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1. Capability of Searching for Kilonova Associated with a Short Gamma-ray Burst by SVOM

Author

Wang, J., Xin, L. P., Qiu, Y. L., Lan, L., Xie, W. J., Jin, Z. P., and Wei, J. Y.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

In spite of the importance of studying the cosmic generation of heavy elements through the r-process, the detection of kilonova resulted from a merger of neutron star binaries is still a challenge task. In this paper, we show that the Visible Telescope (VT) onboard the on-going SVOM space mission is powerful for identifying kilonova candidates associated with short gamma-ray bursts (SGRBs) up to a distance of 600Mpc. A significant color variation, turn blue and then turn red, is revealed by calculating the light curves in both red and blue channels of VT by a linear combination of an afterglow and an associated kilonova. The maximum color variation is as high as $\sim0.5-1$ mag, which is far larger than the small photometry error of $\sim0.2$ mag of VT for a point source with a brightness of 23 mag. Up to a distance of 600Mpc, $\sim1-2$ kilonova candidates per year are predicted to be identified by VT., Comment: 8 pages, 3 figures, to be published in RAA

Published
2024

2. Two successive EUV waves and a transverse oscillation of a quiescent prominence

Author

Zhang, Q. M., Lin, M. S., Yan, X. L., Dai, J., Hou, Z. Y., Li, Y., and Qiu, Y.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

In this paper, we carry out multiwavelength observations of two successive extreme-ultraviolet (EUV) waves originating from active region (AR) NOAA 13575 and a transverse oscillation of a columnar quiescent prominence on 2024 February 9. A hot channel eruption generates an X3.4 class flare and the associated full-halo coronal mass ejection (CME), which drives the first EUV wave front (WF1) at a speed of $\sim$835 km s$^{-1}$. WF1 propagates in the southeast direction and interacts with the prominence, causing an eastward displacement of the prominence immediately. Then, a second EUV wave front (WF2) is driven by a coronal jet at a speed of $\sim$831 km s$^{-1}$. WF2 follows WF1 and decelerates from $\sim$788 km s$^{-1}$ to $\sim$603 km s$^{-1}$ before arriving at and touching the prominence. After reaching the maximum displacement, the prominence turns back and swings for 1$-$3 cycles. The transverse oscillation of horizontal polarization is most evident in 304 {\AA}. The initial displacement amplitude, velocity in the plane of the sky, period, and damping time fall in the ranges of 12$-$34 Mm, 65$-$143 km s$^{-1}$, 18$-$27 minutes, and 33$-$108 minutes, respectively. There are strong correlations among the initial amplitude, velocity, period, and height of the prominence. Surprisingly, the oscillation is also detected in 1600 {\AA}, which is totally in phase with that in 304 {\AA}., Comment: 8 pages, 11 figures, accepted for publication in MNRAS

Published
2024

3. Current progress in corrosion of multi principal element alloys

Author

Ghorbani, M., Li, Z., Qiu, Y., Marcus, P., Scully, J. R., Gharbi, O., Luo, H., Gupta, R. K., Zeng, Z. R., Fraser, H. L., Taheri, M. L., and Birbilis, N.

Subjects
Condensed Matter - Materials Science, Physics - Chemical Physics
Abstract

Whilst multi-principal element alloys (MPEAs) remain a promising class of materials owing to several attractive mechanical properties, their corrosion performance is also unique. In this concise review, we present an emerging overview of some of the general features related to MPEA corrosion, following a decade of work in the field. This includes highlighting some of the key aspects related to the electrochemical phenomena in MPEA corrosion, and the relevant future works required for a holistic mechanistic understanding. In addition, a comprehensive database of the reported corrosion performance of MPEAs is presented, based on works reported to date. The database is assembled to also allow users to undertake machine learning or their own data analysis, with a parsed representation of alloy composition, test electrolyte, and corrosion related parameters.

Published
2024

4. Developing an Automated Detection, Tracking and Analysis Method for Solar Filaments Observed by CHASE via Machine Learning

Author

Zheng, Z., Hao, Q., Qiu, Y., Hong, J., Li, C., and Ding, M. D.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Studies on the dynamics of solar filaments have significant implications for understanding their formation, evolution, and eruption, which are of great importance for space weather warning and forecasting. The H$\alpha$ Imaging Spectrograph (HIS) onboard the recently launched Chinese H$\alpha$ Solar Explorer (CHASE) can provide full-disk solar H$\alpha$ spectroscopic observations, which bring us an opportunity to systematically explore and analyze the plasma dynamics of filaments. The dramatically increased observation data require automate processing and analysis which are impossible if dealt with manually. In this paper, we utilize the U-Net model to identify filaments and implement the Channel and Spatial Reliability Tracking (CSRT) algorithm for automated filament tracking. In addition, we use the cloud model to invert the line-of-sight velocity of filaments and employ the graph theory algorithm to extract the filament spine, which can advance our understanding of the dynamics of filaments. The favorable test performance confirms the validity of our method, which will be implemented in the following statistical analyses of filament features and dynamics of CHASE/HIS observations., Comment: 13 pages, 9 figures, Accepted for publication in ApJ

Published
2024

5. Can Channels be Fully Inferred Between Two Antenna Panels?

Author

Qiu, Y., W, D., and Zeng, Y.

Subjects
Computer Science - Information Theory, Electrical Engineering and Systems Science - Signal Processing
Abstract

This letter considers a two-panel massive multiple-input multiple-output (MIMO) communication system, where the base station (BS) is equipped with two antenna panels that may use different frequency bands for communication. By exploiting the geometric relationships between antenna panels, efficient channel inference methods across antenna panels are proposed to reduce the overhead of real-time channel estimation. Four scenarios are considered, namely far-field free-space, near-field free-space, multi-path sharing far-field scatterers, and multi-path sharing near-field scatterers. For both far-field and near-field free-space scenarios, we show that the channel of one panel can be fully inferred from that of the other panel, as long as the multi-path components (MPCs) composing the channel can be resolved. On the other hand, for the multi-path scenarios sharing far-field or near-field scatterers, only the angles or range of angles of the MPCs can be inferred, respectively. Simulation results based on commercial 3D ray-tracing software are presented to validate our developed channel inference techniques., Comment: 5 pages, 6figures, IEEE Communications Letters

Published
2024
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8. Changing-look NLS1 galaxies, their detection with SVOM, and the case of NGC 1566

Author

Xu, D. W., Komossa, S., Grupe, D., Wang, J., Xin, L. P., Han, X. H., Wei, J. Y., Bai, J. Y., Bon, E., Cangemi, F., Cordier, B., Dennefeld, M., Gallo, L. C., Kollatschny, W., Kong, De-Feng, Ochmann, M. W., Qiu, Y. L., and Schartel, N.

Subjects
Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We discuss applications of the study of the new and barely explored class of changing-look (CL) narrow-line Seyfert 1 (NLS1) galaxies and comment on their detection with the space mission SVOM (Space Variable Objects Monitor). We highlight the case of NGC 1566, which is outstanding in many respects, for instance as one of the nearest known CL AGN undergoing exceptional outbursts. Its NLS1 nature is discussed, and we take it as a nearby prototype for systems that could be discovered and studied in the near future, including with SVOM. Finally, we briefly examine the broader implications and applications of CL events in NLS1 galaxies and show that such systems, once discovered in larger numbers, will greatly advance our understanding of the physics of the environment of rapidly growing supermassive black holes. This White Paper is part of a sequence of publications which explore aspects of our understanding of (CL) NLS1 galaxy physics with future missions., Comment: 14 pages, 4 figures. Accepted for publication in the Universe Special Issue "A Multimessenger View of Supermassive Black Holes and the Quasar Main Sequence"

Published
2024

9. FENDL: A library for fusion research and applications

Author

Schnabel, G., Aldama, D. L., Bohm, T., Fischer, U., Kunieda, S., Trkov, A., Konno, C., Capote, R., Koning, A. J., Breidokaite, S., Eade, T., Fabbri, M., Flammini, D., Isolan, L., Kodeli, I., Košťál, M., Kwon, S., Laghi, D., Leichtle, D., Nakayama, S., Ohta, M., Packer, L. W., Qiu, Y., Sato, S., Sawan, M., Schulc, M., Stankunas, G., Sumini, M., Valentine, A., Villari, R., and Žohar, A.

Subjects
Nuclear Theory, Computer Science - Digital Libraries, Nuclear Experiment
Abstract

The Fusion Evaluated Nuclear Data Library (FENDL) is a comprehensive and validated collection of nuclear cross section data coordinated by the International Atomic Energy Agency (IAEA) Nuclear Data Section (NDS). FENDL assembles the best nuclear data for fusion applications selected from available nuclear data libraries and has been under development for decades. FENDL contains sub-libraries for incident neutron, proton, and deuteron cross sections including general purpose and activation files used for particle transport and nuclide inventory calculations. We describe the history, selection of evaluations for the various sub-libraries (neutron, proton, deuteron) with the focus on transport and reactor dosimetry applications, the processing of the nuclear data for application codes, and the development of the TENDL-2017 library which is the currently recommended activation library for FENDL. We briefly describe the IAEA IRDFF library as the recommended library for dosimetry fusion applications. We also present work on validation of the neutron sub-library using a variety of fusion relevant computational and experimental benchmarks. A variety of cross section libraries are used for the validation work including FENDL-2.1, FENDL-3.1d, FENDL-3.2, ENDF/B-VIII.0, and JEFF-3.2 with the emphasis on the FENDL libraries. The results of the experimental validation showed that the performance of FENDL-3.2b is at least as good and in most cases better than FENDL-2.1. Future work will consider improved evaluations developed by the International Nuclear Data Evaluation Network (INDEN). Additional work will be needed to investigate differences in gas production in structural materials. Covariance matrices need to be updated to support the development of fusion technology. Additional validation work for high-energy neutrons, protons and deuterons, and the activation library will be needed., Comment: 81 pages, 114 figures

