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2. Cultural Adaptation and Psychometric Evaluation of the Chinese Version of the Perceived Stress Reactivity Scale

Author

Qu X, Luo Y, Liu Y, He X, and Zhang Y

Subjects
perceived stress reactivity, individual differences, gender, age, measurement invariance, psychometrics, Psychology, BF1-990, Industrial psychology, HF5548.7-5548.85
Abstract

Xinlei Qu,1,2 Yu Luo,1,2 Yuanyi Liu,1 Xiangcai He,3 Yu Zhang1,2 1School of Psychology, Guizhou Normal University, Guiyang, Guizhou, 550025, People’s Republic of China; 2Key Laboratory of Brain Function and Brain Disease Prevention and Treatment of Guizhou Province, Guizhou Normal University, Guiyang, Guizhou, 550025, People’s Republic of China; 3School of Psychology, Chengdu Medical College, Chengdu, Sichuan, 610500, People’s Republic of ChinaCorrespondence: Yu Luo, Email yuluo@gznu.edu.cnObjective: This study aimed to evaluate the cultural adaptation and psychometric properties of the Perceived Stress Reactivity Scale (PSRS) in the Chinese population.Methods: A total of 3560 Chinese participants aged 18– 60 years from various provinces and cities in mainland China were included. Sample 1 (n = 3316) was used for CFA, MI, internal consistency, convergent, criterion-related validity, and difference analysis. Sample 2 (n = 244) was employed to evaluate test–retest reliability over a four-week interval.Results: The study validated a robust 23-item, five-factor structure for the Chinese PSRS, demonstrating strong reliability with a Cronbach’s α of 0.90 and a test–retest reliability of 0.83. The PSRS and its subscales were significantly correlated with measures of depression, stress, anxiety, and self-efficacy. Strict invariance was observed across gender and age groups (18– 40 and 41– 60 years). Women and young adults scored higher on the overall scale and most subscales compared with their counterparts.Conclusion: The PSRS is a reliable instrument for assessing perceived stress reactivity within the Chinese population. By validating its cultural adaptation and psychometric properties, this study lays a foundation for its cross-cultural application. The findings contribute to a deeper understanding of perceived stress reactivity differences across gender and age groups and provide practical insights for future interventions and stress management research in the Chinese population.Keywords: perceived stress reactivity, individual differences, gender, age, measurement invariance, psychometrics

Published
2025

3. Observation of gamma rays up to 320 TeV from the middle-aged TeV pulsar wind nebula HESS J1849$-$000

Author

Amenomori, M., Asano, S., Bao, Y. W., Bi, X. J., Chen, D., Chen, T. L., Chen, W. Y., Chen, Xu, Chen, Y., Cirennima, Cui, S. W., Danzengluobu, Ding, L. K., Fang, J. H., Fang, K., Feng, C. F., Feng, Zhaoyang, Feng, Z. Y., Gao, Qi, Gomi, A., Gou, Q. B., Guo, Y. Q., Guo, Y. Y., Hayashi, Y., He, H. H., He, Z. T., Hibino, K., Hotta, N., Hu, Haibing, Hu, H. B., Hu, K. Y., Huang, J., Jia, H. Y., Jiang, L., Jiang, P., Jin, H. B., Kasahara, K., Katayose, Y., Kato, C., Kato, S., Kawahara, I., Kawashima, T., Kawata, K., Kozai, M., Kurashige, D., Labaciren, Le, G. M., Li, A. F., Li, H. J., Li, W. J., Li, Y., Lin, Y. H., Liu, B., Liu, C., Liu, J. S., Liu, L. Y., Liu, M. Y., Liu, W., Lu, H., Meng, X. R., Meng, Y., Munakata, K., Nagaya, K., Nakamura, Y., Nakazawa, Y., Nanjo, H., Ning, C. C., Nishizawa, M., Noguchi, R., Ohnishi, M., Okukawa, S., Ozawa, S., Qian, X., Qian, X. L., Qu, X. B., Saito, T., Sakakibara, Y., Sakata, M., Sako, T., Sako, T. K., Sasaki, T., Shao, J., Shibata, M., Shiomi, A., Sugimoto, H., Takano, W., Takita, M., Tan, Y. H., Tateyama, N., Torii, S., Tsuchiya, H., Udo, S., Wang, H., Wang, S. F., Wang, Y. P., Wangdui, Wu, H. R., Wu, Q., Xu, J. L., Xue, L., Yang, Z., Yao, Y. Q., Yin, J., Yokoe, Y., Yu, Y. L., Yuan, A. F., Zhai, L. M., Zhang, H. M., Zhang, J. L., Zhang, X., Zhang, X. Y., Zhang, Y., Zhang, Yi, Zhang, Ying, Zhao, S. P., Zhaxisangzhu, Zhou, X. X., and Zou, Y. H.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Gamma rays from HESS J1849$-$000, a middle-aged TeV pulsar wind nebula (PWN), are observed by the Tibet air shower array and the muon detector array. The detection significance of gamma rays reaches $4.0\, \sigma$ and $4.4\, \sigma$ levels above 25 TeV and 100 TeV, respectively, in units of Gaussian standard deviation $\sigma$. The energy spectrum measured between $40\, {\rm TeV} < E < 320\, {\rm TeV}$ for the first time is described with a simple power-law function of ${\rm d}N/{\rm d}E = (2.86 \pm 1.44) \times 10^{-16}(E/40\, {\rm TeV})^{-2.24 \pm 0.41}\, {\rm TeV}^{-1}\, {\rm cm}^{-2}\, {\rm s}^{-1}$. The gamma-ray energy spectrum from the sub-TeV ($E < 1\, {\rm TeV}$) to sub-PeV ($100\, {\rm TeV} < E < 1\, {\rm PeV}$) ranges including the results of previous studies can be modeled with the leptonic scenario, inverse Compton scattering by high-energy electrons accelerated by the PWN of PSR J1849$-$0001. On the other hand, the gamma-ray energy spectrum can also be modeled with the hadronic scenario in which gamma rays are generated from the decay of neutral pions produced by collisions between accelerated cosmic-ray protons and the ambient molecular cloud found in the gamma-ray emitting region. The cutoff energy of cosmic-ray protons $E_{\rm p\, cut}$, cut is estimated at ${\rm log}_{10}(E_{\rm p,\, cut}/{\rm TeV}) = 3.73^{+2.98}_{-0.66}$, suggesting that protons are accelerated up to the PeV energy range. Our study thus proposes that HESS J1849$-$000 should be further investigated as a new candidate for a Galactic PeV cosmic-ray accelerator, PeVatron., Comment: 10 pages, 2 figures, Accepted for publication from the Astrophysical Journal

Published
2023
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4. Measurement of the Gamma-Ray Energy Spectrum beyond 100 TeV from the HESS J1843$-$033 Region

Author

Amenomori, M., Asano, S., Bao, Y. W., Bi, X. J., Chen, D., Chen, T. L., Chen, W. Y., Chen, Xu, Chen, Y., Cirennima, Cui, S. W., Danzengluobu, Ding, L. K., Fang, J. H., Fang, K., Feng, C. F., Feng, Zhaoyang, Feng, Z. Y., Gao, Qi, Gomi, A., Gou, Q. B., Guo, Y. Q., Guo, Y. Y., He, H. H., He, Z. T., Hibino, K., Hotta, N., Hu, Haibing, Hu, H. B., Hu, K. Y., Huang, J., Jia, H. Y., Jiang, L., Jiang, P., Jin, H. B., Kasahara, K., Katayose, Y., Kato, C., Kato, S., Kawashima, T., Kawata, K., Kozai, M., Kurashige, D., Labaciren, Le, G. M., Li, A. F., Li, H. J., Li, W. J., Li, Y., Lin, Y. H., Liu, B., Liu, C., Liu, J. S., Liu, L. Y., Liu, M. Y., Liu, W., Liu, X. L., Lou, Y. -Q., Lu, H., Meng, X. R., Meng, Y., Munakata, K., Nagaya, K., Nakamura, Y., Nakazawa, Y., Nanjo, H., Ning, C. C., Nishizawa, M., Ohnishi, M., Okukawa, S., Ozawa, S., Qian, L., Qian, X., Qian, X. L., Qu, X. B., Saito, T., Sakakibara, Y., Sakata, M., Sako, T., Sako, T. K., Shao, J., Shibata, M., Shiomi, A., Sugimoto, H., Takano, W., Takita, M., Tan, Y. H., Tateyama, N., Torii, S., Tsuchiya, H., Udo, S., Wang, H., Wang, Y. P., Wangdui, Wu, H. R., Wu, Q., Xu, J. L., Xue, L., Yang, Z., Yao, Y. Q., Yin, J., Yokoe, Y., Yu, N. P., Yuan, A. F., Zhai, L. M., Zhang, C. P., Zhang, H. M., Zhang, J. L., Zhang, X., Zhang, X. Y., Zhang, Y., Zhang, Yi, Zhang, Ying, Zhao, S. P., Zhaxisangzhu, and Zhou, X. X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

HESS J1843$-$033 is a very-high-energy gamma-ray source whose origin remains unidentified. This work presents, for the first time, the energy spectrum of gamma rays beyond $100\, {\rm TeV}$ from the HESS J1843$-$033 region using the data recorded by the Tibet air shower array and its underground muon detector array. A gamma-ray source with an extension of $0.34^{\circ} \pm 0.12^{\circ}$ is successfully detected above $25\, {\rm TeV}$ at $(\alpha,\, \delta) = (281.09^{\circ}\pm 0.10^{\circ},\, -3.76^{\circ}\pm 0.09^{\circ})$ near HESS J1843$-$033 with a statistical significance of $6.2\, \sigma$, and the source is named TASG J1844$-$038. The position of TASG J1844$-$038 is consistent with those of HESS J1843$-$033, eHWC J1842$-$035, and LHAASO J1843$-$0338. The measured gamma-ray energy spectrum in $25\, {\rm TeV} < E < 130\, {\rm TeV}$ is described with ${\rm d}N/{\rm d}E = (9.70\pm 1.89)\times 10^{-16} (E/40\, {\rm TeV})^{-3.26\pm 0.30}\, {\rm TeV}^{-1} {\rm cm}^{-2} {\rm s}^{-1}$, and the spectral fit to the combined spectra of HESS J1843$-$033, LHAASO J1843$-$0338, and TASG J1844$-$038 implies the existence of a cutoff at $49.5\pm 9.0\, {\rm TeV}$. Associations of TASG J1844-038 with SNR G28.6$-$0.1 and PSR J1844-0346 are also discussed in detail for the first time., Comment: 11 pages, 4 figures, 1 table

Published
2023
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5. A Molecular Signature of the Ubiquitin-Proteasome System for Forecasting Prognosis in Thyroid Carcinoma Patients

