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21 results on '"Qian, Tongrui"'

7. An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

Author

Jing, Miao, Li, Yuexuan, Zeng, Jianzhi, Huang, Pengcheng, Skirzewski, Miguel, Kljakic, Ornela, Peng, Wanling, Qian, Tongrui, Tan, Ke, Zou, Jing, Trinh, Simon, Wu, Runlong, Zhang, Shichen, Pan, Sunlei, Hires, Samuel A., Xu, Min, Li, Haohong, Saksida, Lisa M., Prado, Vania F., Bussey, Timothy J., Prado, Marco A. M., Chen, Liangyi, Cheng, Heping, and Li, Yulong

Published
2020
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8. Improved dual-color GRAB sensors for monitoring dopaminergic activityin vivo

Author

Zhuo, Yizhou, primary, Luo, Bin, additional, Yi, Xinyang, additional, Dong, Hui, additional, Wan, Jinxia, additional, Cai, Ruyi, additional, Williams, John T., additional, Qian, Tongrui, additional, Campbell, Malcolm G., additional, Miao, Xiaolei, additional, Li, Bozhi, additional, Wei, Yu, additional, Li, Guochuan, additional, Wang, Huan, additional, Zheng, Yu, additional, Watabe-Uchida, Mitsuko, additional, and Li, Yulong, additional

Published
2023
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9. GESIAP: A Versatile Genetically Encoded Sensor-based Image Analysis Program

Author

Zheng, W. Sharon, primary, Zhang, Yajun, additional, Zhu, Roger E., additional, Zhang, Peng, additional, Gupta, Smriti, additional, Huang, Limeng, additional, Sahoo, Deepika, additional, Guo, Kaiming, additional, Glover, Matthew E., additional, Vadodaria, Krishna C., additional, Li, Mengyao, additional, Qian, Tongrui, additional, Jing, Miao, additional, Feng, Jiesi, additional, Wan, Jinxia, additional, Borden, Philip M., additional, Ali, Farhan, additional, Kwan, Alex C., additional, Gan, Li, additional, Lin, Li, additional, Gage, Fred H., additional, Venton, B. Jill, additional, Marvin, Jonathan S., additional, Podgorski, Kaspar, additional, Clinton, Sarah M., additional, Zhang, Miaomiao, additional, Looger, Loren L., additional, Li, Yulong, additional, and Zhu, J. Julius, additional

Published
2022
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11. A toolkit of highly selective and sensitive genetically encoded neuropeptide sensors

Author

Wang, Huan, primary, Qian, Tongrui, additional, Zhao, Yulin, additional, Zhuo, Yizhou, additional, Wu, Chunling, additional, Osakada, Takuya, additional, Chen, Peng, additional, Ren, Huixia, additional, Yan, Yuqi, additional, Geng, Lan, additional, Fu, Shengwei, additional, Mei, Long, additional, Li, Guochuan, additional, Wu, Ling, additional, Jiang, Yiwen, additional, Qian, Weiran, additional, Peng, Wanling, additional, Xu, Min, additional, Hu, Ji, additional, Chen, Liangyi, additional, Tang, Chao, additional, Lin, Dayu, additional, Zhou, Jiang-Ning, additional, and Li, Yulong, additional

Published
2022
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12. Compartmental Neuropeptide Release Measured Using a New Oxytocin Sensor

Author

Qian, Tongrui, primary, Wang, Huan, additional, Wang, Peng, additional, Geng, Lan, additional, Mei, Long, additional, Osakada, Takuya, additional, Tang, Yan, additional, Kania, Alan, additional, Grinevich, Valery, additional, Stoop, Ron, additional, Lin, Dayu, additional, Luo, Minmin, additional, and Li, Yulong, additional

Published
2022
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15. New and improved GRAB fluorescent sensors for monitoring dopaminergic activity in vivo

Author

Sun, Fangmiao, primary, Zhou, Jingheng, additional, Dai, Bing, additional, Qian, Tongrui, additional, Zeng, Jianzhi, additional, Li, Xuelin, additional, Zhuo, Yizhou, additional, Zhang, Yajun, additional, Tan, Ke, additional, Feng, Jiesi, additional, Dong, Hui, additional, Qian, Cheng, additional, Lin, Dayu, additional, Cui, Guohong, additional, and Li, Yulong, additional

Published
2020
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16. A genetically encoded GRAB sensor for measuring serotonin dynamics in vivo

Author

Wan, Jinxia, primary, Peng, Wanling, additional, Li, Xuelin, additional, Qian, Tongrui, additional, Song, Kun, additional, Zeng, Jianzhi, additional, Deng, Fei, additional, Hao, Suyu, additional, Feng, Jiesi, additional, Zhang, Peng, additional, Zhang, Yajun, additional, Zou, Jing, additional, Pan, Sunlei, additional, Zhu, J. Julius, additional, Jing, Miao, additional, Xu, Min, additional, and Li, Yulong, additional

