91 results on '"Qian-Li Ma"'
Search Results
2. Insecticidal Activity of the Leaf and Stem Water Extract of Gelsemium elegans against Solenopsis invicta
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Qun Zheng, Liu-Peng Yang, Su-Kun Lin, Qian-Li Ma, De-Qiang Qin, and Zhi-Xiang Zhang
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Gelsemium elegans Benth.,koumine,worker ant,bioactivity ,Zoology ,QL1-991 ,Ecology ,QH540-549.5 ,Natural history (General) ,QH1-278.5 - Abstract
A comprehensive green worker ants control method that can be used to replace traditional chemical synthetic insecticides. In this study, the leaves and stems of Gelsemium elegans were extracted with water as the solvent, and the bioactivity of G. elegans against worker ants was determined by the “water tube” method. The bioassay results of insecticidal activity showed that when the time was extended to the 10th day, the mortality of worker ants treated with G. elegans extract reached 55.00% (1/20 leaf extract), 46.67% (1/20 stem extract) and 45.00% (1 mg/kg koumine). And the behavioral impact test results showed that the aggregation rate was reduced to 56.67% (1/100 leaf extract), 60.00% (1/100 stem extract) and 60.00% (0.5 mg/kg koumine); the climbing rate was reduced to 60.00 % (1/100 leaf extract), 58.33% (1/100 stem extract) and 58.33% (0.5 mg/kg koumine). The effect on the walking ability of worker ants is obvious. The walking rate drops to 1.53cm/s (1/100 leaf extract), 1.60cm/s (1/100 stem extract) and 1.47cm/s (0.5 mg/kg koumine). Therefore, we conclude that the water extract of G. elegans can be used for long-term continuous control of worker ants, which can be used to replace traditional chemical synthetic insecticides.
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- 2020
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3. Effects of traditional trabeculectomy, mitomycin C trabeculectomy and sclera pool trabeculectomy on post-surgical life quality in glaucoma patients
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Zhuo-Lin Zhou, Qian-Li Ma, Xin-Guang Yang, and Hong-Xia Fang
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glaucoma ,trabeculectomy ,mitomycin C ,sclera pool ,Ophthalmology ,RE1-994 - Abstract
AIM: To explore and compare the effects of trabeculectomy, mitomycin C(MMC)trabeculectomy and sclera pool trabeculectomy on life quality of patients with glaucoma. METHODS: Totally, 60 patients(60 eyes)with glaucoma were divided into group A, B and C equally and randomly. Twenty patients(20 eyes)in group A received treatment of traditional trabeculectomy; Twenty patients(20 eyes)in group B received MMC trabeculectomy; while twenty patients(20 eyes)in group C received sclera pool trabeculectomy. One-year follow study was proposed, Chinese version low vision quality of life questionnaire(CLVQOL)and self- assessment score were used to evaluate effects of surgeries on life quality of patients. RESULTS: Compared with group A, scoring of CLVQOL increased significantly in group B and C, and more significantly in group C(distant vision, movement, sensitization and fine work)when compared with group B(PPCONCLUSION: The improvement effect of sclera pool trabeculectomy on life quality of patient with glaucoma is better than traditional and MMC trabeculectomy.
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- 2013
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4. An outbreak of type π vaccine-derived poliovirus in Sichuan province, China: emergence and circulation in an under-immunized population.
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Hai-Bo Wang, Gang Fang, Wen-Zhou Yu, Fei Du, Chun-Xiang Fan, Qing-Lian Liu, Li-Xin Hao, Yu Liu, Jing-Shan Zheng, Zhi-Ying Qin, Wei Xia, Shi-Yue Zhang, Zun-Dong Yin, Qiong Jing, Yan-Xia Zhang, Rong-Na Huang, Ru-Pei Yang, Wen-Bin Tong, Qi Qi, Xu-Jing Guan, Yu-Lin Jing, Qian-Li Ma, Jin Wang, Xiao-Zhen Ma, Na Chen, Hong-Ru Zheng, Yin-Qiao Li, Chao Ma, Qi-Ru Su, Kathleen H Reilly, Hui-Ming Luo, Xian-Ping Wu, Ning Wen, and Wei-Zhong Yang
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Medicine ,Science - Abstract
BACKGROUND: During August 2011-February 2012, an outbreak of type Π circulating vaccine-derived poliovirus (cVDPVs) occurred in Sichuan Province, China. METHODS: A field investigation of the outbreak was conducted to characterize outbreak isolates and to guide emergency response. Sequence analysis of poliovirus capsid protein VP1 was performed to determine the viral propagation, and a coverage survey was carried out for risk assessment. RESULTS: One clinical compatible polio case and three VDPV cases were determined in Ngawa County, Ngawa Tibetan and Qiang Autonomous Prefecture, Sichuan Province. Case patients were unimmunized children, 0.8-1 years old. Genetic sequencing showed that the isolates diverged from the VP1 region of the type Π Sabin strain by 5-12 nucleotides (nt) and shared the same 5 nt VP1 substitutions, which indicate single lineage of cVDPVs. Of the 7 acute flaccid paralysis cases (all>6 months) reported in Ngawa Prefecture in 2011, 4 (57.1%) cases (including 2 polio cases) did not receive oral attenuated poliovirus vaccine. Supplementary immunization activities (SIAs) were conducted in February-May, 2012, and the strain has not been isolated since. CONCLUSION: High coverage of routine immunization should be maintained among children until WPV transmission is globally eradicated. Risk assessments should be conducted regularly to pinpoint high risk areas or subpopulations, with SIAs developed if necessary.
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- 2014
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5. Experimental study on wax deposition of highly paraffinic oil in intermittent gas-oil flow in pipelines.
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Chuan-Shuo Wang, Qian-Li Ma, Xiao-Fang Lv, Jie Zhang, Yang Liu, and Shi-Dong Zhou
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WAXES , *SMALL-angle X-ray scattering , *PIPELINE transportation , *PHASE velocity , *PETROLEUM , *SOLVENT extraction - Abstract
Oil-gas two phase wax deposition is a fairly common and open-ended question in flow assurance of multiphase transportation pipelines. This paper investigated the two main aspects of oil-gas two phase wax deposition layer: apparent thickness and crystal structure characteristics. A typical highly paraffinic oil in Bohai Sea, China, was used as the experimental material to investigate the wax deposition thickness in oil-gas two phase under the influence of different oil temperatures, superficial gas/liquid phase velocities and gas-oil ratios by using multiphase flow loop experimental device. Just as in the classical theory of wax molecular diffusion, it showed that wax deposition thickness of oil-gas two phase increased with increasing oil temperature. Analysis of the impact of different superficial phase velocities found that the actual liquid flow heat transfer and shear stripping was the gas phase dominant mechanisms determining wax deposit thickness. In addition, the crystal structure of the wax deposition layer was characterized with the help of small-angle X-ray scattering (SAXS) for different circumferential positions, flow rates and gas-oil ratios. The bottom deposition layer had a complex crystal structure and high hardness, which were subject to change over flow rate variations. Furthermore, the SAXS results provided evidence that the indirect effect of the actual liquid velocity modified by the gas phase was the main mechanism. Our study of the effect of gas phase on the wax deposition of oil-gas two phase will help shed light onto the mechanism by which this important process occurs. Our findings address a very urgent need in the field of wax deposition of highly paraffinic oil to understand the flow security of oilgas two phase that occurs easily in multiphase field pipelines. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Investigation on synergistic deposition of wax and hydrates in waxy water-in-oil (W/O) flow systems
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Yang Liu, Xiao-Fang Lv, Qian-Li Ma, Shi-Dong Zhou, Bo-Hui Shi, Hui Du, Yun Lei, Peng-Fei Yu, Shang-Fei Song, Jing Gong, and Bing-Cai Sun
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Geophysics ,Fuel Technology ,Geochemistry and Petrology ,Energy Engineering and Power Technology ,Economic Geology ,Geology ,Geotechnical Engineering and Engineering Geology - Published
