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3. Author Correction: Comparative and demographic analysis of orang-utan genomes

Author

Locke, Devin P., Hillier, LaDeana W., Warren, Wesley C., Worley, Kim C., Nazareth, Lynne V., Muzny, Donna M., Yang, Shiaw-Pyng, Wang, Zhengyuan, Chinwalla, Asif T., Minx, Pat, Mitreva, Makedonka, Cook, Lisa, Delehaunty, Kim D., Fronick, Catrina, Schmidt, Heather, Fulton, Lucinda A., Fulton, Robert S., Nelson, Joanne O., Magrini, Vincent, Pohl, Craig, Graves, Tina A., Markovic, Chris, Cree, Andy, Dinh, Huyen H., Hume, Jennifer, Kovar, Christie L., Fowler, Gerald R., Lunter, Gerton, Meader, Stephen, Heger, Andreas, Ponting, Chris P., Marques-Bonet, Tomas, Alkan, Can, Chen, Lin, Cheng, Ze, Kidd, Jeffrey M., Eichler, Evan E., White, Simon, Searle, Stephen, Vilella, Albert J., Chen, Yuan, Flicek, Paul, Ma, Jian, Raney, Brian, Suh, Bernard, Burhans, Richard, Herrero, Javier, Haussler, David, Faria, Rui, Fernando, Olga, Darré, Fleur, Farré, Domènec, Gazave, Elodie, Oliva, Meritxell, Navarro, Arcadi, Roberto, Roberta, Capozzi, Oronzo, Archidiacono, Nicoletta, Della Valle, Giuliano, Purgato, Stefania, Rocchi, Mariano, Konkel, Miriam K., Walker, Jerilyn A., Ullmer, Brygg, Batzer, Mark A., Smit, Arian F. A., Hubley, Robert, Casola, Claudio, Schrider, Daniel R., Hahn, Matthew W., Quesada, Victor, Puente, Xose S., Ordoñez, Gonzalo R., López-Otín, Carlos, Vinar, Tomas, Brejova, Brona, Ratan, Aakrosh, Harris, Robert S., Miller, Webb, Kosiol, Carolin, Lawson, Heather A., Taliwal, Vikas, Martins, André L., Siepel, Adam, RoyChoudhury, Arindam, Ma, Xin, Degenhardt, Jeremiah, Bustamante, Carlos D., Gutenkunst, Ryan N., Mailund, Thomas, Dutheil, Julien Y., Hobolth, Asger, Schierup, Mikkel H., Ryder, Oliver A., Yoshinaga, Yuko, de Jong, Pieter J., Weinstock, George M., Rogers, Jeffrey, Mardis, Elaine R., Gibbs, Richard A., and Wilson, Richard K.

Published
2022
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6. Supplementary Figure 5 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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7. Supplementary Figure 2 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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8. CCR Translation for This Article from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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9. Supplementary Figure 3 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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10. Supplementary Figure 6 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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11. Supplementary Tables 1-3 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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12. Supplementary Tables 6-7 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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13. Supplementary Figure 4 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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14. Supplementary Materials and Methods from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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15. Supplementary Figure 1 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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16. Supplementary Table 4 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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17. Supplementary Table 5 from Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, primary, Camerin, Consuelo, primary, Walters, Zoë S., primary, Di Leo, Korinne, primary, Selfe, Joanna, primary, Purgato, Stefania, primary, Missiaglia, Edoardo, primary, Tortori, Andrea, primary, Renshaw, Jane, primary, Astolfi, Annalisa, primary, Taylor, Kathryn R., primary, Serravalle, Salvatore, primary, Bishop, Ryan, primary, Nanni, Cristina, primary, Valentijn, Linda J., primary, Faccini, Andrea, primary, Leuschner, Ivo, primary, Formica, Serena, primary, Reis-Filho, Jorge S., primary, Ambrosini, Valentina, primary, Thway, Khin, primary, Franzoni, Monica, primary, Summersgill, Brenda, primary, Marchelli, Rosangela, primary, Hrelia, Patrizia, primary, Cantelli-Forti, Giorgio, primary, Fanti, Stefano, primary, Corradini, Roberto, primary, Pession, Andrea, primary, and Shipley, Janet, primary

