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2. Palladium-Catalyzed Cascade Synthesis of Novel Quinolone- Bis(indolyl)methane Hybrids as Promising α-Glucosidase Inhibitors.

Author

Duan, Lian, Zuo, Ming-Xing, Xie, Kai-Qiang, Liu, Yuan-Cui, Qiu, Wen-Zhuang, Wang, Li-Ping, and Liu, Sheng

Subjects
ALKENYLATION, PALLADIUM, POTS, CONSTRUCTION, INDOLE
Abstract

An unexpected cascade reaction is developed for the construction of functionalized 3-bis(indol-3-yl)methylquinoline-2(1 H)-ones. Three C–C bonds and one ring are created in one pot triggered by Pd-catalyzed C-3 alkenylation of indole with 2-acyl- N -acrylaniline derivatives. A series of complex and specific quinoline-2(1 H)-ones were produced, most of them showed significant α-glucosidase inhibitory activities. [ABSTRACT FROM AUTHOR]

Published
2020
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