Author

Zeng H, Geng X, Wan H, Qu X, Tang S, Zhang R, Zhou M, Yu Z, Pan J, Zheng H, Zhu Y, Huang S, and Huang D

Subjects
ubiquitin-proteasome system, thyroid carcinoma, prognostic model, immune microenvironment, drug sensitivity, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Hong Zeng,1,2,&ast; Xitong Geng,2,&ast; Hao Wan,3,&ast; Xiaoyu Qu,2 Shengwei Tang,2 Ruiyu Zhang,3 Minqin Zhou,2 Zichuan Yu,2 Jingying Pan,3 Hao Zheng,2 Yanting Zhu,2 Shuhan Huang,2 Da Huang1 1Department of Thyroid Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China; 2Second College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China; 3First College of Clinical Medicine, Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Da Huang, Department of Thyroid Surgery, Second Affiliated Hospital of Nanchang University, 1 minde Road, Nanchang, Jiangxi Province, 330000, People’s Republic of China, Email danmo0904@163.comBackground: The ubiquitin-proteasome system (UPS) is vital for protein quality control and its dysregulation is linked to diseases, including cancer. Targeting the UPS is becoming a promising approach in cancer therapy. However, the role of UPS modulation in thyroid carcinoma (THCA) remains to be fully elucidated.Methods: Initially, we utilized data from The Cancer Genome Atlas (TCGA) database to employ weighted gene co-expression network analysis (WGCNA) with LASSO regression to develop a prognostic model for core UPS genes implicated in THCA. Subsequently, we stratified the THCA training set into two distinct subtypes based on ubiquitin-proteasome system prognostic model score (UPS-PMS) characteristics. Key genes within the model were then subjected to functional analysis, immunotherapy evaluation, and drug sensitivity studies.Results: We delineated a prognostic model of the UPS comprising six genes, which we subsequently demonstrated was capable of forecasting patient prognosis. Moreover, our findings indicated a substantial correlation between UPS-PMS and immune microenvironmental factors, notably a negative correlation with myeloid immune cells and a potential influence on the Th1 to Th2 cells ratio. Especially, we observed a significant association between high UPS-PMS and an immunosuppressive microenvironment. Then, we elucidated the biological distinctions among various THCA sample subtypes, highlighting that the cluster_1 subtype is associated with an unfavorable prognosis. Of note, KCNA1 was identified as a pivotal prognostic gene within the UPS-PMS framework. We constructed a three-tiered regulatory network centered on KCNA1-related competing endogenous RNA (ceRNA). Furthermore, our results suggested that KCNA1 has potential as a target for immunotherapeutic strategies. Concurrently, drug sensitivity analyses demonstrated that high KCNA1 expression promoted gemcitabine resistance in patients, while KCNA1 knockdown increased sensitivity to gemcitabine.Conclusion: In conclusion, we developed a novel UPS-based prognostic model for THCA, identified key gene KCNA1, and assessed immunotherapy and drug sensitivity, revealing new therapeutic targets.Keywords: ubiquitin-proteasome system, thyroid carcinoma, prognostic model, immune microenvironment, drug sensitivity

Published
2024

7. Potential PeVatron supernova remnant G106.3+2.7 seen in the highest-energy gamma rays

Author

Amenomori, M., Bao, Y. W., Bi, X. J., Chen, D., Chen, T. L., Chen, W. Y., Chen, Xu, Chen, Y., Cirennima, Cui, S. W., Danzengluobu, Ding, L. K., Fang, J. H., Fang, K., Feng, C. F., Feng, Zhaoyang, Feng, Z. Y., Gao, Qi, Gou, Q. B., Guo, Y. Q., Guo, Y. Y., He, H. H., He, Z. T., Hibino, K., Hotta, N., Hu, Haibing, Hu, H. B., Huang, J., Jia, H. Y., Jiang, L., Jin, H. B., Kasahara, K., Katayose, Y., Kato, C., Kato, S., Kawata, K., Kihara, W., Ko, Y., Kozai, M., Labaciren, Le, G. M., Li, A. F., Li, H. J., Li, W. J., Lin, Y. H., Liu, B., Liu, C., Liu, J. S., Liu, M. Y., Liu, W., Lou, Y. -Q., Lu, H., Meng, X. R., Munakata, K., Nakada, H., Nakamura, Y., Nanjo, H., Nishizawa, M., Ohnishi, M., Ohura, T., Ozawa, S., Qian, X. L., Qu, X. B., Saito, T., Sakata, M., Sako, T. K., Shao, J., Shibata, M., Shiomi, A., Sugimoto, H., Takano, W., Takita, M., Tan, Y. H., Tateyama, N., Torii, S., Tsuchiya, H., Udo, S., Wang, H., Wu, H. R., Xue, L., Yamamoto, Y., Yang, Z., Yokoe, Y., Yuan, A. F., Zhai, L. M., Zhang, H. M., Zhang, J. L., Zhang, X., Zhang, X. Y., Zhang, Y., Zhang, Yi, Zhang, Ying, Zhao, S. P., Zhaxisangzhu, and Zhou, X. X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Cosmic rays (protons and other atomic nuclei) are believed to gain energies of petaelectronvolts (PeV) and beyond at astrophysical particle accelerators called 'PeVatrons' inside our Galaxy. Although a characteristic feature of a PeVatron is expected to be a hard gamma-ray energy spectrum that extends beyond 100 teraelectronvolts (TeV) without a cutoff, none of the currently known sources exhibits such a spectrum due to the low maximum energy of accelerated cosmic rays or insufficient detector sensitivity around 100 TeV. Here we report the observation of gamma-ray emission from the supernova remnant G106.3+2.7 above 10 TeV. This work provides flux data points up to and above 100 TeV and indicates that the very-high-energy gamma-ray emission above 10 TeV is well correlated with a molecular cloud rather than the pulsar PSR J2229+6114. Regarding the gamma-ray emission mechanism of G106.3+2.7, this morphological feature appears to favor a hadronic origin via the {\pi}0 decay caused by accelerated relativistic protons over a leptonic one via the inverse-Compton scattering by relativistic electrons. Furthermore, we point out that an X-ray flux upper limit on the synchrotron spectrum would provide important information to firmly establish the hadronic scenario as the mechanism of particle acceleration at the source., Comment: Published in Nature Astronomy

Published
2021
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8. Gamma-ray Observation of the Cygnus Region in the 100 TeV Energy Region

Author

Amenomori, M., Bao, Y. W., Bi, X. J., Chen, D., Chen, T. L., Chen, W. Y., Chen, Xu, Chen, Y., Cirennima, Cui, S. W., Danzengluobu, Ding, L. K., Fang, J. H., Fang, K., Feng, C. F., Feng, Zhaoyang, Feng, Z. Y., Gao, Qi, Gomi, A., Gou, Q. B., Guo, Y. Q., Guo, Y. Y., He, H. H., He, Z. T., Hibino, K., Hotta, N., Hu, Haibing, Hu, H. B., Huang, J., Jia, H. Y., Jiang, L., Jiang, P., Jin, H. B., Kasahara, K., Katayose, Y., Kato, C., Kato, S., Kawata, K., Kozai, M., Kurashige, D., Labaciren, Le, G. M., Li, A. F., Li, H. J., Li, W. J., Li, Y., Lin, Y. H., Liu, B., Liu, C., Liu, J. S., Liu, L. Y., Liu, M. Y., Liu, W., Liu, X. L., Lou, Y. -Q., Lu, H., Meng, X. R., Munakata, K., Nakada, H., Nakamura, Y., Nakazawa, Y., Nanjo, H., Ning, C. C., Nishizawa, M., Ohnishi, M., Ohura, T., Okukawa, S., Ozawa, S., Qian, L., Qian, X., Qian, X. L., Qu, X. B., Saito, T., Sakata, M., Sako, T., Sako, T. K., Shao, J., Shibata, M., Shiomi, A., Sugimoto, H., Takano, W., Takita, M., Tan, Y. H., Tateyama, N., Torii, S., Tsuchiya, H., Udo, S., Wang, H., Wang, Y. P., Wangdui, Wu, H. R., Wu, Q., Xu, J. L., Xue, L., Yamamoto, Y., Yang, Z., Yao, Y. Q., Yin, J., Yokoe, Y., Yu, N. P., Yuan, A. F., Zhai, L. M., Zhang, C. P., Zhang, H. M., Zhang, J. L., Zhang, X., Zhang, X. Y., Zhang, Y., Zhang, Yi, Zhang, Ying, Zhao, S. P., Zhaxisangzhu, and Zhou, X. X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report observations of gamma-ray emissions with energies in the 100 TeV energy region from the Cygnus region in our Galaxy. Two sources are significantly detected in the directions of the Cygnus OB1 and OB2 associations. Based on their positional coincidences, we associate one with a pulsar PSR J2032+4127 and the other mainly with a pulsar wind nebula PWN G75.2+0.1 with the pulsar moving away from its original birthplace situated around the centroid of the observed gamma-ray emission. This work would stimulate further studies of particle acceleration mechanisms at these gamma-ray sources., Comment: Accepted for publication in the Physical Review Letters

Published
2021
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9. First Detection of sub-PeV Diffuse Gamma Rays from the Galactic Disk: Evidence for Ubiquitous Galactic Cosmic Rays beyond PeV Energies

Author

Amenomori, M., Bao, Y. W., Bi, X. J., Chen, D., Chen, T. L., Chen, W. Y., Chen, Xu, Chen, Y., Cirennima, Cui, S. W., Danzengluobu, Ding, L. K., Fang, J. H., Fang, K., Feng, C. F., Feng, Zhaoyang, Feng, Z. Y., Gao, Qi, Gou, Q. B., Guo, Y. Q., Guo, Y. Y., He, H. H., He, Z. T., Hibino, K., Hotta, N., Hu, Haibing, Hu, H. B., Huang, J., Jia, H. Y., Jiang, L., Jin, H. B., Kasahara, K., Katayose, Y., Kato, C., Kato, S., Kawata, K., Kihara, W., Ko, Y., Kozai, M., Labaciren, Le, G. M., Li, A. F., Li, H. J., Li, W. J., Lin, Y. H., Liu, B., Liu, C., Liu, J. S., Liu, M. Y., Liu, W., Lou, Y. -Q., Lu, H., Meng, X. R., Munakata, K., Nakada, H., Nakamura, Y., Nanjo, H., Nishizawa, M., Ohnishi, M., Ohura, T., Ozawa, S., Qian, X. L., Qu, X. B., Saito, T., Sakata, M., Sako, T. K., Shao, J., Shibata, M., Shiomi, A., Sugimoto, H., Takano, W., Takita, M., Tan, Y. H., Tateyama, N., Torii, S., Tsuchiya, H., Udo, S., Wang, H., Wu, H. R., Xue, L., Yamamoto, Y., Yang, Z., Yokoe, Y., Yuan, A. F., Zhai, L. M., Zhang, H. M., Zhang, J. L., Zhang, X., Zhang, X. Y., Zhang, Y., Zhang, Yi, Zhang, Ying, Zhao, S. P., Zhaxisangzhu, and Zhou, X. X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report, for the first time, the long-awaited detection of diffuse gamma rays with energies between 100 TeV and 1 PeV in the Galactic disk. Particularly, all gamma rays above 398 TeV are observed apart from known TeV gamma-ray sources and compatible with expectations from the hadronic emission scenario in which gamma rays originate from the decay of $\pi^0$'s produced through the interaction of protons with the interstellar medium in the Galaxy. This is strong evidence that cosmic rays are accelerated beyond PeV energies in our Galaxy and spread over the Galactic disk., Comment: Accepted for publication in the Physical Review Letters

