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3. Anti-pulmonary fibrosis activity analysis of methyl rosmarinate obtained from Salvia castanea Diels f. tomentosa Stib. using a scalable process

Author

Ma, Li, primary, Liu, Chuntong, additional, Zhao, Yuxiang, additional, Liu, Mengke, additional, Liu, Yunyi, additional, Zhang, Huachang, additional, Yang, Shude, additional, An, Jing, additional, Tian, Yuheng, additional, Cao, Yinchuan, additional, Qu, Guiwu, additional, Song, Shuling, additional, and Cao, Qizhi, additional

Published
2024
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12. Additional file 1 of Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway

Author

Li, Dongze, Xu, Na, Hou, Yanyan, Ren, Wenjing, Zhang, Na, Wang, Xi, Sun, Yeying, Lu, Wenxue, Qu, Guiwu, Yu, Yan, Lv, Changjun, and Han, Fang

Abstract

Additional file 1: S1. CIH treatment did not significant influence the expression of PDP1/PDHA1 in vitro. (A, B) The IH program and the sequence of experiment process. (C) BODIPY (green) and DAPI (blue) staining of the HT22. Magnification:600��. (D-F) The number of LDs per cell. Compared with the NC group, the number of LDs in the IH group were obviously increased. However, treated with 3-FP could not reduce the number of LDs. (G, H) Quantitative real-time PCR experiments showed the expression levels of PDP1 and PDHA1 in Ht22 cells. The results showed no statistically difference among four groups. (I-L) The PDP1/PDHA1 pathway was activated by Western blot, and no statistically difference among four groups. (M) The activity of PDC and no significant difference could be found. All experiments were repeated three times. Data are expressed as the mean �� SEM. Statistical analysis was performed through two-way ANOVA. The treated samples were different from the controls at p < 0.05.

Published
2022
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14. Acetyl oxygen benzoate engeletin ester promotes KLF4 degradation leading to the attenuation of pulmonary fibrosis via inhibiting TGFβ1–smad/p38MAPK–lnc865/lnc556–miR-29b-2-5p–STAT3 signal pathway

Author

Shen, Ke, primary, Li, Ruiqiong, additional, Zhang, Xiaoli, additional, Qu, Guiwu, additional, Li, Rongrong, additional, Wang, Youlei, additional, Liu, Bo, additional, Lv, Changjun, additional, Li, Minge, additional, and Song, Xiaodong, additional

Published
2021
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21. Five ETS family members, ELF-1, ETV-4, ETV-3L, ETS-1, and ETS-2 upregulate human leukocyte-associated immunoglobulin-like receptor-1 gene basic promoter activity

Author

Cao, Qizhi, primary, Yang, Shude, additional, Lv, Qing, additional, Liu, Yan, additional, Li, Li, additional, Wu, Xiaojie, additional, Qu, Guiwu, additional, He, Xiaoli, additional, Zhang, Xiaoshu, additional, Sun, Shuqin, additional, Li, Boqing, additional, An, Jing, additional, Hu, Tao, additional, and Xue, Jiangnan, additional

Published
2018
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25. Anti-pulmonary fibrosis activity analysis of methyl rosmarinate obtained from Salvia castan ea Diels f. tomentosa Stib. using a scalable process.

Author

Ma L, Liu C, Zhao Y, Liu M, Liu Y, Zhang H, Yang S, An J, Tian Y, Cao Y, Qu G, Song S, and Cao Q

Abstract

Pulmonary fibrosis is a progressive, irreversible, chronic interstitial lung disease associated with high morbidity and mortality rates. Current clinical drugs, while effective, do not reverse or cure pulmonary fibrosis and have major side effects, there are urgent needs to develop new anti-pulmonary fibrosis medicine, and corresponding industrially scalable process as well. Salvia castanea Diels f. tomentosa Stib., a unique herb in Nyingchi, Xizang, China, is a variant of S. castanea . and its main active ingredient is rosmarinic acid (RA), which can be used to prepare methyl rosmarinate (MR) with greater drug potential. This study presented an industrially scalable process for the preparation of MR, which includes steps such as polyamide resin chromatography, crystallization and esterification, using S. castanea Diels f. tomentosa Stib. as the starting material and the structure of the product was verified by NMR technology. The anti-pulmonary fibrosis effects of MR were further investigated in vivo and in vitro . Results showed that this process can easily obtain high-purity RA and MR, and MR attenuated bleomycin-induced pulmonary fibrosis in mice. In vitro , MR could effectively inhibit TGF-β1-induced proliferation and migration of mouse fibroblasts L929 cells, promote cell apoptosis, and decrease extracellular matrix accumulation thereby suppressing progressive pulmonary fibrosis. The anti-fibrosis effect of MR was stronger than that of the prodrug RA. Further study confirmed that MR could retard pulmonary fibrosis by down-regulating the phosphorylation of the TGF-β1/Smad and MAPK signaling pathways. These results suggest that MR has potential therapeutic implications for pulmonary fibrosis, and the establishment of this scalable preparation technology ensures the development of MR as a new anti-pulmonary fibrosis medicine., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Ma, Liu, Zhao, Liu, Liu, Zhang, Yang, An, Tian, Cao, Qu, Song and Cao.)

Published
2024
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26. [Chemical constituents contained in Salvia castanea].

Author

Qu G, Yue X, An F, Dai S, Li G, and Li B

Subjects
Chromatography methods, Medicine, Chinese Traditional, Drugs, Chinese Herbal chemistry, Salvia chemistry
Abstract

Objective: To investigate chemical constituents contained in Salvia castanea., Method: The compounds were separated and purified by silica gel, macroporous resin, RP-C18 and Sephadex LH-20 column chromatography. The structures were identified on the basis of physicochemical property and spectral data., Result: Nineteen compounds were separated and identified as tanshinone II(A) (1) , tanshinone II(B) (2), hydroxytanshinone II(A) (3), tanshinone I(4), dihydrotanshinone I(5), cryptotanshinone (6) , neotanshinone A(7) , neotanshinone B(8) , tanshinoldehyde(9), przewaquinone A(10), przewaquinone B(11), sugiol(12), caffeic acid(13), rosmarinci acid(14), ethylrosmarinate(15), lithospermic acid(16), pro-lithospermic acid ( 17) , protocatechualdehyde (18), and danshensu(19)., Conclusion: Compounds 2, 3, 7-13 and 15-19 were separated from S. castanea for the first time.

Published
2012

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