Published
2023
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18. Supplementary Figures from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Author

O'Brien, Rosemary, primary, Tran, Sieu L., primary, Maritz, Michelle F., primary, Liu, Bing, primary, Kong, Cheng Fei, primary, Purgato, Stefania, primary, Yang, Chen, primary, Murray, Jayne, primary, Russell, Amanda J., primary, Flemming, Claudia L., primary, von Jonquieres, Georg, primary, Pickett, Hilda A., primary, London, Wendy B., primary, Haber, Michelle, primary, Gunaratne, Preethi H., primary, Norris, Murray D., primary, Perini, Giovanni, primary, Fletcher, Jamie I., primary, and MacKenzie, Karen L., primary

Published
2023
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19. Supplementary Figure Legends from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Author

O'Brien, Rosemary, primary, Tran, Sieu L., primary, Maritz, Michelle F., primary, Liu, Bing, primary, Kong, Cheng Fei, primary, Purgato, Stefania, primary, Yang, Chen, primary, Murray, Jayne, primary, Russell, Amanda J., primary, Flemming, Claudia L., primary, von Jonquieres, Georg, primary, Pickett, Hilda A., primary, London, Wendy B., primary, Haber, Michelle, primary, Gunaratne, Preethi H., primary, Norris, Murray D., primary, Perini, Giovanni, primary, Fletcher, Jamie I., primary, and MacKenzie, Karen L., primary

Published
2023
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20. Supplementary Methods from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Author

O'Brien, Rosemary, primary, Tran, Sieu L., primary, Maritz, Michelle F., primary, Liu, Bing, primary, Kong, Cheng Fei, primary, Purgato, Stefania, primary, Yang, Chen, primary, Murray, Jayne, primary, Russell, Amanda J., primary, Flemming, Claudia L., primary, von Jonquieres, Georg, primary, Pickett, Hilda A., primary, London, Wendy B., primary, Haber, Michelle, primary, Gunaratne, Preethi H., primary, Norris, Murray D., primary, Perini, Giovanni, primary, Fletcher, Jamie I., primary, and MacKenzie, Karen L., primary

Published
2023
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21. Supplementary Figure 6 from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Author

O'Brien, Rosemary, primary, Tran, Sieu L., primary, Maritz, Michelle F., primary, Liu, Bing, primary, Kong, Cheng Fei, primary, Purgato, Stefania, primary, Yang, Chen, primary, Murray, Jayne, primary, Russell, Amanda J., primary, Flemming, Claudia L., primary, von Jonquieres, Georg, primary, Pickett, Hilda A., primary, London, Wendy B., primary, Haber, Michelle, primary, Gunaratne, Preethi H., primary, Norris, Murray D., primary, Perini, Giovanni, primary, Fletcher, Jamie I., primary, and MacKenzie, Karen L., primary

Published
2023
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22. Supplementary Tables from MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Author

O'Brien, Rosemary, primary, Tran, Sieu L., primary, Maritz, Michelle F., primary, Liu, Bing, primary, Kong, Cheng Fei, primary, Purgato, Stefania, primary, Yang, Chen, primary, Murray, Jayne, primary, Russell, Amanda J., primary, Flemming, Claudia L., primary, von Jonquieres, Georg, primary, Pickett, Hilda A., primary, London, Wendy B., primary, Haber, Michelle, primary, Gunaratne, Preethi H., primary, Norris, Murray D., primary, Perini, Giovanni, primary, Fletcher, Jamie I., primary, and MacKenzie, Karen L., primary

Published
2023
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24. Centromere sliding on a mammalian chromosome