Published
2021
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10. Optimal management of radiation pneumonitis: Findings of an international Delphi consensus study

Author

Voruganti Maddali, Indu S., Cunningham, Cicely, McLeod, Lorraine, Bahig, Houda, Chaudhuri, Nazia, L. M. Chua, Kevin, Evison, Matthew, Faivre-Finn, Corinne, Franks, Kevin, Harden, Susan, Videtic, Gregory, Lee, Percy, Senan, Suresh, Siva, Shankar, Palma, David A., Phillips, Iain, Kruser, Jacqueline, Kruser, Timothy, Peedell, Clive, Melody Qu, X., Robinson, Clifford, Wright, Angela, Harrow, Stephen, and Louie, Alexander V.

Published
2024
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13. Application of MR Imaging Characteristics in the Differentiation of Renal Changes Between Patients with Stage III Type 2 Diabetic Kidney Disease and Healthy People

Author

Zhang H, Yu B, Yang H, Ying H, Qu X, Zhu L, Wang C, and Ding J

Subjects
diabetic kidney disease, magnetic resonance imaging, radiomics, Specialties of internal medicine, RC581-951
Abstract

Hao Zhang,&ast; Baoting Yu,&ast; Hongsheng Yang, Hongfei Ying, Xiaolong Qu, Lilan Zhu, Cong Wang, Jun Ding Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, 130021, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jun Ding, Department of Radiology, China-Japan Union Hospital of Jilin University, No. 829 of Xinmin Street, Chaoyang District, Changchun, 130021, People’s Republic of China, Tel/Fax +86 04 70 8499 7637, Email dingjun@jlu.edu.cnObjective: To explore the value of 1.5T magnetic resonance (MR) fat saturation-T2-weighted imaging (FS-T2WI) and apparent diffusion coefficient (ADC) imaging texture features in distinguishing the renal changes of patients with stage III type 2 diabetic kidney disease (DKD) from healthy people.Methods: This study collected 55 patients with stage III DKD (39 males and 16 females) and 33 healthy controls (13 males and 20 females) from December 2021 to June 2022 in the China-Japan Union Hospital of Jilin University. All subjects were randomly divided in a ratio of 6:4 to extract and screen the FS-T2WI and ADC texture features of the right kidney of the subjects. The area under the curve (AUC) was used to assess the diagnostic accuracy of each model.Results: There were significant differences between urea, creatinine and sex (p< 0.05) of the two groups in the training and test set, and no significant difference in age and body mass index (BMI). We extracted 1409 imaging features from the original ADC sequence and selected them by wavelet and Laplace-Gaussian filter and LASSO algorithm, and using the same methods of FS-T2WI. Finally, FS-T2WI and ADC models were selected to construct the united model, including 3 first-order features and 8 texture features. The AUC values of the training set of FS-T2WI, ADC, FS-T2WI+ADC combined logistic regression model were 0.96, 0.91, 0.98; the AUC values of the test set were 0.91, 0.89 and 0.93, and the specificity and accuracy values of the united model were 0.90 and 0.89, respectively.Conclusion: FS-T2WI and ADC imaging features based on 1.5 T MR had diagnostic value in the early diagnosis of DKD stage III, and the combined model of FS-T2WI and ADC had high diagnostic efficiency.Keywords: diabetic kidney disease, magnetic resonance imaging, radiomics

Published
2023

14. First Detection of Photons with Energy Beyond 100 TeV from an Astrophysical Source

Author

Amenomori, M., Bao, Y. W., Bi, X. J., Chen, D., Chen, T. L., Chen, W. Y., Chen, Xu, Chen, Y., Cirennima, Cui, S. W., Danzengluobu, Ding, L. K., Fang, J. H., Fang, K., Feng, C. F., Feng, Zhaoyang, Feng, Z. Y., Gao, Qi, Gou, Q. B., Guo, Y. Q., He, H. H., He, Z. T., Hibino, K., Hotta, N., Hu, Haibing, Hu, H. B., Huang, J., Jia, H. Y., Jiang, L., Jin, H. B., Kajino, F., Kasahara, K., Katayose, Y., Kato, C., Kato, S., Kawata, K., Kozai, M., Labaciren, Le, G. M., Li, A. F., Li, H. J., Li, W. J., Lin, Y. H., Liu, B., Liu, C., Liu, J. S., Liu, M. Y., Lou, Y. -Q., Lu, H., Meng, X. R., Mitsui, H., Munakata, K., Nakamura, Y., Nanjo, H., Nishizawa, M., Ohnishi, M., Ohta, I., Ozawa, S., Qian, X. L., Qu, X. B., Saito, T., Sakata, M., Sako, T. K., Sengoku, Y., Shao, J., Shibata, M., Shiomi, A., Sugimoto, H., Takita, M., Tan, Y. H., Tateyama, N., Torii, S., Tsuchiya, H., Udo, S., Wang, H., Wu, H. R., Xue, L., Yagisawa, K., Yamamoto, Y., Yang, Z., Yuan, A. F., Zhai, L. M., Zhang, H. M., Zhang, J. L., Zhang, X., Zhang, X. Y., Zhang, Y., Zhang, Yi, Zhang, Ying, Zhaxisangzhu, and Zhou, X. X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report on the highest energy photons from the Crab Nebula observed by the Tibet air shower array with the underground water-Cherenkov-type muon detector array. Based on the criterion of muon number measured in an air shower, we successfully suppress 99.92% of the cosmic-ray background events with energies $E>100$ TeV. As a result, we observed 24 photon-like events with $E>100$ TeV against 5.5 background events, which corresponds to 5.6$\sigma$ statistical significance. This is the first detection of photons with $E>100$ TeV from an astrophysical source., Comment: April 4, 2019; Submitted to the Physical Review Letters

Published
2019
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15. Enabling materials informatics for 29Si solid-state NMR of crystalline materials

Author

Sun, H, Dwaraknath, S, Ling, H, Qu, X, Huck, P, Persson, KA, and Hayes, SE

Abstract

Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for obtaining precise information about the local bonding of materials, but difficult to interpret without a well-vetted dataset of reference spectra. The ability to predict NMR parameters and connect them to three-dimensional local environments is critical for understanding more complex, long-range interactions. New computational methods have revealed structural information available from 29Si solid-state NMR by generating computed reference spectra for solids. Such predictions are useful for the identification of new silicon-containing compounds, and serve as a starting point for determination of the local environments present in amorphous structures. In this study, we have used 42 silicon sites as a benchmarking set to compare experimentally reported 29Si solid-state NMR spectra with those computed by CASTEP-NMR and Vienna Ab Initio Simulation Program (VASP). Data-driven approaches enable us to identify the source of discrepancies across a range of experimental and computational results. The information from NMR (in the form of an NMR tensor) has been validated, and in some cases corrected, in an effort to catalog these for the local spectroscopy database infrastructure (LSDI), where over 10,000 29Si NMR tensors for crystalline materials have been computed. Knowledge of specific tensor values can serve as the basis for executing NMR experiments with precision, optimizing conditions to capture the elements accurately. The ability to predict and compare experimental observables from a wide range of structures can aid researchers in their chemical assignments and structure determination, since the computed values enables the extension beyond tables of typical chemical shift (or shielding) ranges.

Published
2020

16. The Inhibition of Evolocumab on Non-Infarct-Related Artery Disease in Patients with ST-Elevation Myocardial Infarction

Author

Zhao Q, Sun S, Zhou F, Yue J, Luo X, and Qu X

Subjects
pcsk9 inhibition, c-reactive protein, inflammation, physiological assessment, quantitative flow ratio, non-infarct-related artery., Medicine (General), R5-920
Abstract

Qi Zhao,1,&ast; Siyuan Sun,2,&ast; Fanghui Zhou,3,&ast; Jingkun Yue,2 Xing Luo,4 Xiufen Qu1 1Department of Cardiology, 1st Affiliated Hospital of Harbin Medical University, Harbin, 150086, People’s Republic of China; 2Department of Cardiology, People’s Hospital of Taihe County, Taihe, Anhui, 236600, People’s Republic of China; 3Department of Hematology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China; 4Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xing Luo; Xiufen Qu, Email luoxing321@163.com; quxiufenhmu@126.comPurpose: The effects of combing evolocumab and statin on the clinical outcome and physiological function of coronary arteries in STEMI patients with non-infarct-related artery (NIRA) disease are still unclear.Methods: A total of 355 STEMI patients with NIRA were enrolled in this study, who underwent combined quantitative flow ratio (QFR) at baseline and after 12 months of treatment with statin monotherapy or statin plus evolocumab.Results: Diameter stenosis and lesion length were significantly lower in the group undergoing statin plus evolocumab. While the group exhibited significantly higher minimum lumen diameter (MLD), and QFR values. Statin plus evolocumab (OR = 0.350; 95% CI: 0.149– 0.824; P = 0.016) and plaque lesion length (OR = 1.223; 95% CI: 1.102– 1.457; P = 0.033) were independently associated with rehospitalization for unstable angina (UA) within 12 months.Conclusion: Evolocumab combined with statin therapy can significantly improve the anatomical and physiological function of the coronary arteries and downregulate the re-hospitalization rate due to UA in STEMI patients with NIRA.Keywords: PCSK9 inhibition, C-reactive protein, inflammation, physiological assessment, quantitative flow ratio, non-infarct-related artery

