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1. Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies.

Author

Brouwer, Ingeborg, De Faire, Ulf, Eiriksdottir, Gudny, Ferrucci, Luigi, Forouhi, Nita, Geleijnse, Johanna, Hodge, Allison, Kimura, Hitomi, Laakso, Markku, Risérus, Ulf, van Westing, Anniek, Bandinelli, Stefania, Baylin, Ana, Giles, Graham, Gudnason, Vilmundur, Iso, Hiroyasu, Lemaitre, Rozenn, Ninomiya, Toshiharu, Post, Wendy, Psaty, Bruce, Salonen, Jukka, Schulze, Matthias, Tsai, Michael, Uusitupa, Matti, Wareham, Nicholas, Oh, Seung-Won, Wood, Alexis, Harris, William, Siscovick, David, Mozaffarian, Dariush, Leander, Karin, Laguzzi, Federica, Åkesson, Agneta, Marklund, Matti, Qian, Frank, Gigante, Bruna, Bartz, Traci, Bassett, Julie, Birukov, Anna, Campos, Hannia, Hirakawa, Yoichiro, Imamura, Fumiaki, Jäger, Susanne, Lankinen, Maria, Murphy, Rachel, Senn, Mackenzie, Tanaka, Toshiko, Tintle, Nathan, Virtanen, Jyrki, Yamagishi, Kazumasa, and Allison, Matthew

Subjects
biomarkers, cardiovascular diseases, family medical history, polyunsaturated fatty acids, precision medicine, Animals, Fatty Acids, Omega-3, Cardiovascular Diseases, Risk Factors, Docosahexaenoic Acids, Biomarkers
Abstract

BACKGROUND: It is unknown whether dietary intake of polyunsaturated fatty acids (PUFA) modifies the cardiovascular disease (CVD) risk associated with a family history of CVD. We assessed interactions between biomarkers of low PUFA intake and a family history in relation to long-term CVD risk in a large consortium. METHODS: Blood and tissue PUFA data from 40 885 CVD-free adults were assessed. PUFA levels ≤25th percentile were considered to reflect low intake of linoleic, alpha-linolenic, and eicosapentaenoic/docosahexaenoic acids (EPA/DHA). Family history was defined as having ≥1 first-degree relative who experienced a CVD event. Relative risks with 95% CI of CVD were estimated using Cox regression and meta-analyzed. Interactions were assessed by analyzing product terms and calculating relative excess risk due to interaction. RESULTS: After multivariable adjustments, a significant interaction between low EPA/DHA and family history was observed (product term pooled RR, 1.09 [95% CI, 1.02-1.16]; P=0.01). The pooled relative risk of CVD associated with the combined exposure to low EPA/DHA, and family history was 1.41 (95% CI, 1.30-1.54), whereas it was 1.25 (95% CI, 1.16-1.33) for family history alone and 1.06 (95% CI, 0.98-1.14) for EPA/DHA alone, compared with those with neither exposure. The relative excess risk due to interaction results indicated no interactions. CONCLUSIONS: A significant interaction between biomarkers of low EPA/DHA intake, but not the other PUFA, and a family history was observed. This novel finding might suggest a need to emphasize the benefit of consuming oily fish for individuals with a family history of CVD.

Published
2024

3. Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes: Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE).

Author

Lai, Heidi TM, Imamura, Fumiaki, Korat, Andres V Ardisson, Murphy, Rachel A, Tintle, Nathan, Bassett, Julie K, Chen, Jiaying, Kröger, Janine, Chien, Kuo-Liong, Senn, Mackenzie, Wood, Alexis C, Forouhi, Nita G, Schulze, Matthias B, Harris, William S, Vasan, Ramachandran S, Hu, Frank, Giles, Graham G, Hodge, Allison, Djousse, Luc, Brouwer, Ingeborg A, Qian, Frank, Sun, Qi, Wu, Jason HY, Marklund, Matti, Lemaitre, Rozenn N, Siscovick, David S, Fretts, Amanda M, Shadyab, Aladdin H, Manson, JoAnn E, Howard, Barbara V, Robinson, Jennifer G, Wallace, Robert B, Wareham, Nick J, Chen, Yii-Der Ida, Rotter, Jerome I, Tsai, Michael Y, Micha, Renata, and Mozaffarian, Dariush

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Diabetes, Clinical Research, Metabolic and endocrine, Adolescent, Adult, Biomarkers, Cohort Studies, Diabetes Mellitus, Type 2, Fatty Acids, Humans, Outcome Assessment, Health Care, Prospective Studies, Risk Factors, Trans Fatty Acids, Fatty Acids and Outcomes Research Consortium, Medical and Health Sciences, Endocrinology & Metabolism, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveTrans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis.Research design and methodsWe included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged ≥18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics.ResultsDuring a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-18:2, relative risk (RR) 1.09 (95% CI 0.94-1.25); cis/trans-18:2, 0.89 (0.73-1.07); and trans/cis-18:2, 0.87 (0.73-1.03). Trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated with T2D (RR 0.81 [95% CI 0.67-0.99], 0.86 [0.75-0.99], and 0.84 [0.74-0.96], respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P ≥ 0.1).ConclusionsCirculating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.

