14 results on '"Qin, S M"'
Search Results
2. Elevated homocysteine levels in levodopa-treated idiopathic Parkinsonʼs disease: a meta-analysis
- Author
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Hu, X.-W., Qin, S.-M., Li, D., Hu, L.-F., and Liu, C.-F.
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- 2013
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3. Effect of dietary graded resistant potato starch levels on growth performance, plasma cytokines concentration, and intestinal health in meat ducks
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Qin, S M, primary, Zhang, K Y, additional, Ding, X M, additional, Bai, S P, additional, Wang, J P, additional, and Zeng, Q F, additional
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- 2019
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4. Effects of allergen inhalation and oral glucocorticoid on serum soluble CTLA-4 in allergic asthmatics
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Qin, X.-J., Shi, H.-Z., Qin, S.-M., Kang, L.-F., Huang, C.-P., and Zhong, X.-N.
- Published
- 2005
5. Different microbiomes are found in healthy breeder ducks and those with foot pad dermatitis.
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Qin, S M, Bai, W Q, Zhang, K Y, Ding, X M, Bai, S P, Wang, J P, Peng, H W, Yang, Y F, Chen, C, and Zeng, Q F
- Subjects
- *
DUCKS , *SKIN inflammation , *RIBOSOMAL RNA , *POULTRY industry , *GUT microbiome , *WALKING - Abstract
Foot pad dermatitis (FPD) is a serious problem of the modern poultry industry, negatively affecting birds' welfare and health status, walking and feeding activity, growth performance, carcass quality, and economic performance of meat production. The gut microbiome in poultry with FPD has not been previously investigated. Therefore, we compared the cecal microbiomes of 8 breeding ducks with FPD to 8 control ducks (breeders with apparently healthy feet) by pyrosequencing the bacterial 16S ribosomal RNA gene. The results showed a significant β-diversity (P < 0.05) of cecal microbiota presented between healthy and FPD-affected breeder ducks. The plasma endotoxins, interleukin 1β (IL-1β), IL-17, IL-6, IL-10, and tumor necrosis factor-α concentration, and the abundance of class Clostridia in FPD-affected ducks was markedly higher (P < 0.05), however, the abundance of genus Prevotella, Lactobacillus, Lachnospiraceae UCG-008, and the Firmicutes to Bacteroidetes ratio in FPD-affected ducks was significantly lower (P < 0.05) when compared to healthy ducks. These findings suggest when duck breeders are affected with FPD, ducks show an increased inflammatory response and a difference of structure and composition of the cecal microbiome. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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6. Stability of Nanodevices in the Presence of Casimir and Electrostatic Forces
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Tong, Z.-Y., primary, Deng, H.-M., additional, Qin, S.-M., additional, and Yang, P.-X., additional
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- 2008
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7. LncRNA LINC00342 regulated cell growth and metastasis in non-small cell lung cancer via targeting miR-203a-3p.
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Chen QF, Kong JL, Zou SC, Gao H, Wang F, Qin SM, and Wang W
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- 3' Untranslated Regions, A549 Cells, Carcinoma, Non-Small-Cell Lung genetics, Case-Control Studies, Cell Line, Tumor, Cell Movement, Cell Proliferation, Female, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms genetics, Male, Neoplasm Metastasis, Neoplasm Staging, Up-Regulation, Carcinoma, Non-Small-Cell Lung pathology, Lung Neoplasms pathology, MicroRNAs genetics, RNA, Long Noncoding genetics
- Abstract
Objective: Non-small cell lung cancer (NSCLC) is the main form of lung cancer, leading to major causes of cancer mortality. It is well known that lncRNAs may be involved in the pathogenesis of cancer, including NSCLC. The aim of this study was to provide a novel therapeutic target of LINC00342 for the therapy of NSCLC., Patients and Methods: The expression of LINC00342 and miR-203a-3p was detected by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Cell proliferation was measured using the MTT assay. Colony formation analysis was performed to count the number of colonies. Cell migration and invasion were measured by transwell. Online software DIANA tools were used to predict binding sites of LINC00342 and miR-203a-3p. Luciferase reporter assay was conducted to confirm the interaction between LINC00342 and miR-203a-3p., Results: The expression of LINC00342 was increased in NSCLC tissues and cells compared with normal tissues and cells. Knockdown of LINC00342 suppressed cell proliferation, colony formation, migration, and invasion. LINC00342 regulated the expression of miR-203a-3p by targeting it directly. MiR-203a-3p was down-regulated in NSCLC tissues and cells compared with normal tissues and cells. Furthermore, LINC00342 promoted NSCLC cells proliferation, colony formation, migration, and invasion by depleting the expression of miR-203a-3p., Conclusions: This work implied that LINC00342 functions in NSCLC acting as an oncogene. Briefly, LINC00342 contributes to NSCLC cells growth and metastasis via targeting miR-203a-3p competitively.
