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2. Establishment of a New Hyperglycemic Obesity Cardiac Dysfunction Mouse Model with Triacsin C

Author

ZHAO Xiaona, WANG Peng, YE Maoqing, and QU Xinkai

Subjects
animal model, acyl-coa synthetase long-chain family member 1, brown adipose tissue, cardiac dysfunction, mice, Medicine
Abstract

Objective This study aims to establish a novel hyperglycemic obesity mouse model by utilizing Triacsin C, an inhibitor of acyl-CoA synthetase long-chain family member 1 (ACSL1), combined with a high-fat diet, to simulate the changes in adipose tissue and cardiac function observed in patients with obesity-related type 2 diabetes.MethodsTwenty adult SPF-grade male C57BL/6J mice were randomly divided into two groups: the Control group (injected intraperitoneally with citric acid-sodium citrate buffer, Con group) and the TC group (injected intraperitoneally with Triacsin C, TC group). After four consecutive weeks of intraperitoneal injections, both groups were fed high-fat diets. Body weight and glucose tolerance of the mice were assessed every eight weeks. The models were considered successful if fasting blood glucose exceeded 8 mmol/L or blood glucose was above 15 mmol/L two hours after glucose injection. Cardiac function, including ventricular end-diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), end-diastolic interventricular septal thickness (EDIVS), left ventricular ejection fraction (LVEF), and left ventricular short-axis fractional shortening (FS), was measured by echocardiography. HE staining was used to detect the changes in epididymal white adipose tissue (WAT) and brown adipose tissue (BAT). Immunofluorescence technology was used to analyze changes in CD31 and UCP1 in BAT. ACSL1 expression in myocardial tissue was tested by Western blotting.ResultsThe fasting blood glucose levels were (8.14±1.43) mmol/L in the Con group and (8.18±0.85) mmol/L in the TC group (P>0.05) , and the 2-hour postprandial blood glucose levels were (19.8±4.01) mmol/L in the Con group and (22.60±3.97) mmol/L in the TC group (P

Published
2024
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9. Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): a multicentre, randomised, sham-controlled trial

Author

Xu, Bo, Tu, Shengxian, Song, Lei, Jin, Zening, Yu, Bo, Fu, Guosheng, Zhou, Yujie, Wang, Jian’an, Chen, Yundai, Pu, Jun, Chen, Lianglong, Qu, Xinkai, Yang, Junqing, Liu, Xuebo, Guo, Lijun, Shen, Chengxing, Zhang, Yaojun, Zhang, Qi, Pan, Hongwei, Fu, Xiaogang, Liu, Jian, Zhao, Yanyan, Escaned, Javier, Wang, Yang, Fearon, William F, Dou, Kefei, Kirtane, Ajay J, Wu, Yongjian, Serruys, Patrick W, Yang, Weixian, Wijns, William, Guan, Changdong, Leon, Martin B, Qiao, Shubin, and Stone, Gregg W

Published
2021
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11. Morphological Changes of Peri-Coronary Adipose Tissue Together with Elevated NLR in Acute Myocardial Infarction Patients in-Hospital

Author

Qi,Lin, Li,Yanglei, Kong,Chengqi, Li,Siqi, Wang,Qinyue, Pan,Hanqin, Zhang,Shuyi, Qu,Xinkai, Li,Ming, Li,Mingxuan, Shi,Kailei, Qi,Lin, Li,Yanglei, Kong,Chengqi, Li,Siqi, Wang,Qinyue, Pan,Hanqin, Zhang,Shuyi, Qu,Xinkai, Li,Ming, Li,Mingxuan, and Shi,Kailei