Published
2022

5. Role of Polyunsaturated Fat in Modifying Cardiovascular Risk Associated With Family History of Cardiovascular Disease: Pooled De Novo Results From 15 Observational Studies

Author

Laguzzi, Federica, Åkesson, Agneta, Marklund, Matti, Qian, Frank, Gigante, Bruna, Bartz, Traci M., Bassett, Julie K., Birukov, Anna, Campos, Hannia, Hirakawa, Yoichiro, Imamura, Fumiaki, Jäger, Susanne, Lankinen, Maria, Murphy, Rachel A., Senn, Mackenzie, Tanaka, Toshiko, Tintle, Nathan, Virtanen, Jyrki K., Yamagishi, Kazumasa, Allison, Matthew, Brouwer, Ingeborg A., De Faire, Ulf, Eiriksdottir, Gudny., Ferrucci, Luigi, Forouhi, Nita G., Geleijnse, Johanna M., Hodge, Allison M, Kimura, Hitomi, Laakso, Markku, Risérus, Ulf, van Westing, Anniek C., Bandinelli, Stefania, Baylin, Ana, Giles, Graham G., Gudnason, Vilmundur, Iso, Hiroyasu, Lemaitre, Rozenn N., Ninomiya, Toshiharu, Post, Wendy S., Psaty, Bruce M., Salonen, Jukka T., Schulze, Matthias B., Tsai, Michael Y., Uusitupa, Matti, Wareham, Nicholas J., Oh, Seung-Won, Wood, Alexis C., Harris, William S., Siscovick, David, Mozaffarian, Dariush, and Leander, Karin

Published
2024
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6. Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies

Author

O’Keefe, James H., Tintle, Nathan L., Harris, William S., O’Keefe, Evan L., Sala-Vila, Aleix, Attia, John, Garg, G. Manohar, Hure, Alexis, Bork, Christian Sørensen, Schmidt, Erik Berg, Venø, Stine Krogh, Chien, Kuo-Liong, Chen, Yun-Yu (Amelia), Egert, Sarah, Feldreich, Tobias Rudholm, Ärnlöv, Johan, Lind, Lars, Forouhi, Nita G., Geleijnse, Johanna M., Pertiwi, Kamalita, Imamura, Fumiaki, de Mello Laaksonen, Vanessa, Uusitupa, W. Matti, Tuomilehto, Jaakko, Laakso, Markku, Lankinen, Maria Anneli, Laurin, Danielle, Carmichael, Pierre-Hugues, Lindsay, Joan, Leander, Karin, Laguzzi, Federica, Swenson, Brenton R., Longstreth, William T., Manson, JoAnn E., Mora, Samia, Cook, Nancy R., Marklund, Matti, Melo van Lent, Debora, Murphy, Rachel, Gudnason, Vilmundur, Ninomiya, Toshihara, Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Hu, Frank, Ardisson Korat, Andres V., Risérus, Ulf, Lázaro, Iolanda, Samieri, Cecilia, Le Goff, Mélanie, Helmer, Catherine, Steur, Marinka, Voortman, Trudy, Ikram, M. Kamran, Tanaka, Toshiko, Das, Jayanta K., Ferrucci, Luigi, Bandinelli, Stefania, Tsai, Michael, Guan, Weihua, Garg, Parveen, Verschuren, W.M. Monique, Boer, Jolanda M.A., Biokstra, Anneke, Virtanen, Jyrki, Wagner, Michael, Westra, Jason, Albuisson, Luc, Yamagishi, Kazumasa, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush

Published
2024
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8. n–6 fatty acid biomarkers and incident atrial fibrillation: an individual participant-level pooled analysis of 11 international prospective studies

Author

Garg, Parveen K., Guan, Weihua, Nomura, Sarah, Weir, Natalie L., Tintle, Nathan, Virtanen, Jyrki K., Hirakawa, Yoichiro, Qian, Frank, Sun, Qi, Rimm, Eric, Lemaitre, Rozenn N., Jensen, Paul N., Heckbert, Susan R., Imamura, Fumiaki, Steur, Marinka, Leander, Karin, Laguzzi, Federica, Voortman, Trudy, Ninomiya, Toshiharu, Mozaffarian, Dariush, Harris, William S., Siscovick, David S., and Tsai, Michael Y.