- 2022
7. Numerical simulation study on multiphase flow pattern of hydrate slurry.
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Xiao-Fang Lv, Feng Chen, Jie Zhang, Yang Liu, Qian-Li Ma, Hui Du, Chuan-Shuo Wang, Shi-Dong Zhou, Bo-Hui Shi, Shang-Fei Song, and Jing Gong
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The research on the multiphase flow characteristics of hydrate slurry is the key to implementing the risk prevention and control technology of hydrate slurry in deep-water oil and gas mixed transportation system. This paper established a geometric model based on the high-pressure hydrate slurry experimental loop. The model was used to carry out simulation research on the flow characteristics of gas-liquid-solid three-phase flow. The specific research is as follows: Firstly, the effects of factors such as slurry flow velocity, hydrate particle density, hydrate particle size, and hydrate volume fraction on the stratified smooth flow were specifically studied. Orthogonal test obtained particle size has the most influence on the particle concentration distribution. The slurry flow velocity is gradually increased based on stratified smooth flow. Various flow patterns were observed and their characteristics were analyzed. Secondly, increasing the slurry velocity to 2 m/s could achieve the slurry flow pattern of partial hydrate in the pipeline transition from stratified smooth flow to wavy flow. When the flow rate increases to 3 m/s, a violent wave forms throughout the entire loop. Based on wave flow, as the velocity increased to 4 m/s, and the flow pattern changed to slug flow. When the particle concentration was below 10%, the increase of the concentration would aggravate the slug flow trend; if the particle concentration was above 10%, the increase of the concentration would weaken the slug flow trend, the increase of particle density and liquid viscosity would weaken the tendency of slug flow. The relationship between the pressure drop gradients of several different flow patterns is: slug flow > wave flow > stratified smooth flow. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Zn Anode Surface Engineering for Stable Zinc-Ion Batteries: Carbon Dots Incorporated Mesoporous Tio2 as a Coating Layer
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Song Tianbing, Qian-Li Ma, Xi-Rong Zhang, Jia-Wen Ni, Tian-Le He, and Huan-Ming Xiong
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- 2023
9. Polyethylene liner cementation into a well-fixed metal acetabular shell for the management of periacetabular osteolysis: a systematic review
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Qian-Li Ma, Peter K. Sculco, Marios Loucas, Vasileios S. Nikolaou, Jean-Claude Sedran, Michael-Alexander Malahias, Ioannis Gkiatas, Seong J. Jang, and Alex Gu
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musculoskeletal diseases ,Osteolysis ,business.industry ,medicine.medical_treatment ,technology, industry, and agriculture ,Clinical performance ,Polyethylene liner ,Aseptic loosening ,Dentistry ,Bone grafting ,equipment and supplies ,Cementation (geology) ,medicine.disease ,Acetabular shell ,Medicine ,Orthopedics and Sports Medicine ,Surgery ,business ,Total hip arthroplasty - Abstract
Although various papers have reported on the clinical performance of cup retention with cementation of a new liner and bone grafting in the management of well-fixed cups with polyethylene wear and periacetabular osteolysis after total hip arthroplasty (THA), no systematic review of this topic has been published to date. Medline, EMBASE and Cochrane Library were searched for articles published from January 1999 to January 2019 using “osteolysis” AND “well-fixed”, “osteolysis” AND “retro-acetabular”, “bone graft” AND (“retention” OR “retained” OR “stable”) AND “cup”, and “cemented liner” AND “well-fixed”. Nine articles were selected for review (186 cases, 76.1 months mean follow-up). The overall revision rate was 11.3% (21 hips) most commonly due to aseptic loosening (9/186 hips), dislocation (8/186 hips), and liner wear progression (2/186 cases). The reported square size of osteolytic lesions ranged from a mean of 465.84 mm2 to a max of 4,770 mm2. Almost all reported lesions treated with bone grafts resolved or did not progress 97% (72/74). All studies indicated improved pain and functional scores at follow-up. Cementation of a new liner with periacetabular bone grafting provides an alternative option to isolated liner exchange and cup revision for the management of periacetabular osteolysis in well-fixed cups with a disrupted locking mechanism or unavailable exchange liner. Further higher quality studies are required in order to examine if the use of highly cross-linked polyethylene, highly porous-coated cups, hydroxyapatite-coated cups, and small-diameter cups influence the clinical outcome of liner cementation in well-fixed cups with periacetabular osteolysis.
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- 2021
10. Time expression normalization based on multi-scale classification and temporal focus model with hierarchical discourse transfer.
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Rui-Fang He and Qian-Li Ma
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- 2012
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11. An algorithm for planarity testing by adjacency matrix.
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Shi-Qun Li and Qian-Li Ma
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- 2012
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12. A 3D Dynamic Molecular Dynamics Simulation Study: Diffusion of Two Types of Sphere Janus Colloidal Particles
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Qian Li Ma
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Materials science ,Mechanical Engineering ,Janus particles ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Molecular dynamics ,Mechanics of Materials ,Chemical physics ,Colloidal particle ,General Materials Science ,Janus ,Diffusion (business) ,0210 nano-technology - Abstract
The research of Janus colloidal particles has attracted much attention in recent years because of its huge prospects and applications in materials, chemicals, medicine, catalysis, etc. In order to reduce the cost of conducting experiments, the method of molecular dynamics simulation is used to conduct research on Janus particles. However, the current related simulation study lacks the visualization, dynamization and three-dimensionalization of the Janus particle simulation process. Therefore, the author simulates the free diffusion process of two kinds of Janus particles by using 3D visualization dynamic molecular dynamics related software in this paper. By analyzing the influence of the related parameters of particles and droplet on the diffusion process, new directions of the researches about the simulation of Janus particles can be proposed. The simulation results show that the size of the droplet, the position where the droplet is added to the solution, and the mass of the particles will affect the diffusion process rate of the particles in the droplet in the surrounding solution.
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- 2021
13. Shared reservoir modular echo state networks for chaotic time series prediction.
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Wei-Biao Chen, Qian-Li Ma 0001, and Hong Peng
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- 2010
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14. Multi-step Bridged Refinement for classifying cross-domian data.
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Jiang-Wei Qin, Hong Peng, Peng Liang 0003, Qian-Li Ma 0001, and Jia Wei
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- 2010
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15. Phase space reconstruction and prediction of multivariate chaotic time series.
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Chun-Tao Zhang, Jiao Guo, Qian-Li Ma, Hong Peng, and Xiao-Dong Zhang
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- 2010
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16. Improving diversity in Web search results re-ranking using absorbing random walks.
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Gu-Li Lin, Hong Peng, Qian-Li Ma 0001, Jia Wei, and Jiang-Wei Qin
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- 2010
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17. Automatic Summarization for Chinese Text Based on Combined Words Recognition and Paragraph Clustering.
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Chang-jin Jiang, Hong Peng, Qian-Li Ma, and Jian-chao Chen
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- 2010
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18. Direct model of memory properties and the linear reservoir topologies in echo state networks.
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Qian-Li Ma 0001, Wei-Biao Chen, Jia Wei, and Zhiwen Yu 0002
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- 2014
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19. Modular state space of echo state network.
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Qian-Li Ma 0001 and Wei-Biao Chen
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- 2013
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20. A Keyword Based Prototype for Web Search Result Diversification.