Abstract

Lin Qi,1,* Yanglei Li,2,* Chengqi Kong,2,* Siqi Li,2 Qinyue Wang,2 Hanqin Pan,2 Shuyi Zhang,3 Xinkai Qu,2 Ming Li,1 Mingxuan Li,2,4 Kailei Shi2 1Department of Computed Tomography, Huadong Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China; 2Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China; 3Department of Cardiac Care Unit, Tongren Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 4Department of Cardiology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Kailei Shi; Mingxuan Li, Email shikailei@fudan.edu.cn; 19211280015@fudan.edu.cnBackground: Inflammation triggers atherosclerotic plaque rupture, leading to acute myocardial infarction (AMI). Following AMI, peri-coronary adipose tissue (PCAT) undergoes a transition from lipid-rich to hydrophilic characteristics due to vascular inflammation. This study investigates PCAT changes and neutrophil-to-lymphocyte ratio levels during AMI.Patients and Methods: 60 AMI patients undergoing coronary computed tomography angiography and angiography (Jan 2020-Jun 2022) were studied 60 age, gender, BMI-matched stable angina, and 60 non-coronary artery disease patients were included. Siemens VB20.0 measured PCAT-volume and fat attenuation index (FAI). Neutrophil-to-lymphocyte ratio levels were calculated by peripheral blood tests.Results: The PCAT volume and PCAT-FAI gradually increased across the control, stable angina, and AMI groups, with a corresponding gradual rise in NLR. NLR exhibited weak positive correlation with PCAT-FAI (r=0.35) and PCAT-volume (r=0.24). Multivariable logistic regression identified increased PCAT-volume, PCAT-FAI and neutrophil-to-lymphocyte ratio as possible independent AMI risk factors. No significant PCAT-volume differen

Published
2024

12. Morphological Changes of Peri-Coronary Adipose Tissue Together with Elevated NLR in Acute Myocardial Infarction Patients in-Hospital.

Author

Qi, Lin, Li, Yanglei, Kong, Chengqi, Li, Siqi, Wang, Qinyue, Pan, Hanqin, Zhang, Shuyi, Qu, Xinkai, Li, Ming, Li, Mingxuan, and Shi, Kailei

Subjects
MYOCARDIAL infarction, NEUTROPHIL lymphocyte ratio, ADIPOSE tissues, ARTERIAL diseases, COMPUTED tomography, CARDIOGRAPHIC tomography, ATHEROSCLEROTIC plaque
Abstract

Background: Inflammation triggers atherosclerotic plaque rupture, leading to acute myocardial infarction (AMI). Following AMI, peri-coronary adipose tissue (PCAT) undergoes a transition from lipid-rich to hydrophilic characteristics due to vascular inflammation. This study investigates PCAT changes and neutrophil-to-lymphocyte ratio levels during AMI. Patients and Methods: 60 AMI patients undergoing coronary computed tomography angiography and angiography (Jan 2020-Jun 2022) were studied 60 age, gender, BMI-matched stable angina, and 60 non-coronary artery disease patients were included. Siemens VB20.0 measured PCAT-volume and fat attenuation index (FAI). Neutrophil-to-lymphocyte ratio levels were calculated by peripheral blood tests. Results: The PCAT volume and PCAT-FAI gradually increased across the control, stable angina, and AMI groups, with a corresponding gradual rise in NLR. NLR exhibited weak positive correlation with PCAT-FAI (r=0.35) and PCAT-volume (r=0.24). Multivariable logistic regression identified increased PCAT-volume, PCAT-FAI and neutrophil-to-lymphocyte ratio as possible independent AMI risk factors. No significant PCAT-volume difference was observed between infarct-related artery (IRA) and non-IRA for all three coronary arteries. Only PCAT-FAI around IRA-LAD was higher than non-IRA-LAD (− 74.84± 6.93 HU vs − 79.04± 8.68 HU). PCAT-FAI around culprit vessels in AMI was higher than corresponding lesion related vessel in SA. PCAT-volume around narrowed non-IRA in AMI was higher than that of corresponding LRV in SA. PCAT-FAI of narrowed non-IRA-LADs and non-IRA-LCXs in AMI were elevated compared to LADs (− 78.46± 8.56HU vs − 83.13± 8.34 HU) and LCXs (− 73.83± 10.63 HU vs − 81.38± 7.88 HU) of lesion related vessel in stable angina. Conclusion: We found an association between AMI and inflammation in the coronary perivascular adipose tissue and systemic inflammatory response. [ABSTRACT FROM AUTHOR]