Published
2023

10. The evolution of galaxies and clusters at high spatial resolution with AXIS

Author

Russell, H. R., Lopez, L. A., Allen, S. W., Chartas, G., Choudhury, P. P., Dupke, R. A., Fabian, A. C., Flores, A. M., Garofali, K., Hodges-Kluck, E., Koss, M. J., Lanz, L., Lehmer, B. D., Li, J. -T., Maksym, W. P., Mantz, A. B., McDonald, M., Miller, E. D., Mushotzky, R. F., Qiu, Y., Reynolds, C. S., Tombesi, F., Tozzi, P., Trindade-Falcao, A., Walker, S. A., Wong, K. -W., Yukita, M., and Zhang, C.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Stellar and black hole feedback heat and disperse surrounding cold gas clouds, launching gas flows off circumnuclear and galactic disks and producing a dynamic interstellar medium. On large scales bordering the cosmic web, feedback drives enriched gas out of galaxies and groups, seeding the intergalactic medium with heavy elements. In this way, feedback shapes galaxy evolution by shutting down star formation and ultimately curtailing the growth of structure after the peak at redshift 2-3. To understand the complex interplay between gravity and feedback, we must resolve both the key physics within galaxies and map the impact of these processes over large scales, out into the cosmic web. The Advanced X-ray Imaging Satellite (AXIS) is a proposed X-ray probe mission for the 2030s with arcsecond spatial resolution, large effective area, and low background. AXIS will untangle the interactions of winds, radiation, jets, and supernovae with the surrounding ISM across the wide range of mass scales and large volumes driving galaxy evolution and trace the establishment of feedback back to the main event at cosmic noon., Comment: 29 pages, 18 figures; this white paper is part of a series commissioned for the AXIS Probe mission concept

Published
2023

13. The Lobster Eye Imager for Astronomy Onboard the SATech-01 Satellite

Author

Ling, Z. X., Sun, X. J., Zhang, C., Sun, S. L., Jin, G., Zhang, S. N., Zhang, X. F., Chang, J. B., Chen, F. S., Chen, Y. F., Cheng, Z. W., Fu, W., Han, Y. X., Li, H., Li, J. F., Li, Y., Li, Z. D., Liu, P. R., Lv, Y. H., Ma, X. H., Tang, Y. J., Wang, C. B., Xie, R. J., Xue, Y. L., Yan, A. L., Zhang, Q., Bao, C. Y., Cai, H. B., Cheng, H. Q., Cui, C. Z., Dai, Y. F., Fan, D. W., Hu, H. B., Hu, J. W., Huang, M. H., Jia, Z. Q., Jin, C. C., Li, D. Y., Li, J. Q., Liu, H. Y., Liu, M. J., Liu, Y., Pan, H. W., Qiu, Y. L., Sugizaki, M., Sun, H., Wang, W. X., Wang, Y. L., Wu, Q. Y., Xu, X. P., Xu, Y. F., Yang, H. N., Yang, X., Zhang, B., Zhang, M., Zhang, W. D., Zhang, Z., Zhao, D. H., Cong, X. Q., Jiang, B. W., Li, L. H., Qiu, X. B., Sun, J. N., Su, D. T., Wang, J., Wu, C., Xu, Z., Yang, X. M., Zhang, S. K., Zhang, N., Zhu, Y. F., Ban, H. Y., Bi, X. Z., Cai, Z. M., Chen, W., Chen, X., Chen, Y. H., Cui, Y., Duan, X. L., Feng, Z. G, Gao, Y., He, J. W., He, T., Huang, J. J., Li, F., Li, J. S., Li, T. J., Li, T. T., Liu, H. Q., Liu, L., Liu, R., Liu, S., Meng, N., Shi, Q., Sun, A. T., Wang, Y. M., Wang, Y. B., Wu, H. C., Xu, D. X, Yang, Y. Q, Yang, Y., Yu, X. S., Zhang, K. X., Zhang, Y. L., Zhang, Y. H., Zhang, Y. T., Zhou, H., Zhu, X. C., Cheng, J. S., Qin, L., Wang, L., Wang, Q. L., Bai, M., Gao, R. L., Ji, Z., Liu, Y. R., Ma, F. L., Shi, Y. J., Su, J., Tan, Y. Y., Tong, J. Z., Xu, H. T., Xue, C. B., Xue, G. F., and Yuan, W.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The Lobster Eye Imager for Astronomy (LEIA), a pathfinder of the Wide-field X-ray Telescope of the Einstein Probe (EP) mission, was successfully launched onboard the SATech-01 satellite of the Chinese Academy of Sciences on 27 July 2022. In this paper, we introduce the design and on-ground test results of the LEIA instrument. Using state-of-the-art Micro-Pore Optics (MPO), a wide field-of-view (FoV) of 346 square degrees (18.6 degrees * 18.6 degrees) of the X-ray imager is realized. An optical assembly composed of 36 MPO chips is used to focus incident X-ray photons, and four large-format complementary metal-oxide semiconductor (CMOS) sensors, each of 6 cm * 6 cm, are used as the focal plane detectors. The instrument has an angular resolution of 4 - 8 arcmin (in FWHM) for the central focal spot of the point spread function, and an effective area of 2 - 3 cm2 at 1 keV in essentially all the directions within the field of view. The detection passband is 0.5 - 4 keV in the soft X-rays and the sensitivity is 2 - 3 * 10-11 erg s-1 cm-2 (about 1 mini-Crab) at 1,000 second observation. The total weight of LEIA is 56 kg and the power is 85 W. The satellite, with a design lifetime of 2 years, operates in a Sun-synchronous orbit of 500 km with an orbital period of 95 minutes. LEIA is paving the way for future missions by verifying in flight the technologies of both novel focusing imaging optics and CMOS sensors for X-ray observation, and by optimizing the working setups of the instrumental parameters. In addition, LEIA is able to carry out scientific observations to find new transients and to monitor known sources in the soft X-ray band, albeit limited useful observing time available., Comment: Accepted by RAA

Published
2023
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14. Safety and Efficacy of Neoadjuvant Chemoimmunotherapy versus Chemotherapy for Non-Small Cell Lung Cancer Undergoing Sleeve Resection

Author

Qiu Y, Yu J, Guo Q, and Xu J

Subjects
nsclc, neoadjuvant chemotherapy, immune checkpoint inhibitors, sleeve lobectomy., Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Yanjun Qiu, Jinjiang Yu, Quanmin Guo, Jingyan Xu Department of Cardiothoracic Surgery, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou City, Zhejiang Province, People’s Republic of ChinaCorrespondence: Jingyan Xu, Department of Pharmacy, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, No. 100 Minjiang Boulevard Kecheng District, Quzhou City, Zhejiang Province, 324000, People’s Republic of China, Email xjy32778463@163.comAbstract: The prognosis of locally advanced non-small cell lung cancer (NSCLC) remains poor despite the addition of neoadjuvant chemotherapy, as it has been shown to improve 5-year absolute benefit survival by only 5%. Recently, neoadjuvant immunotherapy with immune checkpoint inhibitors (ICIs), combined with chemotherapy has shown promise in the treatment of locally advanced NSCLC. For NSCLC invading the main bronchus, sleeve resection has become the preferred modality to avoid pneumonectomy and reserve more cardiac or pulmonary function and to reduce postoperative morbidity and mortality. However, there has been a paucity of evidence to evaluate the safety and efficacy of neoadjuvant chemoimmunotherapy on bronchial-vascular reconstruction owing to the limited number of patients treated by sleeve lobectomy. Despite promising initial results, key knowledge gaps remain, including the impact on bronchial-vascular reconstruction, biomarkers predictive of ICI response, and the potential for specific perioperative complications associated with neoadjuvant chemoimmunotherapy in the context of sleeve resection. This review summarizes the latest literature evidence on the efficacy and safety of neoadjuvant chemoimmunotherapy approaches to address the unmet needs of sleeve resection of NSCLC treatment, describes the biomarkers predictive of ICI responses, and perioperative outcomes of sleeve resection after neoadjuvant chemoimmunotherapy.Keywords: NSCLC, neoadjuvant chemotherapy, immune checkpoint inhibitors, sleeve lobectomy

Published
2024

15. Assessing Thoracic Vertebral Bone Mineral Density (T8-T10) for Osteoporosis Diagnosis During CT Lung Cancer Screening in Older Adults

Author

Li S, Hu N, Wei Z, Wang J, Wang R, Gao X, Qiu Y, and Chen X

Subjects
quantitative computed tomography, thoracic vertebral bone mineral density, osteoporosis, computed tomography, lung cancer, Medicine (General), R5-920
Abstract

Song Li,1,* Nandong Hu,2,* Zicheng Wei,2 Jiangchuan Wang,2 Rongzhou Wang,2 Xifa Gao,2 Yingping Qiu,2 Xiao Chen2 1Department of Radiology, The Second Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, 230040, People’s Republic of China; 2Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao Chen; Yingping Qiu, Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Nanjing, 210029, People’s Republic of China, Tel +86 025 86617141, Email chxwin@163.com; ypqiusz@111.comIntroduction: Osteoporosis diagnosis often utilizes quantitative computed tomography (QCT). This study explored the validity of applying lumbar bone mineral density (LBMD) standards to thoracic vertebrae (T8-T10) for osteoporosis detection during CT lung cancer screenings. This study investigated the utility of thoracic BMD (BMD-T8-T10) for detecting osteoporosis in older persons during CT lung cancer screening.Methods: We studied 701 participants who underwent QCT scans for both LBMD and BMD-T8-T10. Osteoporosis was diagnosed using ACR criteria based on LBMD. We determined BMD-T8-T10 thresholds via a receiver operating characteristic (ROC) curve and translated BMD-T8+T9+T10 to LBMD (TTBMD) using linear regression. Kappa test was used to evaluate the accuracy of BMD-T8-T10 thresholds and TTBMD in diagnosing osteoporosis.Results: Raw BMD-T8-T10 poorly identified osteoporosis (kappa = 0.51). ROC curve analysis identified BMD-T8-T10 thresholds for osteopenia (138 mg/cm3) and osteoporosis (97 mg/cm3) with areas under the curve of 0.97 and 0.99, respectively. We normalized BMD-T8-T10 to TTBMD based on the formula: TTBMD = 0.9 × BMD-T8-T10 - 2.56. These thresholds (kappa = 0.74) and TTBMD performed well in detecting osteoporosis/osteopenia (kappa = 0.74).Conclusion: Both calculating BMD-T8-T10 threshold (138.0 mg/cm3 for osteopenia and 97 mg/cm3 for osteoporosis) and normalizing BMD-T8-T10 to LBMD demonstrated good performance in identifying osteoporosis in older adults during CT lung cancer screening.Keywords: quantitative computed tomography, thoracic vertebral bone mineral density, osteoporosis, Computed tomography, lung cancer

