Search

Hepatocellular carcinoma (HCC) represents a leading and fatal malignancy within the gastrointestinal tract. Recent advancements highlight the pivotal role of long non-coding RNAs (lncRNAs) in diverse biological pathways and pathologies, particularly in tumorigenesis. LINC01134, a particular lncRNA, has attracted considerable attention due to its oncogenic potential in hepatoma. Current research underscores LINC01134’s potential in augmenting the onset and progression of HCC, with notable implications in drug resistance. This review comprehensively explores the molecular functions and regulatory mechanisms of LINC01134 in HCC, offering a fresh perspective for therapeutic interventions. By delving into LINC01134’s multifaceted roles, we aim to foster novel strategies in HCC management.

It is well known that the toughness and freeze-thaw resistance of concrete can be improved by rubber aggregate (RA) while it significantly reduces the compressive strength. In this study, a simple semi-empirical prediction model of strength reduction factor (SRF) for rubberized concrete (RuC) is proposed to evaluate the compressive-strength reducing behavior of RuC. The model takes the volume fraction of RA as an independent variable and can be used to quantitatively describe the influence of different composition factors on compressive strength. In addition, a database containing more than 321 groups of reported experimental results is established to validate the proposed model. The main influencing factors of SRF are also clarified, including the content, particle size, surface property and replacement method of RA. According to the above factors, scientific classification and statistical fitting analysis are carried out on the database to determine the model parameter b. It is found that the proposed SRF model has good universality and predictability, which can be used to guide the mix design of RuC.

Due to the body’s systemic distribution of photothermal agents (PTAs), and to the imprecise exposure of lasers, photothermal therapy (PTT) is challenging to use in treating tumor sites selectively. Striving for PTT with high selectivity and precise treatment is nevertheless important, in order to raise the survival rate of cancer patients and lower the likelihood of adverse effects on other body sections. Here, we studied cold atmospheric plasma (CAP) as a supplementary procedure to enhance selectivity of PTT for cancer, using the classical photothermic agent’s gold nanostars (AuNSs). In in vitro experiments, CAP decreases the effective power of PTT: the combination of PTT with CAP at lower power has similar cytotoxicity to that using higher power irradiation alone. In in vivo experiments, combination therapy can achieve rapid tumor suppression in the early stages of treatment and reduce side effects to surrounding normal tissues, compared to applying PTT alone. This research provides a strategy for the use of selective PTT for cancer, and promotes the clinical transformation of CAP.