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27 results on '"Qiu, Bijun"'

4. Supplementary Materials and Methods and Figures from Prognostic Significance of AMPK Activation and Therapeutic Effects of Metformin in Hepatocellular Carcinoma

Author

Zheng, Longyi, primary, Yang, Wen, primary, Wu, Fuquan, primary, Wang, Chao, primary, Yu, Lexing, primary, Tang, Liang, primary, Qiu, Bijun, primary, Li, Yuqiong, primary, Guo, Linna, primary, Wu, Mengchao, primary, Feng, Gensheng, primary, Zou, Dajin, primary, and Wang, Hongyang, primary

Published
2023
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5. Single‐cell transcriptomics uncovers cellular architecture and developmental trajectories in hepatoblastoma

Author

Huang, Hongting, primary, Wu, Liang, additional, Lu, Li, additional, Zhang, Zijie, additional, Qiu, Bijun, additional, Mo, Jialin, additional, Luo, Yi, additional, Xi, Zhifeng, additional, Feng, Mingxuan, additional, Wan, Ping, additional, Zhu, Jianjun, additional, Yu, Dingye, additional, Wu, Wei, additional, Tan, Kezhe, additional, Liu, Jiangbin, additional, Sheng, Qingfeng, additional, Xu, Ting, additional, Huang, Jinyan, additional, Lv, Zhibao, additional, Tang, Yujie, additional, and Xia, Qiang, additional

Published
2023
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7. Pure Laparoscopic Living Donor Hepatectomy With/Without Fluorescence-Assisted Technology and Conventional Open Procedure: A Retrospective Study in Mainland China

Author

He, Kang, Pan, Yixiao, Wang, Hai, Zhu, Jianjun, Qiu, Bijun, Luo, Yi, and Xia, Qiang

Subjects
pure laparoscopic living donor hepatectomy, RD1-811, quality of life, Surgery, open donor hepatectomy, fluorescence-assisted technology, living donor liver transplantation, Original Research
Abstract

Background: The application of laparoscopy in donor liver acquisition for living donor liver transplantation (LDLT) has become increasingly popular in the past decade. Indole cyanide green (ICG) fluorescence technique is a new adjuvant method in surgery. The purpose was to compare the safety and efficacy of laparoscopic and open surgery in living donor left lateral hepatectomy, and to evaluate the application of ICG in laparoscopy.Methods: Donors received LDLT for left lateral lobe resection from November 2016 to November 2020 were selected and divided into pure laparoscopy donor hepatectomy (PLDH) group, fluorescence-assisted pure laparoscopy donor hepatectomy (FAPLDH) group and open donor hepatectomy (ODH) group. We compared perioperative data and prognosis of donors and recipients. Quality of life were evaluated by SF-36 questionnaires.Results: The operation time of PLDH group (169.29 ± 26.68 min) was longer than FAPLDH group (154.34 ± 18.40 min) and ODH group (146.08 ± 25.39 min, p = 0.001). The blood loss was minimum in FAPLDH group (39.48 ± 10.46 mL), compared with PLDH group (52.44 ± 18.44 mL) and ODH group (108.80 ± 36.82 mL, p=0.001). The post-operative hospital stay was longer in PLDH group (5.30 ± 0.98 days) than FAPLDH group (4.81 ± 1.03 days) and ODH group (4.64 ± 1.20 days; p = 0.001). Quality of life of donors undergoing laparoscopic surgery was better.Conclusion: Laparoscopic approaches for LDLT contribute to less blood loss, better cosmetic satisfaction. The fluorescence technique can further reduce bleeding and shorten operation time. In terms of quality of life, laparoscopic surgery is better than open surgery. Laparoscopy procedure for living-donor procurement with/without fluorescence-assist can be performed as safely as open surgery.