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Gu-Li Lin, Hong Peng, Qian-Li Ma 0001, Jia Wei, and Jiang-Wei Qin
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- 2012
21. ASM: An adaptive simplification method for 3D point-based models.
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Zhiwen Yu 0002, Hau-San Wong, Hong Peng, and Qian-Li Ma 0001
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- 2010
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22. Plasma cfDNA as a potential treatment monitoring and prognostic index in patients withnon-small cell lung cancer
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Gao-Feng Li, Xu-Dong Xiang, Qian-Li Ma, Ying Zhang, Chen Nan, Gang Guo, and Heng Li
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medicine.medical_specialty ,Multivariate analysis ,business.industry ,General Medicine ,medicine.disease ,Gastroenterology ,Plasma.cfDNA ,Gefitinib ,Cell-free fetal DNA ,Internal medicine ,Medicine ,In patient ,Non small cell ,business ,Lung cancer ,Pathological ,medicine.drug - Abstract
The purpose of this study was to investigate the potential of cell-free DNA (cfDNA) as a prognostic factor for non-small cell lung cancer (NSCLC). Patients with NSCLC (n = 154) treated with gefitinib were recruited over a 5-year period for this study, and served as the observation group (79 males and 75 females, mean age = 53.74 ± 10.86 years). The control group (normal healthy individuals) consisted of 30 males and 22 females, aged 44 – 64 years (mean age = 54.12 ± 9.83 years). The follow-up lasted 5 years, or until the patient relapsed and died. The plasma level of cfDNA was determined in patients 1 day before treatment, 3 days after treatment, and on the 28th day of treatment.Based on the cfDNA expression level, NSCLC patients were subdivided into high-expression and low-expression groups, and differences in survival were compared. Univariate and multivariate analyses were performed on factors affecting patients survival using COX. Total effectiveness was significantly higher in observation group (49.35%) than in control group (13.95 %) (p
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- 2020
23. Detection and Initial Response to a Type 2 Vaccine-Derived Poliovirus — Sichuan Province, China, 2019
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Aiqiang Xu, Hong Yang, Jiushun Zhou, Lixin Hao, Yong Zhang, Ning Wen, Wenbo Xu, Yong Chen, Xiaoping Zhu, Zundong Yin, Chao Ma, Yu Liu, Xianxiang Ding, Qian-Li Ma, Kun Deng, Huaqing Wang, Chunxiang Fan, Xiaozhen Ma, Ge Shao, Zhijie An, Qi Qi, Lei Cao, Lance Rodewald, Lei Nan, Cheng Wang, Dongmei Yan, Xianping Wu, Zijian Feng, and Shuangli Zhu
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medicine.medical_specialty ,business.industry ,Transmission (medicine) ,Poliovirus ,Public health ,Outbreak ,medicine.disease_cause ,complex mixtures ,Virology ,Vaccination ,Poliomyelitis eradication ,parasitic diseases ,Medicine ,General Agricultural and Biological Sciences ,Vaccine derived poliovirus ,business ,China - Abstract
What is already known about this topic? After the type 2 strain of the live, attenuated poliovirus vaccine was withdrawn globally in 2016, any identification of a type 2 poliovirus is a Public Health Emergency of International Concern. A vaccine-derived type 2 poliovirus (VDPV2) was identified in Sichuan, prompting an urgent, comprehensive investigation and response. What is added by this report? Type 2 monovalent, live, attenuated oral poliovirus vaccine (mOPV2) is being used to respond to the numerous VDPV2 outbreaks seen around the world. In contrast, the response in Sichuan used Sabin strain inactivated poliovirus (sIPV) to stop circulation of the VDPV2. In the 6 months following the vaccination response, there have been no VDPV2s detected in Sichuan, despite extensive search. What are the implications for public health practices? Further search for the VDPV2 must continue in order to determine whether transmission has been stopped. The ongoing investigation and response to the Sichuan VDPV2 is providing evidence to the Global Polio Eradication Initiative on managing VDPV2 outbreaks.
- Published
- 2020
24. Ferroptosis triggered by dihydroartemisinin facilitates chlorin e6 induced photodynamic therapy against lung cancerthrough inhibiting GPX4 and enhancing ROS
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Ning Han, Liu-Gen Li, Xing-Chun Peng, Qian-Li Ma, Zi-Yi Yang, Xi-Yong Wang, Jian Li, Qi-Rui Li, Ting-Ting Yu, Hua-Zhen Xu, Xiang Xu, Xiao Chen, Mei-Fang Wang, and Tong-Fei Li
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Pharmacology ,Lung Neoplasms ,Photosensitizing Agents ,Chlorophyllides ,Photochemotherapy ,Cell Line, Tumor ,Ferroptosis ,Humans ,Apoptosis ,Phospholipid Hydroperoxide Glutathione Peroxidase ,Reactive Oxygen Species ,Artemisinins - Abstract
Photodynamic therapy (PDT) is noninvasive, low toxicity, and photo-selective, but may be resisted by malignant cells. A previous study found chlorin e6 (Ce6) mediated PDT showed drug resistance in lung cancer cells (LLC), which may be associated with PDT-induced DNA damage response (DDR). DDR may up-regulate glutathione peroxidase 4 (GPX4), which in turn degrade ROS induced by PDT. However, dihydroartemisinin (DHA) was found to down-regulate GPX4. Accordingly, the DHA was hypothesized to improve the resistance to PDT. The present work explores the mechanism of Ce6 mediated drug resistance and reveals whether DHA can enhance the efficacy of PDT by suppressing GPX4. The in vitro experiments found Ce6 treatment did not inhibit the viability of LLC within 6 h without inducing significant apoptosis, suggesting LLC were resistant to PDT. Further investigation demonstrated PDT could damage DNA and up-regulate GPX4, thus degrading the generated ROS. DHA effectively inhibited the viability of LLC and induced apoptosis. Importantly, DHA displayed a prominent inhibitory effect on the GPX4 expression and thereby triggered ferroptosis. Combining DHA with Ce6 for treatment of LLC resulted in the suppressed GPX4 and elevated ROS. Finally, the findings showed DHA combined with Ce6 exhibited superb anti-lung cancer efficacy. In summary, Ce6 PDT damages DNA, up-regulates GPX4 to degrade ROS, thereby inducing drug resistance. Down-regulation of GPX4 by DHA-triggered ferroptosis significantly enhances the efficacy of PDT. This study provides an outstanding theoretical basis for the regulation of the intratumoral redox system and improving PDT efficacy against lung cancer by herbal monomer DHA.
- Published
- 2021
25. Analysis of and Study on the Difficulties in the Fire Protection Design of Large Commercial Complex
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Qian-li, MA and Ting-lin, HUANG
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- 2011
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26. Harnessing chlorin e6 loaded by functionalized iron oxide nanoparticles linked with glucose for target photodynamic therapy and improving of the immunogenicity of lung cancer
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Ting-Ting Yu, Xing-Chun Peng, Mei-Fang Wang, Ning Han, Hua-Zhen Xu, Qi-Rui Li, Liu-Gen Li, Xiang Xu, Qian-Li Ma, Bin Liu, Jue Wang, Li Zhao, Xiao Chen, and Tong-Fei Li
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Cancer Research ,Lung Neoplasms ,Photosensitizing Agents ,Porphyrins ,Chlorophyllides ,General Medicine ,Mice ,Glucose ,Oncology ,Photochemotherapy ,Carcinoma, Non-Small-Cell Lung ,Cell Line, Tumor ,Tumor Microenvironment ,Animals ,Humans ,Nanoparticles ,Magnetic Iron Oxide Nanoparticles - Abstract
Non-small-cell lung cancer (NSCLC) is the most common malignant lung tumor and is difficult to be eradicated due to its immunosuppressive microenvironment. Chlorin e6 (Ce6)-mediated photodynamic therapy (PDT) could improve immunogenicity while destroying malignant tumor cells. However, the clinic application of Ce6-mediated PDT is limited by Ce6's poor water solubility and insufficient accumulation in lung cancer. To address this issue, Ce6 was loaded onto functionalized iron oxide nanoparticles linked with glucose to improve the distribution of Ce6 in lung cancer.The results of transmission electron microscopy (TEM), UV-Vis spectrophotometry, dynamic light scattering and near-infrared (NIR) spectroscopy confirmed the successful preparation of the composites. Confocal and flow cytometry showed IO-PG-GLU-Ce6 significantly enhanced the uptake of Ce6 by lung cancer cells and produced more reactive oxygen species (ROS) under NIR light irradiation. In addition, the detection of cell viability, proliferation and apoptosis indicated IO-PG-GLU-Ce6 achieved stronger photo-toxicity to lung cancer cells. Moreover, IO-PG-GLU-Ce6 treatment effectively damaged the DNA of lung cancer cells and thereby activated STING, up-regulated the expression of IFN-β, HMGB1 and HSP90, indicating augmented immunogenicity of lung cancer cells. Further results of in vivo, organ imaging and tissue fluorescence sections demonstrated IO-PG-GLU-Ce6 significantly improved the distribution of Ce6 in tumor tissues of lung cancer-bearing mice as well. Finally, the findings of in vivo study and immunohistochemistry confirmed the better efficacy of IO-PG-GLU-Ce6. HE staining results of vital organs suggested that the composites were less toxic.In conclusion, Ce6 loaded by functionalized iron oxide nanoparticles linked with glucose exhibited both target photodynamic efficacy and the ability to enhance its immunogenicity in lung cancer. This study provides a promising strategy for augment of the targeting delivery of Ce6 and its mediated photodynamic and immunotherapy.