Author

Purgato, Stefania, Belloni, Elisa, Piras, Francesca M., Zoli, Monica, Badiale, Claudia, Cerutti, Federico, Mazzagatti, Alice, Perini, Giovanni, Della Valle, Giuliano, Nergadze, Solomon G., Sullivan, Kevin F., Raimondi, Elena, Rocchi, Mariano, and Giulotto, Elena

Published
2015
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26. Comparative and demographic analysis of orang-utan genomes

Author

Locke, Devin P., Hillier, LaDeana W., Warren, Wesley C., Worley, Kim C., Nazareth, Lynne V., Muzny, Donna M., Yang, Shiaw-Pyng, Wang, Zhengyuan, Chinwalla, Asif T., Minx, Pat, Mitreva, Makedonka, Cook, Lisa, Delehaunty, Kim D., Fronick, Catrina, Schmidt, Heather, Fulton, Lucinda A., Fulton, Robert S., Nelson, Joanne O., Magrini, Vincent, Pohl, Craig, Graves, Tina A., Markovic, Chris, Cree, Andy, Dinh, Huyen H., Hume, Jennifer, Kovar, Christie L., Fowler, Gerald R., Lunter, Gerton, Meader, Stephen, Heger, Andreas, Ponting, Chris P., Marques-Bonet, Tomas, Alkan, Can, Chen, Lin, Cheng, Ze, Kidd, Jeffrey M., Eichler, Evan E., White, Simon, Searle, Stephen, Vilella, Albert J., Chen, Yuan, Flicek, Paul, Ma, Jian, Raney, Brian, Suh, Bernard, Burhans, Richard, Herrero, Javier, Haussler, David, Faria, Rui, Fernando, Olga, Darré, Fleur, Farré, Domènec, Gazave, Elodie, Oliva, Meritxell, Navarro, Arcadi, Roberto, Roberta, Capozzi, Oronzo, Archidiacono, Nicoletta, Valle, Giuliano Della, Purgato, Stefania, Rocchi, Mariano, Konkel, Miriam K., Walker, Jerilyn A., Ullmer, Brygg, Batzer, Mark A., Smit, Arian F. A., Hubley, Robert, Casola, Claudio, Schrider, Daniel R., Hahn, Matthew W., Quesada, Victor, Puente, Xose S., Ordoñez, Gonzalo R., López-Otín, Carlos, Vinar, Tomas, Brejova, Brona, Ratan, Aakrosh, Harris, Robert S., Miller, Webb, Kosiol, Carolin, Lawson, Heather A., Taliwal, Vikas, Martins, André L., Siepel, Adam, RoyChoudhury, Arindam, Ma, Xin, Degenhardt, Jeremiah, Bustamante, Carlos D., Gutenkunst, Ryan N., Mailund, Thomas, Dutheil, Julien Y., Hobolth, Asger, Schierup, Mikkel H., Ryder, Oliver A., Yoshinaga, Yuko, de Jong, Pieter J., Weinstock, George M., Rogers, Jeffrey, Mardis, Elaine R., Gibbs, Richard A., and Wilson, Richard K.

Published
2011
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28. A G316A Polymorphism in the Ornithine Decarboxylase Gene Promoter Modulates MYCN-Driven Childhood Neuroblastoma

Author

Gamble, Laura D., primary, Purgato, Stefania, additional, Henderson, Michelle J., additional, Di Giacomo, Simone, additional, Russell, Amanda J., additional, Pigini, Paolo, additional, Murray, Jayne, additional, Valli, Emanuele, additional, Milazzo, Giorgio, additional, Giorgi, Federico M., additional, Cowley, Mark, additional, Ashton, Lesley J., additional, Bhalshankar, Jaydutt, additional, Schleiermacher, Gudrun, additional, Rihani, Ali, additional, Van Maerken, Tom, additional, Vandesompele, Jo, additional, Speleman, Frank, additional, Versteeg, Rogier, additional, Koster, Jan, additional, Eggert, Angelika, additional, Noguera, Rosa, additional, Stallings, Raymond L., additional, Tonini, Gian Paolo, additional, Fong, Kwun, additional, Vaksman, Zalman, additional, Diskin, Sharon J., additional, Maris, John M., additional, London, Wendy B., additional, Marshall, Glenn M., additional, Ziegler, David S., additional, Hogarty, Michael D., additional, Perini, Giovanni, additional, Norris, Murray D., additional, and Haber, Michelle, additional