Published
2024

16. Naples Prognostic Score: A Novel Predictor of Survival in Patients with Triple-Negative Breast Cancer

Author

Qiu Y, Chen Y, Shen H, Yan S, Li J, and Wu W

Subjects
triple-negative breast cancer, naples prognostic score, prognostic factor, nomogram predictive model, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Yu Qiu,1,2,&ast; Yan Chen,1,2,&ast; Haoyang Shen,1,2 Shuixin Yan,1,2 Jiadi Li,1,2 Weizhu Wu1 1The Affiliated Lihuili Hospital, Ningbo University, Ningbo, 315000, People’s Republic of China; 2Health Science Center, Ningbo University, Ningbo, Zhejiang, 315000, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Weizhu Wu, The Affiliated Lihuili Hospital, 1111 Jiangnan Road, Ningbo, Zhejiang, 315000, People’s Republic of China, Tel +86 574 13957402451, Email wuweizhu1128@163.comPurpose: This study investigated the correlation between the Naples prognostic score (NPS), clinicopathological traits, and the postoperative prognoses of patients with triple-negative breast cancer (TNBC). Based on NPS, a predictive nomogram was developed to estimate the long-term survival probabilities of patients with TNBC post-surgery.Patients and Methods: We retrospectively examined the clinical records of 223 women with TNBC treated at Ningbo Medical Center, Lihuili Hospital between January 1, 2016 and December 31, 2020. Blood tests and biochemical analyses were conducted before surgery. The prognostic nutritional index (PNI), controlling nutritional status (CONUT), neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and NPS were determined based on blood-related markers. A Kaplan-Meier survival analysis assessed the association between NPS, PNI, CONUT score, overall survival (OS), and breast cancer-specific survival (BCSS). Predictive accuracy was evaluated using the area under the receiver operating characteristic curve (AUC) and C index. The patients were randomly divided into the training and the validation group (6:4 ratio). A nomogram prediction model was developed and evaluated using the R Software for Statistical Computing (RMS) package.Results: NPS outperformed other scores in predicting inflammation outcomes. Patients with an elevated NPS had a poorer prognosis (P< 0.001). Lymph node ratio (LNR), surgical method, postoperative chemotherapy, and NPS independently predicted OS, whereas M stage, LNR, and NPS independently predicted BCSS outcome. The OS and BCSS predicted by the nomogram model aligned well with the actual OS and BCSS. The decision curve analysis showed significant clinical utility for the nomogram model.Conclusion: In this study, NPS was an important prognostic indicator for patients with TNBC. The nomogram prognostic model based on NPS outperformed other prognostic scores for predicting patient prognosis. The model demonstrated a clear stratification ability for patient prognosis, which emphasized the potential benefits of early intervention for high-risk patients.Plain Language Summary: In this study, we aimed to understand how the Naples prognostic score (NPS) scoring system could predict the prognosis for patients with triple-negative breast cancer (TNBC). TNBC is a type of breast cancer that can be difficult to treat. Medical records of 223 women with TNBC were retrospectively analyzed. These women had their blood tested before surgery to check for certain markers related to nutrition and inflammation. NPS was used along with other scores to determine their accuracy in predicting survival. NPS was better at predicting outcomes than the other scores. The patients with higher NPS scores tended to have poorer outcomes. We also created a visual tool called a nomogram to help doctors predict patient outcomes based on the NPS scores. NPS can be a valuable tool for doctors treating patients with TNBC because it can help them predict how well a patient might do after surgery. This information could be used to tailor treatment plans for these patients. The nomogram provides a user-friendly way for doctors to use NPS in their practice. Overall, this study showed that NPS is a powerful tool for predicting outcomes for patients with TNBC, which could lead to better treatment decisions and improved outcomes for these patients.Keywords: triple-negative breast cancer, Naples prognostic score, prognostic factor, nomogram predictive model

Published
2024

18. Pushing Forward the DNA Walkers in Connection with Tumor-Derived Extracellular Vesicles

Author

Liu Q, Zhang Q, Yao Z, Yi G, Kang Y, Qiu Y, Yang Y, Yuan H, Fu R, Sheng W, Cheng L, Wang W, Wang H, and Peng C

Subjects
evs, tevs, dna walker, detection, Medicine (General), R5-920
Abstract

Qingyi Liu,1,2 Qiongdan Zhang,1,2 Zhijian Yao,1,2 Gangqiang Yi,2 Yeonseok Kang,3 Yixing Qiu,1,2 Yupei Yang,1,2 Hanwen Yuan,1,2 Ronggeng Fu,2 Wenbing Sheng,1,2 Lidong Cheng,4 Wei Wang,1,2 Huizhen Wang,1,2 Caiyun Peng1,5 1TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, People’s Republic of China; 2School of Pharmacy, Hunan University of Chinese Medicine, Changsha, People’s Republic of China; 3College of Korean Medicine, Wonkwang University, Jeonbuk, Korea; 4Hunan Yirentang Chinese Herbal Pieces Co., Ltd, Changde, People’s Republic of China; 5Institute of Innovation and Applied Research in Chinese Medicine Hunan University of Chinese Medicine, Changsha, People’s Republic of ChinaCorrespondence: Huizhen Wang; Caiyun Peng, Tel +86-151-1648-1295 ; +86-138-7480-7689, Email whuiz0086@163.com; caiyunpeng@hnucm.edu.cnAbstract: Extracellular vesicles (EVs) are microparticles released from cells in both physiological and pathological conditions and could be used to monitor the progression of various pathological states, including neoplastic diseases. In various EVs, tumor-derived extracellular vesicles (TEVs) are secreted by different tumor cells and are abundant in many molecular components, such as proteins, nucleic acids, lipids, and carbohydrates. TEVs play a crucial role in forming and advancing various cancer processes. Therefore, TEVs are regarded as promising biomarkers for the early detection of cancer in liquid biopsy. However, the currently developed TEV detection methods still face several key scientific problems that need to be solved, such as low sensitivity, poor specificity, and poor accuracy. To overcome these limitations, DNA walkers have emerged as one of the most popular nanodevices that exhibit better signal amplification capability and enable highly sensitive and specific detection of the analytes. Due to their unique properties of high directionality, flexibility, and efficiency, DNA walkers hold great potential for detecting TEVs. This paper provides an introduction to EVs and DNA walker, additionally, it summarizes recent advances in DNA walker-based detection of TEVs (2018– 2024). The review highlights the close relationship between TEVs and DNA walkers, aims to offer valuable insights into TEV detection and to inspire the development of reliable, efficient, simple, and innovative methods for detecting TEVs based on DNA walker in the future. Keywords: EVs, TEVs, DNA walker, detection

Published
2024

19. Monte-Carlo simulations for wall-bounded fluid flows via random vortex method

Author

Qian, Z., Qiu, Y., Zhao, L., and Wu, J.

Subjects
Physics - Fluid Dynamics, Mathematics - Analysis of PDEs, Mathematics - Probability
Abstract

In this paper a Monte-Carlo method for simulating the motion of fluid flow moving along a solid wall is proposed. The random vortex method in the present paper is established by using the reflection technology and perturbation technique. The Monte-Carlo method based on this random vortex dynamic may be implemented, and several Monte-Carlo simulations are then carried out for the flows near the solid wall., Comment: 20 pages

Published
2022

22. Elderly’s Homesickness: Development of Elderly Homesickness Questionnaire

Author

Deng Z, Qiu Y, Xiao X, and Jiao C

Subjects
homesickness, elderly, questionnaire development., Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract

Zeming Deng,1,2 Yuehong Qiu,1,2 Xueer Xiao,3 Can Jiao1,2 1The Shenzhen Humanities & Social Sciences Key Research Bases of the Center for Mental Health, Shenzhen University, Shenzhen, Guangdong Province, People’s Republic of China; 2School of Psychology, Shenzhen University, Shenzhen, Guangdong Province, People’s Republic of China; 3Shenzhen College of International Education, Shenzhen, Guangdong Province, People’s Republic of ChinaCorrespondence: Can Jiao, Shenzhen University, 13F-1331, Zhili building L3, Canghai campus, Yuehai Street, Nanshan District, Shenzhen City, Guangdong Province, People’s Republic of China, Tel +86 13926576570, Email jiaocan@szu.edu.cnIntroduction: Homesickness is a result of migration, and is related to adjustment difficulties and health problems, as well as clinical disorders. The aim of this study was to measure and explore the homesickness of Chinese elderly.Methods: A total of 355 non-local Chinese elderly in Shenzhen were recruited to measure demographic information and homesickness. and tested for reliability and validity. Patterns and influences of homesickness among Chinese elderly were explored through latent profile analysis and One-way ANOVA on the basis of EHQ.Results: A three-factor structure was verified in the 19-item elderly homesickness questionnaire (EHQ), namely “positive contact”, “refusal to separate” and “homesickness behavior”. The EHQ reports high validity and reliability. Chinese elderly had a high degree of homesickness, and homesickness among Chinese elderly varied significantly across variables such as age, occupation, and education level. Four homesickness patterns were found in Chinese elderly, named low homesick group, moderate homesick group, middle-high homesick group, and high homesick group. Coming from rural/urban areas and living with grandchildren are factors that affect classification.Conclusion: The present study reveals the high validity and reliability of the EHQ among Chinese elderly. The Chinese elderly reported high levels of homesickness, which varied significantly across levels of demographic factors. Four patterns of homesickness were found among the Chinese elderly, coming from rural/urban areas and living with grandchildren are the factors that affect classification. There may be a masking of the male contribution to the main effect due to the larger female sample.Keywords: homesickness, elderly, questionnaire development

Published
2024

23. Exosomes as Powerful Biomarkers in Cancer: Recent Advances in Isolation and Detection Techniques

Author

Zhang Q, Wang H, Liu Q, Zeng N, Fu G, Qiu Y, Yang Y, Yuan H, Wang W, and Li B

Subjects
tumor, exosomes, nanomaterials, dna signal amplification, Medicine (General), R5-920
Abstract

Qiongdan Zhang,1,2,&ast; Huizhen Wang,1,2,&ast; Qingyi Liu,1,2 Ni Zeng,1,2 Gang Fu,1,2 Yixing Qiu,1,2 Yupei Yang,1,2 Hanwen Yuan,1,2 Wei Wang,1,2 Bin Li1,2 1TCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, People’s Republic of China; 2School of Pharmacy, Hunan University of Chinese Medicine, Changsha, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wei Wang; Bin Li, Tel +86-136-5743-8606 ; +86-158-7410-0917, Email wangwei402@hotmail.com; libin@hnucm.edu.cnAbstract: Exosomes, small extracellular vesicles derived from cells, are known to carry important bioactive molecules such as proteins, nucleic acids, and lipids. These bioactive components play crucial roles in cell signaling, immune response, and tumor metastasis, making exosomes potential diagnostic biomarkers for various diseases. However, current methods for detecting tumor exosomes face scientific challenges including low sensitivity, poor specificity, complicated procedures, and high costs. It is essential to surmount these obstacles to enhance the precision and dependability of diagnostics that rely on exosomes. Merging DNA signal amplification techniques with the signal boosting capabilities of nanomaterials presents an encouraging strategy to overcome these constraints and improve exosome detection. This article highlights the use of DNA signal amplification technology and nanomaterials’ signal enhancement effect to improve the detection of exosomes. This review seeks to offer valuable perspectives for the enhancement of amplification methods applied in practical cancer diagnosis and prognosis by providing an overview of how these novel technologies are utilized in exosome-based diagnostic procedures. Keywords: tumor, exosomes, nanomaterials, DNA signal amplification