Published
2024
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13. A Comparison of Dynamic SPECT Coronary Flow Reserve with TIMI Frame Count in the Treatment of Non-Obstructive Epicardial Coronary Patients

Author

He, Mingping, primary, Han, Wenzheng, additional, Shi, Chuan, additional, Wang, Ming, additional, Li, Junheng, additional, He, Wei, additional, Xu, Xinxin, additional, Gan, Qian, additional, Guan, Shaofeng, additional, Zhang, Liang, additional, Chen, Yang, additional, Chang, Xifeng, additional, Li, Tianqi, additional, and Qu, Xinkai, additional

Published
2023
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14. Sex Differences in Clinical Outcomes Associated With Quantitative Flow Ratio-Guided Percutaneous Coronary Intervention

Author

Chen, Yundai, primary, Gao, Lei, additional, Vogel, Birgit, additional, Tian, Feng, additional, Jin, Qinhua, additional, Guo, Jun, additional, Sun, Zhijun, additional, Yang, Weixian, additional, Jin, Zening, additional, Yu, Bo, additional, Fu, Guosheng, additional, Pu, Jun, additional, Qu, Xinkai, additional, Zhang, Qi, additional, Zhao, Yanyan, additional, Yu, Lilei, additional, Guan, Changdong, additional, Tu, Shengxian, additional, Qiao, Shubin, additional, Xu, Bo, additional, Mehran, Roxana, additional, and Song, Lei, additional

Published
2023
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16. Relationship between the ratio of red cell distribution width to albumin and 28-day mortality among Chinese patients over 80 years with atrial fibrillation

Author

Chen, Conggai, primary, Cai, Jiasheng, additional, Song, Bin, additional, Zhang, Lingyun, additional, Wang, Wei, additional, Luo, Rong, additional, Zhang, Yi, additional, Ling, Yunhao, additional, Wu, Chuntao, additional, Wang, Zilong, additional, Liu, Haibo, additional, Wu, Yumei, additional, and Qu, Xinkai, additional

Published
2023
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22. A Comparison of Dynamic SPECT Coronary Flow Reserve with TIMI Frame Count in the Treatment of Non-Obstructive Epicardial Coronary Patients

Author

He,Mingping, Han,Wenzheng, Shi,Chuan, Wang,Ming, Li,Junheng, He,Wei, Xu,Xinxin, Gan,Qian, Guan,Shaofeng, Zhang,Liang, Chen,Yang, Chang,Xifeng, Li,Tianqi, Qu,Xinkai, He,Mingping, Han,Wenzheng, Shi,Chuan, Wang,Ming, Li,Junheng, He,Wei, Xu,Xinxin, Gan,Qian, Guan,Shaofeng, Zhang,Liang, Chen,Yang, Chang,Xifeng, Li,Tianqi, and Qu,Xinkai