Published
2023

19. Influence of Earth-Directed Coronal Mass Ejections on the Sun's Shadow Observed by the Tibet-III Air Shower Array

Author

Amenomori, M., Bi, X. J., Chen, D., Chen, T. L., Chen, W. Y., Cui, S. W., Danzengluobu, Ding, L. K., Feng, C. F., Feng, Zhaoyang, Feng, Z. Y., Gou, Q. B., Guo, Y. Q., He, H. H., He, Z. T., Hibino, K., Hotta, N., Hu, Haibing, Hu, H. B., Huang, J., Jia, H. Y., Jiang, L., Kajino, F., Kasahara, K., Katayose, Y., Kato, C., Kawata, K., Kozai, M., Labaciren, Le, G. M., Li, A. F., Li, H. J., Li, W. J., Liu, C., Liu, J. S., Liu, M. Y., Lu, H., Meng, X. R., Miyazaki, T., Munakata, K., Nakajima, T., Nakamura, Y., Nanjo, H., Nishizawa, M., Niwa, T., Ohnishi, M., Ohta, I., Ozawa, S., Qian, X. L., Qu, X. B., Saito, T., Saito, T. Y., Sakata, M., Sako, T. K., Shao, J., Shibata, M., Shiomi, A., Shirai, T., Sugimoto, H., Takita, M., Tan, Y. H., Tateyama, N., Torii, S., Tsuchiya, H., Udo, S., Wang, H., Wu, H. R., Xue, L., Yamamoto, Y., Yamauchi, K., Yang, Z., Yuan, S. A. F., Zhai, L. M., Zhang, H. M., Zhang, J. L., Zhang, X. Y., Zhang, Y., Zhang, Yi, Zhang, Ying, Zhaxisangzhu, and Zho, X. X.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

We examine the possible influence of Earth-directed coronal mass ejections (ECMEs) on the Sun's shadow in the 3~TeV cosmic-ray intensity observed by the Tibet-III air shower (AS) array. We confirm a clear solar-cycle variation of the intensity deficit in the Sun's shadow during ten years between 2000 and 2009. This solar-cycle variation is overall reproduced by our Monte Carlo (MC) simulations of the Sun's shadow based on the potential field model of the solar magnetic field averaged over each solar rotation period. We find, however, that the magnitude of the observed intensity deficit in the Sun's shadow is significantly less than that predicted by MC simulations, particularly during the period around solar maximum when a significant number of ECMEs is recorded. The $\chi^2$ tests of the agreement between the observations and the MC simulations show that the difference is larger during the periods when the ECMEs occur, and the difference is reduced if the periods of ECMEs are excluded from the analysis. This suggests the first experimental evidence of the ECMEs affecting the Sun's shadow observed in the 3~TeV cosmic-ray intensity., Comment: 11 pages, 3 figures, accepted for publication in the ApJ

Published
2018
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20. Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy

Author

Korenblik, R., Olij, B., Aldrighetti, L. A., Hilal, M. Abu, Ahle, M., Arslan, B., van Baardewijk, L. J., Baclija, I., Bent, C., Bertrand, C. L., Björnsson, B., de Boer, M. T., de Boer, S. W., Bokkers, R. P. H., Rinkes, I. H. M. Borel, Breitenstein, S., Bruijnen, R. C. G., Bruners, P., Büchler, M. W., Camacho, J. C., Cappelli, A., Carling, U., Chan, B. K. Y., Chang, D. H., choi, J., Font, J. Codina, Crawford, M., Croagh, D., Cugat, E., Davis, R., De Boo, D. W., De Cobelli, F., De Wispelaere, J. F., van Delden, O. M., Delle, M., Detry, O., Díaz-Nieto, R., Dili, A., Erdmann, J. I., Fisher, O., Fondevila, C., Fretland, Å., Borobia, F. Garcia, Gelabert, A., Gérard, L., Giuliante, F., Gobardhan, P. D., Gómez, F., Grünberger, T., Grünhagen, D. J., Guitart, J., Hagendoorn, J., Heil, J., Heise, D., Herrero, E., Hess, G. F., Hoffmann, M. H., Iezzi, R., Imani, F., Nguyen, J., Jovine, E., Kalff, J. C., Kazemier, G., Kingham, T. P., Kleeff, J., Kollmar, O., Leclercq, W. K. G., Ben, S. Lopez, Lucidi, V., MacDonald, A., Madoff, D. C., Manekeller, S., Martel, G., Mehrabi, A., Mehrzad, H., Meijerink, M. R., Menon, K., Metrakos, P., Meyer, C., Moelker, A., Modi, S., Montanari, N., Navines, J., Neumann, U. P., Peddu, P., Primrose, J. N., Qu, X., Raptis, D., Ratti, F., Ridouani, F., Rogan, C., Ronellenfitsch, U., Ryan, S., Sallemi, C., Moragues, J. Sampere, Sandström, P., Sarriá, L., Schnitzbauer, A., Serenari, M., Serrablo, A., Smits, M. L. J., Sparrelid, E., Spüntrup, E., Stavrou, G. A., Sutcliffe, R. P., Tancredi, I., Tasse, J. C., Udupa, V., Valenti, D., Fundora, Y., Vogl, T. J., Wang, X., White, S. A., Wohlgemuth, W. A., Yu, D., Zijlstra, I. A. J., Binkert, C. A., Bemelmans, M. H. A., van der Leij, C., Schadde, E., and van Dam, R. M.

Published
2022
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22. Caries Risk Assessment and Dental Referral by Paediatric Primary Care Physicians in Sichuan Province, China: A Cross-Sectional Study

Author

Wang Q, Qu X, Houser SH, Zhang Y, Tian M, Zhang Q, and Zhang W

Subjects
caries risk assessment, dental referral, paediatric physicians, primary care, china, Public aspects of medicine, RA1-1270
Abstract

Qingyu Wang,1,2 Xing Qu,3 Shannon H Houser,4 Yan Zhang,5 Meirong Tian,3 Qiong Zhang,6,7 Wei Zhang3 1West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, People’s Republic of China; 2HEOA Group, Institute for Healthy Cities and West China Research Center for Rural Health Development, Sichuan University, Chengdu, People’s Republic of China; 3Institute of Hospital Management, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 4Department of Health Services Administration, the University of Alabama at Birmingham, Birmingham, AL, USA; 5Department of Maternity and Child Health Management, Sichuan Provincial Maternity and Child Health Care Hospital, Chengdu, People’s Republic of China; 6Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, People’s Republic of China; 7State Key Laboratory of Oral Diseases & National Clinical Research, Sichuan University, Chengdu, People’s Republic of ChinaCorrespondence: Xing Qu, Institute of Hospital Management, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu, 610041, People’s Republic of China, +86 13880713452, Email qvxing@163.comBackground: Limited information is known about dental implementation by pediatric primary care physicians (PCPs) at the primary care level in China. This study aimed to explore the current status of primary oral care implementation and related influencing factors.Methods: A cross-sectional survey was conducted among PCPs in Sichuan Province, China. Multivariable logistic regression was used to analyse factors associated with CRA and dental referral for high caries-risk children.Results: A total of 504 out of 524 questionnaires remained for analysis. In all, 93.8% of PCPs reported that they usually or sometimes performed dental screening for children, 31.3% performed CRA, and 49.0% referred high caries-risk children to dentists. More CRA activities were associated with PCPs who encountered a greater number of children with caries during systematic care (adjusted OR: 2.37, 95% CI:[1.08,5.18], had dental knowledge training by pediatric dentists (aOR: 2.26, 95% CI:[1.36, 3.75], and learned pediatric dental knowledge on their own (aOR: 2.87, 95% CI: [1.51, 5.45]). In addition to the above associators, a higher rate of dental referrals for high caries-risk children was associated with having a dental department in the same work institute (aOR: 1.72, 95% CI: [1.09, 2.70] and having more confidence in their dental knowledge (aOR: 1.29, 95% CI: [1.04, 1.61]).Conclusion: Paediatric PCPs commonly implement dental screening but perform fewer CRAs and dental referrals for high caries-risk children during systematic health management in western China. To increase CRA activities and dental referral by paediatric PCPs, health policymakers could encourage interdisciplinary cooperation between dental professionals and paediatric PCPs.Keywords: caries risk assessment, dental referral, paediatric physicians, primary care, China

Published
2022

23. Clinical Efficacy, Antibiotic Resistance Genes, Virulence Factors and Outcome of Hospital-Acquired Pneumonia Induced by Klebsiella pneumoniae Carbapenemase 2-Producing with Tigecycline Treatment in the ICU

Author

Bai XR, Cao JR, Wang ZZ, Li WC, Chen DD, Lou R, Qu X, and Yan SY

Subjects
klebsiellapneumoniae, carbapenemase, virulence factors, resistance genes, hospital-acquired pneumonia, Infectious and parasitic diseases, RC109-216
Abstract

Xiang-Rong Bai,1,&ast; Jing-Rong Cao,2,&ast; Zhi-Zhou Wang,1 Wen-Chao Li,1 Dian-Dian Chen,2 Ran Lou,3 Xin Qu,4 Su-Ying Yan1 1Department of Pharmacy, Xuan Wu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People’s Republic of China; 2Department of Clinical Laboratory, Xuan Wu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People’s Republic of China; 3Department of Intensive Medicine, Xuan Wu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People’s Republic of China; 4Intensive Care Unit, Department of Neurosurgery, Xuan Wu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, Beijing, 100053, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Su-Ying Yan, Department of Pharmacy, Xuan Wu Hospital Capital Medical University, National Gerontic Disease Clinical Research Center, No. 45 Changchun Street, Xi Cheng District, Beijing, 100053, People’s Republic of China, Tel/Fax +86 10-63012837, Email yansuying10@sina.cnPurpose: Tigecycline is an agent for carbapenemase-producing Klebsiella pneumonia (KPC-KP), given its penetration into lung tissues. Our study focused on the molecular and clinical efficacy of tigecycline for hospital-acquired pneumonia (HAP) in the ICU.Patients and Methods: A retrospective cohort study of 52 adult KPC-KP HAP patients by searching hospital medical records from January 2018 to December 2020 was established to investigate the epidemiology of KPC-KP infections for tigecycline treatment and the associated clinical efficacy of tigecycline. The KPC-KP isolates underwent multilocus sequence typing. Molecular typing, antimicrobial resistance, and virulence profiling were also analyzed by whole-genome sequencing of KPC-KP.Results: Among 52 patients with KPC-KP, the ICU mortality rate was 14/52 (27%), and there was no significant statistical difference in mortality between the effective group and failure group (p = 0.754). However, the duration of tigecycline was statistically different between the two groups of patients (14.4 vs 10 days, p=0.046). The total bacterial clearance rate was 6/52 (11.5%). There was no significant statistical difference in both groups (p=0.416). Antibiotic resistance genes (aac3iia) and virulence gene (AREO-iutA, Capsule-wzc) were negatively correlated with clinical efficacy (p = 0.011, OR = 1.237).Conclusions: Blakpc was the main carbapenemase in all K. pneumoniae strains. ST11-KL64 KPC-KP was the most common virulence factors in KPC-KP isolates. This study suggested that antibiotic resistance genes (aac3iia) and virulence gene (AREO-iutA, Capsule-wzc) were independent mortality risk factors for patients with Klebsiella pneumoniae carbapenemase-2 producing K. pneumoniae infections, when during the tigecycline treatment. Molecular analysis of K. pneumoniae may provide an option when choosing the antimicrobial treatment.Keywords: Klebsiella pneumoniae, carbapenemase, virulence factors, resistance genes, hospital-acquired pneumonia