Published
2021
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30. Erratum to: Centromere sliding on a mammalian chromosome

Author

Purgato, Stefania, Belloni, Elisa, Piras, Francesca M., Zoli, Monica, Badiale, Claudia, Cerutti, Federico, Mazzagatti, Alice, Perini, Giovanni, Della Valle, Giuliano, Nergadze, Solomon G., Sullivan, Kevin F., Raimondi, Elena, Rocchi, Mariano, and Giulotto, Elena

Published
2015
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31. Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

Author

Gamble, Laura D., Purgato, Stefania, Murray, Jayne, Xiao, Lin, Yu, Denise M. T., Hanssen, Kimberley M., Giorgi, Federico M., Carter, Daniel R., Gifford, Andrew J., Valli, Emanuele, Milazzo, Giorgio, Kamili, Alvin, Mayoh, Chelsea, Liu, Bing, Eden, Georgina, Sarraf, Sara, Allan, Sophie, Di Giacomo, Simone, Flemming, Claudia L., Russell, Amanda J., Cheung, Belamy B., Oberthuer, Andre, London, Wendy B., Fischer, Matthias, Trahair, Toby N., Fletcher, Jamie, I, Marshall, Glenn M., Ziegler, David S., Hogarty, Michael D., Burns, Mark R., Perini, Giovanni, Norris, Murray D., Haber, Michelle, Gamble, Laura D., Purgato, Stefania, Murray, Jayne, Xiao, Lin, Yu, Denise M. T., Hanssen, Kimberley M., Giorgi, Federico M., Carter, Daniel R., Gifford, Andrew J., Valli, Emanuele, Milazzo, Giorgio, Kamili, Alvin, Mayoh, Chelsea, Liu, Bing, Eden, Georgina, Sarraf, Sara, Allan, Sophie, Di Giacomo, Simone, Flemming, Claudia L., Russell, Amanda J., Cheung, Belamy B., Oberthuer, Andre, London, Wendy B., Fischer, Matthias, Trahair, Toby N., Fletcher, Jamie, I, Marshall, Glenn M., Ziegler, David S., Hogarty, Michael D., Burns, Mark R., Perini, Giovanni, Norris, Murray D., and Haber, Michelle

Abstract

Amplification of the MYCN oncogene is associated with an aggressive phenotype and poor outcome in childhood neuroblastoma. Polyamines are highly regulated essential cations that are frequently elevated in cancer cells, and the rate-limiting enzyme in polyamine synthesis, ornithine decarboxylase 1 (ODC1), is a direct transcriptional target of MYCN. Treatment of neuroblastoma cells with the ODC1 inhibitor difluoromethylornithine (DFMO), although a promising therapeutic strategy, is only partially effective at impeding neuroblastoma cell growth due to activation of compensatory mechanisms resulting in increased polyamine uptake from the surrounding microenvironment. In this study, we identified solute carrier family 3 member 2 (SLC3A2) as the key transporter involved in polyamine uptake in neuroblastoma. Knockdown of SLC3A2 in neuroblastoma cells reduced the uptake of the radiolabeled polyamine spermidine, and DFMO treatment increased SLC3A2 protein. In addition, MYCN directly increased polyamine synthesis and promoted neuroblastoma cell proliferation by regulating SLC3A2 and other regulatory components of the polyamine pathway. Inhibiting polyamine uptake with the small-molecule drug AMXT 1501, in combination with DFMO, prevented or delayed tumor development in neuroblastoma-prone mice and extended survival in rodent models of established tumors. Our findings suggest that combining AMXT 1501 and DFMO with standard chemotherapy might be an effective strategy for treating neuroblastoma.