- Published
- 2021
27. Surface properties and phase behavior of Gemini/conventional surfactant mixtures based on multiple quaternary ammonium salts
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Yan-Qun Wang, Lu Lai, Yi Liu, Qi-Xiang Mei, Qian-Li Ma, Sheng-Jing Li, and Ping Mei
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Chemistry ,Vesicle ,Cationic polymerization ,Rhamnolipid ,Atmospheric temperature range ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,Chemical engineering ,Pulmonary surfactant ,Critical micelle concentration ,Phase (matter) ,Materials Chemistry ,Ammonium ,Physical and Theoretical Chemistry ,Spectroscopy - Abstract
The mixing properties of Gemini surfactants are significantly important to the large-scale application of these surfactants. In this study, we studied the mixing properties of multiple quaternary ammonium salts (MQAS) with cationic surfactant DTAB, anionic surfactant SDS, nonionic surfactant Triton X-100 and anionic biosurfactant rhamnolipid, respectively. Moreover, the phase behavior and aggregation properties of MQAS/SDS mixtures in water were examined by ocular observations and DLS. For equilibrium surface properties, unlike MQAS/DTAB and MQAS/TX-100 mixtures, the equimolar cationic/anionic mixtures (MQAS/SDS and MQAS/RL mixtures) have a lower critical micelle concentration than either pure component. This is always attributed to the formation of cationic surfactant complexes through the electrostatic attraction of hydrophilic groups. Results of dynamic surface properties show that MQAS/TX-100 mixtures exhibit the best dynamic surface activity among these surfactant mixtures, resulting from the good dynamic surface activity of TX-100 and the weak interaction between MQAS and TX-100. Considering the large size of cationic/anionic surfactant complexes, the MQAS/SDS and MQAS/RL mixtures have a smaller R1/2 value, but the γm values of equimolar cationic/anionic mixtures are lower than either pure components. This suggests that the formation of cationic/anionic surfactant complexes reduces the electrostatic adsorption barrier. In the anionic-rich side, the MQAS/SDS mixtures are prone to form vesicles, while the addition of a small amount of MQAS will induce the micelle-to-vesicle transition, which can be regulated by the composition of mixtures. Meanwhile, the increase of temperature induces the transition of precipitate to vesicles. But the micelle-to-vesicle or vesicle-to-micelle transitions induced by the increase of temperature have not been observed at the studied temperature range.
- Published
- 2019
28. Polyethylene liner cementation into a well-fixed metal acetabular shell for the management of periacetabular osteolysis: a systematic review
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Michael-Alexander, Malahias, Qian-Li, Ma, Seong J, Jang, Marios, Loucas, Alex, Gu, Ioannis, Gkiatas, Jean-Claude, Sedran, Vasileios S, Nikolaou, and Peter K, Sculco
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Reoperation ,Polyethylene ,Metals ,Arthroplasty, Replacement, Hip ,Humans ,Acetabulum ,Hip Prosthesis ,Osteolysis ,Hydroxyapatites ,Prosthesis Design ,Cementation ,Prosthesis Failure ,Follow-Up Studies - Abstract
Although various papers have reported on the clinical performance of cup retention with cementation of a new liner and bone grafting in the management of well-fixed cups with polyethylene wear and periacetabular osteolysis after total hip arthroplasty (THA), no systematic review of this topic has been published to date.Medline, EMBASE and Cochrane Library were searched for articles published from January 1999 to January 2019 using "osteolysis" AND "well-fixed", "osteolysis" AND "retro-acetabular", "bone graft" AND ("retention" OR "retained" OR "stable") AND "cup", and "cemented liner" AND "well-fixed".Nine articles were selected for review (186 cases, 76.1 months mean follow-up). The overall revision rate was 11.3% (21 hips) most commonly due to aseptic loosening (9/186 hips), dislocation (8/186 hips), and liner wear progression (2/186 cases). The reported square size of osteolytic lesions ranged from a mean of 465.84 mmCementation of a new liner with periacetabular bone grafting provides an alternative option to isolated liner exchange and cup revision for the management of periacetabular osteolysis in well-fixed cups with a disrupted locking mechanism or unavailable exchange liner. Further higher quality studies are required in order to examine if the use of highly cross-linked polyethylene, highly porous-coated cups, hydroxyapatite-coated cups, and small-diameter cups influence the clinical outcome of liner cementation in well-fixed cups with periacetabular osteolysis.
- Published
- 2021
29. Effects of off-pump coronary artery bypass graft on the clinical efficacy, surgical indicators, and cardiac function of patients with coronary heart disease
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Jing-Hui An, Shu-Guang Zhao, Feng-Wu Shi, Hong-Juan Liao, Jie Ma, and Qian-Li Ma
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Cardiac function curve ,Cardiac output ,medicine.medical_specialty ,medicine.medical_treatment ,Cardiac index ,Coronary Artery Bypass, Off-Pump ,Coronary Disease ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Off-pump coronary artery bypass ,Retrospective Studies ,Advanced and Specialized Nursing ,Ejection fraction ,business.industry ,Stroke volume ,medicine.disease ,Anesthesiology and Pain Medicine ,Treatment Outcome ,Ventricular fibrillation ,Cardiology ,Quality of Life ,business - Abstract
Background Coronary heart disease (CHD) is a common clinical cardiovascular disease. This study aimed to analyze the effects of off-pump coronary artery bypass graft on the clinical efficacy, surgical indicators, and cardiac function of patients with CHD. Methods We retrospectively analyzed the clinical data of 120 patients with CHD who were treated in our hospital from May 2017 to May 2020. And they were divided into the control group (extracorporeal coronary artery bypass graft) and the observation group (off-pump coronary artery bypass graft). The clinical efficacy, surgical indicators, cardiac function, myocardial injury, the degree of cardiac autonomic nerve imbalance, incidence of complications and quality of life one year after the operation in the 2 groups were compared. Results The total effective rate of the observation group was significantly higher than that of the control group. Intraoperative blood loss, operation time, intraoperative blood transfusion, and hospital stay in the observation group were significantly better than those in the control group. After treatment, the levels of cardiac index (CI), ejection fraction (EF), stroke volume (SV), and cardiac output (CO) in the observation group and the control group were higher than those before treatment, especially in the observation group. Compared with those before operation, CK-MB and cTnI of the two groups significantly increased at all time points after surgery. After treatment, SDNN, LF, HF, and TP of patients in the two groups increased, which was significant in the observation group. The incidence of complications such as myocardial infarction, ischemic changes, respiratory insufficiency, and intraoperative ventricular fibrillation in the observation group was significantly lower than that in the control group. The score of quality of life in the observation group was significantly higher than the control group. Conclusions In the treatment of patients with CHD, off-pump coronary artery bypass graft has good clinical effects, which can significantly improve the heart function, and cardiac autonomic nerve imbalance of patients, reduce myocardial damage, decrease the incidence of complications, and improve the quality of life. Therefore, off-pump coronary artery bypass graft is worthy of clinical application.