Published
2022

24. Evaluation of the Interplanetary Magnetic Field Strength Using the Cosmic-Ray Shadow of the Sun

Author

Amenomori, M., Bi, X. J., Chen, D., Chen, T. L., Chen, W. Y., Cui, S. W., Danzengluobu, Ding, L. K., Feng, C. F., Feng, Zhaoyang, Feng, Z. Y., Gou, Q. B., Guo, Y. Q., He, H. H., He, Z. T., Hibino, K., Hotta, N., Hu, Haibing, Hu, H. B., Huang, J., Jia, H. Y., Jiang, L., Kajino, F., Kasahara, K., Katayose, Y., Kato, C., Kawata, K., Kozai, M., Labaciren, Le, G. M., Li, A. F., Li, H. J., Li, W. J., Liu, C., Liu, J. S., Liu, M. Y., Lu, H., Meng, X. R., Miyazaki, T., Mizutani, K., Munakata, K., Nakajima, T., Nakamura, Y., Nanjo, H., Nishizawa, M., Niwa, T., Ohnishi, M., Ohta, I., Ozawa, S., Qian, X. L., Qu, X. B., Saito, T., Saito, T. Y., Sakata, M., Sako, T. K., Shao, J., Shibata, M., Shiomi, A., Shirai, T., Sugimoto, H., Takita, M., Tan, Y. H., Tateyama, N., Torii, S., Tsuchiya, H., Udo, S., Wang, H., Wu, H. R., Xue, L., Yamamoto, Y., Yamauchi, K., Yang, Z., Yuan, S. A. F., Yuda, T., Zhai, L. M., Zhang, H. M., Zhang, J. L., Zhang, X. Y., Zhang, Y., Zhang, Yi, Zhang, Ying, Zhaxisangzhu, and Zho, X. X.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Physics - Space Physics
Abstract

We analyze the Sun's shadow observed with the Tibet-III air shower array and find that the shadow's center deviates northward (southward) from the optical solar disc center in the "Away" ("Toward") IMF sector. By comparing with numerical simulations based on the solar magnetic field model, we find that the average IMF strength in the "Away" ("Toward") sector is $1.54 \pm 0.21_{\rm stat} \pm 0.20_{\rm syst}$ ($1.62 \pm 0.15_{\rm stat} \pm 0.22_{\rm syst}$) times larger than the model prediction. These demonstrate that the observed Sun's shadow is a useful tool for the quantitative evaluation of the average solar magnetic field., Comment: 7 pages, 4 figures

Published
2018
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25. The limits of the nuclear landscape explored by the relativistic continuum Hatree-Bogoliubov theory

Author

Xia, X. W., Lim, Y., Zhao, P. W., Liang, H. Z., Qu, X. Y., Chen, Y., Liu, H., Zhang, L. F., Zhang, S. Q., Kim, Y., and Meng, J.

Subjects
Nuclear Theory
Abstract

The ground-state properties of nuclei with 8 $\le$ Z $\le$ 120 from the proton drip line to the neutron drip line have been investigated using the relativistic continuum Hartree-Bogoliubov (RCHB) theory with the relativistic density functional PC-PK1. With the effects of the continuum included, there are totally 9035 nuclei predicted to be bound, which largely extends the existing nuclear landscapes predicted with other methods. The calculated binding energies, separation energies, neutron and proton Fermi surfaces, root-mean-square (rms) radii of neutron, proton, matter, and charge distributions, ground-state spins and parities are tabulated. The extension of the nuclear landscape obtained with RCHB is discussed in detail, in particular for the neutron-rich side, in comparison with the relativistic mean field calculations without pairing correlations and also other predicted landscapes. It is found that the coupling between the bound states and the continuum due to the pairing correlations plays an essential role in extending the nuclear landscape. The systematics of the separation energies, radii, densities, potentials and pairing energies of the RCHB calculations are also discussed. In addition, the alpha-decay energies and proton emitters based on the RCHB calculations are investigated., Comment: 192 pages, 25 figures, Atomic Data and Nuclear Data Tables, in press

Published
2017
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26. High Level of Serum Uric Acid induced Monocyte Inflammation is Related to Coronary Calcium Deposition in the Middle-Aged and Elder Population of China: A five-year Prospective Cohort Study

Author

Wang X, Liu X, Qi Y, Zhang S, Shi K, Lin H, Grossfeld P, Wang W, Wu T, Qu X, Xiao J, and Ye M

Subjects
serum uric acid, calcium deposition, coronary artery calcium score, monocyte inflammation, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950
Abstract

Xiaojun Wang,1,2,&ast; Xuanqi Liu,3,&ast; Yiding Qi,4,&ast; Shuyi Zhang,4 Kailei Shi,4 Huagang Lin,5 Paul Grossfeld,6 Wenhao Wang,1,2 Tao Wu,1,2 Xinkai Qu,4 Jing Xiao,5 Maoqing Ye2,4 1Department of Traditional Chinese Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 2Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 4Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 5Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 6Division of Cardiology UCSD School of Medicine, Rady Children’s Hospital of San Diego, La Jolla, CA, 92093, USA&ast;These authors contributed equally to this workCorrespondence: Maoqing Ye, Department of Cardiology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China, Tel +86-18930721396, Email yemaoqing@fudan.edu.cn Jing Xiao, Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China, Tel +86-13817100256, Email jingxiao13@Fudan.edu.cnBackground: Serum uric acid (SUA) is suspected to be associated with atherosclerosis and calcium deposition in atherosclerosis is known to related poor prognosis, yet there is no cohort study on the aged in China. We aimed to investigate the relationships between SUA levels and coronary calcium deposition in the middle-aged and elderly populations in China.Methods: A total of 326 participants between the ages of 50 and 85 who had undergone a coronary CT scan in 2015 at the Huadong Hospital Affiliated to Fudan University (Shanghai, China) were included in this study. Univariate and multivariate binary logistic regression was performed to analyze the correlation between SUA levels and coronary artery calcium score (CACS). The changes in CACS during a five-year follow-up were analyzed through Kaplan–Meier survival and binary cox regression analysis. An observational study was done on another 104 asymptomatic middle-aged and elderly patients to compare relative mRNA expressions of proinflammatory factors in peripheral blood mononuclear cells (PBMCs) from 104 subjects.Results: Based on the first year of follow-up data analysis, the elevation of SUA levels (P< 0.001) is an independent risk factor for the increase of CACS after coordinating the confounding factors. According to five-year follow-up data, cox regression analysis proved that SUA was a risk factor for CACS (HR =5.86, P< 0.001). The mRNA expression of IL-6 and CXCL8 in the HUA and HUA patients with CAC (HUA-CAC) groups was significantly higher than that in the normal control (NC) and coronary calcium deposition (CAC) groups.Conclusion: Taken together, the findings in this study indicate that high SUA levels (P< 0.001) are an independent risk factor for CACS and elevated SUA levels increase the risk of developing coronary calcium deposition among middle-aged and old people in the Chinese population, which may be related to an increase of pro-inflammatory cytokines in the PBMCs.Keywords: serum uric acid, calcium deposition, coronary artery calcium score, monocyte inflammation

Published
2022

27. Antimicrobial Susceptibility Characteristics and Risk Factors Associated with Adult Sepsis in Wenzhou, China

Author

Qu X, Wang S, Qu Y, Wang H, Ye X, Tang L, and Xie Q

Subjects
adult sepsis, drug susceptibility characteristics, risk factors, d-dimer, Infectious and parasitic diseases, RC109-216
Abstract

Xiaoxiao Qu,1,&ast; Shishi Wang,1,&ast; Ying Qu,2 Huiyan Wang,1 Xuanmei Ye,1 Luming Tang,3 Qipeng Xie1 1Department of Clinical Laboratory, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People’s Republic of China; 2Department of Clinical Laboratory, Wenzhou People’s Hospital, The Third Affiliated Hospital of Shanghai University, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People’s Republic of China; 3Emergency Department, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qipeng Xie, Department of Clinical Laboratory, The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, People’s Republic of China, Tel +86 151 577 87159, Email pandon2002@163.comPurpose: To clarify the distribution of pathogenic bacteria by analyzing the bacterial susceptibility characteristics and risk factors for adult sepsis in The Wenzhou city, Zhejiang province, China, and to aid early diagnosis, monitoring, and prognosis prediction in cases of bacterial sepsis.Patients and Methods: We retrospectively analyzed 329 patients with sepsis admitted to the Second Affiliated Hospital of Wenzhou Medical University between January 2018 and March 2021. Laboratory data were collected before and after treatment; moreover, the bacterial susceptibility characteristics and risk factors for sepsis were comprehensively analyzed using the Sequential Organ Failure Assessment (SOFA) score.Results: The SOFA score was negatively correlated with the prognosis (P < 0.05). We isolated 47 pathogenic strains from blood culture samples, including 29 gram-positive strains, 18 gram-negative strains. The most common gram-negative pathogens in blood cultures are Klebsiella pneumoniae and Escherichia coli, while the most common gram-positive pathogens are Staphylococcus aureus and Staphylococcus hominis. Gram-negative pathogens had resistance rates of 77% and 62.5% to ciprofloxacin and ceftriaxone, respectively. Gram-positive bacteria had a high resistance to penicillin at 100%. Prognostic factors for sepsis included patients’ consciousness, SOFA score, prothrombin time, international normalized ratio, fibrinogen, D-dimer, and aspartate aminotransferase (P < 0.05). Of these, the D-dimer level could predict the outcome of patients with sepsis (AUC = 0.661, P < 0.05).Conclusion: The pathogens detected in adult sepsis in Wenzhou are mainly Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, and Staphylococcus hominis. The pathogens exhibited differences in drug susceptibility. The optimal antibiotics should be chosen based on the principles of rational use and drug susceptibility. Combined with D-dimer levels, these parameters can be used to determine the optimal strategy for preventing and treating pathogenic bacteria.Keywords: adult sepsis, drug susceptibility characteristics, risk factors, D-dimer

Published
2022

28. Discovery and Characterization of a Pourbaix-Stable, 1.8 eV Direct Gap Bismuth Manganate Photoanode

Author

Newhouse, PF, Reyes-Lillo, SE, Li, G, Zhou, L, Shinde, A, Guevarra, D, Suram, SK, Soedarmadji, E, Richter, MH, Qu, X, Persson, K, Neaton, JB, and Gregoire, JM

Subjects
Materials, Chemical Sciences, Engineering
Abstract

Solar-driven oxygen evolution is a critical technology for renewably synthesizing hydrogen- and carbon-containing fuels in solar fuel generators. New photoanode materials are needed to meet efficiency and stability requirements, motivating materials explorations for semiconductors with (i) band-gap energy in the visible spectrum and (ii) stable operation in aqueous electrolyte at the electrochemical potential needed to evolve oxygen from water. Motivated by the oxygen evolution competency of many Mn-based oxides, the existence of several Bi-containing ternary oxide photoanode materials, and the variety of known oxide materials combining these elements with Sm, we explore the Bi-Mn-Sm oxide system for new photoanodes. Through the use of a ferri/ferrocyanide redox couple in high-throughput screening, BiMn2O5 and its alloy with Sm are identified as photoanode materials with a near-ideal optical band gap of 1.8 eV. Using density functional theory-based calculations of the mullite Bi3+Mn3+Mn4+O5 phase, we identify electronic analogues to the well-known BiVO4 photoanode and demonstrate excellent Pourbaix stability above the oxygen evolution Nernstian potential from pH 4.5 to 15. Our suite of experimental and computational characterization indicates that BiMn2O5 is a complex oxide with the necessary optical and chemical properties to be an efficient, stable solar fuel photoanode.