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- 2019
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8. [Efficacy of biventricular pacing on preventing heart failure in patients with high degree atrioventricular block (BIVPACE-AVB Trial)].
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Zhang XY, Shan QJ, Su YG, Yan J, Bao ZH, Gu X, Qiu JP, Qin SM, Xu J, Su H, Zhu H, Guo JF, Lu JP, Zou JG, Chen ML, Xu D, and Cao KJ
- Subjects
- China, Double-Blind Method, Echocardiography, Heart Ventricles, Humans, Natriuretic Peptide, Brain metabolism, Peptide Fragments metabolism, Stroke Volume, Treatment Outcome, Ventricular Function, Left, Atrioventricular Block physiopathology, Cardiac Resynchronization Therapy methods, Heart Failure prevention & control
- Abstract
Objective: To investigate the long-term effect of biventricular (BIV) and right ventricular apical (RVA) pacing on cardiac function in patients with high-degree atrioventricular block (AVB) and left ventricular ejection fraction(LVEF)over 35%., Methods: A total of 118 consecutive patients with high-degree AVB in six hospitals from East China between May 2009 and December 2012 were enrolled in this randomized, double-blind and parallel controlled study. Patients were randomly assigned to BIV and RVA pacing with or without LV lead on after one-week cardiac resynchronization therapy (CRT). Cardiac function including New York Heart Association(NYHA), 6 minute walking distance (6MWD), Minnesota living with heart failure (MLHF) score, LVEF, left ventricular end-diastolic volumes/diameters (LVEDV/LVEDD) and other echocardiography parameters, as well as N-terminal pro-B-type natriuretic peptide (NT-proBNP)were assessed at 6 months and 12 months., Results: A total of 114 patients were successfully implanted with CRT. Cardiac function was significantly improved after one-week BIV pacing (n=57) compared with pre-CRT: rate of patients with NYHA Ⅲ (25.44%(29/114) vs. 9.65%(11/114)), MLHF score (17.1±13.6 vs. 26.9±21.6), 6MWD ((315.4±121.8)m vs. (291.8±102.9)m) and NT-proBNP (157.0(70.0, 639.0) ng/L vs. 444.7(144.0, 1 546.0)ng/L, all P<0.05). In BIV group, 6MWD extended from (314.8±142.7)m to (332.7±117.5)m at 6 months (P<0.05), LVEF increased from (60.7±7.9)% at 1 week to (56.6±10.7)% at 6 months(P<0.05), both LVEDV and LVEDD decreased at 12 months compared with at 1 week ((116.2±39.5)ml vs. (131.4±49.6)ml and (50.2±5.6)mm vs. (52.5±6.8)mm, P<0.05). In RVA group (n=57), 6MWD increased at 6 months compared that at 1week ((342.4±109.9)m vs. (310.2±105.1)m, P<0.05), NT-proBNP was higher at 12 months than that at 1 week (349.5(191.8, 884.3)ng/L vs. 127.0(70.3, 336.7)ng/L, P<0.05). Compared with RVA group, BIV group had a bigger shrink in LVEDV decrease at 12 months was more significant in BIV group ((-16.68±24.30)ml vs. (9.09±29.30)ml, P<0.05)., Conclusions: Cardiac pacing could acutely improve the cardiac function in patients with high-degree AVB and LVEF over 35%. Improvements on cardiac function and remodeling are more significant after 12-month BIV pacing than that of RVA pacing. Clinical Trail Registry: Chinese Clinical Trial Registry, ChiCTR-TRC-10000832.
