1. Gastroprotective effects of arctigenin of Arctium lappa L. on a rat model of gastric ulcers
- Author
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Yu Miao, Xiao‑Mei Li, Hong‑Hua Li, Gui‑Min Zhang, Qin‑Yong Su, and Jing‑Chun Yao
- Subjects
0301 basic medicine ,Pathology ,medicine.medical_specialty ,Antioxidant ,medicine.medical_treatment ,Pharmacology ,General Biochemistry, Genetics and Molecular Biology ,Lesion ,Superoxide dismutase ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,General Pharmacology, Toxicology and Pharmaceutics ,Arctigenin ,Ethanol ,biology ,business.industry ,General Neuroscience ,General Medicine ,Malondialdehyde ,030104 developmental biology ,chemistry ,Apoptosis ,030220 oncology & carcinogenesis ,Arctium lappa ,biology.protein ,medicine.symptom ,business - Abstract
In the present study, the gastroprotective effects of arctigenin of Fructus Arctii were evaluated and the possible underlying mechanisms of action were elucidated. Arctigenin (high-performance liquid chromatography purity, >99.0%) was isolated and purified from the seeds of Arctium lappa L. The anti-ulcerogenic activity of arctigenin against ulcers induced by absolute ethanol and acetic acid was evaluated in a Sprague-Dawley rat model. In addition, the antioxidant activity was assessed by measuring malondialdehyde (MDA) levels in an ethanol-induced model and the anti-inflammatory effects were assessed by measuring five factors in an acetic acid-induced model. In the ethanol-induced model, arctigenin inhibited gastric lesions in a dose-dependent manner, by 53.04, 53.91 and 64.43% at doses of 0.05, 0.15 and 0.45 mg/kg, respectively. In addition, arctigenin reduced MDA (P
- Published
- 2016