Published
2017

29. Computational Design of New Magnesium Electrolytes with Improved Properties

Author

Qu, X, Zhang, Y, Rajput, NN, Jain, A, Maginn, E, and Persson, KA

Subjects
Chemical Sciences, Engineering, Technology, Physical Chemistry
Abstract

In this work, we use computational design to examine 15 new electrolyte salt anions by performing chemical variations and mutations on the bis(trifluoromethane)sulfonamide (TFSI) anion. On the basis of our calculations, we propose two new anions as potential candidates for magnesium energy-storage systems, which are evolved from TFSI with the substitution of sulfur atoms in TFSI and the modification of functional groups. The applicability of these new anion salts is examined through comprehensive calculations using both first-principles as well as benchmarked classical molecular dynamics. We elucidate the important properties of these anions, including the electrochemical stability window, chemical decomposition, preferred solvation structure, diffusion coefficient, and other dynamical properties for 15 rationally designed molecules. Two of the designed anions are found to successfully avoid the vulnerability of TFSI during ion-pair charge-transfer reactions while retaining comparable or better performance of other properties. As such, our work provides, to our knowledge, the first theoretically designed electrolyte salt for contemporary multivalent batteries and provides guidance for the synthesis and testing of novel liquid electrochemical systems. (Figure Presented).

Published
2017

38. Evaluation of sulfur spinel compounds for multivalent battery cathode applications

Author

Liu, M, Jain, A, Rong, Z, Qu, X, Canepa, P, Malik, R, Ceder, G, and Persson, KA

Subjects
Energy
Abstract

The rapid growth of portable consumer electronics and electric vehicles demands new battery technologies with greater energy stored at a reduced cost. Energy storage solutions based on multivalent metals, such as Mg, could significantly increase the energy density as compared to lithium-ion based technology. In this paper, we employ density functional theory calculations to systematically evaluate the performance, such as thermodynamic stability, ion diffusivity and voltage, of a group of 3d transition-metal sulfur-spinel compounds (21 in total) for multivalent cathode applications. Based on our calculations, Cr2S4, Ti2S4 and Mn2S4 spinel compounds exhibit improved Mg2+ mobility (diffusion activation energy

Published
2016

39. Hsa-miR-149-5p Suppresses Prostate Carcinoma Malignancy by Suppressing RGS17

Author

Ma J, Wei H, Li X, and Qu X

Subjects
mir-149-5p, prostate carcinoma (pca), rgs17, malignancy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Jinhua Ma, Hongbing Wei, Xianlin Li, Xi Qu Department of Urinary Surgery, The Third People’s Hospital of Hubei Province, Wuhan, Hubei, 430030, People’s Republic of ChinaCorrespondence: Xi QuDepartment of Urinary Surgery, The Third People’s Hospital of Hubei Province, No. 26 Zhongshan Road, Wuhan, Hubei, 430030, People’s Republic of ChinaTel +86 13476046068Email sunl1347@163.comBackground: MicroRNAs (miRNAs) are key players in the progression of human cancers. While several miRNAs have been reported to regulate the development of tumors, the molecular mechanisms and roles of miR-149-5p in prostate carcinoma (PCa) remain unclear. Our aim was to investigate the interaction and functions of miR-149-5p and RGS17 in PCa.Methods: Microarray analysis was performed to identify the key miRNA and gene involved in PCa progression. The expression levels of miRNA and mRNA in PCa tissues and cells were verified by qRT-PCR. MTT assay, BrdU proliferation assay and wound-healing assay were applied to assess the effect of miR-149-5p and RGS17 on PCa cells’ viability, proliferation, and migration ability. The association between RGS17 and miR-149-5p was identify using dual-luciferase reporter assay and Western blot assay.Results: Data analysis indicated the reduction of miR-149-5p expression in PCa tissues and cells. Experimental investigations also showed that this miRNA suppressed the viability, proliferation and migration ability of PCa cells. RGS17 was found to be the target of miR-149-5p, and the low expression of miR-149-5p upregulated RGS17 in PCa tissues and cells. The results of the cell-function assays showed that RGS17 acted as an oncogene in PCa even though its promotive effect could be reversed by miR-149-5p.Conclusion: This research confirmed that by targeting and inhibiting RGS17, miR-149-5p could suppress PCa development.Keywords: miR-149-5p, prostate carcinoma, PCa, RGS17, malignancy

Published
2021

40. Evaluating the Performance of p16INK4a Immunocytochemistry in Cervical Cancer Screening

Author

Song F, Du H, Xiao A, Wang C, Huang X, Yan P, Liu Z, Qu X, Belinson JL, and Wu R

Subjects
cervical intraepithelial neoplasia, human papillomavirus, p16, immunochemical staining, cervical cancer screening, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Fangbin Song,1,2 Hui Du,1,2 Aimin Xiao,1,2 Chun Wang,1,2 Xia Huang,1,2 Peisha Yan,1,2 Zhihong Liu,1,2 Xinfeng Qu,3 Jerome L Belinson,4,5 Ruifang Wu1,2 1Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, People’s Republic of China; 2Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecological Diseases, Shenzhen, People’s Republic of China; 3Sanming Project of Medicine in Shenzhen, Peking University Shenzhen Hospital, Shenzen, People’s Republic of China; 4Preventive Oncology International, Inc., Cleveland Heights, OH, USA; 5Gynecologic Oncology Division, Women’s Health Institute, Cleveland Clinic, Cleveland, OH,USACorrespondence: Ruifang Wu; Hui DuDepartment of Obstetrics and Gynecology, Peking University Shenzhen Hospital, No. 1120 Lianhua Road, Shenzhen, Guangdong 518036, People’s Republic of ChinaEmail wurfpush@126.com; duhui_107108@163.comPurpose: When used for cervical cancer primary screening, liquid-based cytology (LBC) has a high specificity but a low sensitivity. For histological diagnosis of high-grade lesions, p16INK4a immunostaining has proven to be useful. Therefore, our objective was to evaluate the use of p16INK4a immuno-cytology as a primary screen and a secondary screen after primary high-risk human papillomavirus (hrHPV) screening or LBC screening.Methods: A total of 1197 cytology slides were immuno-stained using automatic p16INK4a staining system (PathCIN®p16INK4a) in two studies from cervical screening programs. In the primary screening study, 875 slides were randomly selected and analyzed for p16INK4a. In the secondary screening study, 322 of the remaining slides were chosen by virtue of being HPV 16/18+, other hrHPV+/LBC≥ASC-US, or HPV-negative/LBC ≥LSIL. The sensitivity and specificity for detection of cervical intraepithelial neoplasia 2/3 or worse (CIN2+/CIN3+) were compared based on p16INK4a, LBC and HPV test results.Results: In combining two studies, there were 431 cases with biopsy pathology. They included 83 cases with CIN2+ and 41 cases with CIN3+. The p16 positivity rate increased with pathologic and cytologic severity (P< 0.0001). For primary screening: p16 immuno-cytology was more specific than HPV testing and was similar in sensitivity. Also, p16 immuno-cytology compared favorably with routine LBC (≥ASC-US or ≥LSIL) in sensitivity and specificity. For secondary screening: after LBC screening, “Triaging ASC-US with p16” gave a higher specificity and a similar sensitivity as compared to the “Triaging ASC-US with hrHPV” algorithm. After HPV primary screening, p16 immuno-cytology was more specific than LBC (≥ASC-US); the calculated colposcopy referral rate was also decreased by using p16 immuno-cytology as triage. Triage of “HPV16/18 and p16” had higher specificity and similar sensitivity as compared to triage of “HPV16/18 and LBC ≥ASC-US”.Conclusion: For primary screening, p16INK4a immuno-cytology compares favorably to routine LBC and HPV testing. p16INK4a immunostaining could be an efficient triage to reduce the colposcopy referral rate after primary hrHPV screening or LBC screening. Therefore, p16INK4a immuno-cytology may be applicable as a favorable technology for cervical cancer screening.Keywords: cervical intraepithelial neoplasia, human papillomavirus, p16, immunochemical staining, cervical cancer screening

Published
2020

41. Plasmid-Encoded blaNDM-5 Gene That Confers High-Level Carbapenem Resistance in Salmonella Typhimurium of Pork Origin

Author

Gao Y, Wen J, Wang S, Xu X, Zhan Z, Chen Z, Bai J, Qu X, Zhang H, Zhang J, and Liao M

Subjects
carbapenem resistance, transferable, multiple drug-resistant, food, public health, Infectious and parasitic diseases, RC109-216
Abstract

