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Your search keyword '"Qin, Xiao-Yan"' showing total 214 results
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214 results on '"Qin, Xiao-Yan"'

13. How incubation temperature affects hatchling performance in reptiles: an integrative insight based on plasticity in metabolic enzyme.

Author

Wu, Dan-Yang, Han, Xing-Zhi, Li, Teng, Sun, Bao-Jun, and Qin, Xiao-Yan

Subjects
GLOBAL warming, TURTLE eggs, TEMPERATURE effect, REPTILES, LOW temperatures
Abstract

Evaluating the effects of temperature variations on animals plays an important role in understanding the threat of climate warming. The effects of developmental temperature on offspring performance are critical in evaluating the effects of warming temperatures on the fitness of oviparous species, but the physiological and biochemical basis of this developmental plasticity is largely unknown. In this study, we incubated eggs of the turtle Pelodiscus sinensis at low (24 °C), medium (28 °C), and high (32 °C) temperatures, and evaluated the effects of developmental temperature on offspring fitness, and metabolic enzymes in the neck and limb muscles of hatchlings. The hatchlings from eggs incubated at the medium temperature showed better fitness-related performance (righting response and swimming capacity) and higher activities of metabolic enzymes (hexokinase, HK; lactate dehydrogenase, LDH) than hatchlings from the eggs incubated at high or low temperatures. In addition, the swimming speed and righting response were significantly correlated with the HK activities in limb (swimming speed) and neck (righting response) muscles, suggesting that the developmental plasticity of energy metabolic pathway might play a role in determining the way incubation temperature affects offspring phenotypes. Integrating the fitness-related performance and the activities of metabolic enzymes, we predict that the P. sinensis from high latitude would not face the detrimental effects of climate warming until the average nest temperatures reach 32 °C. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Network pharmacology analysis of the active ingredients of Corydalis hendersonii Hemsl. and their effects on eliminating neuroinflammation and improving motor functions in MPTP-intoxicated mice

Author

Wang, Jun, primary, Liu, Qiu-Tong, additional, Shen, Dan-Yang, additional, Bai, Jin-Peng, additional, Hu, Yang, additional, Huang, Qin, additional, Yu, Hui-Jing, additional, He, Ning-Ning, additional, Qin, Xiao-Yan, additional, and Lan, Rongfeng, additional

Published
2023
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47. 2,3,5,4′-Tetrahydroxystilbene-2-O-beta-D-glucoside Reverses Stress-Induced Depression via Inflammatory and Oxidative Stress Pathways

Author

Jiang, Cheng-Yong, Qin, Xiao-Yan, Yuan, Mi-Mi, Lu, Gui-Jiang, and Cheng, Yong

Subjects
Inflammation, Male, Restraint, Physical, Article Subject, lcsh:Cytology, Depression, Hippocampus, Antidepressive Agents, Mice, Inbred C57BL, Disease Models, Animal, Mice, Oxidative Stress, Neuroprotective Agents, Glucosides, Stilbenes, Animals, Fallopia multiflora, lcsh:QH573-671, Stress, Psychological, Research Article, Signal Transduction
Abstract

Major depressive disorder (MDD) is a chronic mental disease that adversely affects human mood and cognition. Many first-line antidepressant drugs have high rates of partial responsiveness or nonresponsiveness with side effects, and finding more effective drugs for the treatment of depression is therefore urgently needed. THSG, a main active compound of the traditional Chinese herb Polygonum multiflorum, reportedly acts as a neuroprotective agent. This study aimed to illustrate whether THSG prevents depressive-like behaviors induced by chronic restraint stress (CRS) in an MDD mouse model. Our results demonstrated that the peripheral administration of different THSG doses (10 mg/kg, 20 mg/kg, and 40 mg/kg) reversed the depressive-like behaviors in CRS mice as measured by the tail suspension test, forced swimming test, and open-field test. Further analyses suggested that THSG treatment reduced oxidative stress in both the central and peripheral nervous systems of CRS mice. In addition, heightened inflammatory responses, demonstrated by the increased expression of proinflammatory factors (TNF-α, IL-1β, and IL-6), in hippocampal and prefrontal cortex tissues of CRS mice were inhibited by THSG administration. THSG also restored the diminished Akt signaling pathway in the brains of CRS mice. Moreover, our data suggest increased astrocyte proliferation and neurogenesis in the hippocampus of CRS mice after THSG treatment. Taken together, our results demonstrated an antidepressant effect of THSG in a mouse model of MDD for the first time, and oxidative stress and inflammatory pathways were determined to play roles in this effect.

Published
2018

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