Published
2024

24. A Novel Radiological Scoring System for Anterior Longitudinal Ligament Injuries

Author

Li Y, Sun Y, Wu J, Gao Z, Qiu Y, Han L, and Lu X

Subjects
cervical hyperextension injury, anterior longitudinal ligament injury, cervical spine trauma, scoring system., Medicine (General), R5-920
Abstract

Yang Li,1,&ast; Yuling Sun,1,&ast; Ji Wu,1,&ast; Zhongya Gao,1 Youcai Qiu,1 Lin Han,2 Xuhua Lu1 1Department of Orthopaedics, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, People’s Republic of China; 2Department of Orthopaedics, Third Affiliated Hospital of Naval Medical University, Shanghai, 200433, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xuhua Lu, Department of Orthopaedics, Shanghai Changzheng Hospital, Naval Medical University, No. 415 Fengyang Road, Shanghai, 200003, People’s Republic of China, Tel +86-21-81885793, Email xuhualu415@163.com Lin Han, Department of Orthopaedics, Third Affiliated Hospital of Naval Medical University, Shanghai, 200433, People’s Republic of China, Email hanlin1018@163.comBackground and Aim: Cervical hyperextension injury is very frequent with anterior longitudinal ligament (ALL) injury, and the ligament damage has a remarkable effect on whether and what type of operation should be performed. This study aims to establish a new scoring system for the accurate diagnosis of ALL damage.Methods: The imaging data of the consecutive patients was measured and scored by four radiologists. Intraoperative exploration was performed by three surgeons. The crude and adjusted odds ratios (cOR and aOR) and receiver operating characteristic curve (ROC) were constructed to assess the diagnostic accuracy of the scoring system.Results: A total of 255 patients with cervical spine trauma were included in this study. There was no statistical difference in the relationship between demographics and ALL injuries (P > 0.05). Thickness of prevertebral soft tissue (aOR = 11.922, P = 0.004), intervertebral disk angle (aOR = 13.21, P = 0.002), avulsion fracture of the anterior edge of the vertebral body (aOR = 13.844, P = 0.029), ALL disrupted in T1-weighted sequence (aOR = 18.349, P < 0.001), and high signal area in T2-weighted sequence (aOR = 20.898, P = 0.002) had significantly higher diagnostic accuracy. The scoring system’s sensitivity and specificity were 94.0% and 88.1%, respectively, and the accuracy was 90.8%.Conclusion: The study established a new scoring system for ALL injuries based on the analysis of a series of clinical data and statistics. A total of five scoring items, a total score of 7 points, and an ALL injury may be diagnosed when the score is not less than 3 points. This scoring system enables an efficient and accurate diagnosis of all injuries.Keywords: cervical hyperextension injury, anterior longitudinal ligament injury, cervical spine trauma, scoring system

Published
2024

25. cardiGAN: A Generative Adversarial Network Model for Design and Discovery of Multi Principal Element Alloys

Author

Li, Z., Nash, W. T., Brien, S. P. O, Qiu, Y., Gupta, R. K., and Birbilis, N.

Subjects
Condensed Matter - Materials Science
Abstract

Multi-principal element alloys (MPEAs), inclusive of high entropy alloys (HEAs), continue to attract significant research attention owing to their potentially desirable properties. Although MPEAs remain under extensive research, traditional (i.e. empirical) alloy production and testing is both costly and time-consuming, partly due to the inefficiency of the early discovery process which involves experiments on a large number of alloy compositions. It is intuitive to apply machine learning in the discovery of this novel class of materials, of which only a small number of potential alloys has been probed to date. In this work, a proof-of-concept is proposed, combining generative adversarial networks (GANs) with discriminative neural networks (NNs), to accelerate the exploration of novel MPEAs. By applying the GAN model herein, it was possible to directly generate novel compositions for MPEAs, and to predict their phases. To verify the predictability of the model, alloys designed by the model are presented and a candidate produced; as validation. This suggests that the model herein offers an approach that can significantly enhance the capacity and efficiency of development of novel MPEAs.