Yuan Gao,1 Junping Wen,1 Shaojun Wang,1 Xuebin Xu,2 Zeqiang Zhan,1 Zhengquan Chen,1 Jie Bai,1 Xiaoyun Qu,1 Hongxia Zhang,1 Jianmin Zhang,1 Ming Liao1 1National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, Guangdong Laboratory for Lingnan Modern Agriculture, Key Laboratory of Zoonoses, Ministry of Agriculture, Key Laboratory of Animal Vaccine Development, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, People’s Republic of China; 2Department of Microbiology, Shanghai Municipal Centre for Disease Control and Prevention, Shanghai, People’s Republic of ChinaCorrespondence: Ming Liao; Jianmin ZhangNational and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, Guangdong Laboratory for Lingnan Modern Agriculture, Key Laboratory of Zoonoses, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, No. 483 Wushan Road, Tianhe District, Guangzhou 510642, Guangdong, People’s Republic of ChinaTel +86 020 85290240; +86 020 85280240Fax +86 020 85290240; +86 020 85285282Email mliao@scau.edu.cn; junfeng-v@163.comPurpose: Carbapenem resistance is rarely reported in Salmonella Typhimurium, especially from a food origin. Here, we report a plasmid-mediated mobile carbapenem-resistant blaNDM-5 gene in Salmonella Typhimurium isolated from pork in Shanghai, China in 2016.Patients and Methods: In July 2016, the S. Typhimurium SH160 strain was recovered from minced pork meat purchased from a supermarket in Yangpu District, Shanghai, China. Antimicrobial susceptibility testing, multi-locus sequence typing, conjugation, S1-PFGE, southern hybridization, whole-genome sequencing and data analysis were performed.Results: This isolate was found to be a ST34 strain and resistant to carbapenems, cephalosporins, and most other commonly used antibiotics. The blaNDM-5 gene was harbored by a 46161-bp IncX3 plasmid which was found to be transferable. The IncX3 plasmid contains a composite cassette, consisting of ISSwil-IS3000-ΔISAba125-IS5-blaNDM-5-bleMBL-trpF-dsbC-IS26-ctuA1-ΔumuD. In addition, this strain was found to harbor an additional 161706-bp IncHI2 plasmid which carries nine resistant genes, such as aadA1, aadA3, aph(3ʹ)-la, sul1, sul2, sul3, floR, cmlA and dfrA12.Conclusion: We reported the S. Typhimurium with transferable IncX3 plasmid harboring blaNDM-5 gene from minced pork. We characterized the complete genetic features of the plasmid, which demonstrated the potential for spreading in different bacterial pathogens. Therefore, extensive surveillance and monitoring for carbapenem-resistant bacterium in the food chain and public health are urgently required.Keywords: S. Typhimurium, pork, blaNDM-5, public health

Published
2020

42. Surface Engineering of Metal–Organic Framework as pH-/NIR-Responsive Nanocarrier for Imaging-Guided Chemo-Photothermal Therapy

Author

Guo H, Xia Y, Feng K, Qu X, Zhang C, and Wan F

Subjects
zeolitic imidazolate frameworks-8, ph/nir responsive, chemo-photothermal therapy, dual-modal imaging, Medicine (General), R5-920
Abstract

Haibin Guo,* Yanqing Xia,* Ke Feng, Xiaowei Qu, Cuilian Zhang, Feng Wan Henan Provincial People’s Hospital, Henan Provincial Reproductive Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University, Zhengzhou, Henan 450003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Wan; Cuilian ZhangHenan Provincial People’s Hospital, Henan Provincial Reproductive Hospital, People’s Hospital of Zhengzhou University, People’s Hospital of Henan University, Zhengzhou, Henan 450003, People’s Republic of ChinaTel +86 371 87160762Email fengwanscholar@163.com; zhangcuilian@henu.edu.cnBackground: Metal–organic frameworks (MOFs) have attracted intensive research interest in the biomedical field because of their unique properties. However, in order to realize the high loading capacity and therapeutic efficacy, it is still urgent to develop a multifunctional MOFs-based nanoplatform.Materials and Methods: Herein, a pH/near-infrared (NIR) dual-responsive drug delivery system based on zeolitic imidazolate framework-8 (ZIF-8) is constructed for synergistic chemo-photothermal therapy and dual-modal magnetic resonance (MR)/photoacoustic (PA) imaging. The doxorubicin hydrochloride (DOX) is embedded into ZIF-8 through one-pot method, and the resultant ZIF-8/DOX is then successively modified with polydopamine, Mn ions and poly(ethylene glycol). The obtained ZIF-8/DMPP is systematically characterized, and both its in vitro and in vivo biological effects are evaluated in detail.Results: The ZIF-8/DMPP possesses a high drug-loading content of 18.9% and displays appropriate size and morphology. The pH-dependent degradation and drug release behavior of prepared ZIF-8/DMPP are confirmed. Importantly, the results demonstrate that the photothermal effect of ZIF-8/DMPP under NIR laser irradiation can significantly accelerate its drug releasing rate, further improving the intracellular drug concentrations. Thereafter, the augmented chemotherapeutic efficiency by photothermal effect against cancer cells is verified both in vitro and in vivo. Besides, the favorable MR and PA imaging capacity of ZIF-8/DMPP is also evidenced on the tumor model.Conclusion: Taken together, the surface engineering of ZIF-8-based nanocarrier in this work offers a promising strategy for the multifunctional MOFs-based drug delivery system.Keywords: zeolitic imidazolate framework-8, pH/NIR responsive, chemo-photothermal therapy, dual-modal imaging

Published
2020

43. Systemic Inflammatory Response Markers Associated with Infertility and Endometrioma or Uterine Leiomyoma in Endometriosis

Author

Jing X, Li C, Sun J, Peng J, Dou Y, Xu X, Ma C, Dong Z, Liu Y, Zhang H, Shao Q, Wang L, Zhang Y, and Qu X

Subjects
endometriosis, endometrioma, uterine leiomyoma, infertility, nlr, plr, ca125, Therapeutics. Pharmacology, RM1-950
Abstract

Xuanxuan Jing,1,* Chen Li,1,2,* Jintang Sun,1 Jin Peng,3 Yu Dou,4 Xiaofei Xu,3 Chao Ma,1 Zhaogang Dong,5 Yanguo Liu,6 Hui Zhang,3 Qianqian Shao,1 Hui Zhang,7 Lijie Wang,3 Yun Zhang,1 Xun Qu1 1Institute of Basic Medical Sciences, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, Shandong 250012, People’s Republic China; 2Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan 250012, Shandong, People’s Republic of China; 3Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, People’s Republic of China; 4Department of Stomatology and Institute of Stomatology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, People’s Republic China; 5Department of Clinical Laboratory, Qilu Hospital of Shandong University, Jinan, Shandong 250012, People’s Republic China; 6Department of Medical Oncology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, People’s Republic of China; 7Department of Pathology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xun Qu; Lijie Wang Email quxun@sdu.edu.cn; wangljie@hotmail.comPurpose: The aim of this study was to find the most useful marker of endometriosis-related infertility and evaluate predictive and diagnostic values of systemic inflammatory response markers (preoperative white blood–cell subtypes, neutrophil:lymphocyte ratio [NLR], platelet:lymphocyte ratio [PLR], and monocyte:lymphocyte ratio [MLR]) and CA125 levels in endometriosis patients.Methods: This study comprised 662 women who had undergone laparoscopic surgery and been pathologically confirmed as having endometriosis and 83 patients pathologically confirmed with benign ovarian tumors. Related inflammatory factors in endometriosis complicated by infertility were analyzed via logistic regression analysis. Diagnostic values of the inflammatory response markers were obtained by receiver operating–characteristic analysis.Results: We firstly identified that lower NLR level was an independent risk factor of infertility. Serum lymphocytes were significantly higher in endometriosis patients, while serum CA125, NLR, MLR, and PLR were elevated. For differentiating endometriosis from other benign ovarian tumors, the combination of NLR and CA125 achieved greater sensitivity than CA125 alone. In addition, both CA125 and NLR were positively correlated with stage, oviduct adhesion, and diameter of ovarian ectopic cysts.Conclusion: NLR may be used as a simple and easily obtained predictive marker for endometriosis with infertility. Moreover, NLR can be a neoadjuvant biomarker for serum CA125 to diagnose endometriosis.Keywords: endometriosis, endometrioma, uterine leiomyoma, infertility, NLR, PLR, CA125

Published
2020

44. Assessment of Nine Driver Gene Mutations in Surgically Resected Samples from Patients with Non-Small-Cell Lung Cancer

Author

Wang S, Qu X, Cao L, Hu X, Hou K, Liu Y, and Che X

Subjects
drive gene, lung cancer, multi-mutational profiling, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Shuo Wang,1– 3 Xiujuan Qu,1– 3 Lili Cao,1– 3 Xuejun Hu,4 Kezuo Hou,1– 3 Yunpeng Liu,1– 3 Xiaofang Che1– 3 1Department of Medical Oncology, The First Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 2Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang 110001, People’s Republic of China; 3Liaoning Province Clinical Research Center for Cancer, Shenyang 110001, People’s Republic of China; 4Department of Respiratory Medicine, The First Hospital of China Medical University, Shenyang 110001, People’s Republic of ChinaCorrespondence: Xiaofang Che; Xiujuan Qu Email xfche@cmu.edu.cn; xiujuanqu@yahoo.comBackground: The mutational profile of oncogenic driver genes play an important role in non-small-cell lung cancer (NSCLC). The need of a testing panel capable of comprehensively determining patient genotypes in limited amounts of material has increased since the recent association of nine core oncogenic driver genes as tumor predictive biomarkers.Methods: Surgically resected samples from 214 NSCLC patients (168 patients with adenocarcinomas and 46 with squamous cell cancers) were included. A multiplexed PCR-based assay was developed to simultaneously test 118 hotspot mutations and fusions in nine driver genes.Results: The sensitivity of the kit was 1% for gene mutation and 450 copies for gene fusion. Genetic alterations were detected in 143 (66.8%) patients by the assay. The three most common alterations identified were EGFR mutations (50.9%), KRAS mutations (8.4%) and ALK fusions (4.7%). Eight (3.7%) patients harbored concurrent mutations, and the most common partners were EGFR mutations which were observed in the eight patients. No associations between survival and EGFR, KRAS, and ALK status were observed. Patients with two or more alterations exhibited shorter DFS compared to those with single mutations (P=0.032), whilst had no significant difference in OS (P=0.245). However, only TNM stage was an independent predictor of OS (HR=2.905, P< 0.001) as well as DFS (HR=2.114, P< 0.001) in our cohort in multivariate analysis. Furthermore, patients with the L858R mutation had longer DFS (P=0.014) compared to other sensitizing mutations and tended to have better OS but the differences were not significant (P=0.06).Conclusion: These findings suggest this multiplex gene panel testing technique can be efficiently used to detect nine driver genes in a limited number of specimens. This methodology would have the potential to save both specimens and time compared to the combination of all assays by other methods.Keywords: drive gene, lung cancer, multi-mutational profiling, prognosis

Published
2020

45. Fireworks: A dynamic workflow system designed for highthroughput applications

Author

Jain, A, Ong, SP, Chen, W, Medasani, B, Qu, X, Kocher, M, Brafman, M, Petretto, G, Rignanese, GM, Hautier, G, Gunter, D, and Persson, KA

Subjects
scientific workflows, high-throughput computing, fault-tolerant computing, Distributed Computing, Artificial Intelligence and Image Processing, Computer Software
Abstract

This paper introduces FireWorks, a workflow software for running high-throughput calculation workflows at supercomputing centers. FireWorks has been used to complete over 50 million CPU-hours worth of computational chemistry and materials science calculations at the National Energy Research Supercomputing Center. It has been designed to serve the demanding high-throughput computing needs of these applications, with extensive support for (i) concurrent execution through job packing, (ii) failure detection and correction, (iii) provenance and reporting for long-running projects, (iv) automated duplicate detection, and (v) dynamic workflows (i.e., modifying the workflow graph during runtime). We have found that these features are highly relevant to enabling modern data-driven and high-throughput science applications, and we discuss our implementation strategy that rests on Python and NoSQL databases (MongoDB). Finally, we present performance data and limitations of our approach along with planned future work.