- Published
- 2020
30. Chlorin e6 mediated photodynamic therapy triggers resistance through ATM-related DNA damage response in lung cancer cells
- Author
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Hua-Zhen Xu, Xiang Xu, Ning Han, Mai-Ou Shen, Liu-Gen Li, Xiao Chen, Xing-Chun Peng, Qi-Rui Li, Bin Liu, Mei-Fang Wang, Ting-Ting Yu, Tong-Fei Li, and Qian-Li Ma
- Subjects
Lung Neoplasms ,Porphyrins ,DNA damage ,medicine.medical_treatment ,Biophysics ,Photodynamic therapy ,Ataxia Telangiectasia Mutated Proteins ,Dermatology ,Flow cytometry ,Cell Line, Tumor ,medicine ,Humans ,Pharmacology (medical) ,Viability assay ,chemistry.chemical_classification ,Reactive oxygen species ,Photosensitizing Agents ,Chlorophyllides ,biology ,medicine.diagnostic_test ,Proliferating cell nuclear antigen ,Comet assay ,Photochemotherapy ,Oncology ,chemistry ,Apoptosis ,Cancer research ,biology.protein ,DNA Damage - Abstract
OBJECTIVE Photodynamic therapy (PDT) has emerged as a promising strategy in the treatment of malignant tumors due to its high selectivity, non-toxicity, and non-invasiveness. However, PDT can also induce DNA damage and subsequent repair response, which may reduce the efficacy of PDT. In the present study, we sought to explore the effect of chlorin e6 (Ce6)-mediated PDT on DNA damage and DNA damage response (DDR) in lung cancer cells. In addition, the effect of PDT combined with ATM inhibitor on molecules of DDR and the possibility of improving the efficacy of PDT were further investigated. MATERIALS AND METHODS In the in vitro study, lewis cells were submitted to Ce6 treatment (2, 4, 8, 16, 32 μg/mL). To determine the concentration of Ce6, uptake and toxicity of Ce6 mediated PDT were detected using flow cytometry (FACS), Confocal microscopy, and CCK-8. In the subsequent research, 8 μg/mL of Ce6 was the treatment condition for inducing PDT. The different post-irradiation placement times were further grouped under this condition (2, 4, 6, 12 h). Cellular reactive oxygen species (ROS), damage of DNA were measured by DCFH-DA probe, comet assay respectively. Then the expression of p-ATM, p53, and γ-H2A.X proteins related to DNA damage response, was detected by WB. The efficacy of Ce6 induced PDT was also demonstrated by Annexin-V/PI staining as well as the expression of PCNA, cleaved-caspase-3. On this basis, ATM inhibitor was applied to treat lewis cells combined with Ce6 (2, 4 h) to investigate whether the efficacy of PDT induced by Ce6 can be improved after the ATM-related DDR was blocked. The cell viability, apoptosis, and expression of associated proteins were assayed. RESULTS At 2-4 h after PDT treatment, ROS was dramatically elevated in lewis cells, DNA double-strand breaks (DDSB) occurred, as well as up-regulation of DDR proteins γ-H2A.X, p-ATM, and p53. At the same time, lewis cells did not undergo significant apoptosis. After ATM inhibition, the DDR was significantly blocked within 2-4 hours after Ce6 induced PDT, along with a pronounced decrease in cell viability followed by a prominent increase of apoptosis. CONCLUSION Ce6-mediated PDT generates ROS in a short period time, thus inducing DNA damage, ATM-related DDR as well as promoting resistance of lung cancer cells to PDT. Combining ATM inhibitor with PDT could effectively inhibit the DDR induced by PDT, thereby enhancing the efficacy. This study reveals a new resistance mechanism of PDT and proposes an intervention strategy.
- Published
- 2022
31. GW24-e2948 Small interfering RNA transfection in cultured cardiac fibroblasts
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Jia-bao, Zhu, Yu-zhou, Wu, Qian-li, Ma, and Shu-qin, Li
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- 2013
- Full Text
- View/download PDF
32. A Comparison Between Chinese and Caucasian 3-Dimensional Bony Morphometry in Presimulated and Postsimulated Osteotomy for Total Knee Arthroplasty
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Qian-Li Ma, Yi-Yuan Zhang, Joseph D. Lipman, Xiao-Nan Wang, Cheng-Kung Cheng, and Bin You
- Subjects
Adult ,Male ,musculoskeletal diseases ,China ,Adolescent ,Knee Joint ,medicine.medical_treatment ,Total knee arthroplasty ,Osteotomy ,White People ,Total knee ,Young Adult ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Asian People ,Humans ,Medicine ,Body Weights and Measures ,Knee ,Orthopedics and Sports Medicine ,Femur ,Statistical analysis ,Tibia ,Arthroplasty, Replacement, Knee ,Physical Examination ,Aged ,Aged, 80 and over ,Orthodontics ,030222 orthopedics ,biology ,business.industry ,030229 sport sciences ,Middle Aged ,musculoskeletal system ,biology.organism_classification ,Valgus ,Female ,Knee Prosthesis ,Tomography, X-Ray Computed ,business - Abstract
Background The bone morphologies of intact knees were measured and compared between Chinese and Caucasian populations. However, to assess if distinct designs of implants are necessary for the Chinese population owing to different morphologies and sizes, the knee measurements after osteotomy performed in total knee arthroplasty were evaluated. Methods Thirty-seven Caucasian and 50 Chinese patients' knees were examined using computed tomography scans. Mimics were applied to reconstruct 3-dimensional bone models. Dimensions of the 3-dimensional knee models and simulated bone resections during total knee arthroplasty were measured using Geomagic Studio and Pro/ENGINEER. The morphologic measurements of the native and resected femur and tibia included the anteroposterior (AP) depth, mediolateral (ML) width, notch width, knee physical valgus angle, tibial slope angle, and the ML-to-AP ratio of the femur, tibia, and resected femur. Statistical analysis was performed using the independent samples t test and the Pearson correlation coefficient in SPSS for Windows. Values of P < .05 were considered significant. Results No measurements were significantly different between the Chinese and Caucasian knees. However, the Chinese female showed significant differences compared with the Chinese male on distal femoral measurements both presimulated and postsimulated osteotomy such as a smaller mean ML-to-AP ratio in presimulated (1.3 ± 0.1) and postsimulated (1.3 ± 0.1) osteotomy. Conclusion The necessity of designing a full set of total knee components specifically for the Chinese population is still undetermined. However, we suggest designing femoral components specific for the Chinese females because of different postosteotomy distal femoral ML-to-AP ratio between the Chinese males and the Chinese females.