Abstract

Mingping He,1,&ast; Wenzheng Han,1,&ast; Chuan Shi,1 Ming Wang,1 Junheng Li,2 Wei He,2 Xinxin Xu,3 Qian Gan,1 Shaofeng Guan,1 Liang Zhang,1 Yang Chen,1 Xifeng Chang,1 Tianqi Li,1 Xinkai Qu1 1Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China; 2Department of Nuclear Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China; 3Clinical Research Center for Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wenzheng Han; Xinkai Qu, Department of Cardiology, Huadong Hospital Affiliated to Fudan University, No. 221, Yan’an Road (W), Shanghai, People’s Republic of China, Email wzhan_cardiology@foxmail.com; qxkchest@126.comBackground: Microvascular dysfunction in patients with non-obstructive epicardial coronary may aggravate patient’s symptoms or lead to various clinical events.Objective: To investigate the correlation between dynamic single photon emission computed tomography (D-SPECT) derived coronary flow reserve (CFR) and TIMI frame count (TFC) in patients with non-obstructive epicardial coronary patients.Methods: Patients with suspected or known stable CAD who were recommended to undergo invasive coronary angiography were prospectively enrolled in this study. Those who had non-obstructive coronary received TIMI frame count (TFC) and D-SPECT. A cut-off value of > 40 was defined as slow flow referred to TFC.Results: A total of 47 patients diagnosed with non-obstructive coronary were enrolled. The mean age of patients was 66.09 ± 8.36 years, and 46.8% were male. Dynamic SPECT derived coronary flow reserve (CFR) was significantly correlated with TIMI frame count in 3 epicardial coronary (LAD: r=− 0.506, P = 0.0003; LCX: r= − 0.532, P = 0.0001; RCA: r= − 0.657, P < 0.0001). The sensitivity and specificity of CFR in identi

Published
2023

25. Hourly Ultrafine Particle Exposure and Acute Myocardial Infarction Onset: An Individual-Level Case-Crossover Study in Shanghai, China, 2015–2020

Author

Jiang, Yixuan, primary, Chen, Renjie, additional, Peng, Wenhui, additional, Luo, Yun, additional, Chen, Xiaomin, additional, Jiang, Qianfeng, additional, Han, Bingjiang, additional, Su, Guohai, additional, Duan, Yusen, additional, Huo, Juntao, additional, Qu, Xinkai, additional, Fu, Qingyan, additional, and Kan, Haidong, additional

Published
2023
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26. Cost-Effectiveness of Angiographic Quantitative Flow Ratio-Guided Coronary Intervention: A Multicentre, Randomised, Sham-Controlled Trial

Author

Song, Lei, primary, Zhao, Yanyan, additional, Guan, Changdong, additional, Wang, Yang, additional, Jin, Zening, additional, Yu, Bo, additional, Fu, Guosheng, additional, Chen, Yundai, additional, Guo, Lijun, additional, Qu, Xinkai, additional, Zhang, Yaojun, additional, Dou, Kefei, additional, Wu, Yongjian, additional, Yang, Weixian, additional, Tu, Shengxian, additional, Escaned, Javier, additional, Fearon, William F., additional, Qiao, Shubin, additional, Cohen, David, additional, Krumholz, Harlan, additional, Xu, Bo, additional, and Group, Favor III China Study, additional

Published
2023
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27. Prognostic Nutritional Index Correlates with Adverse Outcomes in Elderly Patients with Acute Myocardial Infarction During Hospitalization: A Single-Center Retrospective Cohort Study in China

Author

Shi, Kailei, primary, Li, Mingxuan, additional, Li, Yanglei, additional, Jiang, Kewei, additional, Li, Siqi, additional, Wang, Qingyue, additional, Cai, Jiasheng, additional, Zhang, Zheng, additional, Wu, Chuntao, additional, Fan, Zhiheng, additional, Sun, Xusen, additional, liu, Haibo, additional, Qu, Xinkai, additional, and Kong, Chengqi, additional

Published
2023
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29. 2-Year Outcomes of Angiographic Quantitative Flow Ratio-Guided Coronary Interventions