Published
2022

26. Precision measurement of forward $Z$ boson production in proton-proton collisions at $\sqrt{s} = 13$ TeV

Author

LHCb collaboration, Aaij, R., Abdelmotteleb, A. S. W., Beteta, C. Abellán, Abudinén, F., Ackernley, T., Adeva, B., Adinolfi, M., Afsharnia, H., Agapopoulou, C., Aidala, C. A., Aiola, S., Ajaltouni, Z., Akar, S., Albrecht, J., Alessio, F., Alexander, M., Albero, A. Alfonso, Aliouche, Z., Alkhazov, G., Cartelle, P. Alvarez, Amato, S., Amey, J. L., Amhis, Y., An, L., Anderlini, L., Andersson, M., Andreianov, A., Andreotti, M., Archilli, F., Artamonov, A., Artuso, M., Arzymatov, K., Aslanides, E., Atzeni, M., Audurier, B., Bachmann, S., Bachmayer, M., Back, J. J., Rodriguez, P. Baladron, Balagura, V., Baldini, W., Leite, J. Baptista de Souza, Barbetti, M., Barlow, R. J., Barsuk, S., Barter, W., Bartolini, M., Baryshnikov, F., Basels, J. M., Bashir, S., Bassi, G., Batsukh, B., Battig, A., Bay, A., Beck, A., Becker, M., Bedeschi, F., Bediaga, I., Beiter, A., Belavin, V., Belin, S., Bellee, V., Belous, K., Belov, I., Belyaev, I., Bencivenni, G., Ben-Haim, E., Berezhnoy, A., Bernet, R., Berninghoff, D., Bernstein, H. C., Bertella, C., Bertolin, A., Betancourt, C., Betti, F., Bezshyiko, Ia., Bhasin, S., Bhom, J., Bian, L., Bieker, M. S., Biesuz, N. V., Bifani, S., Billoir, P., Biolchini, A., Birch, M., Bishop, F. C. R., Bitadze, A., Bizzeti, A., Bjørn, M., Blago, M. P., Blake, T., Blanc, F., Blusk, S., Bobulska, D., Boelhauve, J. A., Garcia, O. Boente, Boettcher, T., Boldyrev, A., Bondar, A., Bondar, N., Borghi, S., Borisyak, M., Borsato, M., Borsuk, J. T., Bouchiba, S. A., Bowcock, T. J. V., Boyer, A., Bozzi, C., Bradley, M. J., Braun, S., Rodriguez, A. Brea, Brodzicka, J., Gonzalo, A. Brossa, Brundu, D., Buonaura, A., Buonincontri, L., Burke, A. T., Burr, C., Bursche, A., Butkevich, A., Butter, J. S., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Calefice, L., Cali, S., Calladine, R., Calvi, M., Gomez, M. Calvo, Magalhaes, P. Camargo, Campana, P., Quezada, A. F. Campoverde, Capelli, S., Capriotti, L., Carbone, A., Carboni, G., Cardinale, R., Cardini, A., Carli, I., Carniti, P., Carus, L., Akiba, K. Carvalho, Vidal, A. Casais, Caspary, R., Casse, G., Cattaneo, M., Cavallero, G., Celani, S., Cerasoli, J., Cervenkov, D., Chadwick, A. J., Chapman, M. G., Charles, M., Charpentier, Ph., Chatzikonstantinidis, G., Barajas, C. A. Chavez, Chefdeville, M., Chen, C., Chen, S., Chernov, A., Chobanova, V., Cholak, S., Chrzaszcz, M., Chubykin, A., Chulikov, V., Ciambrone, P., Cicala, M. F., Vidal, X. Cid, Ciezarek, G., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Cobbledick, J. L., Coco, V., Coelho, J. A. B., Cogan, J., Cogneras, E., Cojocariu, L., Collins, P., Colombo, T., Congedo, L., Contu, A., Cooke, N., Coombs, G., Corredoira, I., Corti, G., Sobral, C. M. Costa, Couturier, B., Craik, D. C., Crkovská, J., Torres, M. Cruz, Currie, R., Da Silva, C. L., Dadabaev, S., Dai, L., Dall'Occo, E., Dalseno, J., D'Ambrosio, C., Danilina, A., d'Argent, P., Dashkina, A., Davies, J. E., Davis, A., Francisco, O. De Aguiar, De Bruyn, K., De Capua, S., De Cian, M., De Lucia, E., De Miranda, J. M., De Paula, L., De Serio, M., De Simone, D., De Simone, P., De Vellis, F., de Vries, J. A., Dean, C. T., Debernardis, F., Decamp, D., Dedu, V., Del Buono, L., Delaney, B., Dembinski, H. -P., Dendek, A., Denysenko, V., Derkach, D., Deschamps, O., Desse, F., Dettori, F., Dey, B., Di Cicco, A., Di Nezza, P., Didenko, S., Maronas, L. Dieste, Dijkstra, H., Dobishuk, V., Dong, C., Donohoe, A. M., Dordei, F., Reis, A. C. dos, Douglas, L., Dovbnya, A., Downes, A. G., Dudek, M. W., Dufour, L., Duk, V., Durante, P., Durham, J. M., Dutta, D., Dziurda, A., Dzyuba, A., Easo, S., Egede, U., Egorychev, V., Eidelman, S., Eisenhardt, S., Ek-In, S., Eklund, L., Ely, S., Ene, A., Epple, E., Escher, S., Eschle, J., Esen, S., Evans, T., Falcao, L. N., Fan, Y., Fang, B., Farry, S., Fazzini, D., Féo, M., Prieto, A. Fernandez, Fernez, A. D., Ferrari, F., Lopes, L. Ferreira, Rodrigues, F. Ferreira, Sole, S. Ferreres, Ferrillo, M., Ferro-Luzzi, M., Filippov, S., Fini, R. A., Fiorini, M., Firlej, M., Fischer, K. M., Fitzgerald, D. S., Fitzpatrick, C., Fiutowski, T., Fkiaras, A., Fleuret, F., Fontana, M., Fontanelli, F., Forty, R., Foulds-Holt, D., Lima, V. Franco, Sevilla, M. Franco, Frank, M., Franzoso, E., Frau, G., Frei, C., Friday, D. A., Fu, J., Fuehring, Q., Gabriel, E., Galati, G., Torreira, A. Gallas, Galli, D., Gambetta, S., Gan, Y., Gandelman, M., Gandini, P., Gao, Y., Garau, M., Martin, L. M. Garcia, Moreno, P. Garcia, Pardiñas, J. García, Plana, B. Garcia, Rosales, F. A. Garcia, Garrido, L., Gaspar, C., Geertsema, R. E., Gerick, D., Gerken, L. L., Gersabeck, E., Gersabeck, M., Gershon, T., Gerstel, D., Giambastiani, L., Gibson, V., Giemza, H. K., Gilman, A. L., Giovannetti, M., Gioventù, A., Gironell, P. Gironella, Giugliano, C., Gizdov, K., Gkougkousis, E. L., Gligorov, V. V., Göbel, C., Golobardes, E., Golubkov, D., Golutvin, A., Gomes, A., Fernandez, S. Gomez, Abrantes, F. Goncalves, Goncerz, M., Gong, G., Gorbounov, P., Gorelov, I. V., Gotti, C., Govorkova, E., Grabowski, J. P., Grammatico, T., Cardoso, L. A. Granado, Graugés, E., Graverini, E., Graziani, G., Grecu, A., Greeven, L. M., Grieser, N. A., Grillo, L., Gromov, S., Cazon, B. R. Gruberg, Gu, C., Guarise, M., Guittiere, M., Günther, P. A., Gushchin, E., Guth, A., Guz, Y., Gys, T., Hadavizadeh, T., Haefeli, G., Haen, C., Haimberger, J., Halewood-leagas, T., Hamilton, P. M., Hammerich, J. P., Han, Q., Han, X., Hancock, T. H., Hansen, E. B., Hansmann-Menzemer, S., Harnew, N., Harrison, T., Hasse, C., Hatch, M., He, J., Hecker, M., Heijhoff, K., Heinicke, K., Henderson, R. D. L., Hennequin, A. M., Hennessy, K., Henry, L., Heuel, J., Hicheur, A., Hill, D., Hilton, M., Hollitt, S. E., Hou, R., Hou, Y., Hu, J., Hu, W., Hu, X., Huang, W., Huang, X., Hulsbergen, W., Hunter, R. J., Hushchyn, M., Hutchcroft, D., Hynds, D., Ibis, P., Idzik, M., Ilin, D., Ilten, P., Inglessi, A., Ishteev, A., Ivshin, K., Jacobsson, R., Jage, H., Jakobsen, S., Jans, E., Jashal, B. K., Jawahery, A., Jevtic, V., Jiang, X., John, M., Johnson, D., Jones, C. R., Jones, T. P., Jost, B., Jurik, N., Kadavath, S. H. Kalavan, Kandybei, S., Kang, Y., Karacson, M., Karpov, M., Kautz, J. W., Keizer, F., Keller, D. M., Kenzie, M., Ketel, T., Khanji, B., Kharisova, A., Kholodenko, S., Kirn, T., Kirsebom, V. S., Kitouni, O., Klaver, S., Kleijne, N., Klimaszewski, K., Kmiec, M. R., Koliiev, S., Kondybayeva, A., Konoplyannikov, A., Kopciewicz, P., Kopecna, R., Koppenburg, P., Korolev, M., Kostiuk, I., Kot, O., Kotriakhova, S., Kravchenko, P., Kravchuk, L., Krawczyk, R. D., Kreps, M., Kress, F., Kretzschmar, S., Krokovny, P., Krupa, W., Krzemien, W., Kubat, J., Kucharczyk, M., Kudryavtsev, V., Kuindersma, H. S., Kunde, G. J., Kvaratskheliya, T., Lacarrere, D., Lafferty, G., Lai, A., Lampis, A., Lancierini, D., Lane, J. J., Lane, R., Lanfranchi, G., Langenbruch, C., Langer, J., Lantwin, O., Latham, T., Lazzari, F., Gac, R. Le, Lee, S. H., Lefèvre, R., Leflat, A., Legotin, S., Leroy, O., Lesiak, T., Leverington, B., Li, H., Li, P., Li, S., Li, Y., Li, Z., Liang, X., Lin, T., Lindner, R., Lisovskyi, V., Litvinov, R., Liu, G., Liu, H., Liu, Q., Liu, S., Salvia, A. Lobo, Loi, A., Castro, J. Lomba, Longstaff, I., Lopes, J. H., Soliño, S. López, Lovell, G. H., Lu, Y., Lucarelli, C., Lucchesi, D., Luchuk, S., Martinez, M. Lucio, Lukashenko, V., Luo, Y., Lupato, A., Luppi, E., Lupton, O., Lusiani, A., Lyu, X., Ma, L., Ma, R., Maccolini, S., Machefert, F., Maciuc, F., Macko, V., Mackowiak, P., Maddrell-Mander, S., Madejczyk, O., Mohan, L. R. Madhan, Maev, O., Maevskiy, A., Majewski, M. W., Malczewski, J. J., Malde, S., Malecki, B., Malinin, A., Maltsev, T., Malygina, H., Manca, G., Mancinelli, G., Manuzzi, D., Marangotto, D., Maratas, J., Marchand, J. F., Marconi, U., Mariani, S., Benito, C. Marin, Marinangeli, M., Marks, J., Marshall, A. M., Marshall, P. J., Martelli, G., Martellotti, G., Martinazzoli, L., Martinelli, M., Santos, D. Martinez, Vidal, F. Martinez, Massafferri, A., Materok, M., Matev, R., Mathad, A., Matiunin, V., Matteuzzi, C., Mattioli, K. R., Mauri, A., Maurice, E., Mauricio, J., Mazurek, M., McCann, M., Mcconnell, L., Mcgrath, T. H., Mchugh, N. T., McNab, A., McNulty, R., Mead, J. V., Meadows, B., Meier, G., Melnychuk, D., Meloni, S., Merk, M., Merli, A., Garcia, L. Meyer, Mikhasenko, M., Milanes, D. A., Millard, E., Milovanovic, M., Minard, M. -N., Minotti, A., Minzoni, L., Mitchell, S. E., Mitreska, B., Mitzel, D. S., Mödden, A., Mohammed, R. A., Moise, R. D., Mokhnenko, S., Mombächer, T., Monroy, I. A., Monteil, S., Morandin, M., Morello, G., Morello, M. J., Moron, J., Morris, A. B., Morris, A. G., Mountain, R., Mu, H., Muheim, F., Mulder, M., Müller, D., Müller, K., Murphy, C. H., Murray, D., Murta, R., Muzzetto, P., Naik, P., Nakada, T., Nandakumar, R., Nanut, T., Nasteva, I., Needham, M., Neri, N., Neubert, S., Neufeld, N., Newcombe, R., Niel, E. M., Nieswand, S., Nikitin, N., Nolte, N. S., Normand, C., Nunez, C., Oblakowska-Mucha, A., Obraztsov, V., Oeser, T., O'Hanlon, D. P., Okamura, S., Oldeman, R., Oliva, F., Olivares, M. E., Onderwater, C. J. G., O'Neil, R. H., Goicochea, J. M. Otalora, Ovsiannikova, T., Owen, P., Oyanguren, A., Padeken, K. O., Pagare, B., Pais, P. R., Pajero, T., Palano, A., Palutan, M., Pan, Y., Panshin, G., Papanestis, A., Pappagallo, M., Pappalardo, L. L., Pappenheimer, C., Parker, W., Parkes, C., Passalacqua, B., Passaleva, G., Pastore, A., Patel, M., Patrignani, C., Pawley, C. J., Pearce, A., Pellegrino, A., Altarelli, M. Pepe, Perazzini, S., Pereima, D., Castro, A. Pereiro, Perret, P., Petric, M., Petridis, K., Petrolini, A., Petrov, A., Petrucci, S., Petruzzo, M., Pham, T. T. H., Philippov, A., Piandani, R., Pica, L., Piccini, M., Pietrzyk, B., Pietrzyk, G., Pili, M., Pinci, D., Pisani, F., Pizzichemi, M., K, Resmi P., Placinta, V., Plews, J., Casasus, M. Plo, Polci, F., Lener, M. Poli, Poliakova, M., Poluektov, A., Polukhina, N., Polyakov, I., Polycarpo, E., Ponce, S., Popov, D., Popov, S., Poslavskii, S., Prasanth, K., Promberger, L., Prouve, C., Pugatch, V., Puill, V., Punzi, G., Qi, H., Qian, W., Qin, N., Qiu, Y., Quagliani, R., Raab, N. V., Trejo, R. I. Rabadan, Rachwal, B., Rademacker, J. H., Rama, M., Pernas, M. Ramos, Rangel, M. S., Ratnikov, F., Raven, G., Reboud, M., Redi, F., Reiss, F., Alepuz, C. Remon, Ren, Z., Renaudin, V., Ribatti, R., Ricci, A. M., Ricciardi, S., Rinnert, K., Robbe, P., Robertson, G., Rodrigues, A. B., Rodrigues, E., Lopez, J. A. Rodriguez, Rodriguez, E. R. R. Rodriguez, Rollings, A., Roloff, P., Romanovskiy, V., Lamas, M. Romero, Vidal, A. Romero, Roth, J. D., Rotondo, M., Rudolph, M. S., Ruf, T., Fernandez, R. A. Ruiz, Vidal, J. Ruiz, Ryzhikov, A., Ryzka, J., Silva, J. J. Saborido, Sagidova, N., Sahoo, N., Saitta, B., Salomoni, M., Gras, C. Sanchez, Santacesaria, R., Rios, C. Santamarina, Santimaria, M., Santovetti, E., Saranin, D., Sarpis, G., Sarpis, M., Sarti, A., Satriano, C., Satta, A., Saur, M., Savrina, D., Sazak, H., Smead, L. G. Scantlebury, Scarabotto, A., Schael, S., Scherl, S., Schiller, M., Schindler, H., Schmelling, M., Schmidt, B., Schmitt, S., Schneider, O., Schopper, A., Schubiger, M., Schulte, S., Schune, M. H., Schwemmer, R., Sciascia, B., Sellam, S., Semennikov, A., Soares, M. Senghi, Sergi, A., Serra, N., Sestini, L., Seuthe, A., Shang, Y., Shangase, D. M., Shapkin, M., Shchemerov, I., Shchutska, L., Shears, T., Shekhtman, L., Shen, Z., Sheng, S., Shevchenko, V., Shields, E. B., Shimizu, Y., Shmanin, E., Shupperd, J. D., Siddi, B. G., Coutinho, R. Silva, Simi, G., Simone, S., Skidmore, N., Skwarnicki, T., Slater, M. W., Slazyk, I., Smallwood, J. C., Smeaton, J. G., Smetkina, A., Smith, E., Smith, M., Snoch, A., Lavra, L. Soares, Sokoloff, M. D., Soler, F. J. P., Solovev, A., Solovyev, I., De Almeida, F. L. Souza, De Paula, B. Souza, Spaan, B., Norella, E. Spadaro, Spradlin, P., Stagni, F., Stahl, M., Stahl, S., Stanislaus, S., Steinkamp, O., Stenyakin, O., Stevens, H., Stone, S., Strekalina, D., Suljik, F., Sun, J., Sun, L., Sun, Y., Svihra, P., Swallow, P. N., Swientek, K., Szabelski, A., Szumlak, T., Szymanski, M., Taneja, S., Tanner, A. R., Tat, M. D., Terentev, A., Teubert, F., Thomas, E., Thompson, D. J. D., Thomson, K. A., Tilquin, H., Tisserand, V., T'Jampens, S., Tobin, M., Tomassetti, L., Tong, X., Machado, D. Torres, Tou, D. Y., Trifonova, E., Trilov, S. M., Trippl, C., Tuci, G., Tully, A., Tuning, N., Ukleja, A., Unverzagt, D. J., Ursov, E., Usachov, A., Ustyuzhanin, A., Uwer, U., Vagner, A., Vagnoni, V., Valassi, A., Valenti, G., Canudas, N. Valls, van Beuzekom, M., Van Dijk, M., Van Hecke, H., van Herwijnen, E., van Veghel, M., Gomez, R. Vazquez, Regueiro, P. Vazquez, Sierra, C. Vázquez, Vecchi, S., Velthuis, J. J., Veltri, M., Venkateswaran, A., Veronesi, M., Vesterinen, M., Vieira, D., Diaz, M. Vieites, Viemann, H., Vilasis-Cardona, X., Figueras, E. Vilella, Villa, A., Vincent, P., Volle, F. C., Bruch, D. Vom, Vorobyev, A., Vorobyev, V., Voropaev, N., Vos, K., Waldi, R., Walsh, J., Wang, C., Wang, J., Wang, M., Wang, R., Wang, Y., Wang, Z., Ward, J. A., Watson, N. K., Weber, S. G., Websdale, D., Weisser, C., Westhenry, B. D. C., White, D. J., Whitehead, M., Wiederhold, A. R., Wiedner, D., Wilkinson, G., Wilkinson, M., Williams, I., Williams, M., Williams, M. R. J., Wilson, F. F., Wislicki, W., Witek, M., Witola, L., Wormser, G., Wotton, S. A., Wu, H., Wyllie, K., Xiang, Z., Xiao, D., Xie, Y., Xu, A., Xu, J., Xu, L., Xu, M., Xu, Q., Xu, Z., Yang, D., Yang, S., Yang, Y., Yang, Z., Yao, Y., Yeomans, L. E., Yin, H., Yu, J., Yuan, X., Yushchenko, O., Zaffaroni, E., Zavertyaev, M., Zdybal, M., Zenaiev, O., Zeng, M., Zhang, D., Zhang, L., Zhang, S., Zhang, Y., Zharkova, A., Zhelezov, A., Zheng, Y., Zhou, T., Zhou, X., Zhou, Y., Zhovkovska, V., Zhu, X., Zhu, Z., Zhukov, V., Zonneveld, J. B., Zou, Q., Zucchelli, S., Zuliani, D., and Zunica, G.