Published
2019

32. Inhibition of polyamine synthesis and uptake reduces tumor progression and prolongs survival in mouse models of neuroblastoma

Author

Gamble, Laura D., primary, Purgato, Stefania, additional, Murray, Jayne, additional, Xiao, Lin, additional, Yu, Denise M. T., additional, Hanssen, Kimberley M., additional, Giorgi, Federico M., additional, Carter, Daniel R., additional, Gifford, Andrew J., additional, Valli, Emanuele, additional, Milazzo, Giorgio, additional, Kamili, Alvin, additional, Mayoh, Chelsea, additional, Liu, Bing, additional, Eden, Georgina, additional, Sarraf, Sara, additional, Allan, Sophie, additional, Di Giacomo, Simone, additional, Flemming, Claudia L., additional, Russell, Amanda J., additional, Cheung, Belamy B., additional, Oberthuer, Andre, additional, London, Wendy B., additional, Fischer, Matthias, additional, Trahair, Toby N., additional, Fletcher, Jamie I., additional, Marshall, Glenn M., additional, Ziegler, David S., additional, Hogarty, Michael D., additional, Burns, Mark R., additional, Perini, Giovanni, additional, Norris, Murray D., additional, and Haber, Michelle, additional

Published
2019
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33. Ring chromosomes, breakpoint clusters, and neocentromeres in sarcomas

Author

Macchia, Gemma, Nord, Karolin H., D'Addabbo, Pietro, Whelan, Christopher W., Carbone, Lucia, Mertens, Fredrik, Rocchi, Mariano, Storlazzi, Clelia Tiziana, ZOLI, MONICA, PURGATO, STEFANIA, PERINI, GIOVANNI, Macchia, Gemma, Nord, Karolin H., Zoli, Monica, Purgato, Stefania, D'Addabbo, Pietro, Whelan, Christopher W., Carbone, Lucia, Perini, Giovanni, Mertens, Fredrik, Rocchi, Mariano, and Storlazzi, Clelia Tiziana

Subjects
Ring Chromosome, Cancer Research, Medicine (all), Centromere, Gene Amplification, Sarcoma, Epigenesis, Genetic, Chromosome Breakpoints, Chromosome Breakpoint, Genetic, Humans, Ring Chromosomes, In Situ Hybridization, Fluorescence, Human
Abstract

Gene amplification is relatively common in tumors. In certain subtypes of sarcoma, it often occurs in the form of ring and/or giant rod-shaped marker (RGM) chromosomes whose mitotic stability is frequently rescued by ectopic novel centromeres (neocentromeres). Little is known about the origin and structure of these RGM chromosomes, including how they arise, their internal organization, and which sequences underlie the neocentromeres. To address these questions, 42 sarcomas with RGM chromosomes were investigated to detect regions prone to double strand breaks and possible functional or structural constraints driving the amplification process. We found nine breakpoint cluster regions potentially involved in the genesis of RGM chromosomes, which turned out to be significantly enriched in poly-pyrimidine traits. Some of the clusters were located close to genes already known to be relevant for sarcomas, thus indicating a potential functional constraint, while others mapped to transcriptionally inactive chromatin domains enriched in heterochromatic sites. Of note, five neocentromeres were identified after analyzing 13 of the cases by fluorescent in situ hybridization. ChIP-on-chip analysis with antibodies against the centromeric protein CENP-A showed that they were a patchwork of small genomic segments derived from different chromosomes, likely joint to form a contiguous sequence during the amplification process.