Author

Song, Lei, primary, Xu, Bo, additional, Tu, Shengxian, additional, Guan, Changdong, additional, Jin, Zening, additional, Yu, Bo, additional, Fu, Guosheng, additional, Zhou, Yujie, additional, Wang, Jian’an, additional, Chen, Yundai, additional, Pu, Jun, additional, Chen, Lianglong, additional, Qu, Xinkai, additional, Yang, Junqing, additional, Liu, Xuebo, additional, Guo, Lijun, additional, Shen, Chengxing, additional, Zhang, Yaojun, additional, Zhang, Qi, additional, Pan, Hongwei, additional, Zhang, Rui, additional, Liu, Jian, additional, Zhao, Yanyan, additional, Wang, Yang, additional, Dou, Kefei, additional, Kirtane, Ajay J., additional, Wu, Yongjian, additional, Wijns, William, additional, Yang, Weixian, additional, Leon, Martin B., additional, Qiao, Shubin, additional, and Stone, Gregg W., additional

Published
2022
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30. Feasibility of Quantitative Flow Ratio Virtual Stenting for Guidance of Serial Coronary Lesions Intervention

Author

Guan, Shaofeng, primary, Gan, Qian, additional, Han, Wenzheng, additional, Zhai, Xinrong, additional, Wang, Ming, additional, Chen, Yang, additional, Zhang, Liang, additional, Li, Tianqi, additional, Chang, Xifeng, additional, Liu, Hongyuan, additional, Hong, Weilin, additional, Li, Zehang, additional, Tu, Shengxian, additional, and Qu, Xinkai, additional

Published
2022
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31. Coronary Intervention Guided by Quantitative Flow Ratio vs Angiography in Patients With or Without Diabetes

Author

Jin, Zening, primary, Xu, Bo, additional, Yang, Xingsheng, additional, Jia, Ruofei, additional, Meng, Shuai, additional, Hu, Hongyu, additional, Deng, Yue, additional, Cao, Xiaojing, additional, Ruan, Yang, additional, Han, Jing, additional, Liu, Jian, additional, Qu, Xinkai, additional, Zhou, Yujie, additional, Wang, Jian’an, additional, Fu, Guosheng, additional, Yu, Bo, additional, Wang, Yang, additional, Guan, Changdong, additional, Song, Lei, additional, Tu, Shengxian, additional, Qiao, Shubin, additional, and Stone, Gregg W., additional

Published
2022
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38. Diagnostic accuracy of CCTA-derived versus angiography-derived quantitative flow ratio (CAREER) study: a prospective study protocol

Author

Weng, Tingwen, primary, Gan, Qian, additional, Li, Zehang, additional, Guan, Shaofeng, additional, Han, Wenzheng, additional, Zhai, Xinrong, additional, Li, Ming, additional, Qi, Lin, additional, Li, Cheng, additional, Chen, Yang, additional, Zhang, Liang, additional, Chang, Xifeng, additional, Tu, Shengxian, additional, and Qu, Xinkai, additional

Published
2022
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39. High Level of Serum Uric Acid induced Monocyte Inflammation is Related to Coronary Calcium Deposition in the Middle-Aged and Elder Population of China: A five-year Prospective Cohort Study

Author

Wang,Xiaojun, Liu,Xuanqi, Qi,Yiding, Zhang,Shuyi, Shi,Kailei, Lin,Huagang, Grossfeld,Paul, Wang,Wenhao, Wu,Tao, Qu,Xinkai, Xiao,Jing, Ye,Maoqing, Wang,Xiaojun, Liu,Xuanqi, Qi,Yiding, Zhang,Shuyi, Shi,Kailei, Lin,Huagang, Grossfeld,Paul, Wang,Wenhao, Wu,Tao, Qu,Xinkai, Xiao,Jing, and Ye,Maoqing