Published
2021

11. Bile Acids Impair Vaccine Response in Children With Biliary Atresia

Author

Liu, Jinchuan, primary, Fei, Yi, additional, Zhou, Tao, additional, Ji, Hao, additional, Wu, Ji, additional, Gu, Xiangqian, additional, Luo, Yi, additional, Zhu, Jianjun, additional, Feng, Mingxuan, additional, Wan, Ping, additional, Qiu, Bijun, additional, Lu, Yefeng, additional, Yang, Tian, additional, Deng, Pengfei, additional, Zhou, Cuiping, additional, Gong, Dongcheng, additional, Deng, Jun, additional, Xue, Feng, additional, and Xia, Qiang, additional

Published
2021
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24. Genome-wide methylation profiling of the different stages of hepatitis B virus-related hepatocellular carcinoma development in plasma cell-free DNA reveals potential biomarkers for early detection and high-risk monitoring of hepatocellular carcinoma

Author

Zhao, Yangxing, primary, Xue, Feng, additional, Sun, Jinfeng, additional, Guo, Shicheng, additional, Zhang, Hongyu, additional, Qiu, Bijun, additional, Geng, Junfeng, additional, Gu, Jun, additional, Zhou, Xiaoyu, additional, Wang, Wei, additional, Zhang, Zhenfeng, additional, Tang, Ning, additional, He, Yinghua, additional, Yu, Jian, additional, and Xia, Qiang, additional

Published
2014
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25. Growth arrest and DNA damage 45G down-regulation contributes to janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma

Author

Zhang, Li, primary, Yang, Zhaojuan, additional, Ma, Aihui, additional, Qu, Yulan, additional, Xia, Suhua, additional, Xu, Dongxu, additional, Ge, Chao, additional, Qiu, Bijun, additional, Xia, Qiang, additional, Li, Jinjun, additional, and Liu, Yongzhong, additional

Published
2013
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27. DJ-1 promotes development of DEN-induced hepatocellular carcinoma and proliferation of liver cancer cells.

Author

Qiu B, Wang J, Yu Y, Zhen C, Gu J, Liu W, Wen Y, Chen L, Gao Y, Xia Q, and Kong X

Subjects
Animals, Carcinoma, Hepatocellular genetics, Carcinoma, Hepatocellular pathology, Cell Line, Tumor, Genetic Predisposition to Disease, Humans, Interleukin-6 metabolism, Liver Neoplasms chemically induced, Liver Neoplasms genetics, Liver Neoplasms pathology, Male, Mice, Inbred C57BL, Mice, Knockout, Mitogen-Activated Protein Kinases metabolism, Phenotype, Protein Deglycase DJ-1 deficiency, Protein Deglycase DJ-1 genetics, Proto-Oncogene Proteins c-akt metabolism, STAT3 Transcription Factor metabolism, Signal Transduction, Time Factors, Transfection, Carcinoma, Hepatocellular enzymology, Cell Proliferation, Diethylnitrosamine, Liver Neoplasms enzymology, Protein Deglycase DJ-1 metabolism
Abstract

Chronic liver inflammation and injuries play a critical role in development of hepatocellular carcinoma (HCC). Parkinson disease (autosomal recessive, early onset) 7, encoding PARK7 protein (also called DJ-1), plays important roles in many carcinogenesis processes and is essential in modulating inflammation. However, whether DJ-1 is involved in HCC development remains largely unknown. To determine the effect of DJ-1 on HCC development, we accessed the correlation of hepatic DJ-1 expression with overall survival (OS) and TNM stage in 96 HCC patients and found a significant inverse correlation between DJ-1 expression and OS. By adopting a classic diethylnitrosamine (DEN)-induced murine HCC model, DJ-1 knockout (KO) mice displayed reduced tumorigenesis and cell proliferation, accompanied by decreased hepatic inflammation and IL-6/STAT3 activation. Furthermore, after an acute DEN challenge, DJ-1 KO mice showed significant decreases in liver injury, hepatocyte proliferation and DNA damage. In a human HCC cell line (MHCC-97L), cancer cell proliferation was induced by overexpression of DJ-1 and is related to oncogenic signaling of MAPKs and AKT. Induction of DJ-1 may serve as a novel regulator for HCC cell proliferation and HCC development possibly through enhanced MAPK signaling and inflammation.

Published
2017
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