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The environmental toxicity caused by heavy metal ions is always taken seriously. Capacitive deionization (CDI), as an emerging and effective treatment method, is widely studied. Among them, the rational design and development of efficient electrodes based on high theoretical capacitance, high conductivity, and high stability have great prospects for CDI applications. In this study, a series of 2D titanium carbide oxide flakes (2D TCOs) are synthesized using a cation‐giving modulation strategy, and the interlayer spacing of materials is successfully controlled by confining cations (tetraalkylammonium hydroxides, TAAH) with different radii between layers. Interestingly, these TCOs exhibit widely varying electrochemical properties due to their different interlayer spacings. Among them, titanium carbide oxide flakes‐tetrapropylammonium hydroxide (TCOs‐TPAH) with the maximum interlayer spacing exhibits the best performance in sodium ion embedding and de‐embedding, with a capacity of 53.11 mg g−1. In addition, the capacitive removal efficiency of heavy metal ions (Fe3+, Cr3+, Cu2+, Cd2+, Co2+, Ni2+, and Pb2+) can reach over 97% within 2 h. This work presents a simple and creative strategy for the bottom‐up synthesis of oversized 2D nanomaterials, thus supporting the further development of high‐performance 2D materials in the fields of environmental and energy applications. [ABSTRACT FROM AUTHOR]

This article explores the metabolic heterogeneity of acute myeloid leukemia (AML) at the single-cell level. The study reveals that AML cells exhibit distinct metabolic features and that metabolic heterogeneity is correlated with cell differentiation and certain genetic alterations. The researchers also found that primitive cell types in both normal bone marrow and AML display higher metabolic heterogeneity. The findings highlight the importance of understanding metabolic heterogeneity for identifying drug-resistant subtypes of cells and improving therapeutic interventions for AML. [Extracted from the article]

Background: The purpose of this article was to report the feasibility and effectiveness of 3-stage Masquelet technique and 1-stage operation for different stages of foot and ankle tuberculosis (TB). Methods: Ten consecutive patients with foot and ankle TB were retrospectively analyzed between January 2014 and December 2018. Five patients were treated with the 3-stage Masquelet technique, including thorough debridement with vacuum sealing drainage, implantation of antibiotic cement spacer, and subsequent reconstruction. Five patients were treated with a 1-stage reconstruction. The American Orthopaedic Foot & Ankle Society (AOFAS) and visual analog scale (VAS) pain scores were recorded at the last follow-up. The follow-up was 30.3 ± 17.8 months. Results: No reactivation of TB was observed in any patients. For the 3-stage operation group, 1 patient developed a distal tibia fracture. The duration of anti-TB therapy was 12.0 ± 0.8 months. The AOFAS score increased from 39.5 ± 9.9 preoperatively to 75.3 ± 7.0 postoperatively (P <.05). The VAS pain score decreased from 6.3 ± 1.9 to 1.5 ± 1.3 (P <.05). For the 1-stage operation, 1 patient had wound necrosis. The duration of anti-TB therapy was 13.8 ± 1.1 months. The AOFAS score increased from 51.8 ± 15.0 to 81.8 ± 6.3 (P <.05). The VAS pain score decreased from 5.4 ± 1.1 to 1.0 ± 0.7 (P <.05). Conclusion: Three-stage operation was effective for foot and ankle TB with stage IV, sinus tracts or other infections, and 1-stage reconstruction was effective for early-stage TBs. Level of Evidence: Level IV, case series. [ABSTRACT FROM AUTHOR]

Alkaline HER, Atomic Charge Distribution, Interfacial Water Orientation, Single-Atom Site, Water Dissociation In their Research Article (e202300873), Emiliano Cortés et al. designed an atomically asymmetric local electric field using Ir-Ru dizygotic single-atom sites (IrRu DSACs) to optimize the dissociation process by tuning the H SB 2 sb O adsorption configuration and orientation. Keywords: Alkaline HER; Atomic Charge Distribution; Interfacial Water Orientation; Single-Atom Site; Water Dissociation EN Alkaline HER Atomic Charge Distribution Interfacial Water Orientation Single-Atom Site Water Dissociation 1 1 1 06/20/23 20230626 NES 230626 B Alkaline water electrolysis b is a promising technology for hydrogen production, but the slow water dissociation process limits the kinetics of the hydrogen evolution reaction (HER). [Extracted from the article]

Keywords: Alkaline HER; Atomic Charge Distribution; Interfacial Water Orientation; Single-Atom Site; Water Dissociation EN Alkaline HER Atomic Charge Distribution Interfacial Water Orientation Single-Atom Site Water Dissociation 1 1 1 06/20/23 20230626 NES 230626 B Alkaline water electrolysis b is a promising technology for hydrogen production, but the slow water dissociation process limits the kinetics of the hydrogen evolution reaction (HER). In their Research Article (e202300873), Emiliano Cortés and co-workers designed an atomically asymmetric local electric field using IrRu dizygotic single-atom sites (IrRu DSACs) to optimize the dissociation process by tuning the H SB 2 sb O adsorption configuration and orientation. Inside Back Cover: Atomically Local Electric Field Induced Interface Water Reorientation for Alkaline Hydrogen Evolution Reaction (Angew. [Extracted from the article]

Objective: The aim of the study was to examine the factors influencing the therapeutic effect of patients with systemic lupus erythematosus combined with immune thrombocytopenia (SLE-ITP) and develop a prediction model to predict the therapeutic effect of SLE-ITP., Methods: Three hundred twenty-four SLE-ITP patients were retrieved from the electronic health record database of SLE patients in Jiangsu Province according to the latest treatment response criteria for ITP. We adopted the Cox model based on the least absolute shrinkage and selection operator to explore the impact factors affecting patient therapeutic effect, and we developed neural network model to predict therapeutic effect, and in prediction model, cost-sensitivity was introduced to address data category imbalance, and variational autoencoder was used to achieve data augmentation. The performance of each model was evaluated by accuracy and the area under the receiver operator curve., Results: The results showed that B-lymphocyte count, H-cholesterol level, complement-3 level, anticardiolipin antibody, and so on could be used as predictors of SLE-ITP curative effect, and abnormal levels of alanine transaminase, immunoglobulin A, and apolipoprotein B predicted adverse treatment response. The neural network treatment effect prediction model based on cost-sensitivity and variational autoencoder was better than the traditional classifiers, with an overall accuracy rate closed to 0.9 and a specificity of more than 0.9, which was useful for clinical practice to identify patients at risk of ineffective treatment response and to achieve better individualized management., Conclusions: By predicting the curative effect of SLE-ITP, the severity of patients can be determined, and then the best treatment strategy can be planned to avoid ineffective treatment., Competing Interests: The authors declare no conflict of interest., (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)

Catalyst deactivation caused by alkali metal poisoning has long been a key bottleneck in the application of selective catalytic reduction of NO x with NH 3 (NH 3 -SCR), limiting the service life of the catalyst and increasing the cost of environmental protection. Despite great efforts, continuous accumulation of alkali metal deposition makes the resistance capacity of 2 wt % K 2 O difficult to enhance via merely loading acid sites on the surface, resulting in rapid deactivation and frequent replacement of the NH 3 -SCR catalyst. To further improve the resistance of alkali metals, encapsulating alkali metals into the bulk phase could be a promising strategy. The bottleneck of 2 wt % K 2 O tolerance has been solved by virtue of ultrahigh potassium storage capacity in the amorphous FePO 4 bulk phase. Amorphous FePO 4 as a support of the NH 3 -SCR catalyst exhibited a self-adaptive alkali-tolerance mechanism, where potassium ions spontaneously migrated into the bulk phase of amorphous FePO 4 and were anchored by PO 4 3- with the generation of Fe 2 O 3 at the NH 3 -SCR reaction temperature. This ingenious potassium storage mechanism could boost the K 2 O resistance capacity to 6 wt % while maintaining approximately 81% NO x conversion. Besides, amorphous FePO 4 also exhibited excellent resistance to individual and coexistence of alkali (K 2 O and Na 2 O), alkali earth (CaO), and heavy metals (PbO and CdO), providing long durability for CePO 4 /FePO 4 catalysts in flue gas with multipollutants. The cheap and accessible amorphous FePO 4 paves the way for the development and implementation of poisoning-resistant NO x abatement.

Unraveling the dynamics of the active sites upon CeO 2 -based catalysts in selective catalytic reduction of nitrogen oxides by ammonia (NH 3 -SCR) is challenging. In this work, we prepared tungsten-acidified and sulfated CeO 2 catalysts and used operando spectroscopy to reveal the dynamics of acid sites and redox sites on catalysts during NH 3 -SCR reaction. We found that both Lewis and Brønsted acid sites are needed to participate in the catalytic reaction. Notably, Brønsted acid sites are the main active sites after a tungsten-acidified or sulfated treatment, and the change of Brønsted acid sites significantly affects the NO x removal. Moreover, acid functionalization promotes the cerium species cycle between Ce 4+ and Ce 3+ for the NO x reduction. This work is critical to deeply understanding the natural properties of active sites, and it also provides new insights into the mechanism for NH 3 -SCR over CeO 2 -based catalysts.

Selective catalytic reduction of NO x in the presence of alkali (earth) metals and heavy metals is still a challenge due to the easy deactivation of catalysts. Herein, NO x reduction over smart catalysts with self-created targeted antipoisoning sites is originally demonstrated. The smart catalyst consisted of TiO 2 pillared montmorillonite with abundant cation exchange sites to anchor poisoning substances and active components to catalyze NO x into N 2 . It was not deactivated during the NO x reduction process in the presence of alkali (earth) metals and heavy metals. The enhanced surface acidity, reducible active species, and active chemisorbed oxygen species of the smart catalyst accounted for the remarkable NO x reduction efficiency. More importantly, the self-created targeted antipoisoning sites expressed specific anchoring effects on poisoning substances and protected the active components from poisoning. It was demonstrated that the tetrahedrally coordinated aluminum species of the smart catalyst mainly acted as self-created targeted antipoisoning sites to stabilize the poisoning substances into the interlayers of montmorillonite. This work paves a new way for efficient reduction of NO x from the complex flue gas in practical applications.