Published
2023
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10. Omega-3 Fatty Acid Biomarkers and Incident Atrial Fibrillation

Author

Qian, Frank, Tintle, Nathan, Jensen, Paul N., Lemaitre, Rozenn N., Imamura, Fumiaki, Feldreich, Tobias Rudholm, Nomura, Sarah Oppeneer, Guan, Weihua, Laguzzi, Federica, Kim, Eunjung, Virtanen, Jyrki K., Steur, Marinka, Bork, Christian S., Hirakawa, Yoichiro, O'Donoghue, Michelle L., Sala-Vila, Aleix, Ardisson Korat, Andres V., Sun, Qi, Rimm, Eric B., Psaty, Bruce M., Heckbert, Susan R., Forouhi, Nita G., Wareham, Nicholas J., Marklund, Matti, Risérus, Ulf, Lind, Lars, Ärnlöv, Johan, Garg, Parveen, Tsai, Michael Y., Pankow, James, Misialek, Jeffrey R., Gigante, Bruna, Leander, Karin, Pester, Julie A., Albert, Christine M., Kavousi, Maryam, Ikram, Arfan, Voortman, Trudy, Schmidt, Erik B., Ninomiya, Toshiharu, Morrow, David A., Bayés-Genís, Antoni, O’Keefe, James H., Ong, Kwok Leung, Wu, Jason H.Y., Mozaffarian, Dariush, Harris, William S., and Siscovick, David S.

Published
2023
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16. Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers

Author

Qian, Frank, Rookus, Matti A, Leslie, Goska, Risch, Harvey A, Greene, Mark H, Aalfs, Cora M, Adank, Muriel A, Adlard, Julian, Agnarsson, Bjarni A, Ahmed, Munaza, Aittomäki, Kristiina, Andrulis, Irene L, Arnold, Norbert, Arun, Banu K, Ausems, Margreet GEM, Azzollini, Jacopo, Barrowdale, Daniel, Barwell, Julian, Benitez, Javier, Białkowska, Katarzyna, Bonadona, Valérie, Borde, Julika, Borg, Ake, Bradbury, Angela R, Brunet, Joan, Buys, Saundra S, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Carter, Jonathan, Chiquette, Jocelyne, Chung, Wendy K, Claes, Kathleen BM, Collée, J Margriet, Collonge-Rame, Marie-Agnès, Couch, Fergus J, Daly, Mary B, Delnatte, Capucine, Diez, Orland, Domchek, Susan M, Dorfling, Cecilia M, Eason, Jacqueline, Easton, Douglas F, Eeles, Ros, Engel, Christoph, Evans, D Gareth, Faivre, Laurence, Feliubadaló, Lidia, Foretova, Lenka, Friedman, Eitan, Frost, Debra, Ganz, Patricia A, Garber, Judy, Garcia-Barberan, Vanesa, Gehrig, Andrea, Glendon, Gord, Godwin, Andrew K, Gómez Garcia, Encarna B, Hamann, Ute, Hauke, Jan, Hopper, John L, Hulick, Peter J, Imyanitov, Evgeny N, Isaacs, Claudine, Izatt, Louise, Jakubowska, Anna, Janavicius, Ramunas, John, Esther M, Karlan, Beth Y, Kets, Carolien M, Laitman, Yael, Lázaro, Conxi, Leroux, Dominique, Lester, Jenny, Lesueur, Fabienne, Loud, Jennifer T, Lubiński, Jan, Łukomska, Alicja, McGuffog, Lesley, Mebirouk, Noura, Meijers-Heijboer, Hanne EJ, Meindl, Alfons, Miller, Austin, Montagna, Marco, Mooij, Thea M, Mouret-Fourme, Emmanuelle, Nathanson, Katherine L, Nehoray, Bita, Neuhausen, Susan L, Nevanlinna, Heli, Nielsen, Finn C, Offit, Kenneth, Olah, Edith, Ong, Kai-ren, Oosterwijk, Jan C, Ottini, Laura, Parsons, Michael T, Peterlongo, Paolo, Pfeiler, Georg, and Pradhan, Nisha

