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1. A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish

Author

Winton James R, Purcell Maureen K, Laing Kerry J, and Hansen John D

Subjects
Evolution, QH359-425
Abstract

Abstract Background A large multigene family of NOD-like receptor (NLR) molecules have been described in mammals and implicated in immunity and apoptosis. Little information, however, exists concerning this gene family in non-mammalian taxa. This current study, therefore, provides an in-depth investigation of this gene family in lower vertebrates including extensive phylogenetic comparison of zebrafish NLRs with orthologs in tetrapods, and analysis of their tissue-specific expression. Results Three distinct NLR subfamilies were identified by mining genome databases of various non-mammalian vertebrates; the first subfamily (NLR-A) resembles mammalian NODs, the second (NLR-B) resembles mammalian NALPs, while the third (NLR-C) appears to be unique to teleost fish. In zebrafish, NLR-A and NLR-B subfamilies contain five and six genes respectively. The third subfamily is large, containing several hundred NLR-C genes, many of which are predicted to encode a C-terminal B30.2 domain. This subfamily most likely evolved from a NOD3-like molecule. Gene predictions for zebrafish NLRs were verified using sequence derived from ESTs or direct sequencing of cDNA. Reverse-transcriptase (RT)-PCR analysis confirmed expression of representative genes from each subfamily in selected tissues. Conclusion Our findings confirm the presence of multiple NLR gene orthologs, which form a large multigene family in teleostei. Although the functional significance of the three major NLR subfamilies is unclear, we speculate that conservation and abundance of NLR molecules in all teleostei genomes, reflects an essential role in cellular control, apoptosis or immunity throughout bony fish.

Published
2008
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2. Disease in Central Valley Salmon: Status and Lessons from Other Systems

Author

Lehman, Brendan M., Johnson, Rachel C., Adkison, Mark, Burgess, Oliver T., Connon, Richard E., Fangue, Nann A., Foott, J. Scott, Hallett, Sascha L., Martinez–López, Beatriz, Miller, Kristina M., Purcell, Maureen K., Som, Nicholas A., Valdes–Donoso, Pablo, and Collins, Alison L.

Subjects
pathogen, infectious disease, Ceratonova shasta, %22">/i>, Pacific salmon
Abstract

Chinook Salmon (Oncorhynchus tshawytscha) are increasingly vulnerable to anthropogenic activities and climate change, especially at their most southern species range in California’s Central Valley. There is considerable interest in understanding stressors that contribute to population decline and in identifying management actions that reduce the impacts of those stressors. Along the west coast of North America, disease has been linked to declining numbers of salmonids and identified as a key stressor resulting in mortality. In the Central Valley, targeted studies have revealed extremely high prevalence of infectious agents and disease. However, there has been insufficient monitoring to understand the effect that disease may have on salmon populations. In order to inform future research, monitoring, and management efforts, a two-day workshop on salmon disease was held at UC Davis on March 14-15, 2018. This paper summarizes the science presented at this workshop, including the current state of knowledge of salmonid disease in the Central Valley and current and emerging tools to better understand its impacts on salmon. We highlight case studies from other systems where successful monitoring programs have been implemented. First, in the Klamath River where the integration of several data collection and modeling approaches led to the development of successful management actions, and second in British Columbia where investment in researching novel technologies led to breakthroughs in the understanding of salmon disease dynamics. Finally, we identify key information and knowledge gaps necessary to guide research and management of disease in Central Valley salmon populations.

Published
2020

4. Genome-wide association analysis of the resistance to infectious hematopoietic necrosis virus in two rainbow trout aquaculture lines confirms oligogenic architecture with several moderate effect quantitative trait loci

Author

Palti, Yniv, primary, Vallejo, Roger L., additional, Purcell, Maureen K., additional, Gao, Guangtu, additional, Shewbridge, Kristy L., additional, Long, Roseanna L., additional, Setzke, Christopher, additional, Fragomeni, Breno O., additional, Cheng, Hao, additional, Martin, Kyle E., additional, and Naish, Kerry A., additional

Published
2024
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10. Major histocompatibility complex loci are associated with susceptibility of Atlantic salmon to infectious hematopoietic necrosis virus

Author

Miller, Kristina M., Winton, James R., Schulze, Angela D., Purcell, Maureen K., Ming, Tobi J., Noakes, David L. G., editor, Gharrett, Anthony J., editor, Gustafson, Richard G., editor, Nielsen, Jennifer L., editor, Seeb, James E., editor, Seeb, Lisa W., editor, Smoker, William W., editor, Thorgaard, Gary H., editor, and Wilmot, Richard L., editor

Published
2004
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20. Disruption of the Francisella noatunensis subsp. orientalis pdpA Gene Results in Virulence Attenuation and Protection in Zebrafish

Author

Hansen, John D., primary, Ray, Karina, additional, Chen, Po-Jui, additional, Yun, Susan, additional, Elliott, Diane G., additional, Conway, Carla M., additional, Calcutt, Michael J., additional, Purcell, Maureen K., additional, Welch, Timothy J., additional, Bellah, John P., additional, Davis, Ellie M., additional, Greer, Justin B., additional, and Soto, Esteban, additional

Published
2021
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21. Development of a real-time PCR assay for detection of planktonic red king crab (Paralithodes camtschaticus (Tilesius 1815)) larvae

Author

Jensen, Pamela C., Purcell, Maureen K., Morado, J. Frank, and Eckert, Ginny L.

