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707 results on '"Qiu, Shuang-Jian"'

3. Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma

Author

Lu, Jia-Cheng, Wu, Lei-Lei, Sun, Yi-Ning, Huang, Xiao-Yong, Gao, Chao, Guo, Xiao-Jun, Zeng, Hai-Ying, Qu, Xu-Dong, Chen, Yi, Wu, Dong, Pei, Yan-Zi, Meng, Xian-Long, Zheng, Yi-Min, Liang, Chen, Zhang, Peng-Fei, Cai, Jia-Bin, Ding, Zhen-Bin, Yang, Guo-Huan, Ren, Ning, Huang, Cheng, Wang, Xiao-Ying, Gao, Qiang, Sun, Qi-Man, Shi, Ying-Hong, Qiu, Shuang-Jian, Ke, Ai-Wu, Shi, Guo-Ming, Zhou, Jian, Sun, Yi-Di, and Fan, Jia

Published
2024
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5. Single-cell and spatial architecture of primary liver cancer

Author

Zhou, Pei-Yun, Zhou, Cheng, Gan, Wei, Tang, Zheng, Sun, Bao-Ye, Huang, Jin-Long, Liu, Gao, Liu, Wei-Ren, Tian, Meng-Xin, Jiang, Xi-Fei, Wang, Han, Tao, Chen-Yang, Fang, Yuan, Qu, Wei-Feng, Huang, Run, Zhu, Gui-Qi, Huang, Cheng, Fu, Xiu-Tao, Ding, Zhen-Bin, Gao, Qiang, Zhou, Jian, Shi, Ying-Hong, Yi, Yong, Fan, Jia, and Qiu, Shuang-Jian

Published
2023
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7. Toripalimab combined with lenvatinib and GEMOX is a promising regimen as first-line treatment for advanced intrahepatic cholangiocarcinoma: a single-center, single-arm, phase 2 study

Author

Shi, Guo-Ming, Huang, Xiao-Yong, Wu, Dong, Sun, Hui-Chuan, Liang, Fei, Ji, Yuan, Chen, Yi, Yang, Guo-Huan, Lu, Jia-Cheng, Meng, Xian-Long, Wang, Xin-Ying, Sun, Lei, Ge, Ning-Ling, Huang, Xiao-Wu, Qiu, Shuang-Jian, Yang, Xin-Rong, Gao, Qiang, He, Yi-Feng, Xu, Yang, Sun, Jian, Ren, Zheng-Gang, Fan, Jia, and Zhou, Jian

Published
2023
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14. Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions

Author

Lee, Jin, Liao, Rui, Wang, Gaowei, Yang, Bi-Huei, Luo, Xiaolin, Varki, Nissi M, Qiu, Shuang-Jian, Ren, Bing, Fu, Wenxian, and Feng, Gen-Sheng

Subjects
Biological Sciences, Digestive Diseases, Prevention, Rare Diseases, Liver Disease, Cancer, Liver Cancer, Genetics, 2.1 Biological and endogenous factors, Aetiology, Oral and gastrointestinal, Animals, Carcinogenesis, Dendritic Cells, Immunity, Innate, Interferon Inducers, Killer Cells, Natural, Liver Neoplasms, Macrophage Activation, Macrophages, Male, Mice, Mice, Inbred C57BL, Poly I-C, RNA, Double-Stranded, dsRNA, immunotherapy, innate immune system, liver cancer, liver tumor-initiating cells, macrophage polarization, preventive therapy, Biochemistry and Cell Biology, Medical Physiology, Biological sciences
Abstract

Liver cancer has become the second most deadly malignant disease, with no efficient targeted or immune therapeutic agents available yet. While dissecting the roles of cytoplasmic signaling molecules in hepatocarcinogenesis using an inducible mouse gene targeting system, Mx1-cre, we identified a potent liver tumor-inhibitory effect of synthetic double-stranded RNA (dsRNA), polyinosinic-polycytidylic acid (pIC), an inducer of the Mx1-cre system. Injection of pIC at the pre-cancer stage robustly suppressed liver tumorigenesis either induced by chemical carcinogens or by Pten loss and associated hepatosteatosis. The immunostimulatory dsRNA inhibited liver cancer initiation, apparently by boosting multiple anti-tumor activities of innate immunity, including induction of immunoregulatory cytokines, activation of NK cells and dendritic cells, and reprogramming of macrophage polarization. This study paves the way for the development of preventive and early interfering strategies for liver cancer to reduce the rapidly increasing incidences of liver cancer in an ever-growing population with chronic liver disorders.

Published
2017

18. Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.