Published
2014

34. The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer

Author

Macchia, Gemma, primary, Severgnini, Marco, additional, Purgato, Stefania, additional, Tolomeo, Doron, additional, Casciaro, Hilen, additional, Cifola, Ingrid, additional, L’Abbate, Alberto, additional, Loverro, Anna, additional, Palumbo, Orazio, additional, Carella, Massimo, additional, Bianchini, Laurence, additional, Perini, Giovanni, additional, De Bellis, Gianluca, additional, Mertens, Fredrik, additional, Rocchi, Mariano, additional, and Storlazzi, Clelia Tiziana, additional

Published
2018
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36. Gene amplification as double minutes or homogeneously staining regions in solid tumors: origin and structure

Author

Storlazzi, Clelia Tiziana, Lonoce, Angelo, Guastadisegni, Maria C., Trombetta, Domenico, D'Addabbo, Pietro, Daniele, Giulia, L'Abbate, Alberto, Macchia, Gemma, Surace, Cecilia, Kok, Klaas, Ullmann, Reinhard, Purgato, Stefania, Palumbo, Orazio, Carella, Massimo, Ambros, Peter F., and Rocchi, Mariano

Subjects
Neuroblastoma -- Genetic aspects, Neuroblastoma -- Research, Genetic transcription -- Analysis, Cancer -- Genetic aspects, Cancer -- Research, Health
Published
2010

38. Epigenetic origin of evolutionary novel centromeres

Author

Tolomeo, Doron, primary, Capozzi, Oronzo, additional, Stanyon, Roscoe R., additional, Archidiacono, Nicoletta, additional, D’Addabbo, Pietro, additional, Catacchio, Claudia R., additional, Purgato, Stefania, additional, Perini, Giovanni, additional, Schempp, Werner, additional, Huddleston, John, additional, Malig, Maika, additional, Eichler, Evan E., additional, and Rocchi, Mariano, additional

Published
2017
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39. MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Author

O'Brien, Rosemary, primary, Tran, Sieu L., additional, Maritz, Michelle F., additional, Liu, Bing, additional, Kong, Cheng Fei, additional, Purgato, Stefania, additional, Yang, Chen, additional, Murray, Jayne, additional, Russell, Amanda J., additional, Flemming, Claudia L., additional, von Jonquieres, Georg, additional, Pickett, Hilda A., additional, London, Wendy B., additional, Haber, Michelle, additional, Gunaratne, Preethi H., additional, Norris, Murray D., additional, Perini, Giovanni, additional, Fletcher, Jamie I., additional, and MacKenzie, Karen L., additional

Published
2016
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40. Abstract 488: High DKC1 expression supports neuroblastoma tumor cell proliferation and is strongly associated with poor patient outcomes

Author

O'Brien, Rosemary, primary, Maritz, Michelle F., additional, Kong, Cheng Fei, additional, Purgato, Stefania, additional, Liu, Bing, additional, Yang, Chen, additional, Russell, Amanda, additional, Murray, Jayne, additional, Flemming, Claudia, additional, Haber, Michelle, additional, Perini, Giovanni, additional, Norris, Murray D., additional, Fletcher, Jamie I., additional, and Mackenzie, Karen L., additional

Published
2015
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41. Inibizione selettiva del gene MYCN mediante PNA (acidi peptido nucleici) anti-gene nel rabdomiosarcoma umano