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Prevention, Ovarian Cancer, Breast Cancer, Genetics, Aging, Cancer, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Adult, Aged, Body Height, Body Mass Index, Female, Genes, BRCA1, Genes, BRCA2, Heterozygote, Humans, Mendelian Randomization Analysis, Menopause, Middle Aged, Mutation, Ovarian Neoplasms, Proportional Hazards Models, KConFab Investigators, HEBON Investigators, GEMO Study Collaborators, EMBRACE Collaborators, CIMBA, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundHeight and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown.MethodsWe applied a Mendelian randomisation approach to examine height/BMI with ovarian cancer risk using the Consortium of Investigators for the Modifiers of BRCA1/2 (CIMBA) data set, comprising 14,676 BRCA1 and 7912 BRCA2 mutation carriers, with 2923 ovarian cancer cases. We created a height genetic score (height-GS) using 586 height-associated variants and a BMI genetic score (BMI-GS) using 93 BMI-associated variants. Associations were assessed using weighted Cox models.ResultsObserved height was not associated with ovarian cancer risk (hazard ratio [HR]: 1.07 per 10-cm increase in height, 95% confidence interval [CI]: 0.94-1.23). Height-GS showed similar results (HR = 1.02, 95% CI: 0.85-1.23). Higher BMI was significantly associated with increased risk in premenopausal women with HR = 1.25 (95% CI: 1.06-1.48) and HR = 1.59 (95% CI: 1.08-2.33) per 5-kg/m2 increase in observed and genetically determined BMI, respectively. No association was found for postmenopausal women. Interaction between menopausal status and BMI was significant (Pinteraction

Published
2019

17. Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study.

Author

Qian, Frank, Wang, Shengfeng, Mitchell, Jonathan, McGuffog, Lesley, Barrowdale, Daniel, Leslie, Goska, Oosterwijk, Jan C, Chung, Wendy K, Evans, D Gareth, Engel, Christoph, Kast, Karin, Aalfs, Cora M, Adank, Muriel A, Adlard, Julian, Agnarsson, Bjarni A, Aittomäki, Kristiina, Alducci, Elisa, Andrulis, Irene L, Arun, Banu K, Ausems, Margreet GEM, Azzollini, Jacopo, Barouk-Simonet, Emmanuelle, Barwell, Julian, Belotti, Muriel, Benitez, Javier, Berger, Andreas, Borg, Ake, Bradbury, Angela R, Brunet, Joan, Buys, Saundra S, Caldes, Trinidad, Caligo, Maria A, Campbell, Ian, Caputo, Sandrine M, Chiquette, Jocelyne, Claes, Kathleen BM, Margriet Collée, J, Couch, Fergus J, Coupier, Isabelle, Daly, Mary B, Davidson, Rosemarie, Diez, Orland, Domchek, Susan M, Donaldson, Alan, Dorfling, Cecilia M, Eeles, Ros, Feliubadaló, Lidia, Foretova, Lenka, Fowler, Jeffrey, Friedman, Eitan, Frost, Debra, Ganz, Patricia A, Garber, Judy, Garcia-Barberan, Vanesa, Glendon, Gord, Godwin, Andrew K, Gómez Garcia, Encarna B, Gronwald, Jacek, Hahnen, Eric, Hamann, Ute, Henderson, Alex, Hendricks, Carolyn B, Hopper, John L, Hulick, Peter J, Imyanitov, Evgeny N, Isaacs, Claudine, Izatt, Louise, Izquierdo, Ángel, Jakubowska, Anna, Kaczmarek, Katarzyna, Kang, Eunyoung, Karlan, Beth Y, Kets, Carolien M, Kim, Sung-Won, Kim, Zisun, Kwong, Ava, Laitman, Yael, Lasset, Christine, Hyuk Lee, Min, Won Lee, Jong, Lee, Jihyoun, Lester, Jenny, Lesueur, Fabienne, Loud, Jennifer T, Lubinski, Jan, Mebirouk, Noura, Meijers-Heijboer, Hanne EJ, Meindl, Alfons, Miller, Austin, Montagna, Marco, Mooij, Thea M, Morrison, Patrick J, Mouret-Fourme, Emmanuelle, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Niederacher, Dieter, Nielsen, Finn C, Nussbaum, Robert L, and Offit, Kenneth

Subjects
GEMO Study Collaborators, HEBON, EMBRACE, Humans, Breast Neoplasms, Genetic Predisposition to Disease, BRCA1 Protein, BRCA2 Protein, Body Mass Index, Body Height, Prognosis, Risk Factors, Mutation, Polymorphism, Single Nucleotide, Adult, Female, Mendelian Randomization Analysis, Oncology & Carcinogenesis, Oncology and Carcinogenesis
Abstract

BackgroundBRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear.MethodsWe used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided.ResultsObserved height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m2 increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer.ConclusionHeight is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management.

Published
2019

20. Reply

Author

Qian, Frank, primary and Siscovick, David, additional

Published
2023
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23. Modifiable Lifestyle Factors, Genetic Risk, and Incident Peripheral Artery Disease Among Individuals With Type 2 Diabetes: A Prospective Study.