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- 2016
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9. THIN-LAYER CHROMATOGRAPHY IDENTIFICATION FOR RHUBARB AND PHELLODENDRI AMURENSIS CORTEX IN SHUANG-BAI CATAPLASM AND STUDY OF SKIN IRRITATION ASSAY.
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Tian YG, Qin SM, and Ding L
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- Administration, Cutaneous, Animals, Drug Evaluation, Preclinical, Drugs, Chinese Herbal toxicity, Female, Guinea Pigs, Hydrogels, Male, Phellodendron toxicity, Powders, Rabbits, Random Allocation, Rheum toxicity, Skin drug effects, Chromatography, Thin Layer methods, Drug Eruptions etiology, Drug Hypersensitivity etiology, Drugs, Chinese Herbal analysis, Phellodendron chemistry, Phytotherapy, Rheum chemistry
- Abstract
This paper aimed to raise a thin-layer chromatography (TLC) identification method for rhubarb and Phellodendri Amurensis Cortex and inspected skin irritation induced by them. It applied the TLC identification for Rhubarb and Phellodendri Amurensis Cortex in Shuang-bai cataplasm prescription. In this study six rabbits were divided into two groups to observe the skin irritation from Shuang-bai cataplasm on intact and defected skin. Another 36 were randomly divided into 6 groups to observe the acute toxicity from Shuang-bai cataplasm on intact and defected skin. Also 30 guinea pigs were divided into 3 groups to observe skin allergy to Shuang-bai cataplasm. The results showed that the average weight of the group of intact-skin rabbits was 2.026±0.10 kg and 2.427±0.023 kg after medication; the average weight of the group of defected-skin rabbits was 2.170±0.05 kg and 2.540±0.15 kg after medication; Shuang-bai cataplasm produced no irritation on intact or defected rabbit skin, no acute toxicity in rabbits and no allergy on the skin of guinea pigs. The skin allergy rate on guinea pigs of the medication group was 0 at each time quantum. Therefore, it can be concluded that this preparation produces no extreme skin irritation for rabbits, guinea pigs or human beings, and it can be safely put into practice.
- Published
- 2015
10. Effect of inhaled interleukin-5 on number and activity of eosinophils in circulation from asthmatics.
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Shi HZ, Li CQ, Qin SM, Xie ZF, and Liu Y
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- Administration, Inhalation, Adult, Blood Proteins metabolism, Double-Blind Method, Eosinophil Granule Proteins, Female, Humans, Immunoglobulin E blood, Interleukin-5 pharmacology, Male, Middle Aged, Recombinant Proteins immunology, Recombinant Proteins pharmacology, Asthma immunology, Eosinophils cytology, Interleukin-5 immunology, Ribonucleases
- Abstract
The aim of the present study was to examine the effects of interleukin-5 (IL-5) inhalation on changes in the activity and number of circulating eosinophils, as well as concentrations of serum total IgE, in allergic asthmatics. A randomized double-blind, placebo-controlled study design was employed in which each subject acted as his or her own control. Eight nonsmoking patients with allergic asthma were administered recombinant human IL-5 by nebulization. Total white blood cell counts and differentials, as well as concentrations of ECP and total IgE in serum, were determined before and at 2, 24, and 48 h after inhalation. Our results demonstrated that eosinophil numbers increased from baseline (3.6 +/- 1.1 x 10(5)/ml) to 6.3 +/- 1.2 x 10(5)/ml (P < 0.01) at 24 h and to 5.7 +/- 0.9 x 10(5)/ml (P < 0.01) at 48 h after IL-5 inhalation in asthmatics. Accompanying this significantly increased blood eosinophilia were significantly elevated serum ECP levels. Compared with baseline (6.3 +/- 1.1 ng/ml), ECP levels increased with time following IL-5 inhalation, reaching 17.6 +/- 2.8 ng/ml (P < 0.01) at 24 h and remaining elevated at 48 h (18.1 +/- 2.9 ng/ml, P < 0.01). IL-5 inhalation had no significant effect on levels of serum total IgE, however. These findings provide direct evidence that nebulized IL-5 not only induces a significant blood eosinophilia but also results in the activation of circulating eosinophils. Our data further support the importance of IL-5 in the pathogenesis of bronchial asthma in humans., (Copyright 1999 Academic Press.)