Author

Purgato, Stefania <1978>

Subjects
BIO/14 Farmacologia, neoplasms
Abstract

MYCN oncogene amplification/expression is a feature of many childhood tumors, and some adult tumors, and it is associated with poor prognosis. While MYC expression is ubiquitary, MYCN has a restricted expression after birth and it is an ideal target for an effective therapy. PNAs belong to the latest class of nucleic acid-based therapeutics, and they can bind chromosomal DNA and block gene transcription (anti-gene activity). We have developed an anti-gene PNA that targets specifically the MYCN gene to block its transcription. We report for the first time MYCN targeted inhibition in Rhabdomyosarcoma (RMS) by the anti-MYCN-PNA in RMS cell lines (four ARMS and four ERMS) and in a xenograft RMS mouse model. Rhabdomyosarcoma is the most common pediatric soft-tissue sarcoma, comprising two main subgroups [Alveolar (ARMS) and Embryonal (ERMS)]. ARMS is associated with a poorer prognosis. MYCN amplification is a feature of both the ERMS and ARMS, but the MYCN amplification and expression levels shows a significant correlation and are greater in ARMS, in which they are associated with adverse outcome. We found that MYCN mRNA and protein levels were higher in the four ARMS (RH30, RH4, RH28 and RMZ-RC2) than in the four ERMS (RH36, SMS-CTR, CCA and RD) cell lines. The potent inhibition of MYCN transcription was highly specific, it did not affect the MYC expression, it was followed by cell-growth inhibition in the RMS cell lines which correlated with the MYCN expression rate, and it led to complete cell-growth inhibition in ARMS cells. We used a mutated- PNA as control. MYCN silencing induced apoptosis. Global gene expression analysis (Affymetrix microarrays) in ARMS cells treated with the anti-MYCN-PNA revealed genes specifically induced or repressed, with both genes previously described as targets of N-myc or Myc, and new genes undescribed as targets of N-myc or Myc (mainly involved in cell cycle, apoptosis, cell motility, metastasis, angiogenesis and muscle development). The changes in the expression of the most relevant genes were confirmed by Real-Time PCR and western blot, and their expression after the MYCN silencing was evaluated in the other RMS cell lines. The in vivo study, using an ARMS xenograft murine model evaluated by micro-PET, showed a complete elimination of the metabolic tumor signal in most of the cases (70%) after anti-MYCN-PNA treatment (without toxicity), whereas treatment with the mutated-PNA had no effect. Our results strongly support the development of MYCN anti-gene therapy for the treatment of RMS, particularly for poor prognosis ARMS, and of other MYCN-expressing tumors.

Published
2008

42. Analisi in vitro ed in vivo dell'attività anti-tumorale dopo inibizione specifica di MYCN mediante PNA-NLS anti-gene nel rabdomiosarcoma umano

Author

TONELLI, ROBERTO, CAMERIN, CONSUELO, PESSION, ANDREA, Di Leo K., PURGATO, STEFANIA, Tortori A., Faccini A., Nanni C., AMBROSINI, VALENTINA, Serravalle S., FANTI, STEFANO, Corradini R., Tonelli R., Di Leo K., Purgato S., Camerin C., Tortori A., Faccini A., Nanni C., Ambrosini V., Serravalle S., Fanti S., Corradini R., and Pession A.

Published
2006

45. Erratum to: Centromere sliding on a mammalian chromosome

Author

Purgato, Stefania, primary, Belloni, Elisa, additional, Piras, Francesca M., additional, Zoli, Monica, additional, Badiale, Claudia, additional, Cerutti, Federico, additional, Mazzagatti, Alice, additional, Perini, Giovanni, additional, Della Valle, Giuliano, additional, Nergadze, Solomon G., additional, Sullivan, Kevin F., additional, Raimondi, Elena, additional, Rocchi, Mariano, additional, and Giulotto, Elena, additional

Published
2014
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46. Centromere sliding on a mammalian chromosome

Author

Purgato, Stefania, primary, Belloni, Elisa, additional, Piras, Francesca M., additional, Zoli, Monica, additional, Badiale, Claudia, additional, Cerutti, Federico, additional, Mazzagatti, Alice, additional, Perini, Giovanni, additional, Della Valle, Giuliano, additional, Nergadze, Solomon G., additional, Sullivan, Kevin F., additional, Raimondi, Elena, additional, Rocchi, Mariano, additional, and Giulotto, Elena, additional

Published
2014
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47. Inibizione selettiva del gene MYCN mediante PNA (acidi peptido nucleici) anti-gene nel rabdomiosarcoma umano