Author

Zhu, Kai, Qian, Frank, Lu, Qi, Li, Rui, Qiu, Zixin, Li, Lin, Li, Ruyi, Yu, Hancheng, Deng, Yulei, Yang, Kun, Pan, An, and Liu, Gang

Subjects
*PERIPHERAL vascular diseases, *TYPE 2 diabetes, *GENETIC risk score, *SLEEP duration, *SINGLE nucleotide polymorphisms
Abstract

OBJECTIVE: To prospectively evaluate the association between modifiable lifestyle factors and peripheral artery disease (PAD) among individuals with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We included 14,543 individuals with T2D from the UK Biobank. We defined a weighted healthy lifestyle score using nonsmoking, regular physical activity, high-quality diet, moderate alcohol consumption, optimal waist-to-hip ratio, and adequate sleep duration, and categorized into unfavorable, intermediate, and favorable lifestyles. We created a genetic risk score (GRS) using 19 single nucleotide polymorphisms previously found to be associated with PAD. We modeled the association between lifestyle score and PAD, overall and stratified by PAD genetic susceptibility. RESULTS: After a median 13.5 years of follow-up, 628 incident cases of PAD were documented. A linear inverse association between the weighted lifestyle score and PAD was observed, with a hazard ratio (HR) (95% CI) of 0.27 (0.19, 0.38) for favorable compared with unfavorable lifestyle (Ptrend < 0.0001). An estimated 58.3% (45.0%, 69.1%) of PAD in this population could be potentially avoidable if all participants attained a favorable lifestyle. Moreover, the PAD GRS was associated with increased PAD risk (HR [95% CI] per SD increment: 1.13 [1.03, 1.23]). A favorable lifestyle was able to partially mitigate the excess risk of PAD associated with higher GRS, albeit as a nonsignificant interaction. Several biomarkers in the lipid metabolism, hepatic/renal function, and systemic inflammation pathways collectively explained 13.3% (8.5%, 20.1%) of the association between weighted lifestyle score and PAD. CONCLUSIONS: A favorable lifestyle was associated with lower risk of PAD among individuals with T2D, independent of genetic predisposition to PAD. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Author

Harris, William S., Tintle, Nathan L., Imamura, Fumiaki, Qian, Frank, Korat, Andres V. Ardisson, Marklund, Matti, Djoussé, Luc, Bassett, Julie K., Carmichael, Pierre-Hugues, Chen, Yun-Yu, Hirakawa, Yoichiro, Küpers, Leanne K., Laguzzi, Federica, Lankinen, Maria, Murphy, Rachel A., Samieri, Cécilia, Senn, Mackenzie K., Shi, Peilin, Virtanen, Jyrki K., Brouwer, Ingeborg A., Chien, Kuo-Liong, Eiriksdottir, Gudny, Forouhi, Nita G., Geleijnse, Johanna M., Giles, Graham G., Gudnason, Vilmundur, Helmer, Catherine, Hodge, Allison, Jackson, Rebecca, Khaw, Kay-Tee, Laakso, Markku, Lai, Heidi, Laurin, Danielle, Leander, Karin, Lindsay, Joan, Micha, Renata, Mursu, Jaako, Ninomiya, Toshiharu, Post, Wendy, Psaty, Bruce M., Risérus, Ulf, Robinson, Jennifer G., Shadyab, Aladdin H., Snetselaar, Linda, Sala-Vila, Aleix, Sun, Yangbo, Steffen, Lyn M., Tsai, Michael Y., Wareham, Nicholas J., Wood, Alexis C., Wu, Jason H. Y., Hu, Frank, Sun, Qi, Siscovick, David S., Lemaitre, Rozenn N., and Mozaffarian, Dariush

Published
2021
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26. Omega-6 fatty acid biomarkers and incident atrial fibrillation: an individual participant-level pooled analysis of 11 international prospective studies

Author

Garg, Parveen K., primary, Guan, Weihua, additional, Nomura, Sarah, additional, Weir, Natalie L., additional, Tintle, Nathan, additional, Virtanen, Jyrki K., additional, Hirakawa, Yoichiro, additional, Qian, Frank, additional, Sun, Qi, additional, Rimm, Eric, additional, Lemaitre, Rozenn N., additional, Jensen, Paul N., additional, Heckbert, Susan R., additional, Imamura, Fumiaki, additional, Steur, Marinka, additional, Leander, Karin, additional, Laguzzi, Federica, additional, Voortman, Trudy, additional, Ninomiya, Toshiharu, additional, Mozaffarian, Dariush, additional, Harris, William S., additional, Siscovick, David S., additional, and Tsai, Michael Y., additional

Published
2023
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29. Genome–phenome wide association study of broadly-defined headache

