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6. Characterization of Nanomaterials

Author

Mudalige, Thilak, primary, Qu, Haiou, additional, Van Haute, Desiree, additional, Ansar, Siyam M., additional, Paredes, Angel, additional, and Ingle, Taylor, additional

Published
2019
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7. Contributors

Author

Ansar, Siyam M., primary, Artiga-Artigas, María, additional, Aschberger, Karin, additional, Assadpour, Elham, additional, Brown, David M., additional, Catalá, Ramón, additional, Cerisuelo, Josep Pasqual, additional, Correia, Manuel, additional, Di Giorgio, Luciana, additional, Domínguez, Irene, additional, Fabra, M.J., additional, Gavara, Rafael, additional, Gómez-Mascaraque, Laura G., additional, Gottardo, Stefania, additional, Hernández-Muñoz, Pilar, additional, Ho, K.C., additional, Hoekstra, Eddo, additional, Ingle, Taylor, additional, Jafari, Seid Mahdi, additional, Kermanizadeh, Ali, additional, Knijnenburg, Jesper T.N., additional, Loeschner, Katrin, additional, López Rubio, Amparo, additional, López-Carballo, Gracia, additional, Martín-Belloso, Olga, additional, Martínez Sanz, M., additional, Mauri, Adriana N., additional, Mohammad, A.W., additional, Møller, Peter, additional, Mudalige, Thilak, additional, Musso, Yanina S., additional, Neethirajan, Suresh, additional, Odriozola-Serrano, Isabel, additional, Oms-Oliu, Gemma, additional, Paredes, Angel, additional, Peters, Ruud, additional, Posavec, Lidija, additional, Qu, Haiou, additional, Ragavan, K.V., additional, Raghavarao, K.S.M.S., additional, Rasmussen, Kirsten, additional, Rauscher, Hubert, additional, Rosnan, N.A., additional, Salgado, Pablo R., additional, Schoonjans, Reinhilde, additional, Sharma, Richa, additional, Teleki, Alexandra, additional, Teow, Y.H., additional, Van Haute, Desiree, additional, and Verleysen, Eveline, additional

Published
2019
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18. Polyethylene Oxide Molecular Size Determines the Severity of Atypical Thrombotic Microangiopathy in a Guinea Pig Model of Acute Intravenous Exposure

Author

Baek, Jin Hyen, primary, Shin, Hye Kyung H, additional, Koo, Soo Min, additional, Gao, Yamei, additional, Qu, Haiou, additional, Feng, Xin, additional, Xu, Xiaoming, additional, Pinto, Julia, additional, Katneni, Upendra, additional, Kimchi-Sarfaty, Chava, additional, and Buehler, Paul W, additional

Published
2020
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19. STOML2 as a novel prognostic biomarker modulates cell proliferation, motility and chemo-sensitivity via IL6-Stat3 pathway in head and neck squamous cell carcinoma

Author

Qu, Haiou, Jiang, Weifeng, Wang, Yongxu, and Chen, Peng

Subjects
stomatognathic diseases, stomatognathic system, Original Article
Abstract

STOML2 (Stomatin-like protein 2) is up-regulated and acts as an oncogenic protein in multiple cancers. However, the role and regulatory mechanism of STOML2 in head and neck squamous cell carcinoma remain unclear. Here, we found that STOML2 is overexpressed and indicates poor outcomes in HNSCC. In addition, the expression of STOML2 correlates positively with T stage, lymph node metastasis and recurrence. Reduced STOML2 dramatically inhibits cell proliferation, colony formation and motility of HNSCC cells in vitro. Furthermore, the sensitivity of HNSCC cells towards cisplatin is obviously improved in STOML2-silencing cells. Subsequent studies suggest that STOML2 could regulate the expression of IL6 transcriptionally and then further induce the phosphorylation of Tyr705 residue of Stat3, whose activation plays a critical role in HNSCC. Taken together, these results for the first time demonstrate that STOML2 promotes HNSCC progression through activating IL6-Stat3 pathway and provide a promise for diagnosis and treatment for HNSCC.

Published
2019

21. Analytical considerations for measuring the globule size distribution of cyclosporine ophthalmic emulsions

Author

Petrochenko, Peter E., primary, Pavurala, Naresh, additional, Wu, Yong, additional, Yee Wong, Sook, additional, Parhiz, Hamideh, additional, Chen, Kang, additional, Patil, Sharadrao M., additional, Qu, Haiou, additional, Buoniconti, Patrick, additional, Muhammad, Absar, additional, Choi, Stephanie, additional, Kozak, Darby, additional, Ashraf, Muhammad, additional, Cruz, Celia N., additional, Zheng, Jiwen, additional, and Xu, Xiaoming, additional

Published
2018
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41. Surface Functionalized Water-Dispersible Magnetite Nanoparticles: Preparation, Characterization and the Studies of Their Bioapplications

Author

Qu, Haiou

Subjects
Iron oxide magnetic nanoparticles, Water-dispersible, One-pot synthesis, Surface functionalization, Drug delivery, Bioseparation, Inorganic Chemistry, Materials Chemistry
Abstract

Iron oxide magnetic nanoparticle synthesis and their surface functionalization hold a crucial position in the design and fabrication of functional materials for a variety of biomedical applications. Non-uniform nanoparticles with poor crystallinity, prepared by conventional methods, have only limited value in biological areas. Large scale synthesis methods that are able to produce high quality, mono-dispersed iron oxide nanoparticles using low cost and environment friendly chemicals are highly desirable. Following synthesis, appropriate surface functionalization is necessary to direct the dispersibility of nanoparticles in aqueous solution in order to provide them with acceptable colloidal stability against the ion strength and many biomolecules that nanoparticles may encounter under physiological conditions. Poorly stabilized nanoparticles that easily aggregate and form large size agglomerates would be quickly cleared by the liver and other organs and are not suitable for clinical purposes. Additionally, many interesting functionalities such as fluorescence, targeting and anti-cancer properties can be immobilized onto the surface of iron oxide magnetic nanoparticles during the surface functionalization process so as to build multifunctional platforms for disease diagnosis and treatment. Polyol method can be an effective way to prepare magnetite nanoparticles that are suitable for biological applications. In a polyol system, selected surface functionalities were introduced to the nanoparticle surface via a hot injection technique. The morphology, uniformity, crystallinity and magnetic properties were examined to understand the effect of different ligand molecules on the final product. Their surface chemistry, colloidal properties and surface reactivity were also studied to evaluate their practicability in different applications. A high efficiency in-situ method for the preparation of magnetite nanoparticles attached to silica nanospheres was also developed in a polyol system. This approach eliminates several time-consuming processing steps that are in the conventional fabrication route and directly produces water-stable magnetite-silica hybrid materials with surface availability for subsequent modifications. In addition to polyalcohol, the potential of polyamine in the preparation of water-soluble magnetite nanoparticles with amine surface functionalities was also evaluated. And it is suggested that polyamine acts as solvent, stabilizing agent and reducing agent simultaneously during the synthesis. The characterization of polyamine coated nanoparticles, their surface functionalization, and subsequent application for bioseparation and drug delivery were reported.

Published
2012

42. STOML2 as a novel prognostic biomarker modulates cell proliferation, motility and chemo-sensitivity via IL6-Stat3 pathway in head and neck squamous cell carcinoma.

Author

Qu H, Jiang W, Wang Y, and Chen P

Abstract

STOML2 (Stomatin-like protein 2) is up-regulated and acts as an oncogenic protein in multiple cancers. However, the role and regulatory mechanism of STOML2 in head and neck squamous cell carcinoma remain unclear. Here, we found that STOML2 is overexpressed and indicates poor outcomes in HNSCC. In addition, the expression of STOML2 correlates positively with T stage, lymph node metastasis and recurrence. Reduced STOML2 dramatically inhibits cell proliferation, colony formation and motility of HNSCC cells in vitro . Furthermore, the sensitivity of HNSCC cells towards cisplatin is obviously improved in STOML2-silencing cells. Subsequent studies suggest that STOML2 could regulate the expression of IL6 transcriptionally and then further induce the phosphorylation of Tyr705 residue of Stat3, whose activation plays a critical role in HNSCC. Taken together, these results for the first time demonstrate that STOML2 promotes HNSCC progression through activating IL6-Stat3 pathway and provide a promise for diagnosis and treatment for HNSCC., Competing Interests: None.

Published
2019

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