Author: "Puras Lutzke, Ramon A." - Searchworks@Jio Institute Digital Library Search Results

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Author: Eijkelenboom, Astrid P.A.M., primary, Sprangers, Remco, additional, H�rd, Karl, additional, Puras Lutzke, Ramon A., additional, Plasterk, Ronald H.A., additional, Boelens, Rolf, additional, and Kaptein, Robert, additional
Published: 1999
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Author: Eijkelenboom, Astrid P.A.M., primary, Puras Lutzke, Ramon A., additional, Boelens, Rolf, additional, Plasterk, Ronald H.A., additional, Kaptein, Robert, additional, and Hård, Karl, additional
Published: 1995
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Author: Puras Lutzke, Ramon A., primary, Vink, Cornells, additional, and Plasterk, Ronald H.A., additional
Published: 1994
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Author: Granzin, Joachim, primary, Puras-Lutzke, Ramon, additional, Landt, Olfert, additional, Grunert, Hans-Peter, additional, Heinemann, Udo, additional, Saenger, Wolfram, additional, and Hahn, Ulrich, additional
Published: 1992
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Author: Eijkelenboom, Astrid P.A.M., Puras Lutzke, Ramon A., Boelens, Rolf, Plasterk, Ronald H.A., Kaptein, Robert, and Hård, Karl
Abstract: We have determined the solution structure of the DNA-binding domain of HIV-1 integrase by nuclear magnetic resonance spectroscopy. In solution, this carboxy-terminal region of integrase forms a homodimer, consisting of two structures that closely resemble Src-homology 3 (SH3) domains. Lys 264, previously identified by mutagenesis studies to be important for DNA binding of the integrase, as well as several adjacent basic amino acids are solvent exposed. The identification of an SH3-like domain in integrase provides a new potential target for drug design.
Published: 1995
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