1. Congenital pyloric atresia associated with epidermolysis bullosa junctionalis: a novel lethal variant.
- Author
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Reddy MSP, Anand R, Padhi P, and Katravath S
- Subjects
- Humans, Infant, Newborn, Male, Fatal Outcome, Epidermolysis Bullosa, Junctional genetics, Epidermolysis Bullosa, Junctional pathology, Epidermolysis Bullosa, Junctional complications, Gastric Outlet Obstruction etiology, Gastric Outlet Obstruction surgery, Integrin beta4 genetics, Pylorus abnormalities, Pylorus pathology
- Abstract
A term male baby was born vaginally to a primi mother. An antenatal ultrasound revealed polyhydramnios and a distended stomach in the baby. At birth, the baby had well-defined areas of peeling skin on the face and blisters on the forearm region. The abdominal X-ray revealed a single gastric bubble, which is consistent with pyloric atresia and needs surgery. Pyloroplasty was initially performed, but it was unsuccessful. Therefore, a feeding jejunostomy and gastrostomy were performed. However, the baby developed sepsis and septic shock and died at about 2 months of age. Skin biopsy revealed cleavage above the lamina densa, and genetic analysis indicated heterozygosity in ITGB4 exons 10 and 16, which are associated with epidermolysis bullosa junctionalis and pyloric atresia., Competing Interests: Competing interests: None declared., (© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2024
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