Subjects
Larval development -- Research, Methodology -- Usage, Plankton research -- Methods, Company growth, Biological sciences, Zoology and wildlife conservation
Abstract

ABSTRACT The Alaskan red king crab (Paralithodes camtschaticus) fishery was once one of the most economically important single-species fisheries in the world, but is currently depressed. This fishery would benefit [...]

Published
2012
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30. Exploration of the 2016 Yellowstone River fish kill and proliferative kidney disease in wild fish populations

Author

Hutchins, Patrick R., primary, Sepulveda, Adam J., additional, Hartikainen, Hanna, additional, Staigmiller, Ken D., additional, Opitz, Scott T., additional, Yamamoto, Renee M., additional, Huttinger, Amberly, additional, Cordes, Rick J., additional, Weiss, Tammy, additional, Hopper, Lacey R., additional, Purcell, Maureen K., additional, and Okamura, Beth, additional

Published
2021
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41. Recommended reporting standards for test accuracy studies of infectious diseases of finfish, amphibians, molluscs and crustaceans: the STRADAS-aquatic checklist

Author

Gardner, Ian A., Whittington, Richard J., Caraguel, Charles G. B., Hick, Paul, Moody, Nicholas J. G., Corbeil, Serge, Garver, Kyle A., Warg, Janet V., Arzul, Isabelle, Purcell, Maureen K., Crane, Mark St J., Waltzek, Thomas B., Olesen, Niels J., Gallardo Lagno, Alicia, Gardner, Ian A., Whittington, Richard J., Caraguel, Charles G. B., Hick, Paul, Moody, Nicholas J. G., Corbeil, Serge, Garver, Kyle A., Warg, Janet V., Arzul, Isabelle, Purcell, Maureen K., Crane, Mark St J., Waltzek, Thomas B., Olesen, Niels J., and Gallardo Lagno, Alicia

Abstract

Complete and transparent reporting of key elements of diagnostic accuracy studies for infectious diseases in cultured and wild aquatic animals benefits end-users of these tests, enabling the rational design of surveillance programs, the assessment of test results from clinical cases and comparisons of diagnostic test performance. Based on deficiencies in the Standards for Reporting of Diagnostic Accuracy (STARD) guidelines identified in a prior finfish study (Gardner et al. 2014), we adapted the Standards for Reporting of Animal Diagnostic Accuracy Studies—paratuberculosis (STRADAS-paraTB) checklist of 25 reporting items to increase their relevance to finfish, amphibians, molluscs, and crustaceans and provided examples and explanations for each item. The checklist, known as STRADAS-aquatic, was developed and refined by an expert group of 14 transdisciplinary scientists with experience in test evaluation studies using field and experimental samples, in operation of reference laboratories for aquatic animal pathogens, and in development of international aquatic animal health policy. The main changes to the STRADAS-paraTB checklist were to nomenclature related to the species, the addition of guidelines for experimental challenge studies, and the designation of some items as relevant only to experimental studies and ante-mortem tests. We believe that adoption of these guidelines will improve reporting of primary studies of test accuracy for aquatic animal diseases and facilitate assessment of their fitness-for-purpose. Given the importance of diagnostic tests to underpin the Sanitary and Phytosanitary agreement of the World Trade Organization, the principles outlined in this paper should be applied to other World Organisation for Animal Health (OIE)-relevant species.

Published
2016
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42. Potential drivers of virulence evolution in aquaculture

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Brito, Ilana Lauren, Kennedy, David A., Kurath, Gael, Purcell, Maureen K., Read, Andrew F., Winton, James R., Wargo, Andrew R., Massachusetts Institute of Technology. Department of Biological Engineering, Brito, Ilana Lauren, Kennedy, David A., Kurath, Gael, Purcell, Maureen K., Read, Andrew F., Winton, James R., and Wargo, Andrew R.

Abstract

Infectious diseases are economically detrimental to aquaculture, and with continued expansion and intensification of aquaculture, the importance of managing infectious diseases will likely increase in the future. Here, we use evolution of virulence theory, along with examples, to identify aquaculture practices that might lead to the evolution of increased pathogen virulence. We identify eight practices common in aquaculture that theory predicts may favor evolution toward higher pathogen virulence. Four are related to intensive aquaculture operations, and four others are related specifically to infectious disease control. Our intention is to make aquaculture managers aware of these risks, such that with increased vigilance, they might be able to detect and prevent the emergence and spread of increasingly troublesome pathogen strains in the future.

Published
2016

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