related Adverse Events and Immune Checkpoint Inhibitor Efficacy in Patients with Gastrointestinal Cancer with Food and Drug Administration-Approved Indications for Immunotherapy

Author

Das, Satya, primary, Ciombor, Kristen K., additional, Haraldsdottir, Sigurdis, additional, Pumpalova, Yoanna, additional, Sahin, Ibrahim H., additional, Pineda, G., additional, Shyr, Yu, additional, Lin, E.P., additional, Hsu, Chih-Yuan, additional, Chu, Shih-Kai, additional, Goff, Laura W., additional, Cardin, Dana B., additional, Bilen, Mehmet A., additional, Fisher, George A., additional, Wu, Christina, additional, and Berlin, Jordan, additional

Published
2020
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34. Immune checkpoint inhibitors (ICIs) in gastrointestinal (GI) cancer: Immune-related adverse events (IRAEs) and efficacy.

Author

Das, Satya, primary, Ciombor, Kristen Keon, additional, Haraldsdottir, Sigurdis, additional, Pumpalova, Yoanna S, additional, Sahin, Ibrahim Halil, additional, Shyr, Yu, additional, Chu, Shih-Kai, additional, Lin, Emily Pei-Ying, additional, Hsu, Chih-Yuan, additional, Goff, Laura Williams, additional, Cardin, Dana Backlund, additional, Bilen, Mehmet Asim, additional, Berlin, Jordan, additional, and Wu, Christina, additional

Published
2019
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38. A modified Community Assessment for Public Health Emergency Response (CASPER) four months after Hurricane Sandy.

Author

Subaiya, Saleena, Stillman, Joshua, and Pumpalova, Yoanna

Subjects
HURRICANE Sandy, 2012, PUBLIC health, EMERGENCY management, HUMANITARIAN assistance, INTERNATIONAL relief
Abstract

This study sought to assess access to utilities, basic needs, financial burden, and perceived safety among households in the Rockaway Peninsula of New York City, United States, four months after Hurricane Sandy struck in 2012. A modified cluster survey design was used to select households for inclusion in the study. Survey content was created using the Community Assessment for Public Health Emergency Response (CASPER) toolkit, gathering relevant data on access to food and water, basic utilities, financial burden, household demographics, and safety. Four months after Sandy, electricity and heat had been restored to all households. However, around one‐third of them still had difficulty in obtaining food, and about one‐half believed that their neighborhood was unsafe. One‐quarter had problems in acquiring prescription medications, and approximately one‐half reported anxiety. While basic utilities were almost entirely restored, there were ongoing challenges in Rockaway four months after Sandy, relating to financial hardship, food insecurity, healthcare, and psychologic distress. [ABSTRACT FROM AUTHOR]

Published
2019
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