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R is becoming the standard for teaching statistics due to its flexibility, and open-source nature, replacing software programs like Minitab and SPSS. The main driver for reform within Scottish statistical undergraduate programs is the creation of the Scottish Qualification Authority's Higher Applications of Mathematics course which has statistics as a core topic. The course saw R introduced into the Scottish high school curriculum for the first time from August 2021. This facilitates the need for R to be introduced into Higher Education courses at an earlier stage. In academic year 2021/22 we introduced RStudio into our first year introductory statistics class. This class is taken by students studying Mathematics, and those studying Biomedical Sciences. Both cohorts were surveyed in order to assess their anxiety and enjoyment of learning how to use R, with a goal of assessing any differences between the groups. We found that there was no association in software anxiety at the start of the class. However, as the class progressed the Mathematics students reported lower levels of anxiety compared to the Biomedical Sciences students. The Mathematics students seemed to enjoy the class more than the Biomedical Sciences students, thus, needing further investigation into enjoyment versus anxiety. [ABSTRACT FROM AUTHOR]

[Display omitted] For solid oral dosage forms drug solubility in intestinal fluid is an important parameter influencing product performance and bioavailability. Solubility along with permeability are the two parameters applied in the Biopharmaceutics and Developability Classification Systems (DCS) to assess a drug's potential for oral administration. Intestinal solubility varies with the intestinal contents and the differences between the fasted and fed states are recognised to influence solubility and bioavailability. In this study a novel fed state simulated media system comprising of nine media has been utilised to measure the solubility of seven drugs (ibuprofen, mefenamic acid, furosemide, dipyridamole, griseofulvin, paracetamol and acyclovir) previously studied in the fasted state DCS. The results demonstrate that the fed nine media system provides a range of solubility values for each drug and solubility behaviour is consistent with published design of experiment studies conducted in either the fed or fasted state. Three drugs (griseofulvin, paracetamol and acyclovir) exhibit very narrow solubility distributions, a result that matches published behaviour in the fasted state, indicating that this property is not influenced by the concentration of simulated media components. The nine solubility values for each drug can be utilised to calculate a dose/solubility volume ratio to visualise the drug's position on the DCS grid. Due to the derivation of the nine media compositions the range and catergorisation could be considered as bioequivalent and can be combined with the data from the original fed intestinal fluid analysis to provide a population based solubility distribution. This provides further information on the drugs solubility behaviour and could be applied to quality by design formulation approaches. Comparison of the fed results in this study with similar published fasted results highlight that some differences detected match in vivo behaviour in food effect studies. This indicates that a combination of the fed and fasted systems may be a useful in vitro biopharmaceutical performance tool. However, it should be noted that the fed media recipes in this study are based on a liquid meal (Ensure Plus) and this may not be representative of alternative fed states achieved through ingestion of a solid meal. Nevertheless, this novel approach provides greater in vitro detail with respect to possible in vivo biopharmaceutical performance, an improved ability to apply risk-based approaches and the potential to investigate solubility based food effects. The system is therefore worthy of further investigation but studies will be required to expand the number of drugs measured and link the in vitro measurements to in vivo results. [ABSTRACT FROM AUTHOR]