Published
2020
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17. An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

Author

Jing, Miao, primary, Li, Yuexuan, additional, Zeng, Jianzhi, additional, Huang, Pengcheng, additional, Skirzewski, Miguel, additional, Kljakic, Ornela, additional, Peng, Wanling, additional, Qian, Tongrui, additional, Tan, Ke, additional, Wu, Runlong, additional, Zhang, Shichen, additional, Pan, Sunlei, additional, Xu, Min, additional, Li, Haohong, additional, Saksida, Lisa M., additional, Prado, Vania F., additional, Bussey, Tim, additional, Prado, Marco A.M., additional, Chen, Liangyi, additional, Cheng, Heping, additional, and Li, Yulong, additional

Published
2019
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19. Current and emerging methods for probing neuropeptide transmission.

Author

Qian, Tongrui, Wang, Huan, Xia, Xiju, and Li, Yulong

Subjects
*G protein coupled receptors, *CENTRAL nervous system, *NEUROPEPTIDES
Abstract

Neuropeptides comprise the most diverse category of neurochemicals in the brain, playing critical roles in a wide range of physiological and pathophysiological processes. Monitoring neuropeptides with high spatial and temporal resolution is essential for understanding how peptidergic transmission is regulated throughout the central nervous system. In this review, we provide an overview of current non-optical and optical approaches used to detect neuropeptides, including their design principles, intrinsic properties, and potential limitations. We also highlight the advantages of using G protein‒coupled receptor (GPCR) activation‒based (GRAB) sensors to monitor neuropeptides in vivo with high sensitivity, good specificity, and high spatiotemporal resolution. Finally, we present a promising outlook regarding the development and optimization of new GRAB neuropeptide sensors, as well as their potential applications. [ABSTRACT FROM AUTHOR]

Published
2023
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20. A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors.

Author

Wang H, Qian T, Zhao Y, Zhuo Y, Wu C, Osakada T, Chen P, Chen Z, Ren H, Yan Y, Geng L, Fu S, Mei L, Li G, Wu L, Jiang Y, Qian W, Zhang L, Peng W, Xu M, Hu J, Jiang M, Chen L, Tang C, Zhu Y, Lin D, Zhou JN, and Li Y

Subjects
Humans, Fluorescence, HEK293 Cells, Cerebral Cortex chemistry, Animals, Rats, Biosensing Techniques, Neuropeptides analysis, Neuropeptides metabolism, Receptors, G-Protein-Coupled agonists, Receptors, G-Protein-Coupled genetics, Neurons chemistry, Islets of Langerhans chemistry
Abstract

Neuropeptides are key signaling molecules in the endocrine and nervous systems that regulate many critical physiological processes. Understanding the functions of neuropeptides in vivo requires the ability to monitor their dynamics with high specificity, sensitivity, and spatiotemporal resolution. However, this has been hindered by the lack of direct, sensitive, and noninvasive tools. We developed a series of GRAB (G protein-coupled receptor activation‒based) sensors for detecting somatostatin (SST), corticotropin-releasing factor (CRF), cholecystokinin (CCK), neuropeptide Y (NPY), neurotensin (NTS), and vasoactive intestinal peptide (VIP). These fluorescent sensors, which enable detection of specific neuropeptide binding at nanomolar concentrations, establish a robust tool kit for studying the release, function, and regulation of neuropeptides under both physiological and pathophysiological conditions.

Published
2023
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21. Improved dual-color GRAB sensors for monitoring dopaminergic activity in vivo .

Author

Zhuo Y, Luo B, Yi X, Dong H, Wan J, Cai R, Williams JT, Qian T, Campbell MG, Miao X, Li B, Wei Y, Li G, Wang H, Zheng Y, Watabe-Uchida M, and Li Y

Abstract

Dopamine (DA) plays multiple roles in a wide range of physiological and pathological processes via a vast network of dopaminergic projections. To fully dissect the spatiotemporal dynamics of DA release in both dense and sparsely innervated brain regions, we developed a series of green and red fluorescent GPCR activation-based DA (GRAB DA ) sensors using a variety of DA receptor subtypes. These sensors have high sensitivity, selectivity, and signal-to-noise properties with subsecond response kinetics and the ability to detect a wide range of DA concentrations. We then used these sensors in freely moving mice to measure both optogenetically evoked and behaviorally relevant DA release while measuring neurochemical signaling in the nucleus accumbens, amygdala, and cortex. Using these sensors, we also detected spatially resolved heterogeneous cortical DA release in mice performing various behaviors. These next-generation GRAB DA sensors provide a robust set of tools for imaging dopaminergic activity under a variety of physiological and pathological conditions., Competing Interests: Competing interests None to declare.

Published
2023
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