Author

Strocchi, Paola, Purgato, Stefania <1978>, Strocchi, Paola, and Purgato, Stefania <1978>

Abstract

MYCN oncogene amplification/expression is a feature of many childhood tumors, and some adult tumors, and it is associated with poor prognosis. While MYC expression is ubiquitary, MYCN has a restricted expression after birth and it is an ideal target for an effective therapy. PNAs belong to the latest class of nucleic acid-based therapeutics, and they can bind chromosomal DNA and block gene transcription (anti-gene activity). We have developed an anti-gene PNA that targets specifically the MYCN gene to block its transcription. We report for the first time MYCN targeted inhibition in Rhabdomyosarcoma (RMS) by the anti-MYCN-PNA in RMS cell lines (four ARMS and four ERMS) and in a xenograft RMS mouse model. Rhabdomyosarcoma is the most common pediatric soft-tissue sarcoma, comprising two main subgroups [Alveolar (ARMS) and Embryonal (ERMS)]. ARMS is associated with a poorer prognosis. MYCN amplification is a feature of both the ERMS and ARMS, but the MYCN amplification and expression levels shows a significant correlation and are greater in ARMS, in which they are associated with adverse outcome. We found that MYCN mRNA and protein levels were higher in the four ARMS (RH30, RH4, RH28 and RMZ-RC2) than in the four ERMS (RH36, SMS-CTR, CCA and RD) cell lines. The potent inhibition of MYCN transcription was highly specific, it did not affect the MYC expression, it was followed by cell-growth inhibition in the RMS cell lines which correlated with the MYCN expression rate, and it led to complete cell-growth inhibition in ARMS cells. We used a mutated- PNA as control. MYCN silencing induced apoptosis. Global gene expression analysis (Affymetrix microarrays) in ARMS cells treated with the anti-MYCN-PNA revealed genes specifically induced or repressed, with both genes previously described as targets of N-myc or Myc, and new genes undescribed as targets of N-myc or Myc (mainly involved in cell cycle, apoptosis, cell motility, metastasis, angiogenesis and muscle development). The

Published
2008

48. Abstract 3808: MYCN coordinately regulates the entire polyamine gene pathway to drive polyamine biosynthesis in neuroblastoma, with expression of every synthetic and catabolic polyamine pathway gene being highly prognostic of clinical outcome.

Author

Norris, Murray D., primary, Gamble, Laura D., additional, Murray, Jayne, additional, Purgato, Stefania, additional, Milazzo, Giorgio, additional, Ashton, Lesley J., additional, Oberthuer, Andrei, additional, London, Wendy B., additional, Hogarty, Mike D., additional, Fischer, Mattias, additional, Ziegler, David, additional, Marshall, Glenn M., additional, Perini, Giovanni, additional, and Haber, Michelle, additional

Published
2013
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49. Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy

Author

Tonelli, Roberto, primary, McIntyre, Alan, additional, Camerin, Consuelo, additional, Walters, Zoë S., additional, Di Leo, Korinne, additional, Selfe, Joanna, additional, Purgato, Stefania, additional, Missiaglia, Edoardo, additional, Tortori, Andrea, additional, Renshaw, Jane, additional, Astolfi, Annalisa, additional, Taylor, Kathryn R., additional, Serravalle, Salvatore, additional, Bishop, Ryan, additional, Nanni, Cristina, additional, Valentijn, Linda J., additional, Faccini, Andrea, additional, Leuschner, Ivo, additional, Formica, Serena, additional, Reis-Filho, Jorge S., additional, Ambrosini, Valentina, additional, Thway, Khin, additional, Franzoni, Monica, additional, Summersgill, Brenda, additional, Marchelli, Rosangela, additional, Hrelia, Patrizia, additional, Cantelli-Forti, Giorgio, additional, Fanti, Stefano, additional, Corradini, Roberto, additional, Pession, Andrea, additional, and Shipley, Janet, additional

Published
2012
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