Author

Hsu, Wan-Ting, primary, Lee, Yu-Ting, additional, Tan, Jasmine, additional, Chang, Yung-Han, additional, Qian, Frank, additional, Liu, Kuei-Yu, additional, Hsiung, Jo-Ching, additional, Yo, Chia-Hung, additional, Tang, Sung-Chun, additional, Jiang, Xia, additional, and Lee, Chien-Chang, additional

Published
2023
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30. Prediction of In-Hospital Cardiac Arrest in the Intensive Care Unit: A Machine Learning-Based Multimodal Approach (Preprint)

Author

Lee, Hsin-Ying, primary, Kuo, Po-Chih, additional, Qian, Frank, additional, Li, Chien-Hung, additional, Hu, Jiun-Ruey, additional, Hsu, Wan-Ting, additional, Jhou, Hong-Jie, additional, Chen, Po-Huang, additional, Lee, Cho-Hao, additional, Su, Chin-Hua, additional, Liao, Po-Chun, additional, Wu, I-Ju, additional, and Lee, Chien-Chang, additional

Published
2023
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34. Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis

Author

Trieu, Kathy, Bhat, Saiuj, Dai, Zhaoli, Leander, Karin, Gigante, Bruna, Qian, Frank, Korat, Andres V. Ardisson, Sun, Qi, Pan, Xiong-Fei, Laguzzi, Federica, Cederholm, Tommy, de Faire, Ulf, Hellénius, Mai-Lis, Wu, Jason H. Y., Risérus, Ulf, and Marklund, Matti

Subjects
Saturated fatty acids -- Health aspects -- Measurement, Dietary fat -- Physiological aspects -- Health aspects, Dairy products -- Nutritional aspects, Cardiovascular diseases -- Risk factors -- Patient outcomes, Biological sciences
Abstract

Background We aimed to investigate the association of serum pentadecanoic acid (15:0), a biomarker of dairy fat intake, with incident cardiovascular disease (CVD) and all-cause mortality in a Swedish cohort study. We also systematically reviewed studies of the association of dairy fat biomarkers (circulating or adipose tissue levels of 15:0, heptadecanoic acid [17:0], and trans-palmitoleic acid [t16:1n-7]) with CVD outcomes or all-cause mortality. Methods and findings We measured 15:0 in serum cholesterol esters at baseline in 4,150 Swedish adults (51% female, median age 60.5 years). During a median follow-up of 16.6 years, 578 incident CVD events and 676 deaths were identified using Swedish registers. In multivariable-adjusted models, higher 15:0 was associated with lower incident CVD risk in a linear dose-response manner (hazard ratio 0.75 per interquintile range; 95% confidence interval 0.61, 0.93, P = 0.009) and nonlinearly with all-cause mortality (P for nonlinearity = 0.03), with a nadir of mortality risk around median 15:0. In meta-analyses including our Swedish cohort and 17 cohort, case-cohort, or nested case-control studies, higher 15:0 and 17:0 but not t16:1n-7 were inversely associated with total CVD, with the relative risk of highest versus lowest tertile being 0.88 (0.78, 0.99), 0.86 (0.79, 0.93), and 1.01 (0.91, 1.12), respectively. Dairy fat biomarkers were not associated with all-cause mortality in meta-analyses, although there were [less than or equal to]3 studies for each biomarker. Study limitations include the inability of the biomarkers to distinguish different types of dairy foods and that most studies in the meta-analyses (including our novel cohort study) only assessed biomarkers at baseline, which may increase the risk of misclassification of exposure levels. Conclusions In a meta-analysis of 18 observational studies including our new cohort study, higher levels of 15:0 and 17:0 were associated with lower CVD risk. Our findings support the need for clinical and experimental studies to elucidate the causality of these relationships and relevant biological mechanisms., Author(s): Kathy Trieu 1, Saiuj Bhat 2, Zhaoli Dai 3,4, Karin Leander 5, Bruna Gigante 6, Frank Qian 7,8, Andres V. Ardisson Korat 9, Qi Sun 7,9, Xiong-Fei Pan 1,10,11, [...]