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- 1999
- Full Text
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11. Inhaled IL-5 increases concentrations of soluble intracellular adhesion molecule-1 in sputum from atopic asthmatic subjects.
- Author
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Shi HZ, Chen YQ, and Qin SM
- Subjects
- Administration, Inhalation, Adult, Albumins analysis, Asthma complications, Double-Blind Method, Female, Humans, Hypersensitivity, Immediate complications, Interleukin-5 administration & dosage, Male, Middle Aged, Nebulizers and Vaporizers, Recombinant Fusion Proteins pharmacology, Solubility, Stimulation, Chemical, Asthma metabolism, Hypersensitivity, Immediate metabolism, Intercellular Adhesion Molecule-1 analysis, Interleukin-5 pharmacology, Sputum chemistry
- Abstract
Background: Both IL-5 and intracellular adhesion molecule-1 (ICAM-1) have been shown to play important roles in the production of allergic inflammation, including atopic asthma., Objective: The aim of this study was to investigate the effects of recombinant human IL-5 on changes of soluble (s) ICAM-1 concentrations in induced sputum from allergic asthmatic subjects., Methods: In a randomized, double-blind, placebo-controlled study design, 8 nonsmoking patients with allergic asthma and 6 nonallergic normal subjects were administered recombinant human IL-5 by nebulization, and the concentrations of sICAM-1 in induced sputum from each subject were determined before and at 2, 24, 48, and 72 hours after inhalation., Results: sICAM-1 levels in sputum within the control group did not appear to change from baseline at any time throughout the study. In allergic asthmatic subjects vehicle challenge was not able to cause any changes in sputum sICAM-1 concentrations. However, there were increases in sputum sICAM-1 concentrations after IL-5 inhalation, which increased with time to significantly greater levels than those at baseline, reaching a maximum at 48 hours and lasting no less than 72 hours. The concentrations of sICAM-1 in sputum after IL-5 challenge exceeded levels that could be accounted for by passive transudation from the circulation on the basis of the magnitude of increases in sputum albumin concentration., Conclusion: Our results indicated that IL-5 inhalation was capable of inducing an elevation of sputum sICAM-1 concentration by stimulating its local release in allergic asthmatic, but not in nonallergic normal, subjects.
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- 1999
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12. Effect of inhaled interleukin-4 on airway hyperreactivity in asthmatics.
- Author
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Shi HZ, Deng JM, Xu H, Nong ZX, Xiao CQ, Liu ZM, Qin SM, Jiang HX, Liu GN, and Chen YQ
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- Administration, Inhalation, Adolescent, Adult, Bronchial Provocation Tests, Eosinophils, Female, Humans, Leukocyte Count, Male, Methacholine Chloride, Middle Aged, Recombinant Proteins administration & dosage, Sputum cytology, Asthma physiopathology, Bronchial Hyperreactivity physiopathology, Interleukin-4 administration & dosage
- Abstract
lnterleukin-4 (IL-4) has been shown to play a crucial role in the pathogenesis of allergic disease including bronchial asthma. In order to investigate the role of IL-4 in airway hyperreactivity, we investigated the effect of inhaled recombinant human IL-4 on airway responsiveness to methacholine and eosinophil numbers in induced sputum in eight patients with allergic asthma using a placebo-controlled study design. Our results demonstrated that in the control experiments receiving vehicle inhalation, methacholine PC20 values did not change nor did the numbers of eosinophils in sputum change from baseline values. In contrast, after IL-4 inhalation, methacholine PC20 fell from baseline (0.43 +/- 1.81 mg/mI) to 0.22 +/- 1.73 mg/mI (p < 0.01) at 24 h, and to 0.21 +/- 1. 74 mg/ml (p < 0.01) at 48 h. Accompanying this increased airway sensitivity was a significant eosinophilia in sputum. Our data indicated that IL-4 increases airway responsiveness by recruiting eosinophils into the airway in patients with allergic bronchial asthma.
