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16. The Effects of Aflatoxin B 1 on Liver Cholestasis and Its Nutritional Regulation in Ducks.

Author

Yu, Aimei, Wang, Huanbin, Cheng, Qianhui, Rajput, Shahid Ali, and Qi, Desheng

Subjects
EMODIN, CHOLESTASIS, AFLATOXINS, LIVER, DUCKS, GLUTATHIONE peroxidase, CYTOCHROME P-450, BILE acids
Abstract

The aim of this study was to investigate the effects of aflatoxin B1 (AFB1) on cholestasis in duck liver and its nutritional regulation. Three hundred sixty 1-day-old ducks were randomly divided into six groups and fed for 4 weeks. The control group was fed a basic diet, while the experimental group diet contained 90 μg/kg of AFB1. Cholestyramine, atorvastatin calcium, taurine, and emodin were added to the diets of four experimental groups. The results show that in the AFB1 group, the growth properties, total bile acid (TBA) serum levels and total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), and glutathione (GSH) liver levels decreased, while the malondialdehyde (MDA) and TBA liver levels increased (p < 0.05). Moreover, AFB1 caused cholestasis. Cholestyramine, atorvastatin calcium, taurine, and emodin could reduce the TBA serum and liver levels (p < 0.05), alleviating the symptoms of cholestasis. The qPCR results show that AFB1 upregulated cytochrome P450 family 7 subfamily A member 1 (CYP7A1) and cytochrome P450 family 8 subfamily B member 1 (CYP8B1) gene expression and downregulated ATP binding cassette subfamily B member 11 (BSEP) gene expression in the liver, and taurine and emodin downregulated CYP7A1 and CYP8B1 gene expression (p < 0.05). In summary, AFB1 negatively affects health and alters the expression of genes related to liver bile acid metabolism, leading to cholestasis. Cholestyramine, atorvastatin calcium, taurine, and emodin can alleviate AFB1-induced cholestasis. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Ameliorative Effects of Luteolin and Activated Charcoal on Growth Performance, Immunity Function, and Antioxidant Capacity in Broiler Chickens Exposed to Deoxynivalenol

Author

Hassan, Mubashar, primary, Wang, Yanan, additional, Rajput, Shahid Ali, additional, Shaukat, Aftab, additional, Yang, Ping, additional, Farooq, Muhammad Zahid, additional, Cheng, Qianhui, additional, Ali, Mehboob, additional, Mi, Xiaomei, additional, An, Yu, additional, and Qi, Desheng, additional

Published
2023
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41. Regulatory Role of Apoptotic and Inflammasome Related Proteins and Their Possible Functional Aspect in Thiram Associated Tibial Dyschondroplasia of Poultry

Author

Kulyar, Muhammad Fakhar-e-Alam, primary, Yao, Wangyuan, additional, Mo, Quan, additional, Ding, Yanmei, additional, Zhang, Yan, additional, Gao, Jindong, additional, Li, Kewei, additional, Pan, Huachun, additional, Nawaz, Shah, additional, Shahzad, Muhammad, additional, Mehmood, Khalid, additional, Iqbal, Mudassar, additional, Akhtar, Muhammad, additional, Bhutta, Zeeshan Ahmad, additional, Waqas, Muhammad, additional, Li, Jiakui, additional, and Qi, Desheng, additional

Published
2022
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43. Novel Strategies for the Biodegradation and Detoxification of Mycotoxins in Post-Harvest Grain.

Author

Zhao, Lihong, Qi, Desheng, and Ma, Qiugang

Subjects
*MYCOTOXINS, *FOOD additives, *MANGANESE peroxidase, *BIODEGRADATION, *METABOLITES, *ORGANIC acids
Abstract

Mycotoxins are toxic secondary metabolites produced by filamentous fungi belonging, in particular, to the I Aspergillus i , I Fusarium i , and I Penicillium i genera. This Special Issue therefore summarizes various strategies for the detoxification of mycotoxins through post-harvest detoxification methods, which are divided into physical, chemical, biological, and other developing innovative strategies. Aflatoxins, zearalenone (ZEN), deoxynivalenol (DON), T-2 toxin, ochratoxin A (OTA), fumonisins, patulin, and ergot alkaloids are the most contaminating mycotoxins found in food and feed, posing potentially carcinogenic, mutagenic, teratogenic, cytotoxic, neurotoxic, nephrotoxic, estrogenic, and immunosuppressant effects on both humans and animals [[1]]. 34941719 11 Xiong D., Wen J., Lu G., Li T., Long M. Isolation, Purification, and Characterization of a Laccase-Degrading Aflatoxin B1 from Bacillus amyloliquefaciens B10. [Extracted from the article]

Published
2023
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44. A Novel PEEK Foam with Ultra‐High Temperature‐Resistant by Temperature Induced Phase Separation.

Author

Meng, Lingcheng, Zhang, Jinling, Zhao, Shuang, Qi, Desheng, Xu, Pan, Wu, Shuoqi, Wang, Le, Yue, Xigui, and Jiang, Zhenhua

Subjects
PHASE separation, FOAM, THERMAL properties, ENGINEERING plastics, HIGH temperatures, PLASTICS engineering
Abstract

Polyaryletherketone is a kind of special engineering plastics with excellent comprehensive properties, high strength, good stability, and almost insoluble in any common solvent except concentrated sulfuric acid at room temperature. However, its high processing temperature also hinders its application and development in the foam. Here, a series of polyetheretherketone (PEEK) and diphenyl polyetheretherketone (PEDEK) composite foams are prepared by temperature induced phase separation, using diphenyl sulfone as solvent. The microstructure, thermal and mechanical properties of PEEK and PEDEK foam are compared. Highly porous PEEK and PEDEK foams with densities ranging from 0.13 to 0.25 g cm−3, with compressive strength ranging from 0.68 to 2.6 MPa, respectively, are produced. Meanwhile, the introduction of diphenyl structure can effectively improve the performance of PEEK foams at high temperature. It is found that PEDEK foam has a higher operating temperature than PEEK, and the compressive strength of 0.24 g cm−3 foam is still ≈1 MPa at 200 °C. [ABSTRACT FROM AUTHOR]

Published
2023
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