Author

Luo, Xiaolin, Liao, Rui, Hanley, Kaisa L, Zhu, Helen He, Malo, Kirsten N, Hernandez, Carolyn, Wei, Xufu, Varki, Nissi M, Alderson, Nazilla, Chu, Catherine, Li, Shuangwei, Fan, Jia, Loomba, Rohit, Qiu, Shuang-Jian, and Feng, Gen-Sheng

Subjects
Liver, Animals, Mice, Knockout, Humans, Carcinoma, Hepatocellular, Liver Neoplasms, Disease Models, Animal, JNK Mitogen-Activated Protein Kinases, Signal Transduction, Gene Expression Regulation, Neoplastic, PTEN Phosphohydrolase, Neoplastic Stem Cells, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Carcinogenesis, Non-alcoholic Fatty Liver Disease, Proto-Oncogene Mas, PTEN, Shp2, liver tumorigenesis, non-alcoholic steatohepatitis, tumor suppressor, tumor-initiating cells, Hepatitis, Stem Cell Research - Nonembryonic - Non-Human, Cancer, Chronic Liver Disease and Cirrhosis, Liver Cancer, Stem Cell Research, Rare Diseases, Liver Disease, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Oral and gastrointestinal, Biochemistry and Cell Biology, Medical Physiology
Abstract

The complexity of liver tumorigenesis is underscored by the recently observed anti-oncogenic effects of oncoproteins, although the mechanisms are unclear. Shp2/Ptpn11 is a proto-oncogene in hematopoietic cells and antagonizes the effect of tumor suppressor Pten in leukemogenesis. In contrast, we show here cooperative functions of Shp2 and Pten in suppressing hepatocarcinogenesis. Ablating both Shp2 and Pten in hepatocytes induced early-onset non-alcoholic steatohepatitis (NASH) and promoted genesis of liver tumor-initiating cells likely due to augmented cJun expression/activation and elevated ROS and inflammation in the hepatic microenvironment. Inhibiting cJun partially suppressed NASH-driven liver tumorigenesis without improving NASH. SHP2 and PTEN deficiencies were detected in liver cancer patients with poor prognosis. These data depict a mechanism of hepato-oncogenesis and suggest a potential therapeutic strategy.

Published
2016

20. Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma

Author

Sun, Yun-Fan, Wu, Liang, Liu, Shi-Ping, Jiang, Miao-Miao, Hu, Bo, Zhou, Kai-Qian, Guo, Wei, Xu, Yang, Zhong, Yu, Zhou, Xiao-Rui, Zhang, Ze-Fan, Liu, Geng, Liu, Sheng, Shi, Ying-Hong, Ji, Yuan, Du, Min, Li, Nan-Nan, Li, Gui-Bo, Zhao, Zhi-Kun, Huang, Xiao-Yun, Xu, Li-Qin, Yu, Qi-Chao, Peng, David H., Qiu, Shuang-Jian, Sun, Hui-Chuan, Dean, Michael, Wang, Xiang-Dong, Chung, Wen-Yuan, Dennison, Ashley R., Zhou, Jian, Hou, Yong, Fan, Jia, and Yang, Xin-Rong

Published
2021
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22. High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma

Author

Liao, Rui, Sun, Jian, Wu, Han, Yi, Yong, Wang, Jia-Xing, He, Hong-Wei, Cai, Xiao-Yan, Zhou, Jian, Cheng, Yun-Feng, Fan, Jia, and Qiu, Shuang-Jian

Abstract

Abstract Background Hepatocellular carcinoma (HCC) is a typical malignancy in a background of chronic inflammation. Th17 cells (a major source of IL-17) constitute crucial components of infiltrating inflammatory/immune cells in HCC and can amplify inflammatory response via binding to interleukin-17 receptor (IL-17R). Thus, we investigated the expression and clinical significance of IL-17 and IL-17 receptor family cytokines in HCC. Methods The expression and prognostic value of IL-17 and IL-17R (A-E) were examined in 300 HCC patients after resection. Six Th17 associated cytokines in serum (n = 111) were quantified using enzyme-linked immunosorbent assays. Phenotypic features of IL-17+ CD4+ T cells were determined by flow cytometry analysis. Results High expression of intratumoral IL-17 and IL1-7RE were significantly associated with poorer survival (p = 0.016 and

Published
2013

26. Supplementary tables and figures from Circulating Tumor Cells with Stem-Like Phenotypes for Diagnosis, Prognosis, and Therapeutic Response Evaluation in Hepatocellular Carcinoma