- Published
- 2017
33. Preoperative statins as modifiers of cardiac and inflammatory outcomes following coronary artery bypass graft surgery: a meta-analysis
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Feng-Wu Shi, Jie Ma, Qian-Li Ma, Su Liu, and Jing-Hui An
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Statin ,medicine.drug_class ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Preoperative care ,03 medical and health sciences ,Coronary artery bypass surgery ,Postoperative Complications ,0302 clinical medicine ,Internal medicine ,Preoperative Care ,medicine ,Humans ,030212 general & internal medicine ,Myocardial infarction ,Coronary Artery Bypass ,biology ,business.industry ,C-reactive protein ,Atrial fibrillation ,Odds ratio ,medicine.disease ,Confidence interval ,Surgery ,biology.protein ,Cardiology ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Cardiology and Cardiovascular Medicine ,business - Abstract
Early postoperative cardiac complications of coronary artery bypass graft surgery, such as atrial fibrillation (AF) or myocardial infarction (MI), may be beneficially modulated by preoperative statins, involving their anti-inflammatory effects. There is uncertainty on the clinical merit of statin pretreatment. Addressing this, we conducted a meta-analysis of early cardiac complications and inflammatory markers following statin pretreatment in coronary artery bypass graft surgery. A search of Medline and Cochrane databases was undertaken to identify suitable studies. A meta-analysis was carried out for early cardiac (AF, MI, myocardial injury markers) and inflammatory (cytokines, C-reactive protein) outcomes. We identified 17 suitable studies that featured data from the total of 2796 patients. Twelve studies (1260 treated and 1263 untreated patients) reported AF incidence. Statin pretreatment was associated with a significant decrease of AF incidence: odds ratio 0.44 (95% confidence interval: 0.27-0.70; P = 0.003). Seven studies (381 treated and 277 untreated patients) reported useful data on MI. Unlike in AF, no significant modulation of postoperative MI in association with statin pretreatment could be observed: odds ratio 0.62 (95% confidence interval: 0.21-1.81; P = 0.62). Five studies (248 treated and 245 untreated patients) provided data on postoperative rise of C-reactive protein. This rise was significantly downregulated in statin-pretreated patients: standardized mean difference -0.44 (95% confidence interval: -0.78 to -0.11; P = 0.02). Thus, postoperative AF incidence is the biggest beneficiary of statin pretreatment in coronary artery bypass graft surgery. This effect is associated with beneficial modulation of systemic inflammatory markers.
- Published
- 2017
34. [Column-integrated Aerosol Optical Properties Determined Using Ground-based Sun Photometry Measurements in the Hangzhou Region]
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Bing, Qi, Hui-Zheng, Che, Ting-Ting, Xu, Rong-Guang, Du, De-Yun, Hu, Zhuo-Ran, Liang, Qian-Li, Ma, and Jie, Yao
- Abstract
To investigate the optical properties of aerosols in the Hangzhou region (Hangzhou, Tonglu, Jiande, and Chun'an), the aerosol optical depth (AOD), Ångström exponent (AE), single scattering albedo (SSA), and aerosol size distribution (ASD) were measured using CIMEL sun-photometers in 2012. The results showed that the annual average values of AOD
- Published
- 2019
35. Optimizing the Cooling Process of the Quartz Glass in an Electric Furnace
- Author
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Guo-jun Zhang, Qian-li Ma, and Jing Wang
- Subjects
Materials science ,Scientific method ,Metallurgy ,Quartz - Published
- 2019
36. [Distribution and Bioaccumulation Characteristics of Cadmium in Fish Species from the Longjiang River in the Guangxi Autonomous Region]
- Author
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Jun-Neng, Wang, Xue-Min, Zhao, Guo-Cheng, Hu, Song-Xiong, Zhong, Ling-Ai, Yao, Qian-Li, Ma, and Zhen-Cheng, Xu
- Subjects
China ,Rivers ,Metals, Heavy ,Fishes ,Animals ,Water Pollutants, Chemical ,Cadmium ,Environmental Monitoring - Abstract
Emergent cadmium pollution can cause water quality deterioration in rivers, which destroys the aquatic eco-environment and poses threats to human health. Fish species in these aquatic systems are prone to such pollution incidents and act as important indicators of the pollution level. Because cadmium enters the systematic circulation of fish and is non-biodegradable, the investigation of cadmium accumulation in fish bodies provides insights into the detrimental effects of cadmium pollution on the aquatic biological system. This research aims to validate the eco-environmental risks associated with emergent cadmium pollution incidents based on the investigation of the different tissues and organs of diverse fish species. The investigation was conducted six times along the Longjiang River using sampling methods during which all fish species were also classified and analyzed based on the water layer they reside in and their feeding habits. The results show that the cadmium concentration in the fish tissues is significantly higher in the former three investigations compared with that of the latter three analyses. For herbivorous, carnivorous, and omnivorous fish species, the cadmium concentration of their different tissues and organs follows the order:kidneylivergutgilleggscale ≈ muscle. The cadmium concentration in the kidney is significantly higher (
- Published
- 2019
37. [Nitrogen and Phosphorous Adsorption Characteristics of Suspended Solids Input into a Drinking Water Reservoir via Typhoon Heavy Rainfall]
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Ling-Ai, Yao, Xue-Min, Zhao, Qian-Li, Ma, Rong-Chang, Liang, Bei-Cheng, Xia, and Qiong-Fang, Zhuo
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China ,Geologic Sediments ,Cyclonic Storms ,Nitrogen ,Drinking Water ,Rain ,Phosphorus ,Adsorption ,Water Pollutants, Chemical - Abstract
During typhoon "Mujigae" in October 2015, water samples and surface sediments were collected from Gaozhou Reservoir, a drinking water reservoir, for simulation and analysis of the kinetics of suspended solids adsorption to nitrogen and phosphorus and the adsorption isotherms of suspended solids with different particle sizes and different concentrations. The results showed no obvious nitrogen adsorption of suspended solids of Gaozhou Reservoir. However, the adsorption effect to phosphorus by suspended solids was significant and the equilibrium time of phosphorus adsorption was 10 hours. The adsorption capacity of phosphorus increased with the decrease of sediment particle size when particle sizes were less than 0.25 mm, whereas it increased with the increase of suspended solids concentration when the concentration was in the range of 0.2-2.0 kg·m
- Published
- 2018
38. [Eutrophication and Characteristics of Cyanobacteria Bloom in the Summer in Guishi Reservoir]
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Ting, Gou, Qian-Li, Ma, Zhen-Xing, Wang, Li, Wang, Ling-Ai, Yao, Zhen-Cheng, Xu, Xue-Min, Zhao, Rong-Chang, Liang, and Yu, Lan
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China ,Nitrogen ,Chlorophyll A ,Drinking Water ,Phytoplankton ,Phosphorus ,Seasons ,Eutrophication ,Cyanobacteria - Abstract
Large-scale cyanobacteria bloom occurred in the summer of 2014 in the Guishi Reservoir that is an important drinking water source for Hezhou City. The dynamic change regularity, external pollution sources, and the phytoplankton community characteristics during the bloom were investigated to evaluate the eutrophication in the reservoir and to present effective prevention and control measures. The results showed that nitrogen and phosphorus concentrations increased year by year; water quality on some sites has been out of class Ⅱ of national water quality standards; and the main pollution source was the agricultural non-point sources. Phytoplankton cell density was in the range of 8.60×10
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- 2018
39. [Comparison of Chemical Components Characteristics of PM
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Lin-Lin, Liang, Jun-Ying, Sun, Yang-Mei, Zhang, Chang, Liu, Wan-Yun, Xu, Gen, Zhang, Xu-Yan, Liu, and Qian-Li, Ma
- Abstract
PM
- Published
- 2018
40. Ant Colony Optimization for Factory Layout
- Author
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Xiu Zeng and Qian Li Ma
- Subjects
Engineering ,Mathematical optimization ,Relation (database) ,Heuristic (computer science) ,business.industry ,Ant colony optimization algorithms ,Genetic algorithm ,Simulated annealing ,General Engineering ,P versus NP problem ,Process (computing) ,Factory (object-oriented programming) ,business - Abstract
Factory layout is NP problem[1]. There are many methods to solve it ,such as engineering diagram, flow chart method, various heuristic algorithms, SA( simulated annealing) and GA(genetic algorithm) [2].ACO (ant colony optimization) is used to solve it in this paper. The logistics costs exist between two workshops that are treated as pheromone that guides ants to search the best solution. Smaller logistics cost is, stronger the two workshops of relation is. In the process of optimization theworkshop with low logistics cost is more likely to be chosen, which minimizes the system logistics cost. Compared with GA, ACO has the advantage in speed. The mean value of the solution, the best solution, the worst solution is better too. More the number of workshop is, more obvious the superiority is.