Abstract

Xiaojun Wang,1,2,&ast; Xuanqi Liu,3,&ast; Yiding Qi,4,&ast; Shuyi Zhang,4 Kailei Shi,4 Huagang Lin,5 Paul Grossfeld,6 Wenhao Wang,1,2 Tao Wu,1,2 Xinkai Qu,4 Jing Xiao,5 Maoqing Ye2,4 1Department of Traditional Chinese Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 2Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 3Department of Respiratory and Critical Care Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 4Department of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 5Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China; 6Division of Cardiology UCSD School of Medicine, Rady Children’s Hospital of San Diego, La Jolla, CA, 92093, USA&ast;These authors contributed equally to this workCorrespondence: Maoqing Ye, Department of Cardiology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China, Tel +86-18930721396, Email yemaoqing@fudan.edu.cn Jing Xiao, Department of Nephrology, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, People’s Republic of China, Tel +86-13817100256, Email jingxiao13@Fudan.edu.cnBackground: Serum uric acid (SUA) is suspected to be associated with atherosclerosis and calcium deposition in atherosclerosis is known to related poor prognosis, yet there is no cohort study on the aged in China. We aimed to investigate the relationships between SUA levels and coronary calcium deposition in the middle-aged and elderly populations in China.Methods: A total of 326 participants between the ages of 50 and 85 who had undergone a coronary CT scan in 2015 at the Huadong Hospital Affi

Published
2022

41. High Level of Serum Uric Acid induced Monocyte Inflammation is Related to Coronary Calcium Deposition in the Middle-Aged and Elder Population of China: A five-year Prospective Cohort Study

Author

Wang, Xiaojun, primary, Liu, Xuanqi, additional, Qi, Yiding, additional, Zhang, Shuyi, additional, Shi, Kailei, additional, Lin, Huagang, additional, Grossfeld, Paul, additional, Wang, Wenhao, additional, Wu, Tao, additional, Qu, Xinkai, additional, Xiao, Jing, additional, and Ye, Maoqing, additional

Published
2022
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42. The SYNTAX score and the coronary artery calcium score for the prediction of clinical outcomes in patients undergoing percutaneous coronary intervention

Author

RONG, Yaocong, primary, LI, Tianqi, additional, CHEN, Yang, additional, LIU, Hongyuan, additional, HONG, Weilin, additional, GUAN, Shaofeng, additional, HAN, Wenzheng, additional, GAN, Qian, additional, ZHANG, Liang, additional, CHANG, Xifeng, additional, KONG, Chengqi, additional, WENG, Tingwen, additional, SHI, Chuan, additional, ZHANG, Youjun, additional, and QU, Xinkai, additional

Published
2022
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45. One-step anatomic and function testing by cardiac CT versus second-line functional testing in symptomatic patients with coronary artery stenosis: head-to-head comparison of CT-derived fractional flow reserve and myocardial perfusion imaging

Author

Westra, Jelmer, primary, Li, Zehang, additional, Rasmussen, Laust Dupont, additional, Winther, Simon, additional, Li, Guanyu, additional, Nissen, Louise, additional, Petersen, Steffen E., additional, Ejlersen, June Anita, additional, Isaksen, Christin, additional, Gormsen, Lars Christian, additional, Urbonaviciene, Grazina, additional, Eftekhari, Ashkan, additional, Weng, Tingwen, additional, Qu, Xinkai, additional, Bøtker, Hans Erik, additional, Christiansen, Evald Høj, additional, Holm, Niels Ramsing, additional, Bøttcher, Morten, additional, and Tu, Shengxian, additional

Published
2021
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49. Resting distal to aortic pressure ratio and fractional flow reserve discordance affects the diagnostic performance of quantitative flow ratio: Results from an individual patient data meta‐analysis

Author

Westra, Jelmer, primary, Eftekhari, Ashkan, additional, Tu, Shengxian, additional, Campo, Gianluca, additional, Escaned, Javier, additional, Winther, Simon, additional, Matsuo, Hitoshi, additional, Qu, Xinkai, additional, Koltowski, Lukasz, additional, Chang, Yunxiao, additional, Liu, Tommy, additional, Yang, Junqing, additional, Andersen, Birgitte Krogsgaard, additional, Wijns, William, additional, Böttcher, Morten, additional, Christiansen, Evald Høj, additional, Xu, Bo, additional, and Holm, Niels Ramsing, additional

Published
2020
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