Published
2021
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36. Transmission risk of asymptomatic SARS-CoV-2 infection: a systematic review and meta-analysis

Author

Zhang, Ci, primary, Zhou, Chao, additional, Xu, Wanqing, additional, Zheng, Shimin, additional, Gao, Yanxiao, additional, Li, Peiqi, additional, Deng, Luojia, additional, Zhang, Xuezhixing, additional, Jiang, Qianxue, additional, Qian, Frank, additional, Li, Xianhong, additional, Wang, Honghong, additional, Zou, Huachun, additional, Xia, Yinglin, additional, Wang, Tao, additional, Lu, Hui, additional, and Qian, Han-Zhu, additional

Published
2023
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39. Abstract MP62: Fatty Acid Biomarkers of 15:0, 17:0 and Trans 16:1n-7 and Incident Coronary Heart Disease and Stroke: A Pooling Project of 15 Prospective Cohorts in the Fatty Acids and Outcomes Research Consortium

Author

Ardisson Korat, Andres V, primary, Qian, Frank, additional, Malik, Vasanti, additional, Lehr, Marcus, additional, Imamura, Fumiaki, additional, Tintle, Nathan, additional, Laakso, Markku, additional, van Dam, Rob, additional, Harris, William, additional, Marklund, Matti, additional, Samieri, Cecilia, additional, Senn, MacKenzie, additional, Leander, Karin, additional, Forouhi, Nita, additional, Riserus, Ulf, additional, Chien, Kou-Liong, additional, Chen, Amelia, additional, Wood, Alexis, additional, Guan, Weihua, additional, Tsai, Michael Y, additional, Murphy, Rachel, additional, Siscovick, David S, additional, Lemaitre, Rozenn, additional, Mozaffarian, Dariush, additional, and Sun, Qi, additional

Published
2023
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42. Association of omega 3 polyunsaturated fatty acids with incident chronic kidney disease: pooled analysis of 19 cohorts

Author

Ong, Kwok Leung, primary, Marklund, Matti, additional, Huang, Liping, additional, Rye, Kerry-Anne, additional, Hui, Nicholas, additional, Pan, Xiong-Fei, additional, Rebholz, Casey M, additional, Kim, Hyunju, additional, Steffen, Lyn M, additional, van Westing, Anniek C, additional, Geleijnse, Johanna M, additional, Hoogeveen, Ellen K, additional, Chen, Yun-Yu, additional, Chien, Kuo-Liong, additional, Fretts, Amanda M, additional, Lemaitre, Rozenn N, additional, Imamura, Fumiaki, additional, Forouhi, Nita G, additional, Wareham, Nicholas J, additional, Birukov, Anna, additional, Jäger, Susanne, additional, Kuxhaus, Olga, additional, Schulze, Matthias B, additional, de Mello, Vanessa Derenji, additional, Tuomilehto, Jaakko, additional, Uusitupa, Matti, additional, Lindström, Jaana, additional, Tintle, Nathan, additional, Harris, William S, additional, Yamasaki, Keisuke, additional, Hirakawa, Yoichiro, additional, Ninomiya, Toshiharu, additional, Tanaka, Toshiko, additional, Ferrucci, Luigi, additional, Bandinelli, Stefania, additional, Virtanen, Jyrki K, additional, Voutilainen, Ari, additional, Jayasena, Tharusha, additional, Thalamuthu, Anbupalam, additional, Poljak, Anne, additional, Bustamante, Sonia, additional, Sachdev, Perminder S, additional, Senn, Mackenzie K, additional, Rich, Stephen S, additional, Tsai, Michael Y, additional, Wood, Alexis C, additional, Laakso, Markku, additional, Lankinen, Maria, additional, Yang, Xiaowei, additional, Sun, Liang, additional, Li, Huaixing, additional, Lin, Xu, additional, Nowak, Christoph, additional, Ärnlöv, Johan, additional, Risérus, Ulf, additional, Lind, Lars, additional, Le Goff, Mélanie, additional, Samieri, Cécilia, additional, Helmer, Catherine, additional, Qian, Frank, additional, Micha, Renata, additional, Tin, Adrienne, additional, Köttgen, Anna, additional, de Boer, Ian H, additional, Siscovick, David S, additional, Mozaffarian, Dariush, additional, and Wu, Jason HY, additional

Published
2023
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45. Modifiable risk factors and long term risk of type 2 diabetes among individuals with a history of gestational diabetes mellitus: prospective cohort study

Author

Yang, Jiaxi, primary, Qian, Frank, additional, Chavarro, Jorge E, additional, Ley, Sylvia H, additional, Tobias, Deirdre K, additional, Yeung, Edwina, additional, Hinkle, Stefanie N, additional, Bao, Wei, additional, Li, Mengying, additional, Liu, Aiyi, additional, Mills, James L, additional, Sun, Qi, additional, Willett, Walter C, additional, Hu, Frank B, additional, and Zhang, Cuilin, additional

Published
2022
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46. Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry

Author

Qian, Frank, Feng, Ye, Zheng, Yonglan, Ogundiran, Temidayo O., Ojengbede, Oladosu, Zheng, Wei, Blot, William, Ambrosone, Christine B., John, Esther M., Bernstein, Leslie, Hu, Jennifer J., Ziegler, Regina G., Nyante, Sarah, Bandera, Elisa V., Ingles, Sue A., Press, Michael F., Nathanson, Katherine L., Hennis, Anselm, Nemesure, Barbara, Ambs, Stefan, Kolonel, Laurence N., Olopade, Olufunmilayo I., Haiman, Christopher A., and Huo, Dezheng