- Published
- 2012
41. For non-small cell lung cancer with T3 (central) disease, sleeve lobectomy or pneumonectomy?
- Author
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Yanchu Tian, Deruo Liu, Qian-Li Ma, Zhi-yi Song, Bin Shi, and Yong-Qing Guo
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung ,business.industry ,medicine.medical_treatment ,Sleeve Lobectomy ,Disease ,respiratory system ,030204 cardiovascular system & hematology ,medicine.disease ,respiratory tract diseases ,Surgery ,03 medical and health sciences ,Pneumonectomy ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,medicine ,Original Article ,Non small cell ,Lung cancer ,business - Abstract
Pneumonectomy (PN) has traditionally been the treatment of choice for central lung tumors for which the alternative is sleeve lobectomy (SL). The aim of this study was to compare early and long-term results after SL and PN in focusing on T3 central non-small cell lung cancer (NSCLC).Patients who underwent SL (n=58) or PN (n=42) were retrospectively analyzed. For bias reduction, these 100 patients had been selected according to the following criteria: (I) tumor located in the main bronchus less than 2 cm distal to the carina; (II) there were no N2 disease; (III) no induction therapy was applied; (IV) complete resection (R0) was achieved.SL and PN patients had comparable mean ages, gender distribution, mean forced expiratory volume in 1 second (FEV1), stage and tumor grade. Postoperative mortality (3.4% vs. 4.8%, P=1.0) and morbidity (41% vs. 38%, P=0.74) were similar between the two groups. Recurrences occurred in 48% of patients after SL and in 31% of those after PN (P=0.08). The 5-year survival after SL (64.8%) and PN (61.4%) was not significantly different (P=0.20). Multivariable survival analysis showed that there were no independent prognostic factors.SL does not compromise survival for NSCLC with T3 central disease compared with PN. It is an adequate oncologic resection and should be treated as the first line intervention whenever complete resection can be achieved.
- Published
- 2016
42. Nanocrystallization of Fe-Based Amorphous Alloys Fe73.5Cu1Nb3Si13.5B9 by Yb-Doped Fiber Laser Overlapping Irradiation
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Qian Li Ma, Li Meng Yu, Guo Rui Zhang, Yi Jian Jiang, Ling Fei Ji, and Yong Bao
- Subjects
Amorphous metal ,Materials science ,business.industry ,General Engineering ,Microstructure ,Laser ,Nanocrystalline material ,law.invention ,Optics ,Transmission electron microscopy ,law ,Fiber laser ,Irradiation ,Laser power scaling ,Composite material ,business - Abstract
The paper presents a laser irradiation method for rapidly fabricating Fe-based nanocrystalline alloys using Yb-doped fiber laser with a wavelength of 1070nm by overlapping irradiation of the heated areas. The samples are annular cores rolled with 20μm-thick and 3.2mm-wide belts of amorphous alloy Fe73.5Cu1Nb3Si13.5B9, which have internal diameter of 14 mm and external diameter of 20 mm. Every side of the samples is irradiated for 15 min by fiber laser. X-ray diffraction and transmission electron microscopy (TEM) are used for microstructure analysis and observation. The samples irradiated by a defocus beam with a diameter of 7.1mm through a lens have better soft magnetic properties than directly by an original collimating beam with a diameter of 6.7mm. The dimension of homogeneous ultrafine grains is about 10nm with a bcc α-Fe (Si), which is the foundation of the excellent soft magnetic property. Uniform laser irradiation and the appropriate laser power are necessary for optimum microstructure and soft magnetic properties.
- Published
- 2012
43. Fuzzy Description and Extracting Methods of Complex Feature Regions in Flow Fields
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Hua-Xun Xu, Li Sikun, Qian-Li Ma, and Xun Cai
- Subjects
Flow (mathematics) ,Feature (computer vision) ,Computer science ,business.industry ,Pattern recognition ,Artificial intelligence ,Data mining ,business ,computer.software_genre ,Fuzzy description ,computer ,Software - Published
- 2011
44. Clinical characteristics of 41 patients with intractable asthma
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Li BAI, Xu-sheng ZHANG, Bin WANG, Xiao-ming CHENG, Qiao ZHANG, Hua-ping CHEN, Qian-li MA, Li-guang ZOU, and Chang-zheng WANG
- Subjects
spirometry tests ,lcsh:R5-920 ,lcsh:R ,sputum ,tomography,X-ray computed ,lcsh:Medicine ,respiratory system ,asthma ,lcsh:Medicine (General) ,cell count ,respiratory tract diseases - Abstract
Objective To explore the clinical characteristics of intractable asthma,and to provide new knowledge for diagnosis and treatment of the disease.Methods Forty one patients with intractable asthma,admitted to the Institute of Respiratory Disease,Xinqiao Hospital of Third Military Medical University from Jan.2009 to Dec.2010,were included in present study.Spirometry tests were performed for all the 41 patients.Cell classification and counting were done in the induced sputum of 37 patients,and 34 patients underwent high-resolution chest computed tomography(HRCT).Results Incomplete reversibility of airflow obstruction(FEV1/FVC < 70% after inhalation of bronchodilator) presented in all the 41 patients with intractble asthma.Of 37 patients tested,25(67.6%) showed increased eosinophils in induced sputum( > 0.03 of the total cells),13(35.1%) and increased neutrophils( > 0.61 of total cells),6(16.2%) showed increased both eosinophils and neutrophils,and only that of one patient showed normal percentage of the eosinophils and neutrophils.Chest HRCT of 34 patients showed thickening of bronchial wall in visible segment in 28 cases(82.3%),and in 22 cases(64.7%) thickening of bronchial wall in secondary segments was accompanied with narrowed bronchus lumen,cylindrical bronchiectasis was predominant in 7 patients,and centrilobular emphysema was seen in 5 patients.Conclusion Airway remodeling,incomplete reversibility of airflow obstruction,airway inflammation appear to be the major clinical characteristics of intractable asthma.Combined use of chest HRCT,spirometry test,and cellular analysis of induced sputum may be helpful for identifying intractable asthma,and they provide the basis for individualized strategies to manage the disease.
- Published
- 2011
45. Study on Novel Method to Measure Luminescence Time Interval Between the Initial and Terminal of Light Emission in Frequency Domain
- Author
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Pei Ji Wang, Ru Xi Liu, Jin Zhao Huang, and Qian Li Ma
- Subjects
Materials science ,business.industry ,General Engineering ,Measure (mathematics) ,Intensity (physics) ,Optics ,Terminal (electronics) ,Frequency domain ,Light emission ,Atomic physics ,business ,Luminescence ,Excitation ,Energy (signal processing) - Abstract
In this paper, a novel method to measure the luminescence time interval between the initial and terminal of light emission in frequency domain is proposed. Under the condition that the time of excitation pulse is equal to the luminescence time interval between the initial and terminal of light emission, the energy of excitation is complete dynamically balanced by the light emission and the maximum luminescence intensity can be achieved. So the luminescence time interval between the initial and terminal of light emission can be expressed as (is the driving frequency which is corresponding to the maximum luminescence intensity). The luminescence time interval between the initial and terminal of light emission () of Alq3 (Tris-(8-quinolinolato)aluminum) is [s] measured using the novel method.
- Published
- 2011
46. Nanocrystallization of Fe-Based Amorphous Alloys Fe73.5Cu1Nb3Si13.5B9 by Continuous CO2 Laser Overlapping Irradiation
- Author
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Ling Fei Ji, Li Meng Yu, Yong Bao, Guo Rui Zhang, Qian Li Ma, and Yi Jian Jiang
- Subjects
Diffraction ,Amorphous metal ,Materials science ,Transmission electron microscopy ,Metastability ,Metallurgy ,General Engineering ,Irradiation ,Composite material ,Microstructure ,Shock (mechanics) ,Amorphous solid - Abstract
Continuous CO2laser irradiation is exploited to realize nanocrystallization of Fe based amorphous alloys Fe73.5Cu1Nb3Si13.5B9by overlapping of the heated areas, and to get homogeneous ultrafine grains of about 10nm with a bcc α-Fe(Si) structure, which is the foundation of the excellent soft magnetic property. X-ray diffraction and transmission electron microscopy(TEM) are used for microstructure analysis and observation, and the results show that irradiation power of 71w~99w gives the heat shock to the transformation from the metastable amorphous state to crystallized state, and proper time of about 20~30 seconds is necessary for optimum microstructure and soft magnetic properties.
