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1. The Effects of Ligustrazine on the Expression of Bax Protein and Cytochrome C Following Focal Cerebral Ischemia/Reperfusion Injury in Rats

Author

Qiu Zhen Zhao, Hua Liu, and Hua Guang Li

Subjects
biology, Chemistry, Cytochrome c, General Engineering, Ischemia, In situ hybridization, Pharmacology, medicine.disease, Blot, medicine.anatomical_structure, nervous system, Biochemistry, medicine, Nucleic acid, biology.protein, Hippocampus (mythology), Neuron, Reperfusion injury
Abstract

AIMS: To explore gene expressions of Bax and changes of cytC releasing in the CIR hippocampus neuron; to observe the effect on CIR with ligustrazine. METHODS: According to Bannisters, we made ischemia and reperfusion models of rat, and then using ligustrazine to cure; we observed the expression changes of Bax gene in hippocampus neurons by nucleic acid in situ hybridization, detecting cytC release through Western blotting. RESULTS: Ligustrazine protect neuron by reducing neuronal apoptosis induced by CIR, and inhibiting release of cytc by releasing.

Published
2013

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