1. Effectiveness of Vitamin C Solution in Reducing Adverse Reactions Caused by Painless Lugol Chromoendoscopy
- Author
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Airui Jiang, Xin Yang, Yuanyuan Zhou, Jian-Jun Li, Qiu-Jian Qiao, Liming Wen, Hui Lin, Dingrong Chen, Liangbi Xu, Shi-Ming Yang, Lu Liu, Haiyan Zhao, Yiyang He, Liang Wang, Yong Gao, Zhongrong Wang, Chaoqiang Fan, Jianwei Ding, Chunmei Ren, En Liu, Xi Liu, Xubiao Nie, Jianying Bai, Zhen Yang, Jing Yu, Ying Zuo, and Xue Peng
- Subjects
medicine.medical_specialty ,Esophageal Neoplasms ,Ascorbic Acid ,Sodium thiosulfate ,medicine.disease_cause ,Gastroenterology ,law.invention ,Chromoendoscopy ,chemistry.chemical_compound ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,Coloring Agents ,Vitamin C ,business.industry ,Incidence (epidemiology) ,Heartburn ,Iodides ,Staining ,chemistry ,Esophageal Squamous Cell Carcinoma ,Esophagoscopy ,Irritation ,medicine.symptom ,business ,Iodine - Abstract
GOAL: The purpose of this study was to evaluate the effectiveness of vitamin C solution (VCS) in reducing adverse reactions caused by painless Lugol chromoendoscopy. BACKGROUND: Lugol chromoendoscopy is an effective method for screening superficial esophageal squamous cell carcinoma, although Lugol iodine solution (LIS) causes mucosal irritation. STUDY: In 4 hospitals in China, patients were randomized and divided into a distilled water (DW) group, an sodium thiosulfate solution (STS) group and a VCS group. Patients' esophageal mucosal surfaces were stained with either 1.2% or 0.5% LIS and then sprayed with DW, STS, or VCS at various concentrations. For the current randomized study, 1610 patients were enrolled in the 1.2% LIS group and 1355 patients were enrolled in the 0.5% LIS group. In addition, 150 patients were enrolled to assess the discoloration effect. The primary outcome for evaluation was the incidence of acute or late adverse reactions after Lugol iodine staining. The secondary outcome for evaluation was the discoloration effect on esophageal iodine-stained mucosa. RESULTS: VCS significantly reduced the occurrence of acute adverse reactions due to staining from 1.2% LIS. The effect of VCS was similar to that of STS but better than that of DW (P
- Published
- 2021