Published
2016
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48. Abstract 10616: HIV Infection and the Risk of Heart Failure Hospitalization and Mortality: A Systematic Review and Meta-Analysis of Cohort Studies

Author

Qian, Frank, primary, Zhang, Xuezhixing, additional, Qian, Han-Zhu, additional, Alvi, Raza, additional, Erqou, Sebhat, additional, Chen, Yuqing, additional, Li, Xianhong, additional, Wang, Honghong, additional, Neilan, Tomas, additional, Zanni, Markella V, additional, Vermund, Sten, additional, and Qian, Frank, additional

Published
2021
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49. n-3 Fatty Acid Biomarkers and Incident Type 2 Diabetes: An Individual Participant-Level Pooling Project of 20 Prospective Cohort Studies

Author

Qian, Frank, Ardisson Korat, Andres V, Imamura, Fumiaki, Marklund, Matti, Tintle, Nathan, Virtanen, Jyrki K, Zhou, Xia, Bassett, Julie K, Lai, Heidi, Hirakawa, Yoichiro, Chien, Kuo-Liong, Wood, Alexis C, Lankinen, Maria, Murphy, Rachel A, Samieri, Cecilia, Pertiwi, Kamalita, De Mello, Vanessa D, Guan, Weihua, Forouhi, Nita G, Wareham, Nick, Hu, InterAct Consortium Frank B, Riserus, Ulf, Lind, Lars, Harris, William S, Shadyab, Aladdin H, Robinson, Jennifer G, Steffen, Lyn M, Hodge, Allison, Giles, Graham G, Ninomiya, Toshiharu, Uusitupa, Matti, Tuomilehto, Jaakko, Lindström, Jaana, Laakso, Markku, Siscovick, David S, Helmer, Catherine, Geleijnse, Johanna M, Wu, Jason HY, Fretts, Amanda, Lemaitre, Rozenn N, Micha, Renata, Mozaffarian, Dariush, Sun, Qi, Fatty Acids And Outcomes Research Consortium (FORCE), Qian, Frank [0000-0002-5579-3410], Virtanen, Jyrki K [0000-0002-0648-999X], Hirakawa, Yoichiro [0000-0002-4405-4399], Pertiwi, Kamalita [0000-0003-2861-9051], de Mello, Vanessa D [0000-0003-3414-6983], Forouhi, Nita G [0000-0002-5041-248X], Ninomiya, Toshiharu [0000-0003-1345-9032], Laakso, Markku [0000-0002-3394-7749], Lemaitre, Rozenn N [0000-0002-7038-1844], Sun, Qi [0000-0002-8480-1563], and Apollo - University of Cambridge Repository

Subjects
Cohort Studies, Diabetes Mellitus, Type 2, Docosahexaenoic Acids, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Humans, Prospective Studies, Biomarkers
Abstract

OBJECTIVE: Prospective associations between n-3 fatty acid biomarkers and type 2 diabetes (T2D) risk are not consistent in individual studies. We aimed to summarize the prospective associations of biomarkers of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA) with T2D risk through an individual participant-level pooled analysis. RESEARCH DESIGN AND METHODS: For our analysis we incorporated data from a global consortium of 20 prospective studies from 14 countries. We included 65,147 participants who had blood measurements of ALA, EPA, DPA, or DHA and were free of diabetes at baseline. De novo harmonized analyses were performed in each cohort following a prespecified protocol, and cohort-specific associations were pooled using inverse variance-weighted meta-analysis. RESULTS: A total of 16,693 incident T2D cases were identified during follow-up (median follow-up ranging from 2.5 to 21.2 years). In pooled multivariable analysis, per interquintile range (difference between the 90th and 10th percentiles for each fatty acid), EPA, DPA, DHA, and their sum were associated with lower T2D incidence, with hazard ratios (HRs) and 95% CIs of 0.92 (0.87, 0.96), 0.79 (0.73, 0.85), 0.82 (0.76, 0.89), and 0.81 (0.75, 0.88), respectively (all P < 0.001). ALA was not associated with T2D (HR 0.97 [95% CI 0.92, 1.02]) per interquintile range. Associations were robust across prespecified subgroups as well as in sensitivity analyses. CONCLUSIONS: Higher circulating biomarkers of seafood-derived n-3 fatty acids, including EPA, DPA, DHA, and their sum, were associated with lower risk of T2D in a global consortium of prospective studies. The biomarker of plant-derived ALA was not significantly associated with T2D risk.

Published
2021

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