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Objective: Stress is a non-specific response of the body to any physical or physiological demand. Oxidative stress may occur due to imbalance between pro-oxidants and antioxidants. Restraint stress or immobilization has been used extensively as a stressor for the study of stress-related biological, biochemical, and physiological responses in animals. Nutritional treatment by exogenous supplementation of antioxidants like selenium reactivates which guard against the insult caused ROS during the repeated restraint stress. The objective of the study is to determine the role of selenium on antioxidant changes in Wistar albino rats after chronic restraint stress. Methods: Adult male Wistar albino rats weighing about 180–200 g were taken for the study and were divided into three groups – the control group (n=6) chronic restraint stress group (n=6) and chronic stress treated with selenium (n=6). Restraint stress was given in wire mesh restrainers for 30 days (6 h/day), and the blood from the jugular vein was collected for estimation of antioxidant status (Superoxide dismutase, Glutathione peroxidase, CAT, Vit C, and Vit E) in rats. Results: One-way analysis of variance statistical test was used to analyses the mean and SD among the groups. The rats pre-treated with selenium (p

Pada pembangunan jalan terdapat berbagai macam risiko. Risiko yang muncul dapat berpengaruh pada biaya, waktu, atupun kualitas suatu proyek. Tujuan penelitian ini adalah untuk untuk mengetahui resiko yang terjadi dan tingkat resikonya, serta dapat merekomendasikan penanganan untuk resiko yang terkategori tinggi. Metode penelitian yang digunakan adalah metode pengolahan data yang menggunakan Statical Product and Service Solution (SPSS) dan secara numeris menggunakan metode Severity Index (SI). Dari hasil analisis risiko diketahui bahwa terdapat 4 kategori resiko yaitu resiko teknis, resiko internal dalam bidang manajemen, resiko komersial, dan resiko eksternal. Resiko yang termasuk tingkat tinggi (high) adalah variabel perubahan desain dan waktu pelaksanaan (CCO), penerapan safety di lingkungan kerja, kurangnya komunikasi pekerja dengan pelaksana lapangan, dan perubahan cuaca. Rekomendasi penanganan risiko untuk variabel yang memiliki kategori tinggi (high), yaitu melaksanakan survei awal dengan teliti agar tidak terjadi CCO terus menerus, menerapkan sanksi terhadap pekerja yang tidak mau menerapkan safety, serta mengadakan penyuluhan tentang safety, memberi penjelasan tentang detail pekerjaan sesuai sop, pelaksana selalu mengawasi pekerja, dan melemburkan pekerjaan atau menambah jumlah pekerja.

Preeclampsia is a leading cause of maternal and neonatal mortality and morbidity. It is a complex syndrome of undetermined etiologic origin, usually diagnosed during second half of pregnancy. Elevated levels of oxidative lipid derivatives and reduced antioxidants in the circulation of preeclamptics may contribute to endothelial damage. There is good evidence for a significant increase in the levels of malondialdehyde in plasma and erythrocytes. Group I: Normotensive nonpregnant women (control), Group II: Pregnant women with normal blood pressure, Group III: Preeclamptic (pretreatment), women Preeclamptic women were subdivided into Group IIIA: Pre eclamptic women supplemented with Vitamin E (n=20), Group IIIB: Preeclamptic women supplemented with Omega 3 Fatty Acid, Group IIIC: Preeclamptic women supplemented with Vitamin E 400mg + Omega 3 Fatty Acid. Serum SOD, MDA, GPx, GSH levels were measured in all groups and compared with pre treatment and post treatments results by using the one way ANOVA followed by the Tukey – HSD procedure. Our results showed that supplementation of Vitamin E, Omega 3 fatty acid alone and in combination has significantly increased antioxidant enzyme status and significantly decreased oxidative stress when compared to unsupplemented patients(P< 0.001).