Author

Guo, Wei, primary, Sun, Yun-Fan, primary, Shen, Min-Na, primary, Ma, Xiao-Lu, primary, Wu, Jiong, primary, Zhang, Chun-Yan, primary, Zhou, Yan, primary, Xu, Yang, primary, Hu, Bo, primary, Zhang, Min, primary, Wang, Gang, primary, Chen, Wei-Qin, primary, Guo, Lin, primary, Lu, Ren-Quan, primary, Zhou, Chao-Hui, primary, Zhang, Xin, primary, Shi, Ying-Hong, primary, Qiu, Shuang-jian, primary, Pan, Bai-shen, primary, Cao, Ya, primary, Zhou, Jian, primary, Yang, Xin-Rong, primary, and Fan, Jia, primary

Published
2023
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27. Supplementary Figure 1 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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28. Supplementary Figure 3 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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29. Supplementary Figure 4 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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30. Supplementary Data from CD24 Is a Novel Predictor for Poor Prognosis of Hepatocellular Carcinoma after Surgery

Author

Yang, Xin-Rong, primary, Xu, Yang, primary, Yu, Bin, primary, Zhou, Jian, primary, Li, Jia-Chu, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Wang, Xiao-Ying, primary, Dai, Zhi, primary, Shi, Guo-Ming, primary, Wu, Bin, primary, Wu, Li-Ming, primary, Yang, Guo-Huan, primary, Zhang, Bo-Heng, primary, Qin, Wen-Xin, primary, and Fan, Jia, primary

Published
2023
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32. Supplementary Figure Legend, Tables 1 - 2 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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33. Supplementary Data from Overexpression of PD-L1 Significantly Associates with Tumor Aggressiveness and Postoperative Recurrence in Human Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Yamato, Ichiro, primary, Sho, Masayuki, primary, Nakajima, Yoshiyuki, primary, Zhou, Jian, primary, Li, Bai-Zhou, primary, Shi, Ying-Hong, primary, Xiao, Yong-Sheng, primary, Xu, Yang, primary, and Fan, Jia, primary

Published
2023
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36. Supplementary Figure 2 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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38. Supplementary Methods, Figure Legends, Tables 1 - 5 from HNRNPAB Induces Epithelial–Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL

Author

Zhou, Zheng-Jun, primary, Dai, Zhi, primary, Zhou, Shao-Lai, primary, Hu, Zhi-Qiang, primary, Chen, Qing, primary, Zhao, Yi-Ming, primary, Shi, Ying-Hong, primary, Gao, Qiang, primary, Wu, Wei-Zhong, primary, Qiu, Shuang-Jian, primary, Zhou, Jian, primary, and Fan, Jia, primary

Published
2023
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40. Supplementary Figure 4 from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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41. Supplementary Figure 3 from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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42. Supplementary Methods, Tables 1-6, Figure Legends 1-4 from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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44. Supplementary Figure 2 from HNRNPAB Induces Epithelial–Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL

Author

Zhou, Zheng-Jun, primary, Dai, Zhi, primary, Zhou, Shao-Lai, primary, Hu, Zhi-Qiang, primary, Chen, Qing, primary, Zhao, Yi-Ming, primary, Shi, Ying-Hong, primary, Gao, Qiang, primary, Wu, Wei-Zhong, primary, Qiu, Shuang-Jian, primary, Zhou, Jian, primary, and Fan, Jia, primary

Published
2023
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45. Supplementary Figure 3 from HNRNPAB Induces Epithelial–Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL

Author

Zhou, Zheng-Jun, primary, Dai, Zhi, primary, Zhou, Shao-Lai, primary, Hu, Zhi-Qiang, primary, Chen, Qing, primary, Zhao, Yi-Ming, primary, Shi, Ying-Hong, primary, Gao, Qiang, primary, Wu, Wei-Zhong, primary, Qiu, Shuang-Jian, primary, Zhou, Jian, primary, and Fan, Jia, primary

Published
2023
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46. Supplementary Figure 1 from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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48. Supplementary Figure 2 from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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49. Data from CXCR6 Upregulation Contributes to a Proinflammatory Tumor Microenvironment That Drives Metastasis and Poor Patient Outcomes in Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Zhao, Ying-Jun, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Sun, Jian, primary, Yi, Yong, primary, Shi, Jie-Yi, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Xiao, Yong-Sheng, primary, Zhao, Zhong-Hua, primary, Zhou, Jian, primary, He, Xiang-Huo, primary, and Fan, Jia, primary

Published
2023
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50. Supplementary Figure 1 from HNRNPAB Induces Epithelial–Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL

Author

Zhou, Zheng-Jun, primary, Dai, Zhi, primary, Zhou, Shao-Lai, primary, Hu, Zhi-Qiang, primary, Chen, Qing, primary, Zhao, Yi-Ming, primary, Shi, Ying-Hong, primary, Gao, Qiang, primary, Wu, Wei-Zhong, primary, Qiu, Shuang-Jian, primary, Zhou, Jian, primary, and Fan, Jia, primary

Published
2023
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