- Published
- 2011
47. High-Quality Volume Rendering of Unstructured-Grid Cell-Centered Data in CFD
- Author
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Zhi-Quan Cheng, Li Sikun, Qian-Li Ma, Xiao-Zheng Bai, and Hua-Xun Xu
- Subjects
Computer Networks and Communications ,Computer science ,business.industry ,media_common.quotation_subject ,Volume rendering ,Computational fluid dynamics ,Computer Graphics and Computer-Aided Design ,Unstructured grid ,Computational science ,Hardware and Architecture ,Quality (business) ,business ,Software ,media_common - Published
- 2011
48. [Phytoplankton community structure and eutrophication risk assessment of Beijiang River]
- Author
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Ting, Gou, Qian-Li, Ma, Zhen-Cheng, Xu, Li, Wang, Jie, Li, and Xue-Min, Zhao
- Subjects
Diatoms ,China ,Rivers ,Chlorophyta ,Nitrogen ,Water Quality ,Phytoplankton ,Phosphorus ,Seasons ,Eutrophication ,Cyanobacteria ,Risk Assessment - Abstract
To study the distribution of phytoplankton and water quality of Beijiang River, the community structure of phytoplankton was investigated and analyzed in wet and dry seasons. The results showed that a total of 74 species belonging to six phyla, 29 family and 48 genera of phytoplankton were identified, including 58 species of five phyla, 23 family and 41 genera in wet season and 59 species of six phyla, 26 family and 40 genera in dry season. Phytoplankton community structure in Beijiang River was represented by Bacillariophyta, Chlorophyta and Cyanophyta. Bacillariophyta dominanted the phytoplankton, and the dominant species were Aulacoseira granulate, Fragilaria virescens, Surirella biseriata, Nitzschia amphibia, Navicula simplex, Cyclotella meneghiniana, Synedra ulna, Gomphonema angustatum and Cymbella tumida. There was little difference in phytoplankton density between both seasons with the mean values being 3.54 x 10(5) and 4.87 x 10(5) cells L(-1) in dry and wet seasons, respectively. Based on the RDA results, DO, permanganate index, nitrogen and phosphorus were the important environmental factors affecting the distribution of phytoplankton in Beijiang River. The water quality of Beijiang River was classified as oligo-mesotrophic level even if this river was subjected to nitrogen and phosphorus pollution mainly from agricultural non-point source.
- Published
- 2015
49. Computational insights into allosteric interaction between benzoazepin-2-ones and lung cancer-associated PDK1: Implications for activator design
- Author
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Qian-Li Ma, Qi Guo, Gang Guo, Heng Li, Gaofeng Li, Yang Xiumei, and Cui Yang
- Subjects
animal structures ,biology ,Activator (genetics) ,Hydrogen bond ,Chemistry ,Stereochemistry ,General Chemical Engineering ,Allosteric regulation ,Compound 17 ,General Chemistry ,Biochemistry ,Small molecule ,Industrial and Manufacturing Engineering ,Hydrophobic effect ,Molecular dynamics ,Allosteric enzyme ,Materials Chemistry ,biology.protein - Abstract
3-Phosphoinositide-dependent kinase-1 (PDK1) plays a key role in the regulation of physiological processes and its catalytic activity is tightly regulated by allosteric modulators which bind to the PDK1 Interacting Fragment (PIF) pocket. However, details on the allosteric modulators regulation of the PDK1 catalytic activity remain elusive. Here, molecular docking and molecular dynamics (MD) simulations were performed to investigate the allosteric regulation of PDK1 induced by one of the benzoazepin-2-ones, the most potent compound 17 (BAZ2O). Molecular docking and MD simulation revealed that BAZ2O was located in the PIF pocket formed by residues from β4 and β5 sheets and helices αB and αC. BAZ2O formed a hydrogen bond with Arg131 and participated in hydrophobic interactions with Ile119, Thr148, Gln150, Leu155 and Phe157. Further comparative analyses of PDK1 in its apo and BAZ2O-bound states unveiled that BAZ2O promoted the structural coupling between the important catalytic domains of PDK1, including the activation loop and the helices αB and αC, thereby stabilizing the PDK1 conformation for catalysis. Understanding the allosteric interaction of PDK1 with small molecules provides a potentially valuable possibility of designing more potent allosteric modulators with therapeutic implications for lung cancer.
- Published
- 2015
50. An Outbreak of Type Π Vaccine-Derived Poliovirus in Sichuan Province, China: Emergence and Circulation in an Under-Immunized Population
- Author
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Qian-Li Ma, Jingshan Zheng, Wenbin Tong, Huiming Luo, Gang Fang, Yu Liu, Ru-Pei Yang, Qiru Su, Zhi-ying Qin, Shi-Yue Zhang, Xianping Wu, Lixin Hao, Qiong Jing, Jin Wang, Qi Qi, Kathleen H. Reilly, Rong-Na Huang, Fei Du, Haibo Wang, Chao Ma, Ning Wen, Na Chen, Yu-Lin Jing, Qing-lian Liu, Chunxiang Fan, Hong-Ru Zheng, Weizhong Yang, Yan-Xia Zhang, Yin-Qiao Li, Xiaozhen Ma, Xujing Guan, Wei Xia, Z D Yin, and Wenzhou Yu
- Subjects
Male ,Veterinary medicine ,China ,Adolescent ,Epidemiology ,Population ,lcsh:Medicine ,medicine.disease_cause ,Disease Outbreaks ,medicine ,Medicine and Health Sciences ,Humans ,Paralysis ,Public and Occupational Health ,education ,lcsh:Science ,Child ,Disease surveillance ,education.field_of_study ,Multidisciplinary ,business.industry ,Transmission (medicine) ,Poliovirus ,lcsh:R ,Outbreak ,Infant ,medicine.disease ,Virology ,Poliomyelitis ,Under immunized ,Poliovirus Vaccines ,Infectious Diseases ,Immunization ,Child, Preschool ,lcsh:Q ,Female ,business ,Research Article - Abstract
Background During August 2011–February 2012, an outbreak of type Π circulating vaccine-derived poliovirus (cVDPVs) occurred in Sichuan Province, China. Methods A field investigation of the outbreak was conducted to characterize outbreak isolates and to guide emergency response. Sequence analysis of poliovirus capsid protein VP1 was performed to determine the viral propagation, and a coverage survey was carried out for risk assessment. Results One clinical compatible polio case and three VDPV cases were determined in Ngawa County, Ngawa Tibetan and Qiang Autonomous Prefecture, Sichuan Province. Case patients were unimmunized children, 0.8–1 years old. Genetic sequencing showed that the isolates diverged from the VP1 region of the type Π Sabin strain by 5–12 nucleotides (nt) and shared the same 5 nt VP1 substitutions, which indicate single lineage of cVDPVs. Of the 7 acute flaccid paralysis cases (all>6 months) reported in Ngawa Prefecture in 2011, 4 (57.1%) cases (including 2 polio cases) did not receive oral attenuated poliovirus vaccine. Supplementary immunization activities (SIAs) were conducted in February–May, 2012, and the strain has not been isolated since. Conclusion High coverage of routine immunization should be maintained among children until WPV transmission is globally eradicated. Risk assessments should be conducted regularly to pinpoint high risk areas or subpopulations, with SIAs developed if necessary.
- Published
- 2014
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