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23 results on '"Qin, Chunhong"'

10. Convolutional Neural Networks for Classification of T2DM Cognitive Impairment Based on Whole Brain Structural Features

Author

Tan, Xin, primary, Wu, Jinjian, additional, Ma, Xiaomeng, additional, Kang, Shangyu, additional, Yue, Xiaomei, additional, Rao, Yawen, additional, Li, Yifan, additional, Huang, Haoming, additional, Chen, Yuna, additional, Lyu, Wenjiao, additional, Qin, Chunhong, additional, Li, Mingrui, additional, Feng, Yue, additional, Liang, Yi, additional, and Qiu, Shijun, additional

Published
2022
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14. Identifying Type 2 Diabetic Brains by Investigating Disease-Related Structural Changes in Magnetic Resonance Imaging

Author

Chen, Yuna, primary, Pan, Yongsheng, additional, Kang, Shangyu, additional, Lu, Junshen, additional, Tan, Xin, additional, Liang, Yi, additional, Lyu, Wenjiao, additional, Li, Yifan, additional, Huang, Haoming, additional, Qin, Chunhong, additional, Zhu, Zhangzhi, additional, Li, Saimei, additional, and Qiu, Shijun, additional

Published
2021
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16. Classification of type 2 diabetes mellitus with or without cognitive impairment from healthy controls using high‐order functional connectivity

Author

Chen, Yuna, primary, Zhou, Zhen, additional, Liang, Yi, additional, Tan, Xin, additional, Li, Yifan, additional, Qin, Chunhong, additional, Feng, Yue, additional, Ma, Xiaomeng, additional, Mo, Zhanhao, additional, Xia, Jing, additional, Zhang, Han, additional, Qiu, Shijun, additional, and Shen, Dinggang, additional

Published
2021
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17. Abnormal cerebral blood flow and brain function in type 2 diabetes mellitus

Author

Li, Mingrui, Li, Yifan, Zhao, Kui, Qin, Chunhong, Chen, Yuna, Liu, Yujie, Qiu, Shijun, Tan, Xin, and Liang, Yi

Abstract

T2DM patients have long-term metabolic disorders that affect brain function, thus leading to the occurrence and development of cognitive impairment.CBF reflects blood perfusion in the brain. ALFF and DC reflect brain local spontaneous activity and brain network connection intensity respectively.The purpose of this study was to investigate the changes in brain function in T2DM patients and its relationship with cognitive impairment.

Published
2023
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18. Circular RNA circNRIP1 Sponges microRNA-138-5p to Maintain Hypoxia-Induced Resistance to 5-Fluorouracil Through HIF-1α-Dependent Glucose Metabolism in Gastric Carcinoma

Author

Xu,Guangsong, Li,Mingliang, Wu,Jiang, Qin,Chunhong, Tao,Yin, and He,Hongjie

Subjects
Cancer Management and Research
Abstract

Guangsong Xu, Mingliang Li, Jiang Wu, Chunhong Qin, Yin Tao, Hongjie He Department of General Surgery, The Second Affiliated Hospital of University of South China, Hengyang 421001, Hunan Province, People’s Republic of ChinaCorrespondence: Hongjie HeDepartment of General Surgery, The Second Affiliated Hospital of University of South China, 35 Jiefang Avenue, Hengyang 421001, Hunan Province, People’s Republic of ChinaEmail hehj_surgery@163.comBackground: Hypoxia-induced chemoresistance is recognized as a major obstacle tothe successful treatment of gastric cancer (GC). Circular RNAs (circRNAs) have been proposed to implicate in resistance to chemotherapeutic drugs. However, whether circNRIP1 is involved in the development of hypoxia-induced 5-fluorouracil (5-FU) resistance remains largely unknown.Methods: Gene expression was evaluated using quantitative real-time polymerase chain reaction and Western blot. The impact of circNRIP1 on hypoxia-induced resistance to 5-FU was investigated by determining glucose consumption, lactate production and glucose-6-phosphate (G6P) levels. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolim bromide assay was performed to assess cell survival.Results: circNRIP1 was upregulated in GC cells. Hypoxia induced the upregulation of circNRIP1 and reduced the sensitivity of GC cells to 5-FU, as evidenced by the increase in multidrug resistance 1 gene, P-glycoprotein, hypoxia-inducible factor-1α (HIF-1α) and G6P levels, glucose consumption, lactate production, as well as cell survival. Silencing of circNRIP1 enhanced the sensitivity of GC cells to 5-FU under a hypoxic condition. microRNA (miR)-138-5p was confirmed as a downstream target gene of circNRIP1, and upregulation of miR-138-5p could reverse the effect of circNRIP1 on hypoxia-induced 5-FU resistance. Additionally, HIF-1α was a target gene of miR-138-5p. More significantly, the effect of circNRIP1 on hypoxia-induced 5-FU resistance was markedly blocked by 2-DG treatment.Conclusion: circNRIP1 functioned as a miR-138-5p sponge to enhance hypoxia-induced resistance to 5-FU through modulation of HIF-1α-dependent glycolysis, which provides a novel potential approach to overcome hypoxia-induced 5-FU resistance in GC.Keywords: 5-fluorouracil, gastric carcinoma, circular RNA circNRIP1, miR-138-5p, multidrug resistance 1 gene, P-glycoprotein, hypoxia-inducible factor-1α, glucose-6-phosphate

Published
2020

23. Experience and Ways of Low-carbon Agriculture Development

Author

ZHANG, Xinmin and QIN, Chunhong

Subjects
Low-carbon agriculture, Climate change, Agribusiness, Greenhouse gas
Abstract

Firstly, the status quo of low-carbon agriculture development in China was analyzed, and then advanced experience of developed countries in low-carbon agriculture development was introduced, finally ways of developing low-carbon agriculture in China were put forward.

Published
2013
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