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- 1998
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13. Effect of inhaled interleukin-5 on airway hyperreactivity and eosinophilia in asthmatics.
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Shi HZ, Xiao CQ, Zhong D, Qin SM, Liu Y, Liang GR, Xu H, Chen YQ, Long XM, and Xie ZF
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- Administration, Inhalation, Adult, Asthma complications, Asthma physiopathology, Blood Proteins analysis, Bronchial Provocation Tests, Cross-Over Studies, Eosinophil Granule Proteins, Female, Forced Expiratory Volume, Humans, Inflammation Mediators analysis, Male, Middle Aged, Single-Blind Method, Sputum chemistry, Sputum cytology, Asthma immunology, Bronchial Hyperreactivity immunology, Eosinophilia immunology, Interleukin-5 adverse effects, Interleukin-5 immunology, Ribonucleases
- Abstract
In order to investigate the role of interleukin-5 (IL-5) in airway hyperreactivity and eosinophilia, we observed the effect of inhaled recombinant human IL-5 on airway responsiveness to methacholine and cell populations in induced sputum in eight patients with allergic bronchial asthma using a placebo-controlled study design. Our results demonstrated that the inhalation of IL-5 did not alter lung function in allergic asthmatics. In the control experiments receiving either vehicle or 0.4 ng of endotoxin, methacholine PC20 values did not change nor did the numbers of eosinophils or eosinophil cationic protein (ECP) sputum values change from baseline. In contrast, after IL-5 inhalation, methacholine PC20 fell from baseline (0.90 +/- 166 mg/ml) to 0.32 +/- 1.63 mg/ml (p < 0.01) at 24 h, and to 0.55 +/- 1.49 mg/ml (p < 0.05) at 48 h. Accompanying this increased airway sensitivity was a significant eosinophilia and elevated concentrations of ECP in induced sputum. Our data provided direct evidence that IL-5 increases airway responsiveness and infiltration of activated eosinophils into the airway in patients with allergic bronchial asthma. It also could be concluded that the observed airway hyperreactivity and eosinophilia were not endotoxin related.
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- 1998
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14. [Therapeutic effects of polyI:C and prednisone withdrawal followed by polyI:C on chronic type B hepatitis--results of two double-blind randomized trials].
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Qin SM, Chen LY, and Guo YD
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- Adult, Chronic Disease, Double-Blind Method, Drug Therapy, Combination, Female, Hepatitis, Chronic drug therapy, Humans, Male, Middle Aged, Random Allocation, Hepatitis B drug therapy, Poly I-C therapeutic use, Prednisone therapeutic use
- Abstract
Twenty patients received PolyI:C and twenty patients received inosine in first clinical trial. Final evaluation at 6 months after completion of treatment revealed that SGPT activities fell into normal range or nearly into normal range in 16 (80%) patients of the PolyI:C group and in 8 (40%) patients of the inosine group. These data show that patients treated with PolyI:C have a tendency toward normalization of SGPT activities, but changes of serum HBeAg and DNAP were not significantly different between the two groups. Thirty-five patients were treated with prednisone withdrawal followed by PolyI:C and thirty-five patients received placebo alone in a second clinical trial. Final evaluation at 6 months after completion of treatment revealed that effective rates of reducing serum HBeAg (51.4%) and HBV-DNA (65%) were significantly higher in the treated group than in the control group. It is shown that prednisone withdrawal followed by PolyI:C therapy may be more promising for successful treatment of chronic type B hepatitis than PolyI:C therapy alone.
- Published
- 1989
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