1. Outcome after resection for perihilar cholangiocarcinoma in patients with primary sclerosing cholangitis: an international multicentre study
- Author
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F. Bartsch, J. Hagendoorn, R. Charco, Q.I. Molenaar, Hauke Lang, A. Sultana, F. Heid, J.I. Erdmann, Erik Schadde, G. Kazemier, H.Z. Malik, J. Rolinger, Stefan Buettner, C.L.M. Nota, Andrea Ruzzenente, M.C. Giglio, Mikhail Efanov, Shishir K. Maithel, P. Muiesan, M. Ravaioli, K.J. Roberts, I. Capobianco, Thomas M. van Gulik, J. van Vugt, Ruslan Alikhanov, Hannes Jansson, A. Andreou, Alfredo Guglielmi, Johann Pratschke, M. Malago, Moritz Schmelzle, E. de Savornin Lohman, Silvio Nadalin, Marjolein A P Ligthart, P.R. de Reuver, Bas Groot Koerkamp, S. W. M. Olde Damink, L.E. Nooijen, Francesca Ratti, S. van Laarhoven, C. Gomez-Gavara, B.M. Zonderhuis, C. Benzing, Matteo Serenari, Luca Aldrighetti, L.C. Franken, Annika Bergquist, Cornelis H. C. Dejong, Ernesto Sparrelid, Matteo Cescon, William R. Jarnagin, L.M. Quinn, Pim B. Olthof, J.N.M. IJzermans, Roberto Troisi, RS: NUTRIM - R2 - Liver and digestive health, Surgery, MUMC+: MA Heelkunde (9), Jansson, H., Olthof, P. B., Bergquist, A., Ligthart, M. A. P., Nadalin, S., Troisi, R, Groot Koerkamp, B., Alikhanov, R., Lang, H., Guglielmi, A., Cescon, M., Jarnagin, W. R., Aldrighetti, L., van Gulik, T. M., Sparrelid, E., Andreou, A., Bartsch, F., Benzing, C., Buettner, S., Capobianco, I., Charco, R., de Reuver, P. R., de Savornin Lohman, E., Dejong, C. H. C., Efanov, M., Erdmann, J. I., Franken, L. C., Giglio, M. C., Gomez-Gavara, C., Hagendoorn, J., Heid, F., Ijzermans, J. N. M., Kazemier, G., Maithel, S. K., Malago, M., Malik, H. Z., Molenaar, Q. I., Muiesan, P., Nooijen, L. E., Nota, C. L. M., Olde Damink, S. W. M., Pratschke, J., Quinn, L. M., Ratti, F., Ravaioli, M., Roberts, K. J., Rolinger, J., Ruzzenente, A., Schadde, E., Schmelzle, M., Serenari, M., Sultana, A., van Laarhoven, S., van Vugt, J. L. A., Zonderhuis, B. M., Troisi, R. I., CCA - Cancer Treatment and Quality of Life, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
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medicine.medical_specialty ,endocrine system diseases ,Cholangitis ,Cholangitis, Sclerosing ,030230 surgery ,HILAR CHOLANGIOCARCINOMA ,Gastroenterology ,digestive system ,Article ,Sclerosing ,Resection ,Primary sclerosing cholangitis ,Cholangiocarcinoma ,03 medical and health sciences ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,0302 clinical medicine ,Primary outcome ,Internal medicine ,Overall survival ,medicine ,Humans ,In patient ,Perihilar Cholangiocarcinoma ,Retrospective Studies ,Intrahepatic ,RISK ,Hepatology ,business.industry ,digestive, oral, and skin physiology ,Retrospective cohort study ,medicine.disease ,digestive system diseases ,Bile Ducts, Intrahepatic ,Bile Duct Neoplasms ,Postoperative mortality ,030220 oncology & carcinogenesis ,Bile Ducts ,business ,Klatskin Tumor - Abstract
Contains fulltext : 245473.pdf (Publisher’s version ) (Open Access) BACKGROUND: Resection for perihilar cholangiocarcinoma (pCCA) in primary sclerosing cholangitis (PSC) has been reported to lead to worse outcomes than resection for non-PSC pCCA. The aim of this study was to compare prognostic factors and outcomes after resection in patients with PSC-associated pCCA and non-PSC pCCA. METHODS: The international retrospective cohort comprised patients resected for pCCA from 21 centres (2000-2020). Patients operated with hepatobiliary resection, with pCCA verified by histology and with data on PSC status, were included. The primary outcome was overall survival. Secondary outcomes were disease-free survival and postoperative complications. RESULTS: Of 1128 pCCA patients, 34 (3.0%) had underlying PSC. Median overall survival after resection was 33 months for PSC patients and 29 months for non-PSC patients (p = .630). Complications (Clavien-Dindo grade ≥ 3) were more frequent in PSC pCCA (71% versus 44%, p = .003). The rate of posthepatectomy liver failure (21% versus 17%, p = .530) and 90-day mortality (12% versus 13%, p = 1.000) was similar for PSC and non-PSC patients. CONCLUSION: Median overall survival after resection for pCCA was similar in patients with underlying PSC and non-PSC patients. Complications were more frequent after resection for PSC-associated pCCA, with no difference in postoperative mortality.
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- 2021