Subjects
High Energy Physics - Experiment
Abstract

A precision measurement of the $Z$ boson production cross-section at $\sqrt{s} = 13$ TeV in the forward region is presented, using $pp$ collision data collected by the LHCb detector, corresponding to an integrated luminosity of 5.1 fb$^{-1}$. The production cross-section is measured using $Z\rightarrow\mu^+\mu^-$ events within the fiducial region defined as pseudorapidity $2.0<\eta<4.5$ and transverse momentum $p_{T}>20$ GeV/$c$ for both muons and dimuon invariant mass $60

Published
2021
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30. Spin dynamics in the skyrmion-host lacunar spinel GaV4S8

Author

Pokharel, G., Arachchige, H. Suriya, Gao, S., Do, S. -H., Fishman, R. S., Ehlers, G., Qiu, Y., Rodriguez-Rivera, J. A., Stone, M. B., Zhang, H., Wilson, S. D., Mandrus, D., and Christianson, A. D.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Other Condensed Matter
Abstract

In the lacunar spinel GaV4S8, the interplay of spin, charge, and orbital degrees of freedom produces a rich phase diagram that includes an unusual Neel-type skyrmion phase composed of molecular spins. To provide insight into the interactions underlying this complex phase diagram, we study the spin excitations in GaV4S8 through inelastic neutron scattering measurements on polycrystalline and single-crystal samples. Using linear spin-wave theory, we describe the spin-wave excitations using a model where V4 clusters decorate an FCC lattice. The effective cluster model includes a ferromagnetic interaction and a weaker antisymmetric Dzyaloshinskii-Moriya (DM) interaction between the neighboring molecular spins. Our work clarifies the spin interactions in GaV4S8 and supports the picture of interacting molecular clusters., Comment: 6 pages, 4 figures

Published
2021
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31. Shapes, Softness and Non-Yrast Collectivity in 186W

Author

Prasher, V. S., Mitchell, A. J., Lister, C. J., Chowdhury, P., Afanasieva, L., Albers, M., Chiara, C. J., Carpenter, M. P., Cline, D., D'Olympia, N., Guess, C. J., Hayes, A. B., Hoffman, C. R., Janssens, R. V. F., Kay, B. P., Khoo, T. L., Korichi, A., Lauritsen, T., Merchan, E., Qiu, Y., Seweryniak, D., Shearman, R., Tandel, S. K., Verras, A., Wu, C. Y., and Zhu, S.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Non-yrast, excited states in neutron-rich $^{186}$W were populated via inelastic-scattering reactions using beams of $^{136}$Xe nuclei accelerated to 725 and 800 MeV. Levels populated in the reactions were investigated via particle-$ \gamma $ coincidence techniques using the Gammasphere array of High-Purity Germanium detectors and the compact heavy-ion counter, CHICO2. The $ K^{\pi} = 2 ^{+} $ ($\gamma$), $ K^{\pi} = 0^{+}$ and $ K^{\pi} = 2^{-} $ (octupole) rotational side bands were extended to spins $ 14\hbar $, $ 12\hbar $, and $ 13\hbar $, respectively. A staggering pattern observed in the energies of levels in the $ K^{\pi} = 2^{+} $ band was found to be consistent with a potential that gets softer to vibration in the $ \gamma $ degree of freedom with increasing spin. The odd-even staggering of states in the $ K^{\pi} = 2^{-}$ band was found to exhibit a phase opposite to that seen in the $ \gamma $ band; an effect most probably associated with Coriolis coupling to other, unobserved octupole vibrational bands in $^{186}$W., Comment: 14 pages, 16 figures

Published
2021
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32. Non-magnetic ion site disorder effects on the quantum magnetism of a spin-1/2 equilateral triangular lattice antiferromagnet

Author

Huang, Q., Rawl, R., Xie, W. W., Chou, E. S., Zapf, V. S., Ding, X. X., Mauws, C., Wiebe, C. R., Feng, E. X., Cao, H. B., Tian, W., Ma, J., Qiu, Y., Butch, N., and Zhou, H. D.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

With the motivation to study how non-magnetic ion site disorder affects the quantum magnetism of Ba3CoSb2O9, a spin-1/2 equilateral triangular lattice antiferromagnet, we performed DC and AC susceptibility, specific heat, elastic and inelastic neutron scattering measurements on single crystalline samples of Ba2.87Sr0.13CoSb2O9 with Sr doping on non-magnetic Ba2+ ion sites. The results show that Ba2.87Sr0.13CoSb2O9 exhibits (i) a two-step magnetic transition at 2.7 K and 3.3 K, respectively; (ii) a possible canted 120-degree spin structure at zero field with reduced ordered moment as 1.24{\mu}B/Co; (iii) a series of spin state transitions for both H // ab-plane and H // c-axis. For H // ab-plane, the magnetization plateau feature related to the up-up-down phase is significantly suppressed; (iv) an inelastic neutron scattering spectrum with only one gapped mode at zero field, which splits to one gapless and one gapped mode at 9 T. All these features are distinctly different from those observed for the parent compound Ba3CoSb2O9, which demonstrates that the non-magnetic ion site disorder (the Sr doping) plays a complex role on the magnetic properties beyond the conventionally expected randomization of the exchange interactions. We propose the additional effects including the enhancement of quantum spin fluctuations and introduction of a possible spatial anisotropy through the local structural distortions., Comment: 10 pages, 10 figures

Published
2021
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33. Constrains on optical emission of FAST-detected FRB 20181130B with GWAC synchronized observations

Author

Xin, L. P., Li, H. L., Wang, J., Han, X. H., Qiu, Y. L., Cai, H. B., Niu, C. H., Lu, X. M., Liang, E. W., Dai, Z. G., Wang, X. G., Wang, X. Y., Huang, L., Wu, C., Li, G. W., Feng, Q. C., Deng, J. S., Sun, S. S., Yang, Y. G., and Wei, J. Y.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

Multi-wavelength simultaneous observations are essential to the constraints on the origin of fast radio bursts (FRBs). However, it is a significant observational challenge due to the nature of FRBs as transients with a radio millisecond duration, which occur randomly in the sky regardless of time and position. Here, we report the search for short-time fast optical bursts in the GWAC archived data associated with FRB 20181130B, which were detected by the Five Hundred Meter Spherical Radio Telescope (FAST) and recently reported. No new credible sources were detected in all single GWAC images with an exposure time of 10 s, including image with coverage of the expected arrival time in optical wavelength by taking the high dispersion measurements into account. Our results provide a limiting magnitude of 15.43$\pm0.04$ mag in R band, corresponding to a flux density of 1.66 Jy or 8.35 mag in AB system by assuming that the duration of the optical band is similar to that of the radio band of about 10 ms. This limiting magnitude makes the spectral index of $\alpha<0.367$ from optical to radio wavelength. The possible existence of longer duration optical emission was also investigated with an upper limits of 0.33 Jy (10.10 mag), 1.74 mJy (15.80 mag) and 0.16 mJy (18.39 mag) for the duration of 50 ms, 10 s and 6060 s, respectively. This undetected scenario could be partially attributed to the shallow detection capability, as well as the high inferred distance of FRB 20181130B and the low fluence in radio wavelength. The future detectability of optical flashes associated with nearby and bright FRBs are also discussed in this paper., Comment: Accepted by ApJ

Published
2021
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34. Resumption of Intravenous Anti-Cancer Therapy in Breast Cancer: A Real-World Experience During the SARS-CoV-2 Pandemic

Author

Yang F, Li C, Qiu Y, Chen X, Zheng K, Kang D, Zhang Y, Liu B, Yao Y, and Xie L

Subjects
covid-19 pandemic, sars-cov-2 infection, breast cancer, immune responses, anti-cancer therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Fang Yang,1,&ast; Cong Li,2,&ast; Yuling Qiu,1 Xinjie Chen,3 Kelin Zheng,4 Donglin Kang,5 Yin Zhang,2 Baorui Liu,1 Yongzhong Yao,2 Li Xie1 1The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, People’s Republic of China; 2Department of Breast Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China; 3The Comprehensive Cancer Center, China Pharmaceutical University Nanjing Drum Tower Hospital, Nanjing, People’s Republic of China; 4Department of the Comprehensive Cancer Center, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 5Department of the Comprehensive Cancer Center, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Li Xie, The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, People’s Republic of China, Email xieli@njglyy.com Yongzhong Yao, Department of Breast Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China, Tel/Fax +86-025-83106666, Email yyz1006@hotmail.comPurpose: The coronavirus disease-2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has delayed medical consultations, especially for patients receiving intravenous anti-cancer therapy. We aim to investigate alterations in immune function among breast cancer patients who experience delayed intravenous therapy due to SARS-CoV-2 infection.Patients and Methods: We performed an observational investigation of breast cancer patients in Nanjing Drum Tower Hospital from December 27, 2022, to January 20, 2023. Patients who recovered from SARS-CoV-2 infection were eligible for enrollment. Peripheral blood samples were taken prior to the restart of intravenous anti-cancer therapy to examine hematologic parameters.Results: A total of 131 patients were included in the final analysis. Cough (74.0%), fever (62.6%), and expectoration (46.6%) were identified as the most presenting symptoms of SARS-CoV-2 infection in breast cancer. The average nucleic acid conversion time and delayed treatment time was 13.4 days and 13.9 days, respectively. The patients > 60 years old experienced prolonged nucleic acid conversion time (P = 0.017) and delayed treatment time (P = 0.028) compared to those

Published
2024

35. Fatalism as a Mediator of the Association Between Family Resilience and Self-Management Among Patients with Chronic Wounds in China

Author

Qiu Y, Fan S, Fu Q, Yang M, and Zhu L

Subjects
chronic wounds, fatalism, family resilience, self-management, mediation, Medicine (General), R5-920
Abstract

Yuhuan Qiu,1,2 Shujun Fan,1 Qiuyan Fu,1 Minlie Yang,2 Lihong Zhu2 1Wuxi School of Medicine, Jiangnan University, Wuxi, People’s Republic of China; 2Department of Burn and Plastic Surgery, Affiliated Hospital of Jiangnan University, Wuxi, People’s Republic of ChinaCorrespondence: Minlie Yang, Department of Burn and Plastic Surgery, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi, 214122, People’s Republic of China, Email jndxfsyyyml@163.comPurpose: The purpose of this study was to examine how fatalism acts as a mediator in the correlation between family resilience and self-management among patients with chronic wounds in China.Participants and Methods: This study used a cross-sectional research design. A total of 269 adult patients (18– 94 years old) with chronic wounds residing in Wuxi, China participated in this study. Participants completed the Chinese version of the Walsh Family Resilience Questionnaire, 16-item Chinese version of the Fatalism Scale, and Self-Management Scale of Chronic Wound Patients. We conducted correlation and mediation analyses using SPSS 27.0 and PROCESS 4.0.Results: The results indicated family resilience was a significant positive predictor of self-management (β = 0.7101, p < 0.0001), and the pathway between family resilience and self-management was partially mediated by fatalism (Effect = 0.1432, 95% confidence interval [0.0625, 0.2341]).Conclusion: The results indicated that incorporating spiritual interventions into future person-centered self-management programs could align with the motivation of patients with chronic wounds and their families, and reduce the negative impact of fatalism on health outcomes.Keywords: chronic wounds, fatalism, family resilience, self-management, mediation

Published
2024

36. Serum ACTH and Cortisol Level is Associated with the Acute Gastrointestinal Injury Grade in ICU Patients

Author

Xu W, Qiu Y, Qiu H, Zhong M, and Li L

Subjects
acute gastrointestinal injury, cortisol, adrenocorticotropic hormone, Medicine (General), R5-920
Abstract

Wen Xu,&ast; Yuzhen Qiu,&ast; Hongping Qiu, Ming Zhong, Lei Li Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lei Li; Ming Zhong, Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China, Email ll11354@rjh.com.cn; zm11716@rjh.com.cnBackground: The relationship between acute gastrointestinal symptoms and cortisol or adrenocorticotropic hormone (ACTH) levels has rarely been reported. We hypothesized that the elevation of serum cortisol or ACTH levels may be correlated with the severity of the acute gastrointestinal injury grade (AGI).Methods: This study was an observational study. All patients were admitted to the ICU between 2019.1.1 and 2020.1.1.. Serum ACTH and cortisol levels and clinical data were collected from the electronic medication records. The highest AGI grade during the ICU stay was the major endpoint to observe. The patient was treated in a standard procedure in the ICU.Results: A total of 235 patients were included in our study, 132 of whom developed AGI. In univariate regression, cortisol level was found to be a risk factor for 28-day mortality. Serum cortisol and ACTH levels correlated with APACHE II, AGI grade, PCT, and CRP levels. Spearman analysis and partial correlation analysis indicated that cortisol and ACTH levels were correlated with AGI grade.Conclusion: The ACTH and cortisol levels were positively correlated with the higher severity of AGI grade. The cortisol level may be a useful way to access the GI injury.Keywords: acute gastrointestinal injury, cortisol, adrenocorticotropic hormone

Published
2024

37. Mucus-Permeable Sonodynamic Therapy Mediated Amphotericin B-Loaded PEGylated PLGA Nanoparticles Enable Eradication of Candida albicans Biofilm

Author

Yang M, Xie M, Guo J, Zhang Y, Qiu Y, Wang Z, and Du Y

Subjects
c. albicans biofilm, pegylated nanoparticles, mucus penetration, sonodynamic therapy, Medicine (General), R5-920
Abstract

Min Yang,1,2 Mengyao Xie,1,2 Jiajun Guo,1,2 Yuqing Zhang,1,2 Yan Qiu,1,2 Zhibiao Wang,1,2 Yonghong Du1,2 1State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People’s Republic of ChinaCorrespondence: Zhibiao Wang; Yonghong Du, State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, People’s Republic of China, Tel/Fax +86-23-68485000 ; +86-23-68485021, Email wangzb@cqmu.edu.cn; duyonghong@cqmu.edu.cnBackground: Candida albicans (C. albicans) forms pathogenic biofilms, and the dense mucus layer secreted by the epithelium is a major barrier to the traditional antibiotic treatment of mucosa-associated C. albicans infections. Herein, we report a novel anti-biofilm strategy of mucus-permeable sonodynamic therapy (mp-SDT) based on ultrasound (US)-mediated amphotericin B-loaded PEGylated PLGA nanoparticles (AmB-NPs) to overcome mucus barrier and enable the eradication of C. albicans biofilm.Methods: AmB-NPs were fabricated using ultrasonic double emulsion method, and their physicochemical and sonodynamic properties were determined. The mucus and biofilm permeability of US-mediated AmB-NPs were further investigated. Moreover, the anti-biofilm effect of US-mediated AmB-NPs treatment was thoroughly evaluated on mucus barrier abiotic biofilm, epithelium-associated biotic biofilm, and C. albicans-induced rabbit vaginal biofilms model. In addition, the ultrastructure and secreted cytokines of epithelial cells and the polarization of macrophages were analyzed to investigate the regulation of local cellular immune function by US-mediated AmB-NPs treatment.Results: Polymeric AmB-NPs display excellent sonodynamic performance with massive singlet oxygen (1O2) generation. US-mediated AmB-NPs could rapidly transport through mucus and promote permeability in biofilms, which exhibited excellent eradicating ability to C. albicans biofilms. Furthermore, in the vaginal epithelial cells (VECs)-associated C. albicans biofilm model, the mp-SDT scheme showed the strongest biofilm eradication effect, with up to 98% biofilm re-formation inhibition rate, improved the ultrastructural damage, promoted local immune defense enhancement of VECs, and regulated the polarization of macrophages to the M1 phenotype to enhance macrophage-associated antifungal immune responses. In addition, mp-SDT treatment exhibited excellent therapeutic efficacy against C. albicans-induced rabbit vaginitis, promoted the recovery of mucosal epithelial ultrastructure, and contributed to the reshaping of a healthier vaginal microbiome.Conclusion: The synergistic anti-biofilm strategies of mp-SDT effectively eradicated C. albicans biofilm and simultaneously regulated local antifungal immunity enhancement, which may provide a new approach to treat refractory drug-resistant biofilm-associated mucosal candidiasis.Keywords: C. albicans biofilm, PEGylated nanoparticles, mucus penetration, sonodynamic therapy

Published
2023

39. TRL analysis of IFMIF-DONES

Author

Brañas, B., Maestre, J., Bernardi, D., Ibarra, A., Arbeiter, F., Arena, P., Arranz, F., Becerril, S., Cappelli, M., Chel, S., Castellanos, J., Favuzza, P., Jiménez-Rey, D., Krolas, W., Martin-Fuertes, F., Micciché, G., Nitti, F.S., Podadera, I., Qiu, Y., Regidor, D., Renard, B., Tadic, T., Varela, R., and Weber, M.

Published
2024
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40. High-energy magnetic excitations from heavy quasiparticles in CeCu2Si2

Author

Song, Y, Wang, W, Cao, C, Yamani, Z, Xu, Y, Sheng, Y, Löser, W, Qiu, Y, Yang, YF, Birgeneau, RJ, and Dai, P

Subjects
cond-mat.str-el, cond-mat.supr-con
Abstract

Magnetic fluctuations is the leading candidate for pairing in cuprate, iron-based, and heavy fermion superconductors. This view is challenged by the recent discovery of nodeless superconductivity in CeCu2Si2, and calls for a detailed understanding of the corresponding magnetic fluctuations. Here, we mapped out the magnetic excitations in superconducting (S-type) CeCu2Si2 using inelastic neutron scattering, finding a strongly asymmetric dispersion for E ≲ 1.5 meV, which at higher energies evolves into broad columnar magnetic excitations that extend to E ≳ 5 meV. While low-energy magnetic excitations exhibit marked three-dimensional characteristics, the high-energy magnetic excitations in CeCu2Si2 are almost two-dimensional, reminiscent of paramagnons found in cuprate and iron-based superconductors. By comparing our experimental findings with calculations in the random-phase approximation,we find that the magnetic excitations in CeCu2Si2 arise from quasiparticles associated with its heavy electron band, which are also responsible for superconductivity. Our results provide a basis for understanding magnetism and superconductivity in CeCu2Si2, and demonstrate the utility of neutron scattering in probing band renormalization in heavy fermion metals.

Published
2021

41. Overview of recent advancements in IFMIF-DONES neutronics activities

Author

Qiu, Y., Ansorge, M., Álvarez, I., Ambrožič, K., Berry, T., Bieńkowska, B., Chohan, H., Čufar, A., Dworak, D., Dezsi, T., Eade, T., García, J., Jimenez-Rey, D., Lengar, I., Lopez-Revelles, A.J., Lopez, V., Mendoza, E., Mota, F., Martinez-Echevarria, M.J., Ogando, F., Park, J., Piotrowski, T., Serikov, A., Stankunas, G., Tidikas, A., Tracz, G., Žerovnik, G., Arbeiter, F., Arranz, F., Becerril, S., Cara, P., Bernardi, D., Castellanos, J., Gutiérrez, J., Ibarra, A., Królas, W., Maestre, J., Martín-Fuertes, F., Marugán, J.C., Micciché, G., Martínez-Serrano, J., Nitti, F.S., Podadera, I., Wiącek, U., and Fischer, U.

Published
2024
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44. FENDL: A library for fusion research and applications

Author

Schnabel, G., Aldama, D.L., Bohm, T., Fischer, U., Kunieda, S., Trkov, A., Konno, C., Capote, R., Koning, A.J., Breidokaite, S., Eade, T., Fabbri, M., Flammini, D., Isolan, L., Kodeli, I., Košťál, M., Kwon, S., Laghi, D., Leichtle, D., Nakayama, S., Ohta, M., Packer, L.W., Qiu, Y., Sato, S., Sawan, M., Schulc, M., Stankunas, G., Sumini, M., Valentine, A., Villari, R., and Žohar, A.

Published
2024
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45. Mucus-Permeable Sonodynamic Therapy Mediated Amphotericin B-Loaded PEGylated PLGA Nanoparticles Enable Eradication of Candida Albicans Biofilm [Retraction]

Author

Yang M, Xie M, Guo J, Zhang Y, Qiu Y, Wang Z, and Du Y

Subjects
c. albicans biofilm, pegylated nanoparticles, mucus penetration, sonodynamic therapy, Medicine (General), R5-920
Abstract

Yang M, Xie M, Guo J, et al. Int J Nanomedicine. 2023;18:7941-7963. We, the Editor and Publisher of the journal International Journal of Nanomedicine are retracting the published article. Following publication of the article, the authors raised concerns about the duplication of images from Figures 2, 6, 9, 11 and 12. Specifically, The image for Figure 2A, SEM image of AmB-NPs, has been duplicated with the image for Figure 3B, SEM image of BM2-LVFX-NPs, from Li G, Li J, Hou Y, et al. Levofloxacin-Loaded Nanosonosensitizer as a Highly Efficient Therapy for Bacillus Calmette-Guérin Infections Based on Bacteria-Specific Labeling and Sonotheranostic Strategy. Int J Nanomedicine. 2021;16:6553-6573. https://doi.org/10.2147/IJN.S321631. Images for Figure 6C, AmB-NPs and US+AmB have been duplicated but show a different colour intensity. Images for Figure 9C, Control and US, have been duplicated. Images for Figure 11C, C. albicans CD86, AmB and IL-4 CD206, AmB-NPs, have been duplicated. Images for Figure 11C, C. albicans CD86, US+AmB-NPs and IL-4 CD206, US, have been duplicated but show a different immunofluorescene staining intensity. Images for Figure 12C, AmB and US+AmB, have been duplicated but one of the images has been flipped. Images for Figure 12D, US+AmB and US+AmB-NPs, have been duplicated. The authors were cooperative and responded to our queries but were unable to provide a satisfactory explanation for the duplicated images but did provide some original data for the study. However, as verifying the validity of published work is core to the integrity of the scholarly record, the Publisher and Editor requested to retract the article and the authors agree with this. We have been informed in our decision-making by our editorial policies and COPE guidelines. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.

Published
2024

46. Inelastic neutron scattering determination of the spin Hamiltonian for BaCdVO(PO$_4$)$_2$

Author

Bhartiya, V. K., Hayashida, S., Povarov, K. Yu., Yan, Z., Qiu, Y., Raymond, S., and Zheludev, A.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Single crystal inelastic neutron scattering is used to study spin wave excitations in the fully polarized state of the frustrated quantum ferro-antiferromagnet BaCdVO(PO$_4$)$_2$. The data analysis is based on a Heisenberg spin Hamiltonian that includes as many distinct nearest-neighbor and next-nearest neighbor interactions as allowed by crystal symmetry. All 8 such exchange constants are obtained in a simultaneous fit to over 150 scans across the dispersion manifold. This establishes a definitive quantitative model of this material. It turns out to be substantially different from the one assumed in numerous previous studies based on powder experiments., Comment: Minor updates in the main text and improved title

Published
2021
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47. A $\Delta R\sim 9.5$ mag Super Flare of An Ultracool Star Detected by $\text{SVOM/GWAC}$ System

Author

Xin, L. P., Li, H. L., Wang, J., Han, X. H., Xu, Y., Meng, X. M., Cai, H. B., Huang, L., Lu, X. M., Qiu, Y. L., Wang, X. G., Liang, E. W., Dai, Z. G., Wang, X. Y., Wu, C., Zhang, J. B., Li, G. W., Turpin, D., Feng, Q. C., Deng, J. S., Sun, S. S., Zheng, T. C., Yang, Y. G., and Wei, J. Y.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

In this paper, we report the detection and follow-ups of a super stellar flare GWAC\,181229A with an amplitude of $\Delta R\sim$9.5 mag on a M9 type star by $\text{SVOM/GWAC}$ and the dedicated follow-up telescopes. The estimated bolometric energy $E_{bol}$ is $(5.56-9.25)\times10^{34}$ ergs, which places the event to be one of the most powerful flares on ultracool stars. The magnetic strength is inferred to be (3.6-4.7) kG. Thanks to the sampling with a cadence of 15 seconds, a new component near the peak time with a very steep decay is detected in the $R$-band light curve, followed by the two-component flare template given by Davenport et al. (2014). An effective temperature of $5340\pm40$ K is measured by a blackbody shape fitting to the spectrum at the shallower phase during the flare. The filling factors of the flare are estimated to be $\sim$30\% and 19\% at the peak time and at 54 min after the first detection. The detection of the particular event with large amplitude, huge-emitted energy and a new component demonstrates that a high cadence sky monitoring cooperating with fast follow-up observations is very essential for understanding the violent magnetic activity., Comment: 14 pages, 12 figures, 4 tables, accepted by ApJ

Published
2020
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48. Field-induced magnetic phase transitions and the resultant giant anomalous Hall effect in antiferromagnetic half-Heusler DyPtBi

Author

Zhang, H., Zhu, Y. L., Qiu, Y., Tian, W., Cao, H. B., Mao, Z. Q., and Ke, X.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

We report field-induced magnetic phase transitions and transport properties of antiferromagnetic DyPtBi. We show that DyPtBi hosts a delicate balance between two different magnetic ground states, which can be controlled by a moderate magnetic field. Furthermore, it exhibits giant anomalous Hall effect (\sigma_A=1540 (ohm cm)^{-1},\theta_{AHE} = 24%) in a field-induced Type-I spin structure, presumably attributed to the enhanced Berry curvature associated with avoided band-crossings near the Fermi energy and / or non-zero spin chirality. The latter mechanism points DyPtBi towards a rare potential realization of anomalous Hall effect in an antiferromagnet with face-center-cubic lattice that was proposed in [Physical Review Letters 87, 116801 (2001)]., Comment: Accepted by Phys. Rev. B

Published
2020
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49. Pristine quantum criticality in a Kondo semimetal

Author

Fuhrman, W. T., Sidorenko, A., Hänel, J., Winkler, H., Prokofiev, A., Rodriguez-Rivera, J. A., Qiu, Y., Blaha, P., Si, Q., Broholm, C. L., and Paschen, S.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

The observation of quantum criticality in diverse classes of strongly correlated electron systems has been instrumental in establishing ordering principles, discovering new phases, and identifying the relevant degrees of freedom and interactions. At focus so far have been insulators and metals. Semimetals, which are of great current interest as candidate phases with nontrivial topology, are much less explored in experiments. Here we study the Kondo semimetal CeRu$_4$Sn$_6$ by magnetic susceptibility, specific heat, and inelastic neutron scattering experiments. The power-law divergence of the magnetic Gr\"unesien ratio reveals that, surprisingly, this compound is quantum critical without tuning. The dynamical energy over temperature scaling in the neutron response, seen throughout the Brillouin zone, as well as the temperature dependence of the static uniform susceptibility indicate that temperature is the only energy scale in the criticality. Such behavior, which has been associated with Kondo destruction quantum criticality in metallic systems, may well be generic in the semimetal setting., Comment: 16 pages (preprint format), 4 figures; Sci. Adv. 7 (2021) eabf9134

Published
2020
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50. Unconventional free charge in the correlated semimetal Nd2Ir2O7

Author

Wang, K., Xu, B., Rischau, C. W., Bachar, N., Michon, B., Teyssier, J., Qiu, Y., Ohtsuki, T., Cheng, Bing, Armitage, N. P., Nakatsuji, S., and van der Marel, D.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

Nd2Ir2O7 is a correlated semimetal with the pyrochlore structure, in which competing spin-orbit coupling and electron-electron interactions are believed to induce a time-reversal symmetry broken Weyl semimetal phase characterized by pairs of topologically protected Dirac points at the Fermi energy. However, the emergent properties in these materials are far from clear, and exotic new states of matter have been conjectured. Here we demonstrate optically that at low temperatures the free carrier spectral weight is proportional to T^2 where T is the temperature, as expected for massless Dirac electrons. However, we do {\em not} observe the corresponding T^3 term in the specific heat. That the system is not in a Fermi liquid state is further corroborated by the "Planckian" T-linear temperature dependence of the momentum relaxation rate and the progressive opening of a correlation-induced gap at low temperatures. These observations can not be reconciled within the framework of band theory of electron-like quasiparticles and point toward the effective decoupling of the charge transport from the single particle sector., Comment: 7 pages, 5 figures

Published
2020
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