Published
2015

46. Supramolecular Perylene Bisimide-Polysulfide Gel Networks as Nanostructured Redox Mediators in Dissolved Polysulfide Lithium-Sulfur Batteries

Author

Frischmann, PD, Gerber, LCH, Doris, SE, Tsai, EY, Fan, FY, Qu, X, Jain, A, Persson, KA, Chiang, YM, and Helms, BA

Subjects
Materials, Chemical Sciences, Engineering
Abstract

Here we report a new redox-active perylene bisimide (PBI)-polysulfide (PS) gel that overcomes electronic charge-transport bottlenecks common to lithium-sulfur (Li-S) hybrid redox flow batteries designed for long-duration grid-scale energy storage applications. PBI was identified as a supramolecular redox mediator for soluble lithium polysulfides from a library of 85 polycyclic aromatic hydrocarbons by using a high-throughput computational platform; furthermore, these theoretical predictions were validated electrochemically. Challenging conventional wisdom, we found that π-stacked PBI assemblies were stable even in their reduced state through secondary interactions between PBI nanofibers and Li2Sn, which resulted in a redox-active, flowable 3-D gel network. The influence of supramolecular charge-transporting PBI-PS gel networks on Li-S battery performance was investigated in depth and revealed enhanced sulfur utilization and rate performance (C/4 and C/8) at a sulfur loading of 4 mg cm-2 and energy density of 44 Wh L-1 in the absence of conductive carbon additives.

Published
2015

47. Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture

Author

Hribar, KC, Finlay, D, Ma, X, Qu, X, Ondeck, MG, Chung, PH, Zanella, F, Engler, AJ, Sheikh, F, Vuori, K, and Chen, SC

Subjects
Cancer, Stem Cell Research, Bioengineering, Cell Culture Techniques, Cell Line, Tumor, Embryoid Bodies, Humans, Hydrogel, Polyethylene Glycol Dimethacrylate, Printing, Three-Dimensional, Spheroids, Cellular, Chemical Sciences, Engineering, Analytical Chemistry
Abstract

Long-term culture and monitoring of individual multicellular spheroids and embryoid bodies (EBs) remains a challenge for in vitro cell propagation. Here, we used a continuous 3D projection printing approach - with an important modification of nonlinear exposure - to generate concave hydrogel microstructures that permit spheroid growth and long-term maintenance, without the need for spheroid transfer. Breast cancer spheroids grown to 10 d in the concave structures showed hypoxic cores and signs of necrosis using immunofluorescent and histochemical staining, key features of the tumor microenvironment in vivo. EBs consisting of induced pluripotent stem cells (iPSCs) grown on the hydrogels demonstrated narrow size distribution and undifferentiated markers at 3 d, followed by signs of differentiation by the presence of cavities and staining of the three germ layers at 10 d. These findings demonstrate a new method for long-term (e.g. beyond spheroid formation at day 2, and with media exchange) 3D cell culture that should be able to assist in cancer spheroid studies as well as embryogenesis and patient-derived disease modeling with iPSC EBs.

Published
2015

48. The Electrolyte Genome project: A big data approach in battery materials discovery

Author

Qu, X, Jain, A, Rajput, NN, Cheng, L, Zhang, Y, Ong, SP, Brafman, M, Maginn, E, Curtiss, LA, and Persson, KA

Subjects
High-throughput, Battery, DFT, Ionization potential, Electron affinity, IP/EA, Dissociation constants, Electrolyte, Materials, Materials Engineering, Condensed Matter Physics, Optical Physics
Abstract

We present a high-throughput infrastructure for the automated calculation of molecular properties with a focus on battery electrolytes. The infrastructure is largely open-source and handles both practical aspects (input file generation, output file parsing, and information management) as well as more complex problems (structure matching, salt complex generation, and failure recovery). Using this infrastructure, we have computed the ionization potential (IP) and electron affinities (EA) of 4830 molecules relevant to battery electrolytes (encompassing almost 55,000 quantum mechanics calculations) at the B3LYP/6-31+G∗level. We describe automated workflows for computing redox potential, dissociation constant, and salt-molecule binding complex structure generation. We present routines for automatic recovery from calculation errors, which brings the failure rate from 9.2% to 0.8% for the QChem DFT code. Automated algorithms to check duplication between two arbitrary molecules and structures are described. We present benchmark data on basis sets and functionals on the G2-97 test set; one finding is that a IP/EA calculation method that combines PBE geometry optimization and B3LYP energy evaluation requires less computational cost and yields nearly identical results as compared to a full B3LYP calculation, and could be suitable for the calculation of large molecules. Our data indicates that among the 8 functionals tested, XYGJ-OS and B3LYP are the two best functionals to predict IP/EA with an RMSE of 0.12 and 0.27 eV, respectively. Application of our automated workflow to a large set of quinoxaline derivative molecules shows that functional group effect and substitution position effect can be separated for IP/EA of quinoxaline derivatives, and the most sensitive position is different for IP and EA.

Published
2015

49. Probe of the Solar Magnetic Field Using the 'Cosmic-Ray Shadow' of the Sun

Author

Amenomori, M., Bi, X. J., Chen, D., Chen, T. L., Chen, W. Y., Cui, S. W., Danzengluobu, Ding, L. K., Feng, C. F., Feng, Zhaoyang, Feng, Z. Y., Gou, Q. B., Guo, Y. Q., Hakamada, K., He, H. H., He, Z. T., Hibino, K., Hotta, N., Hu, Haibing, Hu, H. B., Huang, J., Jia, H. Y., Jiang, L., Kajino, F., Kasahara, K., Katayose, Y., Kato, C., Kawata, K., Labaciren, Le, G. M., Li, A. F., Li, H. J., Li, W. J., Liu, C., Liu, J. S., Liu, M. Y., Lu, H., Meng, X. R., Mizutani, K., Munakata, K., Nanjo, H., Nishizawa, M., Ohnishi, M., Ohta, I., Onuma, H., Ozawa, S., Qian, X. L., Qu, X. B., Saito, T., Saito, T. Y., Sakata, M., Sako, T. K., Shao, J., Shibata, M., Shiomi, A., Shirai, T., Sugimoto, H., Takita, M., Tan, Y. H., Tateyama, N., Torii, S., Tsuchiya, H., Udo, S., Wang, H., Wu, H. R., Xue, L., Yamamoto, Y., Yang, Z., Yasue, S., Yuan, A. F., Yuda, T., Zhai, L. M., Zhang, H. M., Zhang, J. L., Zhang, X. Y., Zhang, Y., Zhang, Yi, Zhang, Ying, Zhaxisangzhu, and Zhou, X. X.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We report on a clear solar-cycle variation of the Sun's shadow in the 10 TeV cosmic-ray flux observed by the Tibet air shower array during a full solar cycle from 1996 to 2009. In order to clarify the physical implications of the observed solar cycle variation, we develop numerical simulations of the Sun's shadow, using the Potential Field Source Surface (PFSS) model and the Current Sheet Source Surface (CSSS) model for the coronal magnetic field. We find that the intensity deficit in the simulated Sun's shadow is very sensitive to the coronal magnetic field structure, and the observed variation of the Sun's shadow is better reproduced by the CSSS model. This is the first successful attempt to evaluate the coronal magnetic field models by using the Sun's shadow observed in the TeV cosmic-ray flux., Comment: 11 pages, 4 figures, accepted for publication in Physical Review Letters

Published
2013
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50. A Monte Carlo study to measure the energy spectra of the primary cosmic-ray components at the knee using a new Tibet AS core detector array

Author

Collaboration, The Tibet Asγ, Amenomori, M., Bi, X. J., Chen, D., Chen, W. Y., Cui, S. W., Danzengluobu, Ding, L. K., Ding, X. H., Feng, C. F., Feng, Zhaoyang, Feng, Z. Y., Gou, Q. B., Guo, H. W., Guo, Y. Q., He, H. H., He, Z. T., Hibino, K., Hotta, N., Hu, Haibing, Hu, H. B., Huang, J., Li, W. J., Jia, H. Y., Jiang, L., Kajino, F., Kasahara, K., Katayose, Y., Kato, C., Kawata, K., Labaciren, Le, G. M., Li, A. F., Liu, C., Liu, J. S., Lu, H., Meng, X. R., Mizutani, K., Munakata, K., Nanjo, H., Nishizawa, M., Ohnishi, M., Ohta, I., Ozawa, S., Qian, X. L., Qu, X. B., Saito, T., Saito, T. Y., Sakata, M., Sako, T. K., Shao, J., Shibata, M., Shiomi, A., Shirai, T., Sugimoto, H., Takita, M., Tan, Y. H., Tateyama, N., Torii, S., Tsuchiya, H., Udo, S., Wang, H., Wu, H. R., Xue, L., Yamamoto, Y., Yang, Z., Yasue, S., Yuan, A. F., Yuda, T., Zhai, L. M., Zhang, H. M., Zhang, J. L., Zhang, X. Y., Zhang, Y., Zhang, Yi, Zhang, Ying, Zhaxisangzhu, and Zhou, X. X.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment
Abstract

A new hybrid experiment has been started by AS{\gamma} experiment at Tibet, China, since August 2011, which consists of a low threshold burst-detector-grid (YAC-II, Yangbajing Air shower Core array), the Tibet air-shower array (Tibet-III) and a large underground water Cherenkov muon detector (MD). In this paper, the capability of the measurement of the chemical components (proton, helium and iron) with use of the (Tibet-III+YAC-II) is investigated by means of an extensive Monte Carlo simulation in which the secondary particles are propagated through the (Tibet-III+YAC-II) array and an artificial neural network (ANN) method is applied for the primary mass separation. Our simulation shows that the new installation is powerful to study the chemical compositions, in particular, to obtain the primary energy spectrum of the major component at the knee., Comment: 4 pages,7 figures,In Proc 32nd Int. Cosmic Ray Conf. Vol